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Digestive fate of dietary carrageenan: Evidence of interference with digestive proteolysis and disruption of gut epithelial function

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1 of the 56 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1016/j.carbpol.2014.01.067 (notice 2016-10-20).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1096-9896(2000)9999:9999<::aid-path732>3.0.co;2-xopenalex-snapshot
Distribution of the interleukin-8 receptors, CXCR1 and CXCR2, in inflamed gut tissue
inferredcites →https://doi.org/10.1002/mnfr.200900142openalex-snapshot
Comparative resistance of food proteins to adult and infant in vitro digestion models
inferredcites →https://doi.org/10.1002/mnfr.200900608openalex-snapshot
A review on the beneficial aspects of food processing
inferredcites →https://doi.org/10.1007/s10811-007-9252-xopenalex-snapshot
Public health and carrageenan regulation: a review and analysis
inferredcites →https://doi.org/10.1016/0041-008x(76)90134-4openalex-snapshot
Cecal response to different molecular weights and types of carrageenan in the guinea pig
inferredcites →https://doi.org/10.1016/j.autrev.2015.01.009openalex-snapshot
Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease
inferredcites →https://doi.org/10.1016/j.bbadis.2012.05.001openalex-snapshot
Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by activation of an NFκB‐BCL10 loop
inferredcites →https://doi.org/10.1016/j.bbagen.2008.03.019openalex-snapshot
Carrageenan-induced NFκB activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10
inferredcites →https://doi.org/10.1016/j.bpc.2004.09.005openalex-snapshot
Unperturbed dimensions of Carrageenans in different salt solutions
inferredcites →https://doi.org/10.1016/j.carbpol.2009.01.020openalex-snapshot
Carrageenans: Biological properties, chemical modifications and structural analysis – A review
inferredcites →https://doi.org/10.1016/j.carbpol.2014.01.067openalex-snapshot
RETRACTED: Carrageenan: A natural seaweed polysaccharide and its applications
inferredcites →https://doi.org/10.1016/j.fct.2014.12.022openalex-snapshot
An infant formula toxicity and toxicokinetic feeding study on carrageenan in preweaning piglets with special attention to the immune system and gastrointestinal tract
inferredcites →https://doi.org/10.1016/j.fct.2015.01.003openalex-snapshot
The common food additive carrageenan is not a ligand for Toll-Like- Receptor 4 (TLR4) in an HEK293-TLR4 reporter cell-line model
inferredcites →https://doi.org/10.1016/j.fct.2015.11.014openalex-snapshot
Parameters and pitfalls to consider in the conduct of food additive research, Carrageenan as a case study
inferredcites →https://doi.org/10.1016/j.fct.2016.07.006openalex-snapshot
Effects of carrageenan on cell permeability, cytotoxicity, and cytokine gene expression in human intestinal and hepatic cell lines
inferredcites →https://doi.org/10.1016/j.foodhyd.2012.09.013openalex-snapshot
Impact of dietary fibers on the properties and proteolytic digestibility of lactoferrin nano-particles
inferredcites →https://doi.org/10.1016/j.foodhyd.2013.01.017openalex-snapshot
Comparative performance of milk proteins and their emulsions under dynamic in vitro adult and infant gastric digestion
inferredcites →https://doi.org/10.1016/j.idairyj.2015.01.016openalex-snapshot
Dual function peptides from pepsin hydrolysates of whey protein isolate
inferredcites →https://doi.org/10.1016/j.toxlet.2012.04.012openalex-snapshot
Pro-inflammatory NF-κB and early growth response gene 1 regulate epithelial barrier disruption by food additive carrageenan in human intestinal epithelial cells
inferredcites →https://doi.org/10.1016/s0268-005x(96)80040-3openalex-snapshot
In-vitro gastric stability of carrageenan
inferredcites →https://doi.org/10.1016/s0268-005x(97)80016-1openalex-snapshot
Milk protein-carrageenan interactions
inferredcites →https://doi.org/10.1016/s0924-2244(97)01091-1openalex-snapshot
Carrageenan biotechnology
inferredcites →https://doi.org/10.1016/s1046-2023(03)00029-xopenalex-snapshot
Functional analysis of tight junctions
inferredcites →https://doi.org/10.1021/jf048174dopenalex-snapshot
Angiotensin I Converting Enzyme Inhibitory Peptides from In Vitro Pepsin−Pancreatin Digestion of Soy Protein
inferredcites →https://doi.org/10.1023/b:pham.0000012150.60180.e3openalex-snapshot
Effect of Chitosan on Epithelial Cell Tight Junctions
inferredcites →https://doi.org/10.1038/218770a0openalex-snapshot
Macroanionic Inhibition of Peptic Activity by High and Low Molecular Weight Macroanions
inferredcites →https://doi.org/10.1038/361552a0openalex-snapshot
Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctions
inferredcites →https://doi.org/10.1038/ajg.2013.46openalex-snapshot
An Altered Gut Microbiome Profile in a Child Affected by Crohn's Disease Normalized After Nutritional Therapy
inferredcites →https://doi.org/10.1038/nrm1055openalex-snapshot
Signalling to and from tight junctions
inferredcites →https://doi.org/10.1039/c3fo60702jopenalex-snapshot
A standardised static in vitro digestion method suitable for food – an international consensus
inferredcites →https://doi.org/10.1039/c4fo01165aopenalex-snapshot
Antioxidant activity of bovine alpha lactalbumin Maillard products and evaluation of their in vitro gastro-duodenal digestive proteolysis
inferredcites →https://doi.org/10.1074/jbc.273.45.29745openalex-snapshot
The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton
inferredcites →https://doi.org/10.1074/jbc.m708833200openalex-snapshot
Toll-like Receptor 4 Mediates Induction of the Bcl10-NFκB-Interleukin-8 Inflammatory Pathway by Carrageenan in Human Intestinal Epithelial Cells
inferredcites →https://doi.org/10.1080/10408399609527719openalex-snapshot
Carrageenans and their use in meat products
inferredcites →https://doi.org/10.1080/20024091064282openalex-snapshot
A Critical Review of the Toxicological Effects of Carrageenan and Processed Eucheuma Seaweed on the Gastrointestinal Tract
inferredcites →https://doi.org/10.1093/jn/138.3.469openalex-snapshot
Carrageenan Induces Cell Cycle Arrest in Human Intestinal Epithelial Cells in Vitro3
inferredcites →https://doi.org/10.1097/mib.0000000000000268openalex-snapshot
Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohnʼs Disease in Koreans
inferredcites →https://doi.org/10.1097/mib.0000000000000384openalex-snapshot
Monocyte and M1 Macrophage-induced Barrier Defect Contributes to Chronic Intestinal Inflammation in IBD
inferredcites →https://doi.org/10.1097/mib.0b013e3182802accopenalex-snapshot
Effects of Enteral Nutrition on Crohn’s Disease
inferredcites →https://doi.org/10.1111/j.1365-2621.2004.tb10698.xopenalex-snapshot
Selective Proteolysis of the Glycinin and β‐Conglycinin Fractions in a Soy Protein Isolate by Pepsin and Papain with Controlled pH and Temperature
inferredcites →https://doi.org/10.1111/j.1365-2672.1996.tb03230.xopenalex-snapshot
Digestive fates of soluble polysaccharides from marine macroalgae: involvement of the colonic microflora and physiological consequences for the host
inferredcites →https://doi.org/10.1111/j.1749-6632.2009.04056.xopenalex-snapshot
Roles of ZO‐1 and ZO‐2 in Establishment of the Belt‐like Adherens and Tight Junctions with Paracellular Permselective Barrier Function
inferredcites →https://doi.org/10.1111/j.1750-3841.2011.02455.xopenalex-snapshot
Food Protein‐Derived Bioactive Peptides: Production, Processing, and Potential Health Benefits
inferredcites →https://doi.org/10.1111/j.2042-7158.1967.tb08023.xopenalex-snapshot
Carrageenans and the proteolytic activity of human gastric secretion
inferredcites →https://doi.org/10.1111/j.2042-7158.1967.tb08110.xopenalex-snapshot
Degraded and undegraded carrageenans and antipeptic activity
inferredcites →https://doi.org/10.1152/ajpgi.00380.2006openalex-snapshot
Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells
inferredcites →https://doi.org/10.1289/ehp.01109983openalex-snapshot
Review of Harmful Gastrointestinal Effects of Carrageenan in Animal Experiments
inferredcites →https://doi.org/10.1371/journal.pone.0008666openalex-snapshot
Degraded Carrageenan Causing Colitis in Rats Induces TNF Secretion and ICAM-1 Upregulation in Monocytes through NF-κB Activation
inferredcites →https://doi.org/10.2741/3888openalex-snapshot
Molecular regulation of the intestinal epithelial barrier: implication in human diseases
inferredcites →https://doi.org/10.3109/10408444.2013.861797openalex-snapshot
Food additive carrageenan: Part I: A critical review of carrageenanin vitrostudies, potential pitfalls, and implications for human health and safety
inferredcites →https://doi.org/10.3109/10408444.2013.861798openalex-snapshot
Food additive carrageenan: Part II: A critical review of carrageenanin vivosafety studies
inferredcites →https://doi.org/10.3168/jds.2009-2566openalex-snapshot
Invited review: Physiological properties of bioactive peptides obtained from whey proteins
inferredcites →https://doi.org/10.3181/00379727-214-44093openalex-snapshot
The Influence of Culture Time and Passage Number on the Morphological and Physiological Development of Caco-2 Cells
inferredcites →https://doi.org/10.3382/ps.2008-00485openalex-snapshot
Effect of different concentrations of calcium chloride and potassium chloride on egg white proteins during isoelectric precipitation of ovomucin
inferredcites →https://doi.org/10.3390/nu7031565openalex-snapshot
Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity
inferredcites →https://doi.org/10.3892/mmr.2013.1726openalex-snapshot
κ-carrageenan induces the disruption of intestinal epithelial Caco-2 monolayers by promoting the interaction between intestinal epithelial cells and immune cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths ? (a Review)
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In vitro digestion models for the design of safe and nutritious foods
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Insight on structure-property relationships of carrageenan from marine red algal: A review
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How does carrageenan cause colitis? A review
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Toward sustainable, smart, and multifunctional Carrageenan bio(nano)composites: Mechanistic insights, physicochemical properties, biomedical interfaces, and AI-driven design perspectives
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The effect of corn starch and Kappa-Carrageenan probiotic encapsulation on growth and immune response in Chinook salmon (Oncorhynchus tshawytscha)
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Food additives and their implication in inflammatory bowel disease and metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.crfs.2026.101418openalex-snapshot
High-sugar and carrageenan-containing diets synergistically impair the intestinal mucosal barrier through the gut microbiota: in vitro and in vivo studies
inferred← citeshttps://doi.org/10.1016/j.fbio.2025.105831openalex-snapshot
Microbiome mediated impact of food grade carrageenan on the intestinal barrier function
inferred← citeshttps://doi.org/10.1016/j.fbio.2026.109927openalex-snapshot
Gut bacterial degradation of food-grade iota-carrageenan enhances its pro-inflammatory activity
inferred← citeshttps://doi.org/10.1016/j.fct.2017.06.022openalex-snapshot
Addendum to Weiner, M.L. (2016) Parameters and Pitfalls to Consider in the Conduct of Food Additive Research, Carrageenan as a Case Study. Food Chemical Toxicology 87, 31-44.
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Improving the bioavailability of oil-soluble vitamins by optimizing food matrix effects: A review
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Preparation and evaluation of licochalcone A - integrated casein-pectin nanodelivery system: Insights into its gastrointestinal digestibility and bioavailability
inferred← citeshttps://doi.org/10.1016/j.foodhyd.2022.107553openalex-snapshot
Physicochemical dynamic changes and differences of κ-carrageenan in different vehicles (aqueous and casein solution) during in vitro gastrointestinal digestion
inferred← citeshttps://doi.org/10.1016/j.foodhyd.2022.107850openalex-snapshot
An in vitro digestion model accounting for sex differences in gastro-intestinal functions and its application to study differential protein digestibility
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Food matrix impact on rheological and digestive properties of protein-enriched and texture-modified mushroom creams
inferred← citeshttps://doi.org/10.1016/j.foodres.2019.108964openalex-snapshot
The impact of food-grade carrageenans and consumer age on the in vitro proteolysis of whey proteins
inferred← citeshttps://doi.org/10.1016/j.foodres.2023.113560openalex-snapshot
Carrageenan impact on digestive proteolysis of meat proteins in meatballs or soluble hydrolyzed collagen
inferred← citeshttps://doi.org/10.1016/j.foohum.2025.100646openalex-snapshot
Beneath the Bun: Food additives in fast-food burgers and the path to healthier choices
inferred← citeshttps://doi.org/10.1016/j.foostr.2026.100537openalex-snapshot
Infill density mediates human oral breakdown and nutrient digestion kinetics of 3D-printed wheat-pea protein foods
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Diet in the Pathogenesis and Management of Crohn's Disease
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.123787openalex-snapshot
Recent advances in exploiting carrageenans as a versatile functional material for promising biomedical applications
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Improved antioxidant activity, bioaccessibility and bioavailability of EGCG by delivery in β-lactoglobulin particles
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Possible role of nutrition in the prevention of inflammatory bowel disease–related colorectal cancer: A focus on human studies
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105940openalex-snapshot
λ-carrageenan exacerbates Citrobacter rodentium-induced infectious colitis in mice by targeting gut microbiota and intestinal barrier integrity
inferred← citeshttps://doi.org/10.1039/c7fo01721aopenalex-snapshot
Revisiting the carrageenan controversy: do we really understand the digestive fate and safety of carrageenan in our foods?
inferred← citeshttps://doi.org/10.1039/c9fo00018fopenalex-snapshot
Reply to the Comment on “Revisiting the carrageenan controversy: do we really understand the digestive fate and safety of carrageenan in our foods?” by M. Weiner and J. McKim, Food Funct. , 2019, 10 : DOI: 10.1039/C8FO01282B
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Simulating human digestion: developing our knowledge to create healthier and more sustainable foods
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Influence of consumption of the food additive carrageenan on the gut microbiota and the intestinal homeostasis of mice
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Evidence and hypotheses on adverse effects of the food additives carrageenan (E 407)/processed Eucheuma seaweed (E 407a) and carboxymethylcellulose (E 466) on the intestines: a scoping review
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Algae-derived hydrocolloids in foods: applications and health-related issues
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Is Salt at Fault? Dietary Salt Consumption and Inflammatory Bowel Disease
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Dining With Inflammatory Bowel Disease: A Review of the Literature on Diet in the Pathogenesis and Management of IBD
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Food additive emulsifiers: a review of their role in foods, legislation and classifications, presence in food supply, dietary exposure, and safety assessment
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Food‐grade carrageenans and their implications in health and disease
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Safety of edible coatings on fruits and vegetables
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Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases
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Effectiveness of the Crohn’s Disease Exclusion Diet for the Treatment of Crohn’s Disease in the Older-Adult Population: Real-World Experience
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Unveiling the power of diet and lifestyle in managing Crohn’s disease
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Translocation of intestinal peptidoglycan moieties modulates the early stages of arthritis.
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Re‐evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives
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Pathogenetic substantiation of diet therapy for Crohn’s disease in children
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Metabolic effects in mice of cream formulation: Addition of both thickener and emulsifier does not alter lipid metabolism but modulates mucus cells and intestinal endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.33590/emj/040820openalex-snapshot
Nutritional Management of Paediatric Crohn’s Disease
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Intestinal permeability, food antigens and the microbiome: a multifaceted perspective
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Ultra-processed foods as a possible culprit for the rising prevalence of inflammatory bowel diseases
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Effect of physiological pH on the molecular characteristics, rheological behavior, and molecular dynamics of κ-carrageenan/casein
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Influence of food emulsifiers on cellular function and inflammation, a preliminary study
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Food and Beverages Containing Algae and Derived Ingredients Launched in the Market from 2015 to 2019: A Front-of-Pack Labeling Perspective with a Special Focus on Spain
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Chickpea-Based Milk Analogue Stabilized by Transglutaminase
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Differential Effects of Commercial Food-Grade Carrageenan Preparations on DSS-Induced Colitis and Gut Microbiota in Mice
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Addition of Anionic Polysaccharide Stabilizers Modulates In Vitro Digestive Proteolysis of a Chocolate Milk Drink in Adults and Children
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Experimental Evaluation of Food-Grade Semi-Refined Carrageenan Toxicity
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Crohn’s Disease Exclusion Diet for the Treatment of Crohn’s Disease: Real-World Experience from a Tertiary Center
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Diet in the Pathogenesis and Management of Ulcerative Colitis; A Review of Randomized Controlled Dietary Interventions
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Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn’s Disease
inferred← citeshttps://doi.org/10.3390/nu13103402openalex-snapshot
The Role of Carrageenan in Inflammatory Bowel Diseases and Allergic Reactions: Where Do We Stand?
inferred← citeshttps://doi.org/10.3390/nu14234965openalex-snapshot
Selected Aspects of Nutrition in the Prevention and Treatment of Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.3390/nu16091367openalex-snapshot
Carrageenan as a Potential Factor of Inflammatory Bowel Diseases
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Inflammatory bowel disease in children - part 2: treatment and complications
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Diet as therapeutic intervention in Crohn’s disease
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Etiology of Ulcerative Colitis
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Barrière intestinale, translocation de composés bactériens et développement de l'arthrite inflammatoire : étude du lien mécanistique
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Effets métaboliques des lipides polaires laitiers : mécanismes associés à la régulation de la barrière intestinale et effets spécifiques de la sphingomyéline in vitro
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