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NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.2910450304openalex-snapshot
Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
inferredcites →https://doi.org/10.1002/j.1460-2075.1992.tb05411.xopenalex-snapshot
Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.
inferredcites →https://doi.org/10.1007/bf01114891openalex-snapshot
Distribution of newly synthesized DT-diaphorase in rat liver
inferredcites →https://doi.org/10.1016/0003-9861(80)90269-6openalex-snapshot
Immunochemical studies on two DT diaphorase active antigens isolated from rat liver cytosol by affinity chromatography
inferredcites →https://doi.org/10.1016/0003-9861(81)90026-6openalex-snapshot
Biospecific adsorption of hepatic DT-diaphorase on immobilized dicoumarol
inferredcites →https://doi.org/10.1016/0003-9861(85)90027-xopenalex-snapshot
Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes
inferredcites →https://doi.org/10.1016/0006-291x(60)90193-5openalex-snapshot
Purification and some properties of a highly dicumarol-sensitive liver diaphorase
inferredcites →https://doi.org/10.1016/0006-291x(76)90029-2openalex-snapshot
Induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
inferredcites →https://doi.org/10.1016/0006-291x(92)91329-oopenalex-snapshot
Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex
inferredcites →https://doi.org/10.1016/0006-2952(91)90284-copenalex-snapshot
High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin
inferredcites →https://doi.org/10.1016/0006-2952(92)90694-eopenalex-snapshot
DT-diaphorase and cancer chemotherapy
inferredcites →https://doi.org/10.1016/0006-3002(63)91823-7openalex-snapshot
DT diaphoraseIV. Coupling of extramitochondrial reduced pyridine nucleotide oxidation to mitochondrial respiratory chain
inferredcites →https://doi.org/10.1016/0014-2964(75)90188-7openalex-snapshot
Enzyme histochemical pattern in human tumours—II. Oxidoreductases in carcinoma of the colon and the breast
inferredcites →https://doi.org/10.1016/0065-2571(89)90074-5openalex-snapshot
Mechanisms of induction of enzymes that protect against chemical carcinogenesis
inferredcites →https://doi.org/10.1016/0092-8674(91)90355-3openalex-snapshot
Redox redux: The control of oxidative stress responses
inferredcites →https://doi.org/10.1016/0167-4838(92)90421-9openalex-snapshot
Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol
inferredcites →https://doi.org/10.1016/0304-3835(87)90028-0openalex-snapshot
DT-diaphorase in morbidly obese patients
inferredcites →https://doi.org/10.1016/0304-3835(88)90246-7openalex-snapshot
Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue
inferredcites →https://doi.org/10.1016/b978-0-08-024421-1.50020-3openalex-snapshot
DT Diaphorase: Properties, Reaction Mechanism, Metabolic Function. A Progress Report
inferredcites →https://doi.org/10.1016/s0006-291x(83)80158-2openalex-snapshot
Possible role of DT-diaphorase in the bioactivation of antitumor quinones
inferredcites →https://doi.org/10.1016/s0021-9258(17)32810-7openalex-snapshot
Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.
inferredcites →https://doi.org/10.1016/s0021-9258(17)36101-xopenalex-snapshot
Purification and characterization of two isofunctional forms of NAD(P)H: quinone reductase from mouse liver.
inferredcites →https://doi.org/10.1016/s0021-9258(17)36102-1openalex-snapshot
Preliminary crystallographic X-ray data for an NAD(P)H:quinone reductase from mouse liver.
inferredcites →https://doi.org/10.1016/s0021-9258(18)33730-xopenalex-snapshot
The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.
inferredcites →https://doi.org/10.1016/s0021-9258(18)41669-9openalex-snapshot
Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis.
inferredcites →https://doi.org/10.1016/s0021-9258(18)42151-5openalex-snapshot
Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.
inferredcites →https://doi.org/10.1016/s0021-9258(18)61597-2openalex-snapshot
Direct protective effect of NAD(P)H:quinone reductase against menadione-induced chemiluminescence of postmitochondrial fractions of mouse liver.
inferredcites →https://doi.org/10.1016/s0021-9258(18)66789-4openalex-snapshot
NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation.
inferredcites →https://doi.org/10.1016/s0021-9258(18)68280-8openalex-snapshot
Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.
inferredcites →https://doi.org/10.1016/s0021-9258(18)77351-1openalex-snapshot
Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.
inferredcites →https://doi.org/10.1016/s0021-9258(18)99004-6openalex-snapshot
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
inferredcites →https://doi.org/10.1016/s0021-9258(19)57246-5openalex-snapshot
Rat liver NAD(P)H:quinone reductase. Construction of a quinone reductase cDNA clone and regulation of quinone reductase mRNA by 3-methylcholanthrene and in persistent hepatocyte nodules induced by chemical carcinogens.
inferredcites →https://doi.org/10.1016/s0021-9258(19)81594-6openalex-snapshot
Purification of the Ah receptor from C57BL/6J mouse liver.
inferredcites →https://doi.org/10.1016/s0021-9258(20)64358-7openalex-snapshot
Transcriptional regulation of the rat NAD(P)H:quinone reductase gene
inferredcites →https://doi.org/10.1016/s0021-9258(20)88253-2openalex-snapshot
Rat liver NAD(P)H: Quinone reductase
inferredcites →https://doi.org/10.1016/s0026-895x(25)15064-5openalex-snapshot
DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.
inferredcites →https://doi.org/10.1016/s0031-6997(25)00021-3openalex-snapshot
The molecular biology of cytochrome P450s.
inferredcites →https://doi.org/10.1016/s0031-6997(25)06654-2openalex-snapshot
The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
inferredcites →https://doi.org/10.1016/s0304-3835(78)80034-2openalex-snapshot
The use of the D-T diaphorase for the detection of foci of early neoplastic transformation in rat liver
inferredcites →https://doi.org/10.1021/bi00108a007openalex-snapshot
Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin
inferredcites →https://doi.org/10.1021/bi00441a041openalex-snapshot
Characterization of multiple forms of the Ah receptor: comparison of species and tissues
inferredcites →https://doi.org/10.1021/bi00459a034openalex-snapshot
Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6
inferredcites →https://doi.org/10.1042/bj1870429openalex-snapshot
Human FAD-dependent NAD(P)H diaphorase
inferredcites →https://doi.org/10.1073/pnas.81.6.1696openalex-snapshot
Mutagenicity of quinones: pathways of metabolic activation and detoxification.
inferredcites →https://doi.org/10.1073/pnas.82.23.8232openalex-snapshot
On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.
inferredcites →https://doi.org/10.1073/pnas.85.21.8261openalex-snapshot
Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.
inferredcites →https://doi.org/10.1073/pnas.87.10.3826openalex-snapshot
Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.
inferredcites →https://doi.org/10.1073/pnas.87.16.6258openalex-snapshot
Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.
inferredcites →https://doi.org/10.1073/pnas.88.9.3720openalex-snapshot
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
inferredcites →https://doi.org/10.1073/pnas.89.2.668openalex-snapshot
Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.
inferredcites →https://doi.org/10.1073/pnas.89.6.2394openalex-snapshot
Rapid detection of inducers of enzymes that protect against carcinogens.
inferredcites →https://doi.org/10.1073/pnas.89.6.2399openalex-snapshot
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
inferredcites →https://doi.org/10.1093/carcin/5.6.785openalex-snapshot
A constitutive deficiency in the monooxygenase system of spontaneous mouse liver tumors
inferredcites →https://doi.org/10.1093/carcin/8.10.1549openalex-snapshot
Role of cytochrome P1 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants
inferredcites →https://doi.org/10.1093/carcin/9.4.611openalex-snapshot
Influence of DT diaphorase on the mutagenicity of organic and inorganic compounds
inferredcites →https://doi.org/10.1093/carcin/9.9.1581openalex-snapshot
DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction
inferredcites →https://doi.org/10.1111/j.1432-1033.1991.tb15691.xopenalex-snapshot
The human dioxin‐inducible NAD(P)H:quinone oxidoreductase cDNA‐encoded protein expressed in COS‐1 cells is identical to diaphorase 4
inferredcites →https://doi.org/10.1126/science.2565047openalex-snapshot
Allelotype of Colorectal Carcinomas
inferredcites →https://doi.org/10.1128/mcb.9.6.2378openalex-snapshot
Regulation of Mouse CYP1A1 Gene Expression by Dioxin: Requirement of Two cis- Acting Elements during Induction
inferredcites →https://doi.org/10.1146/annurev.bi.56.070187.004501openalex-snapshot
P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION
inferredcites →https://doi.org/10.1146/annurev.bi.60.070191.001433openalex-snapshot
PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS
inferredcites →https://doi.org/10.1146/annurev.pa.30.040190.001343openalex-snapshot
Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action
inferredcites →https://doi.org/10.3109/10715769009053371openalex-snapshot
Activation And Deactivation Of Quinones Catalyzed By Dt-Diaphorase. Evidence For Bioreductive Activation Of Diaziquone (Azq) In Human Tumor Cells And Detoxification Of Benzene Metabolites In Bone Marrow Stroma
inferredcites →https://doi.org/10.3181/00379727-151-39224openalex-snapshot
Dehydrogenation of Reduced Pyridine Nucleotides by Leydig Cell Tumors of the Rat Testis
inferredcites →https://doi.org/10.3891/acta.chem.scand.12-0595openalex-snapshot
Soluble Diaphorase in Animal Tissues.
inferredcites →https://doi.org/10.3891/acta.chem.scand.14-1837openalex-snapshot
Selective Extraction of DT Diaphorase from Mitochondria and Microsomes.
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NAD(P)H:Quinone Acceptor Oxidoreductase 1 (NQO1) Activatable Salicylamide H+/Cl− Transporters
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Mitochondrial NADH–Quinone Oxidoreductase of the Outer Membrane Is Responsible for Paraquat Cytotoxicity in Rat Livers
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β-Lapachone-Induced Apoptosis in Human Prostate Cancer Cells: Involvement of NQO1/xip3
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Polychlorinated Biphenyl-Induced Effects on Metabolic Enzymes, AP-1 Binding, Vitamin E, and Oxidative Stress in the Rat Liver
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Benzo(a)pyrene Activates Extracellular Signal-Related and p38 Mitogen-Activated Protein Kinases in HT29 Colon Adenocarcinoma Cells: Involvement in NAD(P)H:quinone Reductase Activity and Cell Proliferation
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Gene Expression of DT-Diaphorase in Cancer Cells
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Implication of Nanomedicine in Therapy of Oxidative Stress Induced Cancer
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Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance
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Increased DT-diaphorase activity in transformed and tumorigenic pancreatic acinar cells
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Quinone Reductases
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The plasma membrane redox system in aging
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FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1
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NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms
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Yeast cytotoxic sensitivity to the antitumour agent β-lapachone depends mainly on oxidative stress and is largely independent of microtubule- or topoisomerase-mediated DNA damage
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Hsp90 inhibition: Elimination of shock and stress
inferred← citeshttps://doi.org/10.1016/j.breast.2005.04.012openalex-snapshot
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status
inferred← citeshttps://doi.org/10.1016/j.celbio.2025.100044openalex-snapshot
Mutually reinforced activatable NIR fluorescence/MR bimodal imaging enabled by tumor-specific biomarker amplification
inferred← citeshttps://doi.org/10.1016/j.cell.2025.03.026openalex-snapshot
Precision proteogenomics reveals pan-cancer impact of germline variants
inferred← citeshttps://doi.org/10.1016/j.cobme.2022.100437openalex-snapshot
Designing polymers with stimuli-responsive degradation for biomedical applications
inferred← citeshttps://doi.org/10.1016/j.drup.2012.01.004openalex-snapshot
Starvation, detoxification, and multidrug resistance in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.drup.2023.100977openalex-snapshot
Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis
inferred← citeshttps://doi.org/10.1016/j.dyepig.2016.09.031openalex-snapshot
Rational construction of probes rendering ratiometric response to the cancer-specific enzyme NQO1
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111719openalex-snapshot
Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112396openalex-snapshot
Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents
inferred← citeshttps://doi.org/10.1016/j.ejpb.2012.12.019openalex-snapshot
Administration of the optimized β-Lapachone–poloxamer–cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176511openalex-snapshot
β-Lapachone, an NQO1 bioactivatable drug, prevents lung tumorigenesis in mice
inferred← citeshttps://doi.org/10.1016/j.ejso.2020.04.019openalex-snapshot
Identification of pharmacogenetic biomarkers for efficacy of cytoreductive surgery plus hyperthermic intraperitoneal mitomycin C in patients with colorectal peritoneal metastases
inferred← citeshttps://doi.org/10.1016/j.exer.2018.09.012openalex-snapshot
Light-induced generation and toxicity of docosahexaenoate-derived oxidation products in retinal pigmented epithelial cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.03.026openalex-snapshot
2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1)
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.07.051openalex-snapshot
Biophysical and functional perturbation analyses at cancer-associated P187 and K240 sites of the multifunctional NADP(H):quinone oxidoreductase 1
inferred← citeshttps://doi.org/10.1016/j.ijcard.2010.12.104openalex-snapshot
Effects of exercise and antioxidant supplementation on endothelial gene expression
inferred← citeshttps://doi.org/10.1016/j.jcis.2020.12.028openalex-snapshot
Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy
inferred← citeshttps://doi.org/10.1016/j.jconrel.2007.04.014openalex-snapshot
β-Lapachone-containing PEG–PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells
inferred← citeshttps://doi.org/10.1016/j.jconrel.2014.12.027openalex-snapshot
Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113466openalex-snapshot
Bioanalytical method development and validation of a liquid chromatography-tandem mass spectrometry method for determination of β-lapachone in human plasma
inferred← citeshttps://doi.org/10.1016/j.jpet.2026.104974openalex-snapshot
A novel NAD(P)H:quinone oxidoreductase 1-responsive vascular endothelial growth factor-targeted antibody-drug conjugate induces dual apoptosis and ferroptosis in glioblastoma
inferred← citeshttps://doi.org/10.1016/j.leukres.2008.06.030openalex-snapshot
Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1016/j.lfs.2015.12.017openalex-snapshot
Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones
inferred← citeshttps://doi.org/10.1016/j.lungcan.2009.06.009openalex-snapshot
Clinical significance of NQO1 C609T polymorphisms after postoperative radiation therapy in completely resected non-small cell lung cancer
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2005.05.004openalex-snapshot
Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck
inferred← citeshttps://doi.org/10.1016/j.prp.2020.153173openalex-snapshot
Significant association of PKM2 and NQO1 proteins with poor prognosis in breast cancer
inferred← citeshttps://doi.org/10.1016/j.redox.2019.101114openalex-snapshot
Regulation of stress signaling pathways by protein lipoxidation
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.02.009openalex-snapshot
Applications and strategies in nanodiagnosis and nanotherapy in lung cancer
inferred← citeshttps://doi.org/10.1016/j.taap.2012.08.017openalex-snapshot
Dual effects of N-acetyl-l-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity
inferred← citeshttps://doi.org/10.1016/j.tiv.2014.09.014openalex-snapshot
Cell viability assessment using the Alamar blue assay: A comparison of 2D and 3D cell culture models
inferred← citeshttps://doi.org/10.1016/j.tiv.2025.106127openalex-snapshot
Use of resazurin-based metabolic assays as a continuous measure of viability in three-dimensional (3D) in vitro cell culture: A study with Presto Blue™
inferred← citeshttps://doi.org/10.1016/j.tvjl.2005.05.013openalex-snapshot
Xenobiotic-metabolizing enzymes in canine mammary tumours
inferred← citeshttps://doi.org/10.1016/s0003-9861(02)00273-4openalex-snapshot
Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure–activity relationships
inferred← citeshttps://doi.org/10.1016/s0003-9861(03)00281-9openalex-snapshot
Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress
inferred← citeshttps://doi.org/10.1016/s0006-2952(01)00537-8openalex-snapshot
Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines11Abbreviations: DT-diaphorase, NAD(P)H:(quinone acceptor)oxidoreductase; ARE, antioxidant response element; MMC, mitomycin C; EO9,…
inferred← citeshttps://doi.org/10.1016/s0006-2952(94)00333-5openalex-snapshot
Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism
inferred← citeshttps://doi.org/10.1016/s0009-2797(00)00269-6openalex-snapshot
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5′-upstream regions of…
inferred← citeshttps://doi.org/10.1016/s0009-2797(02)00174-6openalex-snapshot
Transient induction of increased aldehyde dehydrogenase 3A1 levels in cultured human breast (adeno)carcinoma cell lines via 5′-upstream xenobiotic, and electrophile, responsive elements is, respectively, estrogen receptor-dependent and -independent
inferred← citeshttps://doi.org/10.1016/s0021-9258(17)36651-6openalex-snapshot
Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.
inferred← citeshttps://doi.org/10.1016/s0021-9258(17)40716-2openalex-snapshot
Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.
inferred← citeshttps://doi.org/10.1016/s0026-895x(24)12489-3openalex-snapshot
Establishment of an Isogenic Human Colon Tumor Model for NQO1 Gene Expression: Application to Investigate the Role of DT-Diaphorase in Bioreductive Drug Activation In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1016/s0026-895x(24)12864-7openalex-snapshot
Differential Gene Expression of NAD(P)H:Quinone Oxidoreductase and NRH:Quinone Oxidoreductase in Human Hepatocellular and Biliary Tissue
inferred← citeshttps://doi.org/10.1016/s0070-2137(01)80009-1openalex-snapshot
Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens
inferred← citeshttps://doi.org/10.1016/s0076-6879(04)82010-xopenalex-snapshot
Diaziridinylbenzoquinones
inferred← citeshttps://doi.org/10.1016/s0076-6879(04)82011-1openalex-snapshot
Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications
inferred← citeshttps://doi.org/10.1016/s0076-6879(04)82018-4openalex-snapshot
Induction of NQO1 in Cancer Cells
inferred← citeshttps://doi.org/10.1016/s0300-483x(99)00109-2openalex-snapshot
DT-diaphorase protects against menadione-induced oxidative stress
inferred← citeshttps://doi.org/10.1016/s0304-3835(99)00282-7openalex-snapshot
Effects of sulindac, sulindac metabolites, and aspirin on the activity of detoxification enzymes in HT-29 human colon adenocarcinoma cells
inferred← citeshttps://doi.org/10.1016/s0378-4347(99)00245-5openalex-snapshot
High-performance liquid chromatographic method for sensitive determination of the alkylating agent CB1954 in human plasma
inferred← citeshttps://doi.org/10.1016/s1499-3872(15)60425-8openalex-snapshot
Liver expression of Nrf2-related genes in different liver diseases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02094openalex-snapshot
Application of Hypoxia-Activated Prodrugs in Tumor Therapy: Design Strategies and Perspectives
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5b00448openalex-snapshot
β-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.7b00591openalex-snapshot
Intermolecular Interactions between Coencapsulated Drugs Inhibit Drug Crystallization and Enhance Colloidal Stability of Polymeric Micelles
inferred← citeshttps://doi.org/10.1021/acschembio.6b01094openalex-snapshot
A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells
inferred← citeshttps://doi.org/10.1021/jo0602423openalex-snapshot
Design of a Cyclopropyl Quinone Methide Reductive Alkylating Agent. 2
inferred← citeshttps://doi.org/10.1021/jo971808dopenalex-snapshot
Design of a Cyclopropyl Quinone Methide Reductive Alkylating Agent
inferred← citeshttps://doi.org/10.1021/mp300296mopenalex-snapshot
Metabolic Profile, Enzyme Kinetics, and Reaction Phenotyping of β-Lapachone Metabolism in Human Liver and Intestine in Vitro
inferred← citeshttps://doi.org/10.1021/pr7007237openalex-snapshot
Proteomic Profiling of Endothelial Cells in Human Lung Cancer
inferred← citeshttps://doi.org/10.1021/tx200180yopenalex-snapshot
Preclinical Genotoxicology of Nor-β-lapachone in Human Cultured Lymphocytes and Chinese Hamster Lung Fibroblasts
inferred← citeshttps://doi.org/10.1023/a:1013164013375openalex-snapshot
Polymorphisms of metabolizing enzymes and transporter proteins involved in the clearance of anticancer agents
inferred← citeshttps://doi.org/10.1023/a:1022853007710openalex-snapshot
Modulatory effect of Henna leaf (Lawsonia inermis) on drug metabolising phase I and phase II enzymes, antioxidant enzymes, lipid peroxidation and chemically induced skin and forestomach papillomagenesis in mice
inferred← citeshttps://doi.org/10.1023/a:1026143519395openalex-snapshot
Enhancement of Solubility and Bioavailability of β-Lapachone Using Cyclodextrin Inclusion Complexes
inferred← citeshttps://doi.org/10.1038/bjc.1995.373openalex-snapshot
Presence of a heterozygous substitution and its relationship to DT-diaphorase activity
inferred← citeshttps://doi.org/10.1038/bjc.1995.433openalex-snapshot
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
inferred← citeshttps://doi.org/10.1038/bjc.1997.485openalex-snapshot
DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours
inferred← citeshttps://doi.org/10.1038/bjc.1998.209openalex-snapshot
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents
inferred← citeshttps://doi.org/10.1038/s41416-018-0278-4openalex-snapshot
Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis
inferred← citeshttps://doi.org/10.1038/sj.bjc.6602171openalex-snapshot
Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo
inferred← citeshttps://doi.org/10.1038/sj.bjc.6690489openalex-snapshot
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase
inferred← citeshttps://doi.org/10.1038/sj.cgt.7700430openalex-snapshot
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro
inferred← citeshttps://doi.org/10.1038/srep20331openalex-snapshot
Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
inferred← citeshttps://doi.org/10.1039/c2em10947fopenalex-snapshot
Gene-TEQ—a standardized comparative assessment of effects in the comet assay using genotoxicity equivalents
inferred← citeshttps://doi.org/10.1039/d1cs00307kopenalex-snapshot
Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook
inferred← citeshttps://doi.org/10.1042/bj3120535openalex-snapshot
Substrate specificity of an aflatoxin-metabolizing aldehyde reductase
inferred← citeshttps://doi.org/10.1042/bsr20070010openalex-snapshot
Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia)
inferred← citeshttps://doi.org/10.1046/j.1432-1327.1998.2560518.xopenalex-snapshot
Butylated hydroxytoluene modulates DNA methylation in rats
inferred← citeshttps://doi.org/10.1046/j.1432-1327.2000.01606.xopenalex-snapshot
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
inferred← citeshttps://doi.org/10.1046/j.1471-4159.1998.70052156.xopenalex-snapshot
Histochemical Detection of Quinone Reductase Activity In Situ Using LY 83583 Reduction and Oxidation
inferred← citeshttps://doi.org/10.1073/pnas.021558898openalex-snapshot
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1
inferred← citeshttps://doi.org/10.1073/pnas.0608372103openalex-snapshot
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
inferred← citeshttps://doi.org/10.1073/pnas.2436329100openalex-snapshot
p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
inferred← citeshttps://doi.org/10.1074/jbc.270.12.6894openalex-snapshot
ARE- and TRE-mediated Regulation of Gene Expression
inferred← citeshttps://doi.org/10.1074/jbc.275.8.5416openalex-snapshot
NAD(P)H:Quinone Oxidoreductase Activity Is the Principal Determinant of β-Lapachone Cytotoxicity
inferred← citeshttps://doi.org/10.1074/jbc.m117.813923openalex-snapshot
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism
inferred← citeshttps://doi.org/10.1080/02656730701781895openalex-snapshot
Anti-cancer effect of bio-reductive drug β-lapachon is enhanced by activating NQO1 with heat shock
inferred← citeshttps://doi.org/10.1080/02656730903049836openalex-snapshot
Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of β-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein
inferred← citeshttps://doi.org/10.1080/03602532.2016.1225756openalex-snapshot
Non-cytochrome P450-mediated bioactivation and its toxicological relevance
inferred← citeshttps://doi.org/10.1080/10408440590905957openalex-snapshot
Role of Oxidative Stress in Peroxisome Proliferator-Mediated Carcinogenesis
inferred← citeshttps://doi.org/10.1089/ars.2013.5462openalex-snapshot
Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers
inferred← citeshttps://doi.org/10.1089/dna.2016.3588openalex-snapshot
Overexpression of NAD(P)H: Quinone Oxidoreductase 1 Inhibits Hepatocellular Carcinoma Cell Proliferation and Induced Apoptosis by Activating AMPK/PGC-1α Pathway
inferred← citeshttps://doi.org/10.1089/rej.2024.0032openalex-snapshot
Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population
inferred← citeshttps://doi.org/10.1093/abbs/gmy063openalex-snapshot
DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells
inferred← citeshttps://doi.org/10.1093/carcin/19.8.1333openalex-snapshot
The redox-sensitive human antioxidant responsive element induces gene expression under low oxygen conditions
inferred← citeshttps://doi.org/10.1093/jmcb/mjz005openalex-snapshot
p53 as a hub in cellular redox regulation and therapeutic target in cancer
inferred← citeshttps://doi.org/10.1094/pdis-10-11-0906-reopenalex-snapshot
Differential Responses ofColletotrichum gloeosporioidesandC. truncatumIsolates from Different Hosts to Multiple Fungicides Based on Two Assays
inferred← citeshttps://doi.org/10.1097/cad.0b013e328330098dopenalex-snapshot
Cisplatin enhances the anticancer effect of β-lapachone by upregulating NQO1
inferred← citeshttps://doi.org/10.1097/cad.0b013e3283592da8openalex-snapshot
The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway
inferred← citeshttps://doi.org/10.1097/fpc.0b013e32834b6918openalex-snapshot
Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy
inferred← citeshttps://doi.org/10.1097/pai.0b013e31802e91d0openalex-snapshot
NQO1 Expression in Pancreatic Cancer and Its Potential Use as a Biomarker
inferred← citeshttps://doi.org/10.1101/2022.12.19.22283655openalex-snapshot
Association of the 609 C/T NAD(P)H: quinone oxidoreductase (NQO1) polymorphism with development of cutaneous malignant melanoma
inferred← citeshttps://doi.org/10.1111/j.1349-7006.1997.tb00306.xopenalex-snapshot
Establishment by Adriamycin Exposure of Multidrug‐resistant Rat Ascites Hepatoma AH130 Cells Showing Low DT‐diaphorase Activity and High Cross Resistance to Mitomycins
inferred← citeshttps://doi.org/10.1111/j.1432-1033.1994.00t31.xopenalex-snapshot
Human Antioxidant‐Response‐Element‐Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression
inferred← citeshttps://doi.org/10.1111/j.1432-1033.1994.tb20023.xopenalex-snapshot
Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression. Effect of Sulfhydryl Modifying Agents
inferred← citeshttps://doi.org/10.1111/j.1567-1364.2009.00546.xopenalex-snapshot
The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis
inferred← citeshttps://doi.org/10.1111/j.1600-0773.2003.pto930602.xopenalex-snapshot
Induction of NAD(P)H:quinone Reductase by Probucol: A Possible Mechanism for Protection against Chemical Carcinogenesis and Toxicity
inferred← citeshttps://doi.org/10.1124/jpet.116.232694openalex-snapshot
β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1– and Oxidative Stress–Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis
inferred← citeshttps://doi.org/10.1124/pr.110.004333openalex-snapshot
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
inferred← citeshttps://doi.org/10.1152/ajpcell.2001.280.3.c659openalex-snapshot
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-κB in malignant melanoma cells
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6500043.v1openalex-snapshot
Data from β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy
inferred← citeshttps://doi.org/10.1158/0008-5472.can-06-4480openalex-snapshot
In vivo Role of NAD(P)H:Quinone Oxidoreductase 1 in Metabolic Activation of Mitomycin C and Bone Marrow Cytotoxicity
inferred← citeshttps://doi.org/10.1158/0008-5472.can-07-2213openalex-snapshot
Deficiency of NRH:Quinone Oxidoreductase 2 Differentially Regulates TNF Signaling in Keratinocytes: Up-regulation of Apoptosis Correlates with Down-regulation of Cell Survival Kinases
inferred← citeshttps://doi.org/10.1158/0008-5472.can-09-3995openalex-snapshot
β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy
inferred← citeshttps://doi.org/10.1158/1055-9965.epi-06-0661openalex-snapshot
A NAD(P)H:Quinone Oxidoreductase 1 Polymorphism Is a Risk Factor for Human Colon Cancer
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-04-1751openalex-snapshot
Preclinical Evaluation of the Pharmacodynamic Properties of 2,5-Diaziridinyl-3-Hydroxymethyl-6-Methyl-1,4-Benzoquinone
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-04-2185openalex-snapshot
Development of β-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-05-0818openalex-snapshot
Heat-Induced Up-Regulation of NAD(P)H:Quinone Oxidoreductase Potentiates Anticancer Effects of β-Lapachone
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-10-1983openalex-snapshot
Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of β-Lapachone for Pancreatic Cancer Therapy
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-12-1424openalex-snapshot
Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-19-0302openalex-snapshot
Bioactivation of Napabucasin Triggers Reactive Oxygen Species–Mediated Cancer Cell Death
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-07-0519openalex-snapshot
Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1–targeted tripartite quinone drug delivery system
inferred← citeshttps://doi.org/10.1177/002215540104900913openalex-snapshot
Overexpression of NAD(P)H:quinone Oxidoreductase 1 in Human Reproductive System
inferred← citeshttps://doi.org/10.1177/002215540305100304openalex-snapshot
NAD(P)H:Quinone Oxidoreductase 1 Expression in Kidney Podocytes
inferred← citeshttps://doi.org/10.1179/135100003125001198openalex-snapshot
Transplasma membrane electron transport: enzymes involved and biological function
inferred← citeshttps://doi.org/10.1186/1471-2407-8-229openalex-snapshot
Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells
inferred← citeshttps://doi.org/10.1186/s12967-023-04802-3openalex-snapshot
Impact of NQO1 dysregulation in CNS disorders
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