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In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jps.22552openalex-snapshot
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance
inferredcites →https://doi.org/10.1002/prp2.618openalex-snapshot
In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel
inferredcites →https://doi.org/10.1007/bf00560463openalex-snapshot
Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes
inferredcites →https://doi.org/10.1007/bf01068419openalex-snapshot
A comparison of the Two One-Sided Tests Procedure and the Power Approach for assessing the equivalence of average bioavailability
inferredcites →https://doi.org/10.1007/bf03189418openalex-snapshot
Serum concentrations and renal excretion in humans after oral administration of praziquantel — results of three determination methods —
inferredcites →https://doi.org/10.1007/s00228-003-0636-9openalex-snapshot
Identification of human cytochrome P 450 s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data
inferredcites →https://doi.org/10.1007/s00228-019-02663-8openalex-snapshot
The effect of ketoconazole on praziquantel pharmacokinetics and the role of CYP3A4 in the formation of X-OH-praziquantel and not 4-OH-praziquantel
inferredcites →https://doi.org/10.1007/s13318-011-0024-2openalex-snapshot
Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity
inferredcites →https://doi.org/10.1016/j.bcp.2014.05.001openalex-snapshot
Metabolic profiling of praziquantel enantiomers
inferredcites →https://doi.org/10.1016/j.bjid.2014.11.004openalex-snapshot
Impact of human schistosomiasis in sub-Saharan Africa
inferredcites →https://doi.org/10.1016/j.ijpharm.2005.01.033openalex-snapshot
In vitro characterization of some biopharmaceutical properties of praziquantel
inferredcites →https://doi.org/10.1016/s0090-9556(24)15034-9openalex-snapshot
Heterologous Expression and Kinetic Characterization of Human Cytochromes P-450: Validation of a Pharmaceutical Tool for Drug Metabolism Research
inferredcites →https://doi.org/10.1016/s0731-7085(01)00417-4openalex-snapshot
Investigation of Praziquantel metabolism in isolated rat hepatocytes
inferredcites →https://doi.org/10.1067/mcp.2002.129319openalex-snapshot
Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers
inferredcites →https://doi.org/10.1080/00498250310001646353openalex-snapshot
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors
inferredcites →https://doi.org/10.1080/00498250600761662openalex-snapshot
Prediction of metabolic drug clearance in humans:In vitro–in vivoextrapolationvsallometric scaling
inferredcites →https://doi.org/10.1124/dmd.104.000125openalex-snapshot
SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS
inferredcites →https://doi.org/10.1128/aac.02253-17openalex-snapshot
Pharmacokinetics of Praziquantel in Schistosoma mansoni- and Schistosoma haematobium-Infected School- and Preschool-Aged Children
inferredcites →https://doi.org/10.1128/aac.02741-14openalex-snapshot
Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni
inferredcites →https://doi.org/10.1128/aac.41.6.1256openalex-snapshot
Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen
inferredcites →https://doi.org/10.1128/aac.46.5.1614-1616.2002openalex-snapshot
Interaction between Grapefruit Juice and Praziquantel in Humans
inferredcites →https://doi.org/10.1128/mbio.00227-16openalex-snapshot
Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy
inferredcites →https://doi.org/10.1186/s13071-017-2293-3openalex-snapshot
In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium
inferredcites →https://doi.org/10.1212/wnl.37.9.1561openalex-snapshot
Plasma levels of praziquantel decrease when dexamethasone is given simultaneously
inferredcites →https://doi.org/10.1371/journal.pntd.0004700openalex-snapshot
Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients
inferredcites →https://doi.org/10.2147/dddt.s98096openalex-snapshot
The cytotoxicity study of praziquantel enantiomers
inferredcites →https://doi.org/10.2165/00003088-200342060-00002openalex-snapshot
Metabolic Stability for Drug Discovery and Development
inferredcites →https://doi.org/10.2174/1386207013331101openalex-snapshot
In Vitro High Throughput Screening of Compounds for Favorable Metabolic Properties in Drug Discovery.
inferredcites →https://doi.org/10.2174/138920009787846341openalex-snapshot
Methodological Uncertainty in Quantitative Prediction of Human Hepatic Clearance from In Vitro Experimental Systems
inferredcites →https://doi.org/10.3109/03602539709002237openalex-snapshot
Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices
inferredcites →https://doi.org/10.3390/tropicalmed4010040openalex-snapshot
Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination
inferredcites →https://doi.org/10.4172/2329-9088.1000135openalex-snapshot
Bilharzia: Pathology, Diagnosis, Management and Control
inferredcites →https://doi.org/10.4269/ajtmh.13-0467openalex-snapshot
Schistosomiasis Elimination Strategies and Potential Role of a Vaccine in Achieving Global Health Goals
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4797526openalex-extracted
Lc-Ms/Ms Analyzing Praziquantel and 4-Hydroxypraziquantel Enantiomers in Black Goat Plasma and Mechanism of Stereoselective Pharmacokinetics
inferred← citeshttps://doi.org/10.1002/ange.202526152openalex-snapshot
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
inferred← citeshttps://doi.org/10.1002/anie.202526152openalex-snapshot
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
inferred← citeshttps://doi.org/10.1002/bmc.6082openalex-snapshot
LC‐MS/MS Analyzing Praziquantel and 4‐Hydroxypraziquantel Enantiomers in Black Goat Plasma and Mechanism of Stereoselective Pharmacokinetics
inferred← citeshttps://doi.org/10.1002/prp2.769openalex-snapshot
Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir
inferred← citeshttps://doi.org/10.1007/s10928-021-09791-8openalex-snapshot
R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini
inferred← citeshttps://doi.org/10.1007/s11095-024-03766-3openalex-snapshot
The Use of Systemically Absorbed Drugs to Explore An In Vitro Bioequivalence Approach For Comparing Non-Systemically Absorbed Active Pharmaceutical Ingredients in Drug Products For Use in Dogs
inferred← citeshttps://doi.org/10.1007/s11095-025-04007-xopenalex-snapshot
A Top-Down Physiologically Based Pharmacokinetic Modeling Approach to Explore Unexpected Bio-inequivalence of Experimental Oral Formulations in Dogs
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2024.100546openalex-snapshot
Robenidine derivatives as potential antischistosomal drug candidates
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c05964openalex-snapshot
Determination of the Molar Fraction and Enantiomeric Excess of Electrosprayed Amino Acid Anions Employing Photoelectron Circular Dichroism
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c03546openalex-snapshot
Stereoselective Pharmacokinetics and Residue Depletion of Praziquantel and Its Metabolites, 4-Hydroxypraziquantel Enantiomers, in Swine
inferred← citeshttps://doi.org/10.1038/s41598-023-28641-wopenalex-snapshot
Effect of pharmacogenetic variations on praziquantel plasma concentration and safety outcomes among school children in Rwanda
inferred← citeshttps://doi.org/10.1080/03602532.2024.2381021openalex-snapshot
Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic
inferred← citeshttps://doi.org/10.1093/jtm/taag066openalex-snapshot
Drug–drug interaction between praziquantel and nevirapine in HIV-schistosomiasis co-infection: a pharmacokinetic case report
inferred← citeshttps://doi.org/10.1097/fpc.0000000000000467openalex-snapshot
Population genetic polymorphisms of pharmacogenes in Zimbabwe, a potential guide for the safe and efficacious use of medicines in people of African ancestry
inferred← citeshttps://doi.org/10.1097/fpc.0000000000000572openalex-snapshot
Microsampling with dried blood spots and mass spectrometry enables PK/PD profiling of responses to praziquantel in a Schistosoma haematobium–exposed Zimbabwean population
inferred← citeshttps://doi.org/10.1101/2024.04.17.589706openalex-snapshot
The drug disposition in the Spleen: A novel study of CYP and UGT-mediated drug metabolism
inferred← citeshttps://doi.org/10.1109/otcon65728.2025.11070716openalex-snapshot
Computer Aided Drug Design for Enhanced Drug Discovery and Development Processes
inferred← citeshttps://doi.org/10.1124/dmd.123.001400openalex-snapshot
The African Liver Tissue Biorepository Consortium: Capacitating Population-Appropriate Drug Metabolism, Pharmacokinetics, and Pharmacogenetics Research in Drug Discovery and Development
inferred← citeshttps://doi.org/10.1177/09670335221130428openalex-snapshot
A useful quantitative model for determining the optical purity of praziquantel enantiomers based on near infrared spectroscopy with partial least squares
inferred← citeshttps://doi.org/10.1186/s40249-025-01373-xopenalex-snapshot
Mechanisms underlying persistent liver fibrosis progression in Schistosoma-infected individuals post-treatment
inferred← citeshttps://doi.org/10.1638/2023-0031openalex-snapshot
SAFETY AND PHARMACOKINETICS OF PRAZIQUANTEL IN EUROPEAN POND TURTLES (EMYS ORBICULARIS)
inferred← citeshttps://doi.org/10.3389/fgene.2022.914372openalex-snapshot
Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment
inferred← citeshttps://doi.org/10.3389/fimmu.2022.906338openalex-snapshot
Dynamics of host immune response development during Schistosoma mansoni infection
inferred← citeshttps://doi.org/10.3390/fishes11070403openalex-snapshot
Tissue Distribution and Depletion of Praziquantel and Its Main Metabolites in Grass Carp (Ctenopharyngodon idella) Following 24 h Bath Administration
inferred← citeshttps://doi.org/10.3390/molecules26113113openalex-snapshot
Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods
inferred← citeshttps://doi.org/10.3390/pharmaceutics16060776openalex-snapshot
Predicting ADMET Properties from Molecule SMILE: A Bottom-Up Approach Using Attention-Based Graph Neural Networks
inferred← citeshttps://doi.org/10.3390/scipharm94010004openalex-snapshot
Evolution, Validation and Current Challenges in Bioanalytical Methods for Praziquantel: From Fluorometry to LC–MS/MS
inferred← citeshttps://doi.org/10.3390/tropicalmed7110347openalex-snapshot
The Indispensability of Snail Control for Accelerating Schistosomiasis Elimination: Evidence from Zanzibar
inferred← citeshttps://doi.org/10.64898/2026.09.02.26362031openalex-snapshot
Markers of environmental enteric dysfunction are associated with changes in pharmacokinetics of praziquantel in preschool age children with Schistosoma mansoni infection in Albertine region of Uganda
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