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Time and dose-dependence evaluation of nitroheterocyclic drugs for improving efficacy following Trypanosoma cruzi infection: A pre-clinical study

https://doi.org/10.1016/j.bcp.2018.01.005
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00436-010-1780-7openalex-snapshot
New method for quantification of Trypanosoma cruzi in animal’s tissue in the chronic phase of experimental Chagas' disease
inferredcites →https://doi.org/10.1016/0035-9203(87)90020-4openalex-snapshot
Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
inferredcites →https://doi.org/10.1016/j.exppara.2007.08.016openalex-snapshot
Trypanosoma cruzi: Acute and long-term infection in the vertebrate host can modify the response to benznidazole
inferredcites →https://doi.org/10.1016/j.ijpddr.2015.12.001openalex-snapshot
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain
inferredcites →https://doi.org/10.1016/j.pt.2006.09.011openalex-snapshot
The future of Chagas disease control
inferredcites →https://doi.org/10.1016/s0166-6851(03)00093-8openalex-snapshot
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR
inferredcites →https://doi.org/10.1016/s0213-005x(02)72829-2openalex-snapshot
Aspectos farmacocinéticos y farmacodinámicos para la lectura interpretada del antibiograma
inferredcites →https://doi.org/10.1056/nejmc1407914openalex-snapshot
Posaconazole versus benznidazole for chronic Chagas' disease.
inferredcites →https://doi.org/10.1093/infdis/jit420openalex-snapshot
New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice
inferredcites →https://doi.org/10.1093/jac/dks027openalex-snapshot
Safety of benznidazole use in the treatment of chronic Chagas' disease
inferredcites →https://doi.org/10.1096/fj.07-9574lsfopenalex-snapshot
Dose translation from animal to human studies revisited
inferredcites →https://doi.org/10.1128/aac.00104-09openalex-snapshot
Experimental Chemotherapy againstTrypanosoma cruziInfection Using Ruthenium Nitric Oxide Donors
inferredcites →https://doi.org/10.1128/aac.00689-15openalex-snapshot
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease
inferredcites →https://doi.org/10.1128/aac.00745-15openalex-snapshot
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients
inferredcites →https://doi.org/10.1128/aac.01401-12openalex-snapshot
Benznidazole-Related Adverse Drug Reactions and Their Relationship to Serum Drug Concentrations in Patients with Chronic Chagas Disease
inferredcites →https://doi.org/10.1128/aac.04660-14openalex-snapshot
Toxic Profile of Benznidazole in Patients with Chronic Chagas Disease: Risk Factors and Comparison of the Product from Two Different Manufacturers
inferredcites →https://doi.org/10.1128/aac.47.1.223-230.2003openalex-snapshot
Chemotherapy with Benznidazole and Itraconazole for Mice Infected with Different Trypanosoma cruzi Clonal Genotypes
inferredcites →https://doi.org/10.1371/journal.pntd.0000488openalex-snapshot
Feasibility, Drug Safety, and Effectiveness of Etiological Treatment Programs for Chagas Disease in Honduras, Guatemala, and Bolivia: 10-Year Experience of Médecins Sans Frontières
inferredcites →https://doi.org/10.1371/journal.pntd.0001870openalex-snapshot
Fexinidazole: A Potential New Drug Candidate for Chagas Disease
inferredcites →https://doi.org/10.1371/journal.pntd.0002907openalex-snapshot
Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults
inferredcites →https://doi.org/10.1371/journal.pone.0022155openalex-snapshot
Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo
inferredcites →https://doi.org/10.1371/journal.pone.0128707openalex-snapshot
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease
inferredcites →https://doi.org/10.1517/13543784.2014.922952openalex-snapshot
Therapeutical approaches under investigation for treatment of Chagas disease
inferredcites →https://doi.org/10.1586/17512433.2014.909282openalex-snapshot
Potential new clinical therapies for Chagas disease
inferredcites →https://doi.org/10.1590/0074-02760150401openalex-snapshot
Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
inferredcites →https://doi.org/10.1590/s0074-02762002000100001openalex-snapshot
A Critical Review on Chagas Disease Chemotherapy
inferredcites →https://doi.org/10.1590/s0074-02762009000900005openalex-snapshot
Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy
inferredcites →https://doi.org/10.1590/s0074-02762010000200022openalex-snapshot
In vitro and in vivo experimental models for drug screening and development for Chagas disease
inferredcites →https://doi.org/10.4269/ajtmh.2012.11-0471openalex-snapshot
In Vitro and In Vivo Studies of the Trypanocidal Activity of Four Terpenoid Derivatives against Trypanosoma cruzi

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4746016openalex-extracted
Chagas Disease: History, Pathophysiology and Therapeutic Treatment
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167264openalex-snapshot
Identification of host antioxidant effectors as thioridazine targets: Impact on cardiomyocytes infection and Trypanosoma cruzi-induced acute myocarditis
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110218openalex-snapshot
Drug-natural molecule coupling as a rational strategy in the development of an innovative antiparasitic, anti-inflammatory and cardioprotective drug for Chagas disease treatment
inferred← citeshttps://doi.org/10.1016/j.carpath.2024.107653openalex-snapshot
The mitochondrial uncoupler 2,4-dinitrophenol modulates inflammatory and oxidative responses in Trypanosoma cruzi-induced acute myocarditis in mice
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2020.110850openalex-snapshot
Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection
inferred← citeshttps://doi.org/10.1016/j.exppara.2020.107834openalex-snapshot
Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110416openalex-snapshot
Pharmacological potential of new metronidazole/eugenol/dihydroeugenol hybrids against Trypanosoma cruzi in vitro and in vivo
inferred← citeshttps://doi.org/10.1017/s0031182021001001openalex-snapshot
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c01077openalex-snapshot
Late-Stage Diversification of Rewired Purine C-Nucleosides Reveals Potent Antitrypanosomatid Agents with In Vivo Efficacy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00999openalex-snapshot
Discovery of Novel 7-Aryl 7-Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01275openalex-snapshot
Discovery of Pyrrolo[2,3- b ]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti- Trypanosoma cruzi Agents
inferred← citeshttps://doi.org/10.1021/acsinfecdis.6c00228openalex-snapshot
Tissue-Specific Parasite Persistence Following Chemotherapy in a Drug-Resistant Trypanosoma cruzi Preclinical Model
inferred← citeshttps://doi.org/10.1021/acsptsci.6c00179openalex-snapshot
A New Nitroimidazole-Based Drug Attenuates Skeletal Myositis and Overcomes Benznidazole Resistance in Experimental Chagas Disease
inferred← citeshttps://doi.org/10.1080/13543784.2024.2349289openalex-snapshot
Drugs in preclinical and early clinical development for the treatment of Chagas´s disease: the current status
inferred← citeshttps://doi.org/10.1128/aac.02264-18openalex-snapshot
Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.11606/t.9.2021.tde-23022022-160836openalex-snapshot
Estudo eletroquímico de compostos nitro-heterocíclicos potencialmente antichagásicos utilizando eletrodos quimicamente modificados com ftalocianinas
inferred← citeshttps://doi.org/10.1371/journal.pntd.0012968openalex-snapshot
Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease
inferred← citeshttps://doi.org/10.1371/journal.pntd.0013522openalex-snapshot
Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA)
inferred← citeshttps://doi.org/10.2139/ssrn.5240565openalex-snapshot
Dual-Action Metronidazole-5-Nitrodihydroeugenol Hybrid: Reduces Parasitism, Cardiac Risk, and Inflammatory Response, While Boosting Benznidazole Efficacy
inferred← citeshttps://doi.org/10.2147/jep.s267378openalex-snapshot
Review on Experimental Treatment Strategies Against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.3390/pathogens10060729openalex-snapshot
Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
inferred← citeshttps://doi.org/10.3390/pharmaceutics15041126openalex-snapshot
Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment
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