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Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

https://doi.org/10.1016/j.ccell.2018.12.012
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.24516openalex-snapshot
PUMA–mediated apoptosis drives chemical hepatocarcinogenesis in mice
inferredcites →https://doi.org/10.1002/stem.1054openalex-snapshot
Context‐Dependent Enhancement of Induced Pluripotent Stem Cell Reprogramming by Silencing Puma
inferredcites →https://doi.org/10.1007/s00018-016-2358-zopenalex-snapshot
DNA repair mechanisms in embryonic stem cells
inferredcites →https://doi.org/10.1007/s10620-007-9799-zopenalex-snapshot
Pro-Apoptotic PUMA and Anti-Apoptotic Phospho-BAD Are Highly Expressed in Colorectal Carcinomas
inferredcites →https://doi.org/10.1007/s12094-013-1010-8openalex-snapshot
Expression of p53 upregulated modulator of apoptosis (PUMA) and C-myb in gallbladder adenocarcinoma and their pathological significance
inferredcites →https://doi.org/10.1007/s13238-014-0032-5openalex-snapshot
Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template
inferredcites →https://doi.org/10.1016/0092-8674(95)90039-xopenalex-snapshot
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
inferredcites →https://doi.org/10.1016/j.ccr.2007.10.001openalex-snapshot
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm
inferredcites →https://doi.org/10.1016/j.ceb.2017.11.005openalex-snapshot
Deciphering p53 signaling in tumor suppression
inferredcites →https://doi.org/10.1016/j.cell.2009.04.037openalex-snapshot
Blinded by the Light: The Growing Complexity of p53
inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot
Hallmarks of Cancer: The Next Generation
inferredcites →https://doi.org/10.1016/j.cell.2012.04.026openalex-snapshot
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
inferredcites →https://doi.org/10.1016/j.cell.2017.08.028openalex-snapshot
Putting p53 in Context
inferredcites →https://doi.org/10.1016/j.celrep.2014.05.017openalex-snapshot
Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
inferredcites →https://doi.org/10.1016/j.molcel.2014.09.026openalex-snapshot
A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth
inferredcites →https://doi.org/10.1016/j.tcb.2012.08.001openalex-snapshot
The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation
inferredcites →https://doi.org/10.1016/s1535-6108(03)00244-7openalex-snapshot
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
inferredcites →https://doi.org/10.1038/377552a0openalex-snapshot
Radiation-induced cell cycle arrest compromised by p21 deficiency
inferredcites →https://doi.org/10.1038/cdd.2012.9openalex-snapshot
BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax
inferredcites →https://doi.org/10.1038/cddis.2010.38openalex-snapshot
Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
inferredcites →https://doi.org/10.1038/cddis.2014.87openalex-snapshot
p53 induces skin aging by depleting Blimp1+ sebaceous gland cells
inferredcites →https://doi.org/10.1038/nature05949openalex-snapshot
Delayed ageing through damage protection by the Arf/p53 pathway
inferredcites →https://doi.org/10.1038/ncb1211openalex-snapshot
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
inferredcites →https://doi.org/10.1038/ncb2100openalex-snapshot
Puma is required for p53-induced depletion of adult stem cells
inferredcites →https://doi.org/10.1038/ng1282openalex-snapshot
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
inferredcites →https://doi.org/10.1038/nm1146openalex-snapshot
Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors
inferredcites →https://doi.org/10.1038/nrc.2017.109openalex-snapshot
Targeting mutant p53 for efficient cancer therapy
inferredcites →https://doi.org/10.1038/nrc3430openalex-snapshot
MDM2, MDMX and p53 in oncogenesis and cancer therapy
inferredcites →https://doi.org/10.1038/nrm3420openalex-snapshot
DNA damage checkpoints in stem cells, ageing and cancer
inferredcites →https://doi.org/10.1038/nrm4007openalex-snapshot
p53 in survival, death and metabolic health: a lifeguard with a licence to kill
inferredcites →https://doi.org/10.1038/sj.cdd.4401182openalex-snapshot
Regulation of p53 responses by post-translational modifications
inferredcites →https://doi.org/10.1038/sj.emboj.7601167openalex-snapshot
Ser18 and 23 phosphorylation is required for p53‐dependent apoptosis and tumor suppression
inferredcites →https://doi.org/10.1038/sj.onc.1211023openalex-snapshot
Induction of genetic instability by gain-of-function p53 cancer mutants
inferredcites →https://doi.org/10.1042/0264-6021:3420133openalex-snapshot
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
inferredcites →https://doi.org/10.1042/bj20150517openalex-snapshot
Regulation of the p53 response and its relationship to cancer
inferredcites →https://doi.org/10.1073/pnas.1111245108openalex-snapshot
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages
inferredcites →https://doi.org/10.1073/pnas.220252297openalex-snapshot
Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage
inferredcites →https://doi.org/10.1074/jbc.m305135200openalex-snapshot
Phosphorylation Site Interdependence of Human p53 Post-translational Modifications in Response to Stress
inferredcites →https://doi.org/10.1093/emboj/cdf595openalex-snapshot
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
inferredcites →https://doi.org/10.1093/nar/gki393openalex-snapshot
GPS: a comprehensive www server for phosphorylation sites prediction
inferredcites →https://doi.org/10.1096/fj.201600845ropenalex-snapshot
Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis
inferredcites →https://doi.org/10.1101/cshperspect.a026146openalex-snapshot
Regulation of Cellular Metabolism and Hypoxia by p53
inferredcites →https://doi.org/10.1101/gad.10.23.2971openalex-snapshot
Wild-type p53 negatively regulates the expression of a microtubule-associated protein.
inferredcites →https://doi.org/10.1101/gad.1378506openalex-snapshot
Tumor suppression and normal aging in mice with constitutively high p53 activity
inferredcites →https://doi.org/10.1101/gad.14.3.289openalex-snapshot
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
inferredcites →https://doi.org/10.1101/gad.1940110openalex-snapshot
Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
inferredcites →https://doi.org/10.1126/science.1090072openalex-snapshot
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
inferredcites →https://doi.org/10.1126/science.1218530openalex-snapshot
Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-5202openalex-snapshot
Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-3040openalex-snapshot
The Fundamental Role of the p53 Pathway in Tumor Metabolism and Its Implication in Tumor Therapy
inferredcites →https://doi.org/10.1177/030006051204000603openalex-snapshot
Prognostic Significance of PUMA in Pancreatic Ductal Adenocarcinoma
inferredcites →https://doi.org/10.1177/1010428317709128openalex-snapshot
Loss of tumor suppressor miR-126 contributes to the development of hepatitis B virus–related hepatocellular carcinoma metastasis through the upregulation of ADAM9
inferredcites →https://doi.org/10.1186/1471-2105-9-346openalex-snapshot
AccPbFRET: An ImageJ plugin for semi-automatic, fully corrected analysis of acceptor photobleaching FRET images
inferredcites →https://doi.org/10.1371/journal.pgen.1006056openalex-snapshot
Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet
inferredcites →https://doi.org/10.2478/s11658-012-0032-5openalex-snapshot
Puma, a critical mediator of cell death — one decade on from its discovery
inferredcites →https://doi.org/10.4161/cc.6.13.4456openalex-snapshot
Gain of Function of p53 Cancer Mutants in Disrupting Critical DNA Damage Response Pathways

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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PUMA overexpression dissociates thioredoxin from ASK1 to activate the JNK/BCL-2/BCL-XL pathway augmenting apoptosis in ovarian cancer
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Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes
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MDM2 antagonists promote CRISPR/Cas9-mediated precise genome editing in sheep primary cells
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p53 coordinates glucose and choline metabolism during the mesendoderm differentiation of human embryonic stem cells
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TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
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PUMA reduces FASN ubiquitination to promote lipid accumulation and tumor progression in human clear cell renal cell carcinoma
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MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing
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p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance
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Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model
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Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity
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p53 overrides METTL5 loss–induced tumor suppression via mitochondrial respiration
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Comprehensive Understanding and Evolutional Therapeutic Schemes for Pseudomyxoma Peritonei
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High expression of NADH Ubiquinone Oxidoreductase Subunit B11 induces catheter-associated venous thrombosis on continuous blood purification
inferred← citeshttps://doi.org/10.1097/ot9.0000000000000026openalex-snapshot
Celecoxib enhances the response of tumor cells to cisplatin through upregulating PUMA in non–small cell lung cancer carrying wild-type p53
inferred← citeshttps://doi.org/10.1101/2022.04.04.487038openalex-snapshot
3’UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity
inferred← citeshttps://doi.org/10.1101/2023.05.21.541667openalex-snapshot
P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in Pluripotent Cells
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Venetoclax resistance in acute myeloid leukaemia—Clinical and biological insights
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Death‐associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD‐box helicase 20
inferred← citeshttps://doi.org/10.1111/febs.70255openalex-snapshot
Activator of apoptosis harakiri ( HRK ) localisation at mitochondria alters mitochondrial morphology independently of other BCL ‐2 proteins
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Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism
inferred← citeshttps://doi.org/10.1136/jitc-2023-007479openalex-snapshot
TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1152/ajpendo.00074.2022openalex-snapshot
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism
inferred← citeshttps://doi.org/10.1155/2021/5164100openalex-snapshot
Mechanism, Clinical Significance, and Treatment Strategy of Warburg Effect in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1155/2021/5540149openalex-snapshot
RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-21-0098openalex-snapshot
Mutant p53 Attenuates Oxidative Phosphorylation and Facilitates Cancer Stemness through Downregulating miR-200c–PCK2 Axis in Basal-Like Breast Cancer
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-19-0125openalex-snapshot
The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells
inferred← citeshttps://doi.org/10.1182/blood.2021014304openalex-snapshot
Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies
inferred← citeshttps://doi.org/10.1182/bloodadvances.2020003566openalex-snapshot
Study of the antilymphoma activity of pracinostat reveals different sensitivities of DLBCL cells to HDAC inhibitors
inferred← citeshttps://doi.org/10.1186/s12864-024-10055-1openalex-snapshot
Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1186/s12885-024-12017-yopenalex-snapshot
p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme
inferred← citeshttps://doi.org/10.1186/s12967-023-04653-yopenalex-snapshot
Insights into the regulatory role of RNA methylation modifications in glioma
inferred← citeshttps://doi.org/10.1186/s12967-025-07537-5openalex-snapshot
Regulation of drug resistance in bladder urothelial carcinoma by tumor aerobic glycolysis
inferred← citeshttps://doi.org/10.1186/s13045-022-01314-3openalex-snapshot
Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials
inferred← citeshttps://doi.org/10.1186/s13046-020-01767-9openalex-snapshot
The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1
inferred← citeshttps://doi.org/10.1186/s13046-022-02581-1openalex-snapshot
The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer
inferred← citeshttps://doi.org/10.1186/s13046-023-02936-2openalex-snapshot
DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
inferred← citeshttps://doi.org/10.1186/s40164-020-00179-xopenalex-snapshot
Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer
inferred← citeshttps://doi.org/10.1186/s40170-022-00286-9openalex-snapshot
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
inferred← citeshttps://doi.org/10.1186/s40246-023-00517-0openalex-snapshot
Transcriptome and proteome analysis reveals the anti-cancer properties of Hypnea musciformis marine macroalga extract in liver and intestinal cancer cells
inferred← citeshttps://doi.org/10.1360/tb-2020-0638openalex-snapshot
Cancer research driven by cutting-edge multi-disciplinary technologies
inferred← citeshttps://doi.org/10.1371/journal.pgen.1011193openalex-snapshot
P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition
inferred← citeshttps://doi.org/10.1523/jneurosci.0419-19.2019openalex-snapshot
Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc
inferred← citeshttps://doi.org/10.15252/embr.202152537openalex-snapshot
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth
inferred← citeshttps://doi.org/10.20517/2394-4722.2020.32openalex-snapshot
RANBP9 as potential therapeutic target in non-small cell lung cancer
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1136189/v1openalex-snapshot
Effect of Linc-00475 Regulation of p53 on Glycolysis and Survival in Gastric Cancer
inferred← citeshttps://doi.org/10.21203/rs.3.rs-15788/v1openalex-snapshot
TMEM147 promotes hepatocellular carcinoma progress by inducing EGFR/MAPK activity
inferred← citeshttps://doi.org/10.21203/rs.3.rs-15788/v2openalex-snapshot
TMEM147 promotes hepatocellular carcinoma progress by inducing EGFR/MAPK activity
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2568517/v1openalex-snapshot
The Expression of Angiogenesis Genes is Related to Immune Microenvironment and Prognosis of Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3425720/v1openalex-snapshot
Physiological Methylmalonic Acid Contributes to Cell Growth via Mitochondrial Dysfunction in Colorectal Cancer Cell Spheroids
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3978496/v1openalex-snapshot
Linc-00475 and p53 co-expression in gastric cancer: a predictor of clinical prognosis and potential effect on glycolysis
inferred← citeshttps://doi.org/10.2139/ssrn.3678770openalex-snapshot
Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.2147/cmar.s216870openalex-snapshot
Micheliolide Inhibits Liver Cancer Cell Growth Via Inducing Apoptosis And Perturbing Actin Cytoskeleton
inferred← citeshttps://doi.org/10.2147/dddt.s249557openalex-snapshot
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo
inferred← citeshttps://doi.org/10.21926/obm.genet.2302185openalex-snapshot
A Narrative Review of the TP53 and Its Product the p53 Protein
inferred← citeshttps://doi.org/10.21926/obm.genet.2303185openalex-snapshot
A Narrative Review of the TP53 and Its Product the p53 Protein
inferred← citeshttps://doi.org/10.22363/2313-0245-2025-29-4-543-553openalex-snapshot
Immunohistochemical study of P53 protein expression in the development of squamous cell carcinoma of the oral mucosa
inferred← citeshttps://doi.org/10.23889/suthesis.60124openalex-snapshot
Role of Mitochondrial pyruvate carrier in ovarian cancer progression
inferred← citeshttps://doi.org/10.26508/lsa.202101157openalex-snapshot
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity
inferred← citeshttps://doi.org/10.3389/fcell.2020.607670openalex-snapshot
Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches
inferred← citeshttps://doi.org/10.3389/fcell.2021.762742openalex-snapshot
Emerging Roles of the Tumor Suppressor p53 in Metabolism
inferred← citeshttps://doi.org/10.3389/fcell.2021.779169openalex-snapshot
SIPA1 Enhances Aerobic Glycolysis Through HIF-2α Pathway to Promote Breast Cancer Metastasis
inferred← citeshttps://doi.org/10.3389/fcell.2021.801959openalex-snapshot
A Novel Lactate Metabolism-Related Gene Signature for Predicting Clinical Outcome and Tumor Microenvironment in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3389/fgene.2022.1051395openalex-snapshot
P53 protein and the diseases in central nervous system
inferred← citeshttps://doi.org/10.3389/fimmu.2021.715460openalex-snapshot
DNA Damage Repair Profiles Alteration Characterize a Hepatocellular Carcinoma Subtype With Unique Molecular and Clinicopathologic Features
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1239952openalex-snapshot
Advanced applications of DNA nanostructures dominated by DNA origami in antitumor drug delivery
inferred← citeshttps://doi.org/10.3389/fonc.2020.595187openalex-snapshot
Mutant p53 in Cancer Progression and Targeted Therapies
inferred← citeshttps://doi.org/10.3389/fonc.2021.633210openalex-snapshot
Glycolysis and Fatty Acid Oxidation Inhibition Improves Survival in Glioblastoma
inferred← citeshttps://doi.org/10.3389/fonc.2021.634732openalex-snapshot
Using lncRNA Sequencing to Reveal a Putative lncRNA-mRNA Correlation Network and the Potential Role of PCBP1-AS1 in the Pathogenesis of Cervical Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.781903openalex-snapshot
Long Non-Coding RNA AL513318.2 as ceRNA Binding to hsa-miR-26a-5p Upregulates SLC6A8 Expression and Predicts Poor Prognosis in Non-Small Lung Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.895112openalex-snapshot
p53-Mediated Indirect Regulation on Cellular Metabolism: From the Mechanism of Pathogenesis to the Development of Cancer Therapeutics
inferred← citeshttps://doi.org/10.3389/fonc.2022.966089openalex-snapshot
CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor
inferred← citeshttps://doi.org/10.3389/fphar.2025.1529483openalex-snapshot
Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53
inferred← citeshttps://doi.org/10.3390/antiox12091734openalex-snapshot
Phlorotannins: Novel Orally Administrated Bioactive Compounds That Induce Mitochondrial Dysfunction and Oxidative Stress in Cancer
inferred← citeshttps://doi.org/10.3390/biom10071068openalex-snapshot
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
inferred← citeshttps://doi.org/10.3390/biom10081162openalex-snapshot
Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan
inferred← citeshttps://doi.org/10.3390/biom13020261openalex-snapshot
The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease
inferred← citeshttps://doi.org/10.3390/cancers12020332openalex-snapshot
Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models
inferred← citeshttps://doi.org/10.3390/cancers13030399openalex-snapshot
Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective
inferred← citeshttps://doi.org/10.3390/cancers13071488openalex-snapshot
The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
inferred← citeshttps://doi.org/10.3390/cancers14246044openalex-snapshot
N6-Isopentenyladenosine Impairs Mitochondrial Metabolism through Inhibition of EGFR Translocation on Mitochondria in Glioblastoma Cells
inferred← citeshttps://doi.org/10.3390/cancers16051000openalex-snapshot
Jun Dimerization Protein 2 (JDP2) Increases p53 Transactivation by Decreasing MDM2
inferred← citeshttps://doi.org/10.3390/cells13131109openalex-snapshot
MLIP and Its Potential Influence on Key Oncogenic Pathways
inferred← citeshttps://doi.org/10.3390/cells9102308openalex-snapshot
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/cimb45060317openalex-snapshot
How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?
inferred← citeshttps://doi.org/10.3390/cimb45110576openalex-snapshot
Recruiting In Vitro Transcribed mRNA against Cancer Immunotherapy: A Contemporary Appraisal of the Current Landscape
inferred← citeshttps://doi.org/10.3390/curroncol30020124openalex-snapshot
Tumor Suppressor p53 Down-Regulates Programmed Cell Death Protein 4 (PDCD4) Expression
inferred← citeshttps://doi.org/10.3390/genes14030747openalex-snapshot
Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants
inferred← citeshttps://doi.org/10.3390/ijms21144902openalex-snapshot
SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer
inferred← citeshttps://doi.org/10.3390/ijms21228674openalex-snapshot
Glucose Concentration in Cell Culture Medium Influences the BRCA1-Mediated Regulation of the Lipogenic Action of IGF-I in Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/ijms22105297openalex-snapshot
Liver Lipids of Patients with Hepatitis B and C and Associated Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3390/ijms222011047openalex-snapshot
Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts
inferred← citeshttps://doi.org/10.3390/ijms24065257openalex-snapshot
Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis
inferred← citeshttps://doi.org/10.3390/ijms24087076openalex-snapshot
Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
inferred← citeshttps://doi.org/10.3390/ijms26010031openalex-snapshot
TP53I11 Functions Downstream of Multiple MicroRNAs to Increase ER Calcium Levels and Inhibits Cancer Cell Proliferation
inferred← citeshttps://doi.org/10.3390/ijms27010411openalex-snapshot
Echinacoside as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma: Mechanistic Insights from TP53/SLC7A11/GPX4 Pathway Modulation
inferred← citeshttps://doi.org/10.3390/metabo14050249openalex-snapshot
Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells
inferred← citeshttps://doi.org/10.3390/molecules25204831openalex-snapshot
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/nu16121816openalex-snapshot
Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection
inferred← citeshttps://doi.org/10.3390/pharmaceutics14061257openalex-snapshot
HO-3867 Induces Apoptosis via the JNK Signaling Pathway in Human Osteosarcoma Cells
inferred← citeshttps://doi.org/10.3390/pharmaceutics18060738openalex-snapshot
Flavonoids as Modulators of the p53–Bcl-2 Axis in Cancer: Molecular Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.3892/ol.2020.11446openalex-snapshot
Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients
inferred← citeshttps://doi.org/10.3892/ol.2020.11988openalex-snapshot
Low HOXC10 expression in liver cancer regulates proliferation via a mechanism involving miR‑221 and the MAPK signaling pathway
inferred← citeshttps://doi.org/10.3892/ol.2021.12980openalex-snapshot
Identification of GNA12‑driven gene signatures and key signaling networks in ovarian cancer
inferred← citeshttps://doi.org/10.3892/ol.2023.13831openalex-snapshot
miR‑4732‑5p promotes ovarian cancer mobility by targeting MCUR1
inferred← citeshttps://doi.org/10.4149/bll_2020_093openalex-snapshot
Variation of selected genotoxic and epigenetic markers due to therapeutic exposure to PAHs and ultraviolet radiation
inferred← citeshttps://doi.org/10.6084/m9.figshare.13662834openalex-snapshot
Additional file 1 of The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1
inferred← citeshttps://doi.org/10.6084/m9.figshare.22603046openalex-snapshot
Additional file 1 of The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.22603049openalex-snapshot
Additional file 2 of The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.24923754openalex-snapshot
Additional file 1 of DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.24923800openalex-snapshot
Additional file 2 of DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.25367364openalex-snapshot
Additional file 1 of p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme
inferred← citeshttps://doi.org/10.6084/m9.figshare.25367486openalex-snapshot
Additional file 2 of p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme
inferred← citeshttps://doi.org/10.6084/m9.figshare.26657680openalex-snapshot
Additional file 3 of DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26678486openalex-snapshot
Additional file 1 of Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26678489openalex-snapshot
Additional file 2 of Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.70675/2569a111z8c5az4239z8514z245d8314c2b5openalex-snapshot
Antitumoral actions of natural stilbenes derived from Vitis vinifera
inferred← citeshttps://doi.org/10.7150/jca.37958openalex-snapshot
LncRNA NRON promotes the proliferation, metastasis and EMT process in bladder cancer
inferred← citeshttps://doi.org/10.7150/jca.97277openalex-snapshot
Downregulation of Brf1 Induces Liver Failure and Inhibits Hepatocellular Carcinoma Progression by Promoting Apoptosis
inferred← citeshttps://doi.org/10.7287/peerj.14797v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.14797v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.14797v0.1/reviews/3openalex-snapshot
Peer Review #3 of "Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.14797v0.2/reviews/1openalex-snapshot
Peer Review #1 of "Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma (v0.2)"
inferred← citeshttps://doi.org/10.7287/peerj.14797v0.2/reviews/3openalex-snapshot
Peer Review #3 of "Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma (v0.2)"
inferred← citeshttps://doi.org/10.7287/peerj.9774v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.9774v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma (v0.1)"
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