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Hypoxia-targeted drug delivery

https://doi.org/10.1039/c8cs00304a
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Clinical Trial of Metronidazole, an Oral Trichomonacide
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Synthesis of Tumor-Inhibiting Complex Salts Containing the Anion trans-Tetrachlorobis(indazole)ruthenate(III) and Crystal Structure of the Tetraphenylphosphonium Salt
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Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice
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Fatal misonidazole-induced encephalopathy. An RTOG case report
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Cisplatin
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CC‐1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies
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Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre‐Prodrugs of Nitro Analogues of the Duocarmycins
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Development of Azo‐Based Fluorescent Probes to Detect Different Levels of Hypoxia
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Tumor‐Targeting of EGFR Inhibitors by Hypoxia‐Mediated Activation
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A Mitochondria‐Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia
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Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator
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A Quadruple‐Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines
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KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
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Mechanism of Action of AminoCBIs: Highly Reactive but Highly Cytotoxic Analogues of the Duocarmycins
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Studies of a Cobalt( III ) Complex of the MMP Inhibitor Marimastat: A Potential Hypoxia‐Activated Prodrug
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Photoinduced Reduction of PtIV within an Anti‐Proliferative PtIV–Texaphyrin Conjugate
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Cover Picture: Photoinduced Reduction of PtIV within an Anti‐Proliferative PtIV–Texaphyrin Conjugate (Chem. Eur. J. 29/2014)
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Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
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ChemInform Abstract: Synthesis and Evaluation of Novel Electrophilic Nitrofurancarboxamides and ‐carboxylates as Radiosensitizers and Bioreductively Activated Cytotoxins.
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Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours
inferredcites →https://doi.org/10.1002/ejic.200600723openalex-snapshot
Classical and Non‐Classical Ruthenium‐Based Anticancer Drugs: Towards Targeted Chemotherapy
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Activity of the hypoxia‐activated pro‐drug TH‐302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy
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Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
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HIFs, angiogenesis, and cancer
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Photodegradation of the Benzotriazine 1,4-Di-N-Oxide Hypoxia-Activated Prodrug SN30000 in Aqueous Solution
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Design of anticancer prodrugs for reductive activation
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Phase II study of porfiromycin vs mitomycin‐c utilizing acute intermittent schedules
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Quinone Redox Cycling in the Ligninolytic FungusPleurotus eryngiiLeading to Extracellular Production of Superoxide Anion Radical
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A Phase II Trial of JM-216 in Cervical Cancer: An NCIC CTG Study
inferredcites →https://doi.org/10.1006/jmbi.2001.4653openalex-snapshot
The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution
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Hypoxia-Dependent Retinal Toxicity of Bioreductive Anticancer Prodrugs in Mice
inferredcites →https://doi.org/10.1007/978-1-4615-5865-1_26openalex-snapshot
Evaluation of the Concept of “Hypoxic Fraction” as a Descriptor of Tumor Oxygenation Status
inferredcites →https://doi.org/10.1007/978-3-642-74760-1_3openalex-snapshot
New Ruthenium Complexes for the Treatment of Cancer
inferredcites →https://doi.org/10.1007/bf00689804openalex-snapshot
NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues
inferredcites →https://doi.org/10.1007/bf00689806openalex-snapshot
Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
inferredcites →https://doi.org/10.1007/bf00689809openalex-snapshot
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference toin vivo methods of evaluation
inferredcites →https://doi.org/10.1007/s00018-013-1307-3openalex-snapshot
Checkpoint kinase 1 in DNA damage response and cell cycle regulation
inferredcites →https://doi.org/10.1007/s00280-002-0491-xopenalex-snapshot
Therapeutic advantage from combining 5-fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo; comparison with tirapazamine
inferredcites →https://doi.org/10.1007/s00280-002-0521-8openalex-snapshot
Therapeutic advantage from combining paclitaxel with the hypoxia-selective cytotoxin NLCQ-1 in murine tumor- or human xenograft-bearing mice
inferredcites →https://doi.org/10.1007/s00280-003-0739-0openalex-snapshot
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O 6 -alkylguanine-DNA alkyltransferase in cytotoxicity
inferredcites →https://doi.org/10.1007/s00280-003-0740-7openalex-snapshot
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O 6 -alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition
inferredcites →https://doi.org/10.1007/s00280-004-0773-6openalex-snapshot
Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines
inferredcites →https://doi.org/10.1007/s00280-006-0224-7openalex-snapshot
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1α gene
inferredcites →https://doi.org/10.1007/s00280-007-0417-8openalex-snapshot
Role of NADPH cytochrome P450 reductase in activation of RH1
inferredcites →https://doi.org/10.1007/s00280-009-1188-1openalex-snapshot
A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors
inferredcites →https://doi.org/10.1007/s00280-015-2920-7openalex-snapshot
Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
inferredcites →https://doi.org/10.1007/s002800000134openalex-snapshot
Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG)
inferredcites →https://doi.org/10.1007/s002800050464openalex-snapshot
Biotransformation of the platinum drug JM216 following oral administration to cancer patients
inferredcites →https://doi.org/10.1007/s002800050598openalex-snapshot
DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides
inferredcites →https://doi.org/10.1007/s002800100290openalex-snapshot
Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and tirapazamine against EMT6 tumors in mice
inferredcites →https://doi.org/10.1007/s00775-009-0501-0openalex-snapshot
Electronic structural investigations of ruthenium compounds and anticancer prodrugs
inferredcites →https://doi.org/10.1007/s007750050074openalex-snapshot
Binding of ruthenium(III) anti-tumor drugs to human lactoferrin probed by high resolution X-ray crystallographic structure analyses
inferredcites →https://doi.org/10.1007/s10555-007-9060-4openalex-snapshot
Effects of hypoxia on tumor metabolism
inferredcites →https://doi.org/10.1016/0006-2952(69)90267-6openalex-snapshot
2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256
inferredcites →https://doi.org/10.1016/0006-2952(86)90566-6openalex-snapshot
RSU 1069, a nitroimidazole containing an aziridine group
inferredcites →https://doi.org/10.1016/0006-2952(92)90671-5openalex-snapshot
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I
inferredcites →https://doi.org/10.1016/0006-2952(95)02257-0openalex-snapshot
Enzymology of the reduction of the novel fused pyrazine mono-N-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase
inferredcites →https://doi.org/10.1016/0167-8140(91)90202-ropenalex-snapshot
Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. First report from the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85
inferredcites →https://doi.org/10.1016/0169-5002(93)90424-vopenalex-snapshot
Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C
inferredcites →https://doi.org/10.1016/0277-5379(84)90193-7openalex-snapshot
Alkylation of DNA by the new anticancer agent 3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone (AZQ)
inferredcites →https://doi.org/10.1016/0277-5379(88)90338-0openalex-snapshot
Comparative toxicity of cisplatin, carboplatin (CBDCA) and iproplatin (CHIP) in combination with cyclophosphamide in patients with advanced epithelial ovarian cancer
inferredcites →https://doi.org/10.1016/0277-5379(91)90015-6openalex-snapshot
Randomised phase II trial of carboplatin and iproplatin in advanced urothelial cancer
inferredcites →https://doi.org/10.1016/0305-7372(85)90015-5openalex-snapshot
Preclinical studies identifying carboplatin as a viable cisplatin alternative
inferredcites →https://doi.org/10.1016/0306-3623(95)02101-9openalex-snapshot
Bleomycin: Revival of an old drug
inferredcites →https://doi.org/10.1016/0360-3016(81)90460-0openalex-snapshot
SR-2508: A 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use
inferredcites →https://doi.org/10.1016/0360-3016(84)90545-5openalex-snapshot
A phase I clinical study of nimorazole as a hypoxic radiosensitizer
inferredcites →https://doi.org/10.1016/0360-3016(86)90233-6openalex-snapshot
The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor
inferredcites →https://doi.org/10.1016/0360-3016(86)90236-1openalex-snapshot
Phase I trial of the hypoxic cell radiosensitizer SR-2508: The results of the five to six week drug schedule
inferredcites →https://doi.org/10.1016/0360-3016(86)90267-1openalex-snapshot
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
inferredcites →https://doi.org/10.1016/0360-3016(89)90917-6openalex-snapshot
Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the DAHANCA 2 study
inferredcites →https://doi.org/10.1016/0360-3016(90)90105-sopenalex-snapshot
Final report of the phase i trial of the hypoxic cell radiosensitizer SR 2508 (etanidazole) radiation therapy oncology group 83-03
inferredcites →https://doi.org/10.1016/0360-3016(92)90493-2openalex-snapshot
Keynote address: Bioreductive mechanisms
inferredcites →https://doi.org/10.1016/0360-3016(92)90504-bopenalex-snapshot
Evaluation of bioreductive drugs in multicell spheroids
inferredcites →https://doi.org/10.1016/0360-3016(92)90505-copenalex-snapshot
Bis-bioreductive agents as hypoxia-selective cytotoxins: Nitracrine N-oxide
inferredcites →https://doi.org/10.1016/0360-3016(94)90278-xopenalex-snapshot
Relative importance of DT-diaphorase and hypoxia in the bioactivation of e09 by human lung tumor cell lines
inferredcites →https://doi.org/10.1016/0360-3016(94)90282-8openalex-snapshot
Nitrobenzyl mustard quaternary salts: A new class of hypoxia-selective cytotoxins capable of releasing diffusible cytotoxins on bioreduction
inferredcites →https://doi.org/10.1016/0360-3016(94)90283-6openalex-snapshot
Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: The cobalt(III)-nitrogen mustard complex SN 24771
inferredcites →https://doi.org/10.1016/0360-3016(94)90285-2openalex-snapshot
Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity
inferredcites →https://doi.org/10.1016/0360-3016(95)00040-6openalex-snapshot
Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): Radiosensitization efficiency and toxicity
inferredcites →https://doi.org/10.1016/0360-3016(95)02077-2openalex-snapshot
Fused pyrazine mono-n-oxides as bioreductive drugs. II cytotoxicity in human cells and oncogenicity in a rodent transformation assay
inferredcites →https://doi.org/10.1016/0959-8049(94)90134-1openalex-snapshot
Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia
inferredcites →https://doi.org/10.1016/b978-0-12-411638-2.00007-0openalex-snapshot
Molecular Imaging of the Tumor Microenvironment for Precision Medicine and Theranostics
inferredcites →https://doi.org/10.1016/j.bcp.2006.03.007openalex-snapshot
Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator
inferredcites →https://doi.org/10.1016/j.bcp.2007.06.014openalex-snapshot
Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: A role for NADPH:cytochrome P450 oxidoreductase under hypoxia
inferredcites →https://doi.org/10.1016/j.bcp.2011.12.005openalex-snapshot
Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: Comparison with other hypoxia-activated prodrugs
inferredcites →https://doi.org/10.1016/j.bcp.2014.03.001openalex-snapshot
The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs
inferredcites →https://doi.org/10.1016/j.biomaterials.2016.07.010openalex-snapshot
Hypoxia-directed and activated theranostic agent: Imaging and treatment of solid tumor
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Reconsidering azobenzene as a component of small-molecule hypoxia-mediated cancer drugs: A theranostic case study
inferredcites →https://doi.org/10.1016/j.biomaterials.2018.09.006openalex-snapshot
COX-2 Inhibition mediated anti-angiogenic activatable prodrug potentiates cancer therapy in preclinical models
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Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives
inferredcites →https://doi.org/10.1016/j.bmc.2006.06.038openalex-snapshot
New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides
inferredcites →https://doi.org/10.1016/j.bmc.2008.07.087openalex-snapshot
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors
inferredcites →https://doi.org/10.1016/j.bmc.2011.06.073openalex-snapshot
The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins
inferredcites →https://doi.org/10.1016/j.bmc.2011.06.076openalex-snapshot
N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs
inferredcites →https://doi.org/10.1016/j.bmc.2014.02.039openalex-snapshot
Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers
inferredcites →https://doi.org/10.1016/j.bmcl.2005.03.013openalex-snapshot
Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics
inferredcites →https://doi.org/10.1016/j.bmcl.2005.05.070openalex-snapshot
Concise synthesis and voltammetric studies of dielsiquinone, a cytotoxic azaanthraquinone
inferredcites →https://doi.org/10.1016/j.bmcl.2006.12.108openalex-snapshot
Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles
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Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biological evaluation
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Hypoxia-driven elimination of thiopurines from their nitrobenzyl prodrugs
inferredcites →https://doi.org/10.1016/j.bmcl.2015.10.025openalex-snapshot
Bioreductive deprotection of 4-nitrobenzyl group on thymine base in oligonucleotides for the activation of duplex formation
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Structure and function of matrix metalloproteinases and TIMPs
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Metal-based anticancer chemotherapeutic agents
inferredcites →https://doi.org/10.1016/j.clgc.2013.04.007openalex-snapshot
Phase II Study of Satraplatin and Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer: A Pharmacogenetic Assessment of Outcome and Toxicity
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Bioreductive Drugs: from Concept to Clinic
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NIMRAD – A Phase III Trial to Investigate the Use of Nimorazole Hypoxia Modification with Intensity-modulated Radiotherapy in Head and Neck Cancer
inferredcites →https://doi.org/10.1016/j.ctrv.2004.01.002openalex-snapshot
DT-diaphorase: a target for new anticancer drugs
inferredcites →https://doi.org/10.1016/j.ctrv.2006.09.006openalex-snapshot
Molecular mechanisms of resistance and toxicity associated with platinating agents
inferredcites →https://doi.org/10.1016/j.ejca.2013.05.018openalex-snapshot
The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.ejmech.2010.08.061openalex-snapshot
Structural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxins
inferredcites →https://doi.org/10.1016/j.ejmech.2016.06.015openalex-snapshot
Discovery and development of natural product oridonin-inspired anticancer agents
inferredcites →https://doi.org/10.1016/j.ejmech.2017.03.040openalex-snapshot
Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38
inferredcites →https://doi.org/10.1016/j.ejmech.2017.03.055openalex-snapshot
Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation
inferredcites →https://doi.org/10.1016/j.ejmech.2018.01.065openalex-snapshot
New insights in Au-NHCs complexes as anticancer agents
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2009.09.016openalex-snapshot
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
inferredcites →https://doi.org/10.1016/j.ijrobp.2007.04.008openalex-snapshot
Phase I/II Trial of Sequential Chemoradiotherapy Using a Novel Hypoxic Cell Radiosensitizer, Doranidazole (PR-350), in Patients With Locally Advanced Non–Small-Cell Lung Cancer (WJTOG-0002)
inferredcites →https://doi.org/10.1016/j.ijrobp.2007.05.049openalex-snapshot
Oxygen Dependence and Extravascular Transport of Hypoxia-Activated Prodrugs: Comparison of the Dinitrobenzamide Mustard PR-104A and Tirapazamine
inferredcites →https://doi.org/10.1016/j.ijrobp.2017.03.024openalex-snapshot
Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy
inferredcites →https://doi.org/10.1016/j.jconrel.2018.08.036openalex-snapshot
Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy
inferredcites →https://doi.org/10.1016/j.jinorgbio.2006.02.013openalex-snapshot
From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
inferredcites →https://doi.org/10.1016/j.jinorgbio.2016.06.021openalex-snapshot
Anticancer metal drugs and immunogenic cell death
inferredcites →https://doi.org/10.1016/j.urolonc.2012.11.017openalex-snapshot
Phase II trial of bevacizumab and satraplatin in docetaxel-pretreated metastatic castrate-resistant prostate cancer
inferredcites →https://doi.org/10.1016/s0006-2952(03)00199-0openalex-snapshot
Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting
inferredcites →https://doi.org/10.1016/s0006-2952(03)00452-0openalex-snapshot
3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro
inferredcites →https://doi.org/10.1016/s0006-2952(98)00073-2openalex-snapshot
Discussion
inferredcites →https://doi.org/10.1016/s0006-2952(99)00391-3openalex-snapshot
Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice
inferredcites →https://doi.org/10.1016/s0010-8545(02)00025-5openalex-snapshot
Ruthenium metallopharmaceuticals
inferredcites →https://doi.org/10.1016/s0010-8545(02)00026-7openalex-snapshot
Platinum(IV) antitumour compounds: their bioinorganic chemistry
inferredcites →https://doi.org/10.1016/s0010-8545(02)00312-0openalex-snapshot
Ruthenium metallopharmaceuticals
inferredcites →https://doi.org/10.1016/s0021-9258(17)38654-4openalex-snapshot
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
inferredcites →https://doi.org/10.1016/s0026-895x(24)12489-3openalex-snapshot
Establishment of an Isogenic Human Colon Tumor Model for NQO1 Gene Expression: Application to Investigate the Role of DT-Diaphorase in Bioreductive Drug Activation In Vitro and In Vivo
inferredcites →https://doi.org/10.1016/s0026-895x(25)13321-xopenalex-snapshot
pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.
inferredcites →https://doi.org/10.1016/s0040-4020(98)01079-5openalex-snapshot
New compounds derived from dihydropyrazines having DNA strand-breakage activity
inferredcites →https://doi.org/10.1016/s0065-2571(97)00009-5openalex-snapshot
Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase
inferredcites →https://doi.org/10.1016/s0079-6603(08)60611-xopenalex-snapshot
DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability
inferredcites →https://doi.org/10.1016/s0140-6736(76)91285-xopenalex-snapshot
HYPOXIC CELL SENSITISERS IN RADIOTHERAPY
inferredcites →https://doi.org/10.1016/s0162-0134(01)00360-9openalex-snapshot
Studies of the binding of a series of platinum(IV) complexes to plasma proteins
inferredcites →https://doi.org/10.1016/s0162-0134(97)00090-1openalex-snapshot
Bis-tropolonato derivatives of Cobalt(III) complexes of bidentate aliphatic nitrogen mustards as potential hypoxia-selective cytotoxins
inferredcites →https://doi.org/10.1016/s0163-7258(97)00088-0openalex-snapshot
The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
inferredcites →https://doi.org/10.1016/s0167-8140(00)00181-xopenalex-snapshot
Radiosensitivity of human pancreatic cancer cells in vitro and in vivo, and the effect of a new hypoxic cell sensitizer, doranidazole
inferredcites →https://doi.org/10.1016/s0167-8140(02)00284-0openalex-snapshot
Treatment of head and neck cancer with CHART and nimorazole: phase II study
inferredcites →https://doi.org/10.1016/s0167-8140(97)00220-xopenalex-snapshot
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
inferredcites →https://doi.org/10.1016/s0223-5234(00)00112-4openalex-snapshot
New quinoxalinecarbonitrile 1,4-di-N-oxide derivatives as hypoxic-cytotoxic agents
inferredcites →https://doi.org/10.1016/s0360-3016(97)00327-1openalex-snapshot
Results of a european randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas
inferredcites →https://doi.org/10.1016/s0360-3016(98)00333-2openalex-snapshot
NLCQ-1, a novel hypoxic cytotoxin: potentiation of melphalan, cisDDP and cyclophosphamide in vivo
inferredcites →https://doi.org/10.1016/s0360-3016(98)00360-5openalex-snapshot
The influence of elevated levels of platelet-derived endothelial cell growth factor/thymidine phosphorylase on tumourigenicity, tumour growth, and oxygenation
inferredcites →https://doi.org/10.1016/s0360-3016(99)00054-1openalex-snapshot
Irradiation with or without misonidazole for patients with stages IIIb and IVa carcinoma of the cervix: final results of RTOG 80-05
inferredcites →https://doi.org/10.1016/s0889-8588(18)30103-5openalex-snapshot
O6-Alkylguanine-DNA Alkyltransferase: A Target for the Modulation of Drug Resistance
inferredcites →https://doi.org/10.1016/s0889-8588(18)30105-9openalex-snapshot
Physiologic Mechanisms of Therapeutic Resistance: Blood Flow and Hypoxia
inferredcites →https://doi.org/10.1016/s0891-5849(01)00480-4openalex-snapshot
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
inferredcites →https://doi.org/10.1016/s0959-8049(01)00389-6openalex-snapshot
Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A
inferredcites →https://doi.org/10.1016/s0959-8049(97)00277-3openalex-snapshot
Preclinical activity of trans-indazolium [tetrachlorobisindazoleruthenate(III)] (NSC 666158; IndCR; KP 1019) against tumour colony-forming units and haematopoietic progenitor cells
inferredcites →https://doi.org/10.1016/s0960-894x(96)00508-2openalex-snapshot
A novel nitro-substituted seco-CI: Application as a reductively activated adept prodrug
inferredcites →https://doi.org/10.1016/s0968-0896(01)00235-8openalex-snapshot
Synthesis of novel paclitaxel prodrugs designed for bioreductive activation in hypoxic tumour tissue
inferredcites →https://doi.org/10.1016/s1535-6108(03)00085-0openalex-snapshot
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
inferredcites →https://doi.org/10.1021/acs.analchem.5b03336openalex-snapshot
Efficient Two-Photon Fluorescent Probe for Nitroreductase Detection and Hypoxia Imaging in Tumor Cells and Tissues
inferredcites →https://doi.org/10.1021/acs.bioconjchem.6b00184openalex-snapshot
Cancer Targeted Enzymatic Theranostic Prodrug: Precise Diagnosis and Chemotherapy
inferredcites →https://doi.org/10.1021/acs.chemrev.5b00597openalex-snapshot
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
inferredcites →https://doi.org/10.1021/acs.jmedchem.5b00455openalex-snapshot
Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00563openalex-snapshot
Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b01678openalex-snapshot
Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.6b00011openalex-snapshot
Targeting and Treatment of Tumor Hypoxia by Newly Designed Prodrug Possessing High Permeability in Solid Tumors
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.6b00065openalex-snapshot
Evaluation of a Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence-Guided Surgery of Hypoxic Tumors
inferredcites →https://doi.org/10.1021/ar700108gopenalex-snapshot
Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs
inferredcites →https://doi.org/10.1021/bc700394sopenalex-snapshot
A Doxorubicin Prodrug Activated by the Staudinger Reaction
inferredcites →https://doi.org/10.1021/bi00064a013openalex-snapshot
Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase
inferredcites →https://doi.org/10.1021/bi000885ropenalex-snapshot
Sigmatropic Reactions of the Aziridinyl Semiquinone Species. Why Aziridinyl Benzoquinones Are Metabolically More Stable than Aziridinyl Indoloquinones
inferredcites →https://doi.org/10.1021/cb4001537openalex-snapshot
CH-01 is a Hypoxia-Activated Prodrug That Sensitizes Cells to Hypoxia/Reoxygenation Through Inhibition of Chk1 and Aurora A
inferredcites →https://doi.org/10.1021/cr068207jopenalex-snapshot
Direct Cellular Responses to Platinum-Induced DNA Damage
inferredcites →https://doi.org/10.1021/cr4006236openalex-snapshot
Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance
inferredcites →https://doi.org/10.1021/cr9804238openalex-snapshot
Non-Platinum Chemotherapeutic Metallopharmaceuticals
inferredcites →https://doi.org/10.1021/ic0619714openalex-snapshot
Preferential DNA Cleavage under Anaerobic Conditions by a DNA-Binding Ruthenium Dimer
inferredcites →https://doi.org/10.1021/ic400226gopenalex-snapshot
Recent Developments in Texaphyrin Chemistry and Drug Discovery
inferredcites →https://doi.org/10.1021/ic4006967openalex-snapshot
Cross-Bridged Cyclen or Cyclam Co(III) Complexes Containing Cytotoxic Ligands as Hypoxia-Activated Prodrugs
inferredcites →https://doi.org/10.1021/ic400816gopenalex-snapshot
Bulky N(,N)-(Di)alkylethane-1,2-diamineplatinum(II) Compounds as Precursors for Generating Unsymmetrically Substituted Platinum(IV) Complexes
inferredcites →https://doi.org/10.1021/ic400835nopenalex-snapshot
Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation
inferredcites →https://doi.org/10.1021/ja00968a057openalex-snapshot
Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata 1,2
inferredcites →https://doi.org/10.1021/ja105937qopenalex-snapshot
Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia
inferredcites →https://doi.org/10.1021/ja304239gopenalex-snapshot
Specific Cell Surface Protein Imaging by Extended Self-Assembling Fluorescent Turn-on Nanoprobes
inferredcites →https://doi.org/10.1021/ja906860aopenalex-snapshot
Spin Trapping of Radicals Other Than the•OH Radical upon Reduction of the Anticancer Agent Tirapazamine by Cytochrome P450Reductase
inferredcites →https://doi.org/10.1021/ja908689fopenalex-snapshot
Characterization of Radicals Formed Following Enzymatic Reduction of 3-Substituted Analogues of the Hypoxia-Selective Cytotoxin 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
inferredcites →https://doi.org/10.1021/ja9510774openalex-snapshot
DNA Cleavage by the Antitumor Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (SR4233): Evidence for Involvement of Hydroxyl Radical
inferredcites →https://doi.org/10.1021/ja991113popenalex-snapshot
Alterations in the Binding of [Cl(NH3)5RuIII]2+ to DNA by Glutathione: Reduction, Autoxidation, Coordination, and Decomposition
inferredcites →https://doi.org/10.1021/jacs.6b09713openalex-snapshot
Liposomal Texaphyrin Theranostics for Metastatic Liver Cancer
inferredcites →https://doi.org/10.1021/jacs.7b05019openalex-snapshot
Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy
inferredcites →https://doi.org/10.1021/jm00007a021openalex-snapshot
Hypoxia-Selective Antitumor Agents. 11. Chlorambucil N-Oxide: A Reappraisal of Its Synthesis, Stability, and Selective Toxicity for Hypoxic Cells
inferredcites →https://doi.org/10.1021/jm00010a023openalex-snapshot
Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides
inferredcites →https://doi.org/10.1021/jm000159mopenalex-snapshot
Crystal Structure of FMN-Dependent Nitroreductase from Escherichia c oli B: A Prodrug-Activating Enzyme ,
inferredcites →https://doi.org/10.1021/jm000179oopenalex-snapshot
Development of Novel Quinone Phosphorodiamidate Prodrugs Targeted to DT-Diaphorase
inferredcites →https://doi.org/10.1021/jm00022a014openalex-snapshot
Hypoxia-Selective Agents Derived from 2-Quinoxalinecarbonitrile 1,4-Di-N-oxides. 2
inferredcites →https://doi.org/10.1021/jm00029a010openalex-snapshot
Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitizers
inferredcites →https://doi.org/10.1021/jm00037a011openalex-snapshot
Nitrobenzyl Phosphorodiamidates as Potential Hypoxia-Selective Alkylating Agents
inferredcites →https://doi.org/10.1021/jm00040a009openalex-snapshot
Hypoxia-Selective Antitumor Agents. 9. Structure-Activity Relationships for Hypoxia-Selective Cytotoxicity among Analogs of 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
inferredcites →https://doi.org/10.1021/jm00065a006openalex-snapshot
Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards
inferredcites →https://doi.org/10.1021/jm00069a019openalex-snapshot
Nitrobenzyl mustard quaternary salts: a new class of hypoxia-selective cytotoxins showing very high in vitro selectivity
inferredcites →https://doi.org/10.1021/jm00095a018openalex-snapshot
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells
inferredcites →https://doi.org/10.1021/jm00156a001openalex-snapshot
Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells
inferredcites →https://doi.org/10.1021/jm00163a019openalex-snapshot
Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines
inferredcites →https://doi.org/10.1021/jm00171a027openalex-snapshot
Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins
inferredcites →https://doi.org/10.1021/jm00171a040openalex-snapshot
Synthesis and evaluation of .alpha.-[[(2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of .alpha.-[(1-aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogs which are radiosensitizers and bioreductively activated cytotoxins
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dual Stimuli Responsive Nanoparticle Conjugates for Hypoxia Targeted Drug Delivery
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Assembly‐Glued Ligands and Warheads for Hypoxia‐Activatable Supramolecular Covalent Inhibitors
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Tailoring the Properties of Functional Materials With N ‐Oxides
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Designing Hypoxia‐Responsive Nanotheranostic Agents for Tumor Imaging and Therapy
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An Alternating Irradiation Strategy‐Driven Combination Therapy of PDT and RNAi for Highly Efficient Inhibition of Tumor Growth and Metastasis
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Two‐Photon Small‐Molecule Fluorogenic Probes for Visualizing Endogenous Nitroreductase Activities from Tumor Tissues of a Cancer Patient
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Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction
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Multifunctional Zwitterionic N‐Oxide Polymers to Overcome Cascade Physiological Barriers for Efficient Anticancer Drug Delivery
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Donor Optimizing to Boost Type I and Type II Photosensitization for Solid Tumor Therapy
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A General Hypoxia‐Responsive Molecular Container for Tumor‐Targeted Therapy
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Engineered Microorganisms for Advancing Tumor Therapy
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Tumor Microenvironment‐Responsive Nanomedicines for Potentiating Cancer Immunotherapy
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A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H2S) Donor
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DNA‐Peptide Nanoassembly for Mitochondria‐Specific and Programmable Subcellular Apoptotic Regulation
inferred← citeshttps://doi.org/10.1002/anie.201903968openalex-snapshot
Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy
inferred← citeshttps://doi.org/10.1002/anie.201912574openalex-snapshot
Programming DNA Nanoassembly for Enhanced Photodynamic Therapy
inferred← citeshttps://doi.org/10.1002/anie.201916400openalex-snapshot
A Multi‐action and Multi‐target RuII–PtIV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers
inferred← citeshttps://doi.org/10.1002/anie.202012620openalex-snapshot
A Dinuclear Persulfide‐Bridged Ruthenium Compound is a Hypoxia‐Selective Hydrogen Sulfide (H2S) Donor
inferred← citeshttps://doi.org/10.1002/anie.202012687openalex-snapshot
An Ethacrynic Acid‐Brominated BODIPY Photosensitizer (EA‐BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor‐Targeted Photodynamic Therapy
inferred← citeshttps://doi.org/10.1002/anie.202017349openalex-snapshot
Harnessing Hypoxia‐Dependent Cyanine Photocages for In Vivo Precision Drug Release
inferred← citeshttps://doi.org/10.1002/anie.202205429openalex-snapshot
A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway
inferred← citeshttps://doi.org/10.1002/anie.202305744openalex-snapshot
A Radio‐Pharmaceutical Fluorescent Probe for Synergistic Cancer Radiotherapy and Ratiometric Imaging of Tumor Reactive Oxygen Species
inferred← citeshttps://doi.org/10.1002/anie.202306824openalex-snapshot
Stimuli‐Responsive PROTACs for Controlled Protein Degradation
inferred← citeshttps://doi.org/10.1002/anie.202310318openalex-snapshot
Azobenzene‐Based Linker Strategy for Selective Activation of Antibody–Drug Conjugates
inferred← citeshttps://doi.org/10.1002/anie.202402139openalex-snapshot
Expanding the Hydrophobic Cavity Surface of Azocalix[4]arene to Enable Biotin/Avidin Affinity with Controlled Release
inferred← citeshttps://doi.org/10.1002/anie.202406332openalex-snapshot
Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries
inferred← citeshttps://doi.org/10.1002/anie.202411636openalex-snapshot
A Nitroreductase‐Activatable Metabolic Reporter for Covalent Labeling of Pathological Hypoxic Cells in Tumorigenesis
inferred← citeshttps://doi.org/10.1002/anie.202500645openalex-snapshot
Self‐Assembled Triple‐Targeted Radiosensitizer Enhances Hypoxic Tumor Targeting and Radio‐Immunotherapy Efficacy
inferred← citeshttps://doi.org/10.1002/anie.202506412openalex-snapshot
A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy
inferred← citeshttps://doi.org/10.1002/anie.2929190openalex-snapshot
DNA‐Peptide Nanoassembly for Mitochondria‐Specific and Programmable Subcellular Apoptotic Regulation
inferred← citeshttps://doi.org/10.1002/asia.202401226openalex-snapshot
Endoplasmic Reticulum‐Targeting Delayed Fluorescent Probe for Dual‐mode Nitroreductase Sensing
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Hypoxia‐responsive AIEgens for precise disease theranostics
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Cu‐Catalyzed Chan–Evans–Lam Coupling Reactions of 2‐Nitroimidazole with Aryl Boronic Acids: An Effort toward New Bioactive Agents against S. pneumoniae
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Innovative Linker Strategies for Tumor‐Targeted Drug Conjugates
inferred← citeshttps://doi.org/10.1002/chem.202004024openalex-snapshot
Bis(bipyridine)ruthenium(II) Ferrocenyl β‐Diketonate Complexes: Exhibiting Nanomolar Potency against Human Cancer Cell Lines
inferred← citeshttps://doi.org/10.1002/chem.202301412openalex-snapshot
NAD(P)H:Quinone Acceptor Oxidoreductase 1 (NQO1) Activatable Salicylamide H+/Cl− Transporters
inferred← citeshttps://doi.org/10.1002/cjoc.202200459openalex-snapshot
Precise Control of Self‐assembly in vivo Based on Polymer‐Peptide Conjugates†
inferred← citeshttps://doi.org/10.1002/cmdc.202400127openalex-snapshot
Recent Development of Transition Metal Complexes as Chemotherapeutic Hypoxia Activated Prodrug (HAP)
inferred← citeshttps://doi.org/10.1002/cpt.3066openalex-snapshot
Quantitative Analysis of the Concentration of Trifluridine in Tumor Hypoxic Regions Using a Novel Platform Combining Functional Endoscopy and Mass Spectrometry
inferred← citeshttps://doi.org/10.1002/cptc.202000015openalex-snapshot
Photoinduced Release of DNA‐Binding Ligands from the [4+4] Dimers of Benzo[b]quinolizinium and Anthracene Derivatives
inferred← citeshttps://doi.org/10.1002/cptc.202300318openalex-snapshot
Photoinduced [2+2] and [4+4] Cycloaddition and Cycloreversion Reactions for the Development of Photocontrollable DNA Binders
inferred← citeshttps://doi.org/10.1002/ddr.22126openalex-snapshot
Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study
inferred← citeshttps://doi.org/10.1002/inmd.20230004openalex-snapshot
From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology
inferred← citeshttps://doi.org/10.1002/jhet.70002openalex-snapshot
Synthesis and Antitumor Activity of New Metronidazole‐Linked Thiophene or Pyrazole Analogues
inferred← citeshttps://doi.org/10.1002/jum.70140openalex-snapshot
A Comparative Study of Sononeoperfusion Effects Induced by Diagnostic and Therapeutic Ultrasound‐Stimulated Microbubbles
inferred← citeshttps://doi.org/10.1002/mco2.203openalex-snapshot
Hypoxia signaling in cancer: Implications for therapeutic interventions
inferred← citeshttps://doi.org/10.1002/mco2.512openalex-snapshot
Hypoxia‐activated ADCC‐enhanced humanized anti‐CD147 antibody for liver cancer imaging and targeted therapy with improved selectivity
inferred← citeshttps://doi.org/10.1002/med.21913openalex-snapshot
Progress and perspective on hydrogen sulfide donors and their biomedical applications
inferred← citeshttps://doi.org/10.1002/med.22007openalex-snapshot
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives
inferred← citeshttps://doi.org/10.1002/slct.202202538openalex-snapshot
Covalent Organic Frameworks (COFs): A Necessary Choice For Drug Delivery
inferred← citeshttps://doi.org/10.1002/smll.202308599openalex-snapshot
Hypoxia and Matrix Metalloproteinase 13‐Responsive Hydrogel Microspheres Alleviate Osteoarthritis Progression In Vivo
inferred← citeshttps://doi.org/10.1002/smll.73796openalex-snapshot
Mitochondria‐Targeted Zwitterionic Nanogels Trigger Photopyroptosis for Enhanced Cancer Therapy
inferred← citeshttps://doi.org/10.1002/smo.20240010openalex-snapshot
Photodynamic therapy promotes hypoxia‐activated nitrogen mustard drug release
inferred← citeshttps://doi.org/10.1002/smtd.202401742openalex-snapshot
Achieving Precision Phototherapy from Start to Finish: Integrating Endosomal Escape, Respiration Inhibition, and ROS Release in a Single Upconversion Nanoparticle
inferred← citeshttps://doi.org/10.1002/wnan.1736openalex-snapshot
Theragnostic nanomotors: Successes and upcoming challenges
inferred← citeshttps://doi.org/10.1007/978-3-030-83244-5_4openalex-snapshot
DNA Damage Radiosensitizers Geared Towards Hydrated Electrons
inferred← citeshttps://doi.org/10.1007/978-3-031-04071-9_5openalex-snapshot
Harnessing the Power of Nanomaterials to Alleviate Tumor Hypoxia in Favor of Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-981-95-7425-4_36openalex-snapshot
Hypoxia Induced Radio Resistance in Head and Neck Cancers
inferred← citeshttps://doi.org/10.1007/978-981-96-9478-5_2openalex-snapshot
Application of Small Molecule Fluorescent Probe in Tumor Diagnosis and Treatment
inferred← citeshttps://doi.org/10.1007/978-981-99-0313-9_17openalex-snapshot
Identification of Hypoxia-Targeting Drugs in the Tumor Microenvironment and Prodrug Strategies for Targeting Tumor Hypoxia
inferred← citeshttps://doi.org/10.1007/978-981-99-1718-1_13openalex-snapshot
Anaerobic Bacteria Mediated Hypoxia Specific Delivery of Nanoparticles
inferred← citeshttps://doi.org/10.1007/s00418-023-02258-6openalex-snapshot
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
inferred← citeshttps://doi.org/10.1007/s00775-026-02149-wopenalex-snapshot
Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges
inferred← citeshttps://doi.org/10.1007/s10557-021-07182-2openalex-snapshot
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection
inferred← citeshttps://doi.org/10.1007/s10895-021-02800-6openalex-snapshot
A Nitronaphthalimide Probe for Fluorescence Imaging of Hypoxia in Cancer Cells
inferred← citeshttps://doi.org/10.1007/s10895-022-02974-7openalex-snapshot
A Highly Selective Fluorescent Probe for the Detection of Nitroreductase Based on a Naphthalimide Scaffold
inferred← citeshttps://doi.org/10.1007/s11033-022-07802-6openalex-snapshot
Acute vs. chronic vs. intermittent hypoxia in breast Cancer: a review on its application in in vitro research
inferred← citeshttps://doi.org/10.1007/s11033-023-08568-1openalex-snapshot
The evidence for repurposing anti-epileptic drugs to target cancer
inferred← citeshttps://doi.org/10.1007/s11307-023-01855-0openalex-snapshot
Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI)
inferred← citeshttps://doi.org/10.1007/s11426-024-2231-1openalex-snapshot
Hypoxia-triggered photothermal/drug combination therapy of tumors using a perylene diimide molecular capsule
inferred← citeshttps://doi.org/10.1007/s11426-024-2301-3openalex-snapshot
Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene
inferred← citeshttps://doi.org/10.1007/s11426-025-2604-6openalex-snapshot
Hydrogen radical-based prodrug photoactivation by modulating bond dissociation energy of a phenolic photosensitizer
inferred← citeshttps://doi.org/10.1007/s11427-019-1569-4openalex-snapshot
Design strategy of optical probes for tumor hypoxia imaging
inferred← citeshttps://doi.org/10.1007/s12020-023-03390-yopenalex-snapshot
Efficacy and safety of anlotinib-based chemotherapy for locally advanced or metastatic anaplastic thyroid carcinoma
inferred← citeshttps://doi.org/10.1007/s12209-020-00260-wopenalex-snapshot
A Programmable Hybrid DNA Nanogel for Enhanced Photodynamic Therapy of Hypoxic Glioma
inferred← citeshttps://doi.org/10.1007/s12274-021-3552-3openalex-snapshot
Aza-BODIPY-based phototheranostic nanoagent for tissue oxygen auto-adaptive photodynamic/photothermal complementary therapy
inferred← citeshttps://doi.org/10.1007/s12274-023-5377-0openalex-snapshot
Ultrasound cascade regulation of nano-oxygen hybrids triggering ferroptosis augmented sonodynamic anticancer therapy
inferred← citeshttps://doi.org/10.1007/s12274-024-6534-4openalex-snapshot
Synergistic enhancement of ultrasound therapy for tumors using hypoxia-activated 6-diazo-5-oxo-L-norleucine (DON) prodrug nanoparticles
inferred← citeshttps://doi.org/10.1007/s12668-025-02126-8openalex-snapshot
Nanoinformatics: A Potential Tool for Precision Targeting in Pediatric Cancer
inferred← citeshttps://doi.org/10.1007/s13205-021-02692-0openalex-snapshot
Suicide gene therapy-mediated purine nucleoside phosphorylase/fludarabine system for in vitro breast cancer model with emphasis on evaluation of vascular endothelial growth factor promoter efficacy
inferred← citeshttps://doi.org/10.1007/s13346-025-01950-5openalex-snapshot
Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery
inferred← citeshttps://doi.org/10.1007/s13770-021-00403-7openalex-snapshot
Tumor Microenvironment Modulating Functional Nanoparticles for Effective Cancer Treatments
inferred← citeshttps://doi.org/10.1007/s40843-025-3581-2openalex-snapshot
Bacteria outer membrane-based oxygen gels alleviate tumor hypoxia for enhanced systemic immune response to radiotherapy
inferred← citeshttps://doi.org/10.1007/s40843-025-3640-3openalex-snapshot
Nanodrug engineered bacteria for tumor-targeted and synergistic photothermal immunotherapy
inferred← citeshttps://doi.org/10.1007/s43440-020-00138-7openalex-snapshot
Drug resistance in cancer: mechanisms and tackling strategies
inferred← citeshttps://doi.org/10.1016/b978-0-443-15635-9.00013-4openalex-snapshot
Hypoxia-activated prodrugs
inferred← citeshttps://doi.org/10.1016/b978-0-443-15894-0.00013-6openalex-snapshot
Nanoclay-based drug delivery systems
inferred← citeshttps://doi.org/10.1016/b978-0-443-27765-8.00006-0openalex-snapshot
Targeting methylation and acetylation in colon cancer
inferred← citeshttps://doi.org/10.1016/b978-0-443-33641-6.00014-2openalex-snapshot
Hypoxia-responsive nanocarriers for biomedical application
inferred← citeshttps://doi.org/10.1016/b978-0-443-33641-6.00015-4openalex-snapshot
Azo-based compounds for hypoxia-responsive drug delivery
inferred← citeshttps://doi.org/10.1016/j.actbio.2022.05.050openalex-snapshot
Hypoxia-reinforced antitumor RNA interference mediated by micelleplexes with programmed disintegration
inferred← citeshttps://doi.org/10.1016/j.actbio.2025.07.062openalex-snapshot
A hypoxia-leveraged near-IR theranostic nanomedicine enables imaging-guided tumor diagnosis and photothermal therapy
inferred← citeshttps://doi.org/10.1016/j.addr.2022.114296openalex-snapshot
Progress of engineered bacteria for tumor therapy
inferred← citeshttps://doi.org/10.1016/j.addr.2025.115720openalex-snapshot
Microbiome-active drug delivery systems (MADDS): Leveraging microbial stimuli for controlled drug release
inferred← citeshttps://doi.org/10.1016/j.addr.2026.115775openalex-snapshot
Rational modification of PROTACs for tumor-selective protein degradation
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.08.010openalex-snapshot
Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes
inferred← citeshttps://doi.org/10.1016/j.apsb.2025.07.020openalex-snapshot
Photodynamic enhancement of PROTAC prodrug activation in hypoxic tumors
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2022.05.022openalex-snapshot
Oxygen microcapsules improve immune checkpoint blockade by ameliorating hypoxia condition in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2023.02.015openalex-snapshot
Enzyme-triggered deep tumor penetration of a dual-drug nanomedicine enables an enhanced cancer combination therapy
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2024.03.003openalex-snapshot
Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors
inferred← citeshttps://doi.org/10.1016/j.bioadv.2024.213962openalex-snapshot
Near-infrared photoactivatable three-in-one nanoagents to aggravate hypoxia and enable amplified photo-chemotherapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.05.002openalex-snapshot
Nanomaterial designing strategies related to cell lysosome and their biomedical applications: A review
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121576openalex-snapshot
Self-delivery of metal-coordinated mitochondria protonophore uncoupler for O2-exhausting enhanced bioreductive therapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121596openalex-snapshot
Minimalist O2 generator formed by in situ KMnO4 oxidation for tumor cascade therapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121757openalex-snapshot
Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2023.122365openalex-snapshot
Synchronized activating therapeutic nano-agent: Enhancement and tracing for hypoxia-induced chemotherapy
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.103778openalex-snapshot
Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105510openalex-snapshot
Construction of synergistic pH/H2O2-responsive prodrug for prolonging blood circulation and accelerating cellular internalization
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107161openalex-snapshot
Recent advances in hypoxia-activated compounds for cancer diagnosis and treatment
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108468openalex-snapshot
Redox dyshomeostasis-driven prodrug strategy for enhancing camptothecin-based chemotherapy: Selenization of SN38 as a case study
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109246openalex-snapshot
Responsive fluorescent probes for the imaging of cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.109988openalex-snapshot
Pursuing for the better lung cancer therapy effect: Comparison of two different kinds of hyaluronic acid and nitroimidazole co-decorated nanomedicines
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112338openalex-snapshot
Development and biological evaluation of AzoBGNU: A novel hypoxia-activated DNA crosslinking prodrug with AGT-inhibitory activity
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117493openalex-snapshot
Advances in stimuli-responsive gold nanorods for drug-delivery and targeted therapy systems
inferred← citeshttps://doi.org/10.1016/j.bios.2021.113441openalex-snapshot
Trends in small organic fluorescent scaffolds for detection of oxidoreductase
inferred← citeshttps://doi.org/10.1016/j.bmcl.2023.129484openalex-snapshot
Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole
inferred← citeshttps://doi.org/10.1016/j.canlet.2020.07.007openalex-snapshot
Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2021.10.017openalex-snapshot
Gold nanoparticles and obese adipose tissue microenvironment in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.canlet.2024.216940openalex-snapshot
β-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1α-mediated angiogenesis
inferred← citeshttps://doi.org/10.1016/j.carbpol.2020.116119openalex-snapshot
Fluorinated-functionalized hyaluronic acid nanoparticles for enhanced photodynamic therapy of ocular choroidal melanoma by ameliorating hypoxia
inferred← citeshttps://doi.org/10.1016/j.carbpol.2021.118655openalex-snapshot
An intelligent hypoxia-relieving chitosan-based nanoplatform for enhanced targeted chemo-sonodynamic combination therapy on lung cancer
inferred← citeshttps://doi.org/10.1016/j.cclet.2019.08.038openalex-snapshot
Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy
inferred← citeshttps://doi.org/10.1016/j.cclet.2022.08.018openalex-snapshot
Synergetic treatment of oxygen microcapsules and lenvatinib for enhanced therapy of HCC by alleviating hypoxia condition and activating anti-tumor immunity
inferred← citeshttps://doi.org/10.1016/j.cclet.2025.111404openalex-snapshot
A hypoxia-activated copper ion nanoexchanger for cancer immunotherapy by in situ precise production of immunogenic cell death inducer
inferred← citeshttps://doi.org/10.1016/j.cclet.2025.112285openalex-snapshot
Augmenting macropinocytosis enhances the apoptotic body-mediated tumor deep penetration of nanomedicines
inferred← citeshttps://doi.org/10.1016/j.ccr.2020.213460openalex-snapshot
Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases
inferred← citeshttps://doi.org/10.1016/j.ccr.2020.213559openalex-snapshot
Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics
inferred← citeshttps://doi.org/10.1016/j.ccr.2020.213613openalex-snapshot
Recent advances in fluorescent probes for cellular antioxidants: Detection of NADH, hNQO1, H2S, and other redox biomolecules
inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214208openalex-snapshot
Fluorescent probes in public health and public safety
inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214210openalex-snapshot
What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214283openalex-snapshot
Mitochondria targeted fluorogenic theranostic agents for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ccr.2022.214908openalex-snapshot
Engineering of BODIPY-based theranostics for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ccr.2023.215248openalex-snapshot
In vitro and in vivo imaging of Phase I xenobiotic-metabolizing enzymes
inferred← citeshttps://doi.org/10.1016/j.ccr.2023.215560openalex-snapshot
Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy
inferred← citeshttps://doi.org/10.1016/j.ccr.2024.216101openalex-snapshot
Targeted delivery of nano-radiosensitizers for tumor radiotherapy
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.216456openalex-snapshot
Recent mitochondria-immobilized fluorescent probes for high-fidelity bioimaging: From design to application
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.216681openalex-snapshot
Top-down bioinspired nanotheranostics with AIE luminogens
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.217097openalex-snapshot
Tumor microenvironment-responsive self-assembled drug-drug conjugate nanosystems: A smart platform for precision cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ccr.2026.217943openalex-snapshot
Stimuli-responsive, prodrug-activating enzyme-functionalized metal-organic frameworks for cancer therapy and tumor microenvironment modulation
inferred← citeshttps://doi.org/10.1016/j.cej.2019.122540openalex-snapshot
HIF-1 dependent reversal of cisplatin resistance via anti-oxidative nano selenium for effective cancer therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2021.130109openalex-snapshot
Enhanced radiotherapy efficacy and induced anti-tumor immunity in HCC by improving hypoxia microenvironment using oxygen microcapsules
inferred← citeshttps://doi.org/10.1016/j.cej.2021.130536openalex-snapshot
pH/near-infrared light dual activated Ce6-doped silicon nanoparticles with tumor chemo-photodynamic synergistic therapy for improving efficiency of monotherapy
inferred← citeshttps://doi.org/10.1016/j.cej.2022.135566openalex-snapshot
Anaerobic bacteria mediated ‘smart missile’ targeting tumor hypoxic area enhances the therapeutic outcome of lung cancer
inferred← citeshttps://doi.org/10.1016/j.cej.2022.137889openalex-snapshot
State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT
inferred← citeshttps://doi.org/10.1016/j.cej.2022.140465openalex-snapshot
A self-amplified necrotic targeting theranostic nanoparticle with deep tumor penetration for imaging-guided personalized chemo-photodynamic therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2024.150526openalex-snapshot
“Transforming enemy into friend” strategy-based stimuli responsive dual-drug liposomes for synergistic chemo-photodynamic therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2024.153978openalex-snapshot
Tailoring polymeric nanocarriers for hypoxia-specific drug release: Insights into design and applications in clinics
inferred← citeshttps://doi.org/10.1016/j.cej.2024.158081openalex-snapshot
Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors
inferred← citeshttps://doi.org/10.1016/j.cej.2025.164698openalex-snapshot
Hypoxia-responsive polyphenol prodrug for targeted glucose oxidase delivery and enhanced multimodal cancer therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2025.170485openalex-snapshot
Engineered nanotechnology for epigenetic therapy in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.cej.2026.174085openalex-snapshot
Engineering nano-PROTAC platforms: Self-assembly, stimuli-responsiveness, and targeted delivery for precision therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2026.176066openalex-snapshot
Sulfonated azobenzene-derived nanogels: Hypoxia-specific degradation enables superior nucleic acid-mediated tumor therapy
inferred← citeshttps://doi.org/10.1016/j.cej.2026.178161openalex-snapshot
Recent advances in infection microenvironment-responsive antibacterial materials
inferred← citeshttps://doi.org/10.1016/j.cej.2026.183093openalex-snapshot
Vascular normalization-driven copper-based nanoregulator for cuproptosis-potentiated osteosarcoma immunotherapy
inferred← citeshttps://doi.org/10.1016/j.chembiol.2021.04.004openalex-snapshot
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
inferred← citeshttps://doi.org/10.1016/j.chempr.2022.03.010openalex-snapshot
Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe
inferred← citeshttps://doi.org/10.1016/j.coelec.2021.100740openalex-snapshot
Unveiling the relevance of the redox character of nitroaromatic and nitroheteroaromatic compounds as potential medicines
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2023.113277openalex-snapshot
Probiotic Escherichia coli Nissle 1917 propelled micro-robot with pH sensitivity for hypoxia targeted intestinal tumor therapy
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2023.113395openalex-snapshot
CD44-mediated tumor homing of hyaluronic acid nanogels for hypoxia-activated photodynamic therapy against tumor
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2025.115076openalex-snapshot
Exploiting aza-zinc-dipyrromethene dyes for photoacoustic imaging guided synergistic anticancer phototherapy
inferred← citeshttps://doi.org/10.1016/j.ctro.2025.100940openalex-snapshot
Magnetic resonance imaging to detect tumor hypoxia in brain malignant disease: A systematic review of validation studies
inferred← citeshttps://doi.org/10.1016/j.device.2023.100001openalex-snapshot
A light-driven nanopipette ion pump for probing subcellular oxygen levels
inferred← citeshttps://doi.org/10.1016/j.drup.2024.101113openalex-snapshot
Increased oxygen stimulation promotes chemoresistance and phenotype shifting through PLCB1 in gliomas
inferred← citeshttps://doi.org/10.1016/j.dyepig.2022.110583openalex-snapshot
Hypoxia-responsive near infrared thioxanthene-hemicyanine nanoparticle for multimodal imaging-guided photothermal/photodynamic therapy
inferred← citeshttps://doi.org/10.1016/j.dyepig.2024.112208openalex-snapshot
Heavy atom-modified hemicyanine dyes as photosensitizer scaffolds combined with nitric oxide trigger the butterfly effect in tumor therapy
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