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Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders

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2 of the 87 references listed on this page are in the Retraction Watch database as retracted (export 2026-11-04): 10.1210/jc.2018-00197 (notice 2019-07-03), 10.2337/db06-1595 (notice 2016-03-24).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation

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Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

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Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

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PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

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Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

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CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance

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Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

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SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

inferredcites →https://doi.org/10.1016/j.ebiom.2018.11.046openalex-snapshot

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Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways

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Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice

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Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

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LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

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Metformin improves obesity-associated inflammation by altering macrophages polarization

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Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate

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A central role for JNK in obesity and insulin resistance

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SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

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CX3CR1 Deficiency Does Not Influence Trafficking of Adipose Tissue Macrophages in Mice With Diet‐Induced Obesity

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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

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Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

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A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition

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Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

inferredcites →https://doi.org/10.1073/pnas.0906112107openalex-snapshot

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

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Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

inferredcites →https://doi.org/10.1074/jbc.m700412200openalex-snapshot

Disruption of CXC Motif Chemokine Ligand-14 in Mice Ameliorates Obesity-induced Insulin Resistance

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The gut microbiota metabolite indole alleviates liver inflammation in mice

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inferredcites →https://doi.org/10.1210/en.2015-1588openalex-snapshot

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inferredcites →https://doi.org/10.2337/db10-0956openalex-snapshot

Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes

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inferred← citeshttps://doi.org/10.3389/fendo.2026.1919367openalex-snapshot

Adipose tissue ceramides: emerging lipid components of extracellular vesicles and their influence on metabolic dysregulation

inferred← citeshttps://doi.org/10.3389/fimmu.2021.661182openalex-snapshot

Macrophages in Chronic Liver Failure: Diversity, Plasticity and Therapeutic Targeting

inferred← citeshttps://doi.org/10.3389/fimmu.2021.668217openalex-snapshot

A Comparison of Two Structurally Related Human Milk Oligosaccharide Conjugates in a Model of Diet-Induced Obesity

inferred← citeshttps://doi.org/10.3389/fimmu.2022.1022361openalex-snapshot

Monocyte adaptations in patients with obesity during a 1.5 year lifestyle intervention

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1688392openalex-snapshot

Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications

inferred← citeshttps://doi.org/10.3389/fnut.2021.625331openalex-snapshot

Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity

inferred← citeshttps://doi.org/10.3389/fnut.2021.754222openalex-snapshot

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

inferred← citeshttps://doi.org/10.3389/fphar.2021.697483openalex-snapshot

Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation

inferred← citeshttps://doi.org/10.3390/ani10091499openalex-snapshot

Overfeeding-Induced Obesity Could Cause Potential Immuno-Physiological Disorders in Rainbow Trout (Oncorhynchus mykiss)

inferred← citeshttps://doi.org/10.3390/antiox10111741openalex-snapshot

Correlations between Salivary Immuno-Biochemical Markers and HbA1c in Type 2 Diabetes Subjects before and after Dental Extraction

inferred← citeshttps://doi.org/10.3390/antiox15091193openalex-snapshot

Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies

inferred← citeshttps://doi.org/10.3390/biom11070971openalex-snapshot

On the Role of Paraoxonase-1 and Chemokine Ligand 2 (C-C motif) in Metabolic Alterations Linked to Inflammation and Disease. A 2021 Update

inferred← citeshttps://doi.org/10.3390/biomedicines10123045openalex-snapshot

Phenolic Compounds Known to Be Present in Lingonberry (Vaccinium vitis-idaea L.) Enhance Macrophage Polarization towards the Anti-Inflammatory M2 Phenotype

inferred← citeshttps://doi.org/10.3390/biomedicines12081825openalex-snapshot

Revisiting the Immunometabolic Basis for the Metabolic Syndrome from an Immunonutritional View

inferred← citeshttps://doi.org/10.3390/cells13191603openalex-snapshot

Altered Cytokine Secretory Fingerprint of the Adipocytes Derived from Stem Cells of Morbidly Obese Patients—A Preliminary Study

inferred← citeshttps://doi.org/10.3390/ijms21082900openalex-snapshot

Tetragonia tetragonioides Protected against Memory Dysfunction by Elevating Hippocampal Amyloid-β Deposition through Potentiating Insulin Signaling and Altering Gut Microbiome Composition

inferred← citeshttps://doi.org/10.3390/ijms21186973openalex-snapshot

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

inferred← citeshttps://doi.org/10.3390/ijms22158008openalex-snapshot

Effect of Microbiome on Non-Alcoholic Fatty Liver Disease and the Role of Probiotics, Prebiotics, and Biogenics

inferred← citeshttps://doi.org/10.3390/ijms241512259openalex-snapshot

Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

inferred← citeshttps://doi.org/10.3390/ijms25020881openalex-snapshot

Relationships between Circulating Biomarkers and Body Composition Parameters in Patients with Metabolic Syndrome: A Community-Based Study

inferred← citeshttps://doi.org/10.3390/ijms25179366openalex-snapshot

A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

inferred← citeshttps://doi.org/10.3390/jcm10040714openalex-snapshot

Factors Affecting Metabolic Outcomes Post Bariatric Surgery: Role of Adipose Tissue

inferred← citeshttps://doi.org/10.3390/molecules27134058openalex-snapshot

How Curcumin Targets Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions

inferred← citeshttps://doi.org/10.3390/nu12072161openalex-snapshot

Using Dietary Indices—What’s Next?

inferred← citeshttps://doi.org/10.3390/nu13030757openalex-snapshot

Navy Bean Supplementation in Established High-Fat Diet-Induced Obesity Attenuates the Severity of the Obese Inflammatory Phenotype

inferred← citeshttps://doi.org/10.3791/61959openalex-snapshot

A Comprehensive High-Efficiency Protocol for Isolation, Culture, Polarization, and Glycolytic Characterization of Bone Marrow-Derived Macrophages

inferred← citeshttps://doi.org/10.3803/enm.2023.1776openalex-snapshot

The Impact of Taurine on Obesity-Induced Diabetes Mellitus: Mechanisms Underlying Its Effect

inferred← citeshttps://doi.org/10.4093/dmj.2023.0011openalex-snapshot

Adipose Tissue and Metabolic Health

inferred← citeshttps://doi.org/10.47631/jsrmbs.v2i3.297openalex-snapshot

Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats

inferred← citeshttps://doi.org/10.6084/m9.figshare.26715730openalex-snapshot

Additional file 1 of Increased regional body fat is associated with depressive symptoms: a cross-sectional analysis of NHANES data obtained during 2011–2018

inferred← citeshttps://doi.org/10.6084/m9.figshare.26715733openalex-snapshot

Additional file 2 of Increased regional body fat is associated with depressive symptoms: a cross-sectional analysis of NHANES data obtained during 2011–2018

inferred← citeshttps://doi.org/10.61186/jorjanibiomedj.11.4.24openalex-snapshot

The effect of a moderate intensity resistance training course with garlic supplementation on the lipid profile in overweight women

inferred← citeshttps://doi.org/10.62472/kjps.v14.i23.63-73openalex-snapshot

Serum ADAM -17 and Interleukin-6 Levels as a Predictors in Type 2 Diabetic Patients with Myocardial Infarction Patients

inferred← citeshttps://doi.org/10.70675/044ae8ecz4971z4637zb911z4a21f0b27e28openalex-snapshot

Étude des effets d’un régime supplémenté en vitamine D et en acides gras oméga-3 dans la prévention tertiaire des altérations métaboliques et fonctionnelles associées à l’obésité chez le Rat Wistar

inferred← citeshttps://doi.org/10.70675/d9e67410ze857z46a9zaa64zc861d7fac60bopenalex-snapshot

Adipose tissue senescence in the context of high-fat diet-induced obesity and aging : mechanisms associated with the initiation of cellular senescence

inferred← citeshttps://doi.org/10.7555/jbr.34.20200153openalex-snapshot

Fucoidan antagonizes diet-induced obesity and inflammation in mice

inferred← citeshttps://doi.org/10.7759/cureus.60659openalex-snapshot

Effects of Low and High Doses of Aspirin on Inflammatory Markers in Diabesity Patients: A Quasi-Experimental Study

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