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DNA damage checkpoints in stem cells, ageing and cancer

https://doi.org/10.1038/nrm3420
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1939-4640.1999.tb02550.xopenalex-snapshot
Reproductive Aging in the Brown Norway Rat Is Characterized by Accelerated Germ Cell Apoptosis and Is Not Altered by Luteinizing Hormone Replacement
inferredcites →https://doi.org/10.1007/s00391-007-0480-0openalex-snapshot
Telomere shortening and ageing
inferredcites →https://doi.org/10.1016/0014-4827(91)90453-2openalex-snapshot
A role for both RB and p53 in the regulation of human cellular senescence*1
inferredcites →https://doi.org/10.1016/0531-5565(92)90069-copenalex-snapshot
The two-stage mechanism controlling cellular senescence and immortalization
inferredcites →https://doi.org/10.1016/j.cell.2005.01.028openalex-snapshot
DNA Repair, Genome Stability, and Aging
inferredcites →https://doi.org/10.1016/j.cell.2007.08.029openalex-snapshot
Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice
inferredcites →https://doi.org/10.1016/j.cell.2008.06.028openalex-snapshot
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
inferredcites →https://doi.org/10.1016/j.cell.2008.09.017openalex-snapshot
Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
inferredcites →https://doi.org/10.1016/j.cell.2008.09.034openalex-snapshot
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
inferredcites →https://doi.org/10.1016/j.cell.2008.10.048openalex-snapshot
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
inferredcites →https://doi.org/10.1016/j.cell.2009.03.037openalex-snapshot
Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
inferredcites →https://doi.org/10.1016/j.cell.2009.05.046openalex-snapshot
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
inferredcites →https://doi.org/10.1016/j.cell.2009.06.021openalex-snapshot
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
inferredcites →https://doi.org/10.1016/j.cell.2009.06.048openalex-snapshot
The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
inferredcites →https://doi.org/10.1016/j.cell.2010.09.016openalex-snapshot
Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
inferredcites →https://doi.org/10.1016/j.cell.2012.01.040openalex-snapshot
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
inferredcites →https://doi.org/10.1016/j.coi.2011.05.004openalex-snapshot
Immunoaging induced by hematopoietic stem cell aging
inferredcites →https://doi.org/10.1016/j.coi.2011.05.006openalex-snapshot
Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?
inferredcites →https://doi.org/10.1016/j.cub.2011.07.020openalex-snapshot
On the Programmed/Non-Programmed Nature of Ageing within the Life History
inferredcites →https://doi.org/10.1016/j.exphem.2008.04.012openalex-snapshot
Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice
inferredcites →https://doi.org/10.1016/j.molcel.2012.01.020openalex-snapshot
Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/j.mrrev.2010.01.007openalex-snapshot
Response of normal stem cells to ionizing radiation: A balance between homeostasis and genomic stability
inferredcites →https://doi.org/10.1016/j.stem.2007.03.002openalex-snapshot
Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
inferredcites →https://doi.org/10.1016/j.stem.2008.11.006openalex-snapshot
p53 Regulates Hematopoietic Stem Cell Quiescence
inferredcites →https://doi.org/10.1016/j.stem.2010.02.002openalex-snapshot
Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1
inferredcites →https://doi.org/10.1016/j.stem.2010.03.002openalex-snapshot
p53-Mediated Hematopoietic Stem and Progenitor Cell Competition
inferredcites →https://doi.org/10.1016/j.stem.2010.05.016openalex-snapshot
A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal
inferredcites →https://doi.org/10.1016/j.stem.2010.06.014openalex-snapshot
Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
inferredcites →https://doi.org/10.1016/j.stem.2010.12.012openalex-snapshot
DNA-Damage Response in Tissue-Specific and Cancer Stem Cells
inferredcites →https://doi.org/10.1016/s0092-8674(00)80580-2openalex-snapshot
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
inferredcites →https://doi.org/10.1016/s0092-8674(00)80762-xopenalex-snapshot
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
inferredcites →https://doi.org/10.1016/s0092-8674(01)80006-4openalex-snapshot
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
inferredcites →https://doi.org/10.1016/s0140-6736(03)12384-7openalex-snapshot
Association between telomere length in blood and mortality in people aged 60 years or older
inferredcites →https://doi.org/10.1016/s0301-472x(03)00072-9openalex-snapshot
Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice
inferredcites →https://doi.org/10.1016/s0960-9822(03)00542-6openalex-snapshot
DNA Damage Foci at Dysfunctional Telomeres
inferredcites →https://doi.org/10.1038/33345openalex-snapshot
Essential role of mouse telomerase in highly proliferative organs
inferredcites →https://doi.org/10.1038/35020592openalex-snapshot
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
inferredcites →https://doi.org/10.1038/35092592openalex-snapshot
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
inferredcites →https://doi.org/10.1038/362849a0openalex-snapshot
Thymocyte apoptosis induced by p53-dependent and independent pathways
inferredcites →https://doi.org/10.1038/415026aopenalex-snapshot
The price of tumour suppression?
inferredcites →https://doi.org/10.1038/415045aopenalex-snapshot
p53 mutant mice that display early ageing-associated phenotypes
inferredcites →https://doi.org/10.1038/88871openalex-snapshot
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
inferredcites →https://doi.org/10.1038/leu.2011.22openalex-snapshot
Relative fitness of hematopoietic progenitors influences leukemia progression
inferredcites →https://doi.org/10.1038/nature01385openalex-snapshot
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
inferredcites →https://doi.org/10.1038/nature01587openalex-snapshot
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
inferredcites →https://doi.org/10.1038/nature02118openalex-snapshot
A DNA damage checkpoint response in telomere-initiated senescence
inferredcites →https://doi.org/10.1038/nature02989openalex-snapshot
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
inferredcites →https://doi.org/10.1038/nature03884openalex-snapshot
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
inferredcites →https://doi.org/10.1038/nature04958openalex-snapshot
Stem cells, ageing and the quest for immortality
inferredcites →https://doi.org/10.1038/nature05091openalex-snapshot
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
inferredcites →https://doi.org/10.1038/nature05092openalex-snapshot
p16INK4a induces an age-dependent decline in islet regenerative potential
inferredcites →https://doi.org/10.1038/nature05159openalex-snapshot
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
inferredcites →https://doi.org/10.1038/nature05529openalex-snapshot
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
inferredcites →https://doi.org/10.1038/nature05862openalex-snapshot
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
inferredcites →https://doi.org/10.1038/nature05875openalex-snapshot
DNA repair is limiting for haematopoietic stem cells during ageing
inferredcites →https://doi.org/10.1038/nature05949openalex-snapshot
Delayed ageing through damage protection by the Arf/p53 pathway
inferredcites →https://doi.org/10.1038/nature05985openalex-snapshot
The common biology of cancer and ageing
inferredcites →https://doi.org/10.1038/nature06065openalex-snapshot
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
inferredcites →https://doi.org/10.1038/nature06562openalex-snapshot
A role for adult TLX-positive neural stem cells in learning and behaviour
inferredcites →https://doi.org/10.1038/nature07618openalex-snapshot
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
inferredcites →https://doi.org/10.1038/nature08467openalex-snapshot
The DNA-damage response in human biology and disease
inferredcites →https://doi.org/10.1038/nature10599openalex-snapshot
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
inferredcites →https://doi.org/10.1038/nature10600openalex-snapshot
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
inferredcites →https://doi.org/10.1038/ncb1744openalex-snapshot
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
inferredcites →https://doi.org/10.1038/ncb1909openalex-snapshot
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
inferredcites →https://doi.org/10.1038/ncb2059openalex-snapshot
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
inferredcites →https://doi.org/10.1038/ncb2100openalex-snapshot
Puma is required for p53-induced depletion of adult stem cells
inferredcites →https://doi.org/10.1038/ncb2388openalex-snapshot
Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction
inferredcites →https://doi.org/10.1038/ncb2466openalex-snapshot
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
inferredcites →https://doi.org/10.1038/ncb2468openalex-snapshot
The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
inferredcites →https://doi.org/10.1038/ncomms1708openalex-snapshot
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
inferredcites →https://doi.org/10.1038/ng.165openalex-snapshot
Bmi1 is expressed in vivo in intestinal stem cells
inferredcites →https://doi.org/10.1038/ng.426openalex-snapshot
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
inferredcites →https://doi.org/10.1038/ng1382openalex-snapshot
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
inferredcites →https://doi.org/10.1038/ng1937openalex-snapshot
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
inferredcites →https://doi.org/10.1038/ng989openalex-snapshot
Chromosomal instability in ulcerative colitis is related to telomere shortening
inferredcites →https://doi.org/10.1038/nm0996-1011openalex-snapshot
The aging of hematopoietic stem cells
inferredcites →https://doi.org/10.1038/nm1578openalex-snapshot
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
inferredcites →https://doi.org/10.1038/nrm2450openalex-snapshot
ATR: an essential regulator of genome integrity
inferredcites →https://doi.org/10.1038/nrm2848openalex-snapshot
Telomeres: protecting chromosomes against genome instability
inferredcites →https://doi.org/10.1038/nrm3060openalex-snapshot
DNA damage response in adult stem cells: pathways and consequences
inferredcites →https://doi.org/10.1038/onc.2008.482openalex-snapshot
Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
inferredcites →https://doi.org/10.1038/onc.2009.94openalex-snapshot
Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence
inferredcites →https://doi.org/10.1038/sj.emboj.7600542openalex-snapshot
Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice
inferredcites →https://doi.org/10.1038/sj.emboj.7601446openalex-snapshot
ATR‐dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
inferredcites →https://doi.org/10.1038/sj.embor.7400667openalex-snapshot
Increased p53 activity does not accelerate telomere‐driven ageing
inferredcites →https://doi.org/10.1038/sj.onc.1201449openalex-snapshot
Influence of ATM function on telomere metabolism
inferredcites →https://doi.org/10.1038/sj.onc.1207074openalex-snapshot
The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis
inferredcites →https://doi.org/10.1053/j.gastro.2012.02.009openalex-snapshot
Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation
inferredcites →https://doi.org/10.1056/nejmra0804615openalex-snapshot
DNA Damage, Aging, and Cancer
inferredcites →https://doi.org/10.1073/pnas.0503280102openalex-snapshot
Cell intrinsic alterations underlie hematopoietic stem cell aging
inferredcites →https://doi.org/10.1073/pnas.0608557104openalex-snapshot
Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice
inferredcites →https://doi.org/10.1073/pnas.0708043104openalex-snapshot
Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
inferredcites →https://doi.org/10.1073/pnas.0801457105openalex-snapshot
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
inferredcites →https://doi.org/10.1073/pnas.1000834107openalex-snapshot
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
inferredcites →https://doi.org/10.1073/pnas.1113306109openalex-snapshot
Telomere length in early life predicts lifespan
inferredcites →https://doi.org/10.1073/pnas.1116110108openalex-snapshot
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
inferredcites →https://doi.org/10.1073/pnas.131210498openalex-snapshot
A growth-constrained environment drives tumor progression in vivo
inferredcites →https://doi.org/10.1073/pnas.92.20.9363openalex-snapshot
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
inferredcites →https://doi.org/10.1083/jcb.201004096openalex-snapshot
Clearance of apoptotic cells: implications in health and disease
inferredcites →https://doi.org/10.1084/jem.192.9.1273openalex-snapshot
Age-Associated Characteristics of Murine Hematopoietic Stem Cells
inferredcites →https://doi.org/10.1084/jem.20091318openalex-snapshot
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
inferredcites →https://doi.org/10.1084/jem.20091548openalex-snapshot
Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
inferredcites →https://doi.org/10.1084/jem.20111490openalex-snapshot
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
inferredcites →https://doi.org/10.1093/emboj/cdf595openalex-snapshot
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
inferredcites →https://doi.org/10.1093/jnci/12.1.197openalex-snapshot
Modification of Irradiation Injury in Mice and Guinea Pigs by Bone Marrow Injections
inferredcites →https://doi.org/10.1096/fj.01-0977comopenalex-snapshot
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
inferredcites →https://doi.org/10.1096/fj.04-2903fjeopenalex-snapshot
A central role for ceramide in the age‐related acceleration of apoptosis in the female germline
inferredcites →https://doi.org/10.1098/rspb.2009.0517openalex-snapshot
Telomere shortening and survival in free-living corvids
inferredcites →https://doi.org/10.1101/gad.1060603openalex-snapshot
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
inferredcites →https://doi.org/10.1101/gad.1272305openalex-snapshot
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
inferredcites →https://doi.org/10.1101/gad.1378506openalex-snapshot
Tumor suppression and normal aging in mice with constitutively high p53 activity
inferredcites →https://doi.org/10.1101/gad.1940110openalex-snapshot
Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
inferredcites →https://doi.org/10.1101/gad.1940210openalex-snapshot
Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
inferredcites →https://doi.org/10.1101/gad.1940710openalex-snapshot
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
inferredcites →https://doi.org/10.1101/gad.225102openalex-snapshot
EXO1 -dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70 Δ mutants
inferredcites →https://doi.org/10.1101/gad.310304openalex-snapshot
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
inferredcites →https://doi.org/10.1101/gad.430107openalex-snapshot
Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres
inferredcites →https://doi.org/10.1101/gad.949802openalex-snapshot
E2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints
inferredcites →https://doi.org/10.1111/j.1365-2184.1992.tb01460.xopenalex-snapshot
A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation
inferredcites →https://doi.org/10.1111/j.1474-9726.2006.00230.xopenalex-snapshot
Aging is associated with increased clonogenic potential in rat liver in vivo
inferredcites →https://doi.org/10.1111/j.1474-9726.2009.00489.xopenalex-snapshot
Expression of p16 INK4a in peripheral blood T‐cells is a biomarker of human aging
inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00802.xopenalex-snapshot
Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function
inferredcites →https://doi.org/10.1111/j.1558-5646.1957.tb02911.xopenalex-snapshot
PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE
inferredcites →https://doi.org/10.1111/j.1749-6632.2002.tb02086.xopenalex-snapshot
The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart
inferredcites →https://doi.org/10.1126/science.1079161openalex-snapshot
Aging and Genome Maintenance: Lessons from the Mouse?
inferredcites →https://doi.org/10.1126/science.1122446openalex-snapshot
Cellular Senescence in Aging Primates
inferredcites →https://doi.org/10.1126/science.277.5327.831openalex-snapshot
Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
inferredcites →https://doi.org/10.1126/science.279.5349.349openalex-snapshot
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
inferredcites →https://doi.org/10.1126/science.287.5459.1804openalex-snapshot
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
inferredcites →https://doi.org/10.1172/jci22475openalex-snapshot
Ink4a/Arf expression is a biomarker of aging
inferredcites →https://doi.org/10.1182/blood-2002-10-3035openalex-snapshot
Repopulating defect of mismatch repair–deficient hematopoietic stem cells
inferredcites →https://doi.org/10.1182/blood-2004-06-2242openalex-snapshot
A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
inferredcites →https://doi.org/10.1182/blood-2006-03-010413openalex-snapshot
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
inferredcites →https://doi.org/10.1182/blood-2007-11-123547openalex-snapshot
A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells
inferredcites →https://doi.org/10.1182/blood-2011-06-361626openalex-snapshot
Ionizing radiation–induced expression of INK4a/ARF in murine bone marrow–derived stromal cell populations interferes with bone marrow homeostasis
inferredcites →https://doi.org/10.1212/wnl.0b013e318247caa1openalex-snapshot
Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease
inferredcites →https://doi.org/10.1242/dev.02208openalex-snapshot
p53 suppresses the self-renewal of adult neural stem cells
inferredcites →https://doi.org/10.1242/dev.067595openalex-snapshot
An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration
inferredcites →https://doi.org/10.1259/bjr/32774071openalex-snapshot
The role of damage to the cutaneous system in radiation-induced multi-organ failure
inferredcites →https://doi.org/10.1371/journal.pbio.0030401openalex-snapshot
Impaired DNA Replication within Progenitor Cell Pools Promotes Leukemogenesis
inferredcites →https://doi.org/10.1371/journal.pbio.0050201openalex-snapshot
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
inferredcites →https://doi.org/10.1371/journal.pbio.1000324openalex-snapshot
Irradiation Selects for p53-Deficient Hematopoietic Progenitors
inferredcites →https://doi.org/10.1371/journal.pgen.1001159openalex-snapshot
Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
inferredcites →https://doi.org/10.1371/journal.pone.0017487openalex-snapshot
Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging
inferredcites →https://doi.org/10.1634/stemcells.2006-0372openalex-snapshot
A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging
inferredcites →https://doi.org/10.1634/stemcells.2006-0631openalex-snapshot
A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem Cell Functioning
inferredcites →https://doi.org/10.4161/cc.9.19.13301openalex-snapshot
p53: Guardian of reprogramming

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Epidermal Growth Factor Rejuvenates Aged Hematopoietic Stem Cells
inferred← citeshttps://doi.org/10.1002/9781118512074.ch31openalex-snapshot
Neoplasia of the Gastrointestinal Tract
inferred← citeshttps://doi.org/10.1002/9781118647110.ch16openalex-snapshot
Hypotheses for Interpreting Somatic Genome Variation
inferred← citeshttps://doi.org/10.1002/9781118907474.ch27openalex-snapshot
The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
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Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor‐induced senescence in breast cancer cells
inferred← citeshttps://doi.org/10.1002/cnr2.2075openalex-snapshot
Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells
inferred← citeshttps://doi.org/10.1002/dneu.22261openalex-snapshot
Roles of histone H3K27 trimethylase E zh2 in retinal proliferation and differentiation
inferred← citeshttps://doi.org/10.1002/dvdy.24388openalex-snapshot
The effects of proliferation and DNA damage on hematopoietic stem cell function determine aging
inferred← citeshttps://doi.org/10.1002/dvdy.276openalex-snapshot
DNA repair during regeneration in Ambystoma mexicanum
inferred← citeshttps://doi.org/10.1002/dvdy.455openalex-snapshot
Evidence of requirement for homologous‐mediated DNA repair during Ambystoma mexicanum limb regeneration
inferred← citeshttps://doi.org/10.1002/ijc.28152openalex-snapshot
Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent
inferred← citeshttps://doi.org/10.1002/ijc.28900openalex-snapshot
The clinical impact of using p16INK4a immunochemistry in cervical histopathology and cytology: An update of recent developments
inferred← citeshttps://doi.org/10.1002/ijc.29990openalex-snapshot
Stress management by autophagy: Implications for chemoresistance
inferred← citeshttps://doi.org/10.1002/mus.23832openalex-snapshot
Function of death-associated protein 1 in proliferation, differentiation, and apoptosis of chicken satellite cells
inferred← citeshttps://doi.org/10.1002/pbc.24884openalex-snapshot
CLL/SLL diagnosed in an adolescent
inferred← citeshttps://doi.org/10.1002/stem.1488openalex-snapshot
Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence
inferred← citeshttps://doi.org/10.1007/978-1-4614-9302-0_7openalex-snapshot
The DNA Damage Response Mediates Apoptosis and Tumor Suppression
inferred← citeshttps://doi.org/10.1007/978-1-4614-9569-7_17openalex-snapshot
Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging
inferred← citeshttps://doi.org/10.1007/978-1-4939-1935-2_15openalex-snapshot
p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation
inferred← citeshttps://doi.org/10.1007/978-3-319-15630-9_13openalex-snapshot
Chemotherapeutic Agents in Cancer Treatment and Tryptophan Metabolism
inferred← citeshttps://doi.org/10.1007/978-3-319-20291-4_1openalex-snapshot
DNA Repair and Chromosomal Translocations
inferred← citeshttps://doi.org/10.1007/978-3-319-21033-9_4openalex-snapshot
Programmed Cell Death in Plant Immunity: Cellular Reorganization, Signaling, and Cell Cycle Dependence in Cultured Cells as a Model System
inferred← citeshttps://doi.org/10.1007/978-3-319-22380-3_11openalex-snapshot
Regulatory Roles of miRNAs in Aging
inferred← citeshttps://doi.org/10.1007/978-3-319-26239-0_9openalex-snapshot
Cell Cycle Checkpoints and Senescence
inferred← citeshttps://doi.org/10.1007/978-3-319-44703-2_11openalex-snapshot
Genome Stability and Ageing
inferred← citeshttps://doi.org/10.1007/978-3-319-44870-1_87-1openalex-snapshot
Role of Cell Cycle Control, Checkpoints and DNA Repair Mechanisms in Stem Cells and Changes with Aging and Cancerogenesis
inferred← citeshttps://doi.org/10.1007/978-3-319-57415-8_87openalex-snapshot
Role of Cell Cycle Control, Checkpoints, and DNA Repair Mechanisms in Stem Cells and Changes with Aging and Cancerogenesis
inferred← citeshttps://doi.org/10.1007/978-3-319-64597-1_81-1openalex-snapshot
Age-Specific T Cell Homeostasis
inferred← citeshttps://doi.org/10.1007/978-3-319-74470-4_3openalex-snapshot
Treating Age-Related Diseases with Somatic Stem Cells
inferred← citeshttps://doi.org/10.1007/978-3-319-99375-1_81openalex-snapshot
Age-Specific T Cell Homeostasis
inferred← citeshttps://doi.org/10.1007/978-3-7091-1232-8_9openalex-snapshot
Aging of Mammalian Intestinal Stem Cells
inferred← citeshttps://doi.org/10.1007/978-981-16-6016-0_26-1openalex-snapshot
A Multilevel Approach to the Causes of Genetic Instability in Stem Cells
inferred← citeshttps://doi.org/10.1007/978-981-19-2655-6_26openalex-snapshot
A Multilevel Approach to the Causes of Genetic Instability in Stem Cells
inferred← citeshttps://doi.org/10.1007/s00018-018-2891-zopenalex-snapshot
Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging
inferred← citeshttps://doi.org/10.1007/s00109-022-02234-yopenalex-snapshot
Uremic mouse model to study vascular calcification and “inflamm-aging”
inferred← citeshttps://doi.org/10.1007/s00424-015-1718-0openalex-snapshot
Scaffolding during the cell cycle by A-kinase anchoring proteins
inferred← citeshttps://doi.org/10.1007/s10495-014-1010-3openalex-snapshot
The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells
inferred← citeshttps://doi.org/10.1007/s10522-026-10478-1openalex-snapshot
Non-apoptotic role of caspase enzymes in satellite cells from human skeletal muscle
inferred← citeshttps://doi.org/10.1007/s11596-016-1645-0openalex-snapshot
Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice
inferred← citeshttps://doi.org/10.1007/s12015-019-09930-2openalex-snapshot
High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage
inferred← citeshttps://doi.org/10.1007/s12015-020-10095-6openalex-snapshot
MicroRNA Profiling in Mesenchymal Stromal Cells: the Tissue Source as the Missing Piece in the Puzzle of Ageing
inferred← citeshttps://doi.org/10.1007/s12035-016-9937-8openalex-snapshot
Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway
inferred← citeshttps://doi.org/10.1007/s12079-015-0262-1openalex-snapshot
Involvement of the insulin-like growth factor binding proteins in the cancer cell response to DNA damage
inferred← citeshttps://doi.org/10.1007/s12185-018-2432-4openalex-snapshot
The role of telomere binding molecules for normal and abnormal hematopoiesis
inferred← citeshttps://doi.org/10.1007/s12195-014-0358-3openalex-snapshot
Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells
inferred← citeshttps://doi.org/10.1007/s12602-025-10506-5openalex-snapshot
Unlocking Ectoine’s Postbiotic Therapeutic Promise: Mechanisms, Applications, and Future Directions
inferred← citeshttps://doi.org/10.1007/s12672-023-00643-0openalex-snapshot
7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells
inferred← citeshttps://doi.org/10.1007/s13277-013-0779-yopenalex-snapshot
XRCC1 Arg194Trp polymorphism is associated with oral cancer risk: evidence from a meta-analysis
inferred← citeshttps://doi.org/10.1007/s13277-013-1071-xopenalex-snapshot
XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis
inferred← citeshttps://doi.org/10.1007/s13277-013-1319-5openalex-snapshot
Part II—mechanism of adaptation: A549 cells adapt to high concentration of nitric oxide through bypass of cell cycle checkpoints
inferred← citeshttps://doi.org/10.1007/s13277-015-4298-xopenalex-snapshot
Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people
inferred← citeshttps://doi.org/10.1007/s13402-014-0215-3openalex-snapshot
Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis
inferred← citeshttps://doi.org/10.1007/s40778-016-0047-3openalex-snapshot
Modifiers of Neural Stem Cells and Aging: Pulling the Trigger of a Neurogenic Decline
inferred← citeshttps://doi.org/10.1016/b978-0-12-382030-3.00006-4openalex-snapshot
DNA-Interactive Agents
inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.30115-8openalex-snapshot
Stem Cells and Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-397803-5.00006-xopenalex-snapshot
Aging, Immunosenescence, and Cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-416022-4.00014-7openalex-snapshot
Cellular Mechanisms of Somatic Stem Cell Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-803309-8.00014-8openalex-snapshot
Cell-Cycle Control and DNA-Damage Signaling in Mammals
inferred← citeshttps://doi.org/10.1016/b978-0-12-803309-8.00015-xopenalex-snapshot
The Role of p53/p21/p16 in DNA-Damage Signaling and DNA Repair
inferred← citeshttps://doi.org/10.1016/b978-0-12-803582-5.00010-3openalex-snapshot
Diversity and implication of MAPK signal transduction involved in the regulation of chemotherapy-induced DNA damage response
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00138-3openalex-snapshot
Stem Cells and Aging
inferred← citeshttps://doi.org/10.1016/b978-0-323-34126-4.00041-4openalex-snapshot
G1 Phase and Regulation of Cell Proliferation
inferred← citeshttps://doi.org/10.1016/b978-0-323-35775-3.00001-1openalex-snapshot
Mechanisms and Morphology of Cellular Injury, Adaptation, and Death
inferred← citeshttps://doi.org/10.1016/b978-0-323-47674-4.00060-8openalex-snapshot
Cancer in the Elderly
inferred← citeshttps://doi.org/10.1016/b978-0-323-85679-9.00014-3openalex-snapshot
Cell cycle control and DNA-damage signaling in mammals
inferred← citeshttps://doi.org/10.1016/b978-0-323-85679-9.00015-5openalex-snapshot
The role of p53/p21/p16 in DNA damage signaling and DNA repair
inferred← citeshttps://doi.org/10.1016/b978-0-323-90235-9.00005-7openalex-snapshot
Telomerase reactivation for anti-aging
inferred← citeshttps://doi.org/10.1016/j.amc.2014.01.081openalex-snapshot
A mathematical study of the robustness of G2/M regulatory network in response to DNA damage with parameters sensitivity
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102935openalex-snapshot
The potential of marine-derived compounds in geroscience
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2022.119412openalex-snapshot
Two faces of TEMPO (2,2,6,6-tetramethylpiperidinyl-1-oxyl) – An antioxidant or a toxin?
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.02.071openalex-snapshot
Studying the protein expression in human B lymphoblastoid cells exposed to 1.8-GHz (GSM) radiofrequency radiation (RFR) with protein microarray
inferred← citeshttps://doi.org/10.1016/j.biochi.2015.09.003openalex-snapshot
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.biomag.2014.03.006openalex-snapshot
The biological time calendar
inferred← citeshttps://doi.org/10.1016/j.bjp.2015.03.011openalex-snapshot
Fucoidan induces G1 arrest of the cell cycle in EJ human bladder cancer cells through down-regulation of pRB phosphorylation
inferred← citeshttps://doi.org/10.1016/j.canlet.2013.09.036openalex-snapshot
Identification of a mitotic death signature in cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.canlet.2015.11.022openalex-snapshot
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation
inferred← citeshttps://doi.org/10.1016/j.canlet.2019.10.012openalex-snapshot
The influence of patient sex on clinical approaches to malignant glioma
inferred← citeshttps://doi.org/10.1016/j.ccell.2018.12.012openalex-snapshot
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation
inferred← citeshttps://doi.org/10.1016/j.cell.2013.01.010openalex-snapshot
The Role of Telomeres in Stem Cells and Cancer
inferred← citeshttps://doi.org/10.1016/j.cell.2013.09.017openalex-snapshot
A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection
inferred← citeshttps://doi.org/10.1016/j.cellsig.2013.03.026openalex-snapshot
Signaling pathways that control mRNA turnover
inferred← citeshttps://doi.org/10.1016/j.cellsig.2024.111058openalex-snapshot
SIRT7 sustains tumor development and radioresistance by repressing endoplasmic reticulum stress-induced apoptosis in cutaneous melanoma
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.07.049openalex-snapshot
The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.08.053openalex-snapshot
High Nutrient Levels and TORC1 Activity Reduce Cell Viability following Prolonged Telomere Dysfunction and Cell Cycle Arrest
inferred← citeshttps://doi.org/10.1016/j.celrep.2015.08.076openalex-snapshot
Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress
inferred← citeshttps://doi.org/10.1016/j.celrep.2015.10.017openalex-snapshot
Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.06.043openalex-snapshot
Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
inferred← citeshttps://doi.org/10.1016/j.chembiol.2025.04.001openalex-snapshot
Impact of radiation therapy on the immunological tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.clml.2020.08.029openalex-snapshot
SOHO State of the Art Updates and Next Questions: Clonal Evolution in Chronic Lymphocytic Leukemia
inferred← citeshttps://doi.org/10.1016/j.ctrv.2015.02.005openalex-snapshot
The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy
inferred← citeshttps://doi.org/10.1016/j.devcel.2017.03.023openalex-snapshot
Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112524openalex-snapshot
Structure-activity relationships of Wee1 inhibitors: A review
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175937openalex-snapshot
Forkhead box proteins as the critical regulators of cisplatin response in tumor cells
inferred← citeshttps://doi.org/10.1016/j.etap.2017.03.014openalex-snapshot
PM 2.5 -induced alterations of cell cycle associated gene expression in lung cancer cells and rat lung tissues
inferred← citeshttps://doi.org/10.1016/j.exphem.2013.09.007openalex-snapshot
Resilient and resourceful: Genome maintenance strategies in hematopoietic stem cells
inferred← citeshttps://doi.org/10.1016/j.exphem.2021.12.244openalex-snapshot
3022 – CELL SIZE IS A DETERMINANT OF STEM CELL POTENTIAL DURING AGING
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.12.032openalex-snapshot
Deciphering the role of skin aging in pigmentary disorders
inferred← citeshttps://doi.org/10.1016/j.gendis.2015.04.001openalex-snapshot
Bmi-1: At the crossroads of physiological and pathological biology
inferred← citeshttps://doi.org/10.1016/j.gene.2023.148078openalex-snapshot
Clinical significance of tumor suppressor genes methylation in circulating tumor DNA of patients with pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.gpb.2016.04.002openalex-snapshot
DNA Damage Response in Hematopoietic Stem Cell Ageing
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e19862openalex-snapshot
LncRNA CECR7 boosts hepatocellular carcinoma progression by recruiting RNA binding protein U2AF2 to enhance the stability of EXO1 mRNA
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108456openalex-snapshot
Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice
inferred← citeshttps://doi.org/10.1016/j.jare.2025.02.017openalex-snapshot
Toxicological mechanisms of carbon polymers in accelerating cognitive decline in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.08.043openalex-snapshot
Cancer stem cells-emanated therapy resistance: Implications for liposomal drug delivery systems
inferred← citeshttps://doi.org/10.1016/j.kint.2018.12.014openalex-snapshot
Arterial “inflammaging” drives vascular calcification in children on dialysis
inferred← citeshttps://doi.org/10.1016/j.mayocp.2014.01.020openalex-snapshot
Targets of Immune Regeneration in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.1016/j.mce.2013.09.006openalex-snapshot
Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma
inferred← citeshttps://doi.org/10.1016/j.mce.2016.08.021openalex-snapshot
Aging, metabolism and stem cells: Spotlight on muscle stem cells
inferred← citeshttps://doi.org/10.1016/j.mito.2014.10.006openalex-snapshot
GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases
inferred← citeshttps://doi.org/10.1016/j.molimm.2014.02.018openalex-snapshot
Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease
inferred← citeshttps://doi.org/10.1016/j.molmed.2013.07.001openalex-snapshot
Muscular dystrophies share pathogenetic mechanisms with muscle sarcomas
inferred← citeshttps://doi.org/10.1016/j.molmed.2013.08.005openalex-snapshot
Microbiota impact on the epigenetic regulation of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.mrrev.2014.04.002openalex-snapshot
lncRNAs: Insights into their function and mechanics in underlying disorders
inferred← citeshttps://doi.org/10.1016/j.neo.2014.09.012openalex-snapshot
Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.1016/j.phrs.2017.10.014openalex-snapshot
Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells
inferred← citeshttps://doi.org/10.1016/j.scr.2021.102618openalex-snapshot
ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway
inferred← citeshttps://doi.org/10.1016/j.semcdb.2017.08.028openalex-snapshot
Secrets from immortal worms: What can we learn about biological ageing from the planarian model system?
inferred← citeshttps://doi.org/10.1016/j.stem.2015.09.016openalex-snapshot
Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging
inferred← citeshttps://doi.org/10.1016/j.stemcr.2021.07.014openalex-snapshot
Sestrins regulate muscle stem cell metabolic homeostasis
inferred← citeshttps://doi.org/10.1016/j.tcb.2013.03.001openalex-snapshot
Stem cell competition: finding balance in the niche
inferred← citeshttps://doi.org/10.1016/j.tice.2015.05.005openalex-snapshot
Does the maternal age affect the mesenchymal stem cell markers and gene expression in the human placenta? What is the evidence?
inferred← citeshttps://doi.org/10.1016/j.tig.2013.06.007openalex-snapshot
Telomerase at the intersection of cancer and aging
inferred← citeshttps://doi.org/10.1016/j.tips.2017.11.005openalex-snapshot
Modernizing Human Cancer Risk Assessment of Therapeutics
inferred← citeshttps://doi.org/10.1016/j.toxlet.2017.08.008openalex-snapshot
Effects of sulfur mustard on mesenchymal stem cells
inferred← citeshttps://doi.org/10.1016/j.tranon.2015.11.003openalex-snapshot
Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma — Prognostic and Translational Implications
inferred← citeshttps://doi.org/10.1016/j.trsl.2013.02.008openalex-snapshot
Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines
inferred← citeshttps://doi.org/10.1016/j.trsl.2013.03.004openalex-snapshot
Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies
inferred← citeshttps://doi.org/10.1016/j.vetmic.2019.06.017openalex-snapshot
Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis
inferred← citeshttps://doi.org/10.1016/j.yexcr.2015.03.011openalex-snapshot
DNA damage checkpoint recovery and cancer development
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00306openalex-snapshot
Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c01052openalex-snapshot
A Melatonin–Catechol Hybrid Molecule Prolongs Lifespan via Regulating ROS and Reprogramming Mitochondrial Metabolism
inferred← citeshttps://doi.org/10.1021/jm400528topenalex-snapshot
Telomere Maintenance as a Target for Drug Discovery
inferred← citeshttps://doi.org/10.1021/jm500415topenalex-snapshot
Development of Synthetic Lethality Anticancer Therapeutics
inferred← citeshttps://doi.org/10.1038/bjc.2013.758openalex-snapshot
Monitoring response to cytostatic cisplatin in a HER2(+) ovary cancer model by MRI and in vitro and in vivo MR spectroscopy
inferred← citeshttps://doi.org/10.1038/cdd.2014.223openalex-snapshot
Muscle gets stressed? p53 represses and protects
inferred← citeshttps://doi.org/10.1038/cdd.2014.231openalex-snapshot
Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19ARF/p53 axis in hematopoiesis, early T-cell development and tissue differentiation
inferred← citeshttps://doi.org/10.1038/cddis.2013.428openalex-snapshot
Systems biology of cisplatin resistance: past, present and future
inferred← citeshttps://doi.org/10.1038/cddis.2014.443openalex-snapshot
Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway
inferred← citeshttps://doi.org/10.1038/cddis.2014.482openalex-snapshot
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
inferred← citeshttps://doi.org/10.1038/cddis.2015.220openalex-snapshot
Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study
inferred← citeshttps://doi.org/10.1038/nature13013openalex-snapshot
Geriatric muscle stem cells switch reversible quiescence into senescence
inferred← citeshttps://doi.org/10.1038/ncb2928openalex-snapshot
Impact of genomic damage and ageing on stem cell function
inferred← citeshttps://doi.org/10.1038/ncomms4649openalex-snapshot
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
inferred← citeshttps://doi.org/10.1038/ncomms8035openalex-snapshot
Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice
inferred← citeshttps://doi.org/10.1038/nm.4275openalex-snapshot
Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
inferred← citeshttps://doi.org/10.1038/nrc.2017.122openalex-snapshot
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
inferred← citeshttps://doi.org/10.1038/nri3433openalex-snapshot
The ageing haematopoietic stem cell compartment
inferred← citeshttps://doi.org/10.1038/nrrheum.2013.92openalex-snapshot
The influence of ageing on the development and management of rheumatoid arthritis
inferred← citeshttps://doi.org/10.1038/onc.2016.42openalex-snapshot
Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis
inferred← citeshttps://doi.org/10.1038/s41388-021-01885-4openalex-snapshot
E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion
inferred← citeshttps://doi.org/10.1038/s41392-021-00510-wopenalex-snapshot
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells
inferred← citeshttps://doi.org/10.1038/s41418-025-01557-wopenalex-snapshot
PUMA-induced apoptosis drives bone marrow failure and genomic instability in telomerase-deficient mice
inferred← citeshttps://doi.org/10.1038/s41419-017-0032-5openalex-snapshot
Ubiquitin C decrement plays a pivotal role in replicative senescence of bone marrow mesenchymal stromal cells
inferred← citeshttps://doi.org/10.1038/s41419-017-0059-7openalex-snapshot
Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies
inferred← citeshttps://doi.org/10.1038/s41467-017-00935-4openalex-snapshot
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
inferred← citeshttps://doi.org/10.1038/s41467-017-02281-xopenalex-snapshot
p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
inferred← citeshttps://doi.org/10.1038/s41467-018-06277-zopenalex-snapshot
Nuclear lamina dysfunction triggers a germline stem cell checkpoint
inferred← citeshttps://doi.org/10.1038/s41467-020-20213-0openalex-snapshot
Anti-senescent drug screening by deep learning-based morphology senescence scoring
inferred← citeshttps://doi.org/10.1038/s41467-024-49106-2openalex-snapshot
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer
inferred← citeshttps://doi.org/10.1038/s41580-018-0020-3openalex-snapshot
Cellular and epigenetic drivers of stem cell ageing
inferred← citeshttps://doi.org/10.1038/s41580-020-00314-wopenalex-snapshot
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
inferred← citeshttps://doi.org/10.1038/s41589-025-02052-6openalex-snapshot
Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome
inferred← citeshttps://doi.org/10.1038/s41598-019-54554-8openalex-snapshot
Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis
inferred← citeshttps://doi.org/10.1038/s41598-023-43737-zopenalex-snapshot
Regulation of base excision repair during adipogenesis and osteogenesis of bone marrow-derived mesenchymal stem cells
inferred← citeshttps://doi.org/10.1038/s44319-025-00487-5openalex-snapshot
BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia
inferred← citeshttps://doi.org/10.1038/srep15950openalex-snapshot
Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling
inferred← citeshttps://doi.org/10.1038/srep20027openalex-snapshot
Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells
inferred← citeshttps://doi.org/10.1038/srep37667openalex-snapshot
Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury
inferred← citeshttps://doi.org/10.1038/srep41580openalex-snapshot
DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences
inferred← citeshttps://doi.org/10.1042/bj20150372openalex-snapshot
c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21
inferred← citeshttps://doi.org/10.1073/pnas.2017830117openalex-snapshot
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47 phox
inferred← citeshttps://doi.org/10.1074/jbc.m113.471433openalex-snapshot
Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells
inferred← citeshttps://doi.org/10.1074/jbc.m114.553388openalex-snapshot
DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation
inferred← citeshttps://doi.org/10.1080/03602532.2026.2724971openalex-snapshot
Metabolism-driven hepatotoxicity of 5-fluorouracil: molecular mechanisms and future therapeutic directions
inferred← citeshttps://doi.org/10.1080/10428194.2021.2010061openalex-snapshot
Molecular characterization of Novel ATM fusions in chronic lymphocytic leukemia and T-cell prolymphocytic leukemia
inferred← citeshttps://doi.org/10.1080/15384101.2015.1041693openalex-snapshot
Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment
inferred← citeshttps://doi.org/10.1080/15384101.2017.1295185openalex-snapshot
p16 loss rescues functional decline of Brca1-deficient mammary stem cells
inferred← citeshttps://doi.org/10.1080/17474086.2019.1575130openalex-snapshot
Genetic mutations in chronic lymphocytic leukemia: impact on clinical treatment
inferred← citeshttps://doi.org/10.1083/jcb.201306136openalex-snapshot
Death of developing neurons: New insights and implications for connectivity
inferred← citeshttps://doi.org/10.1084/jem.20131436openalex-snapshot
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells
inferred← citeshttps://doi.org/10.1089/ars.2017.7294openalex-snapshot
Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs
inferred← citeshttps://doi.org/10.1089/scd.2016.0259openalex-snapshot
Canonical microRNAs Enable Differentiation, Protect Against DNA Damage, and Promote Cholesterol Biosynthesis in Neural Stem Cells
inferred← citeshttps://doi.org/10.1093/carcin/bgu219openalex-snapshot
Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues
inferred← citeshttps://doi.org/10.1093/carcin/bgv028openalex-snapshot
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
inferred← citeshttps://doi.org/10.1093/carcin/bgv032openalex-snapshot
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
inferred← citeshttps://doi.org/10.1093/carcin/bgx002openalex-snapshot
DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression
inferred← citeshttps://doi.org/10.1093/carcin/bgy149openalex-snapshot
Gene expression profiling informs HPV cervical histopathology but not recurrence/relapse after LEEP in ART-suppressed HIV+HPV+ women
inferred← citeshttps://doi.org/10.1093/gerona/glt082openalex-snapshot
Association Analyses of Insulin Signaling Pathway Gene Polymorphisms With Healthy Aging and Longevity in Americans of Japanese Ancestry
inferred← citeshttps://doi.org/10.1093/jrr/rrv012openalex-snapshot
Effects of dose rates on radiation-induced replenishment of intestinal stem cells determined by Lgr5 lineage tracing
inferred← citeshttps://doi.org/10.1093/nar/gkac588openalex-snapshot
Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction
inferred← citeshttps://doi.org/10.1093/nar/gkae190openalex-snapshot
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner
inferred← citeshttps://doi.org/10.1093/nar/gku746openalex-snapshot
The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo1
inferred← citeshttps://doi.org/10.1093/noajnl/vdaa115openalex-snapshot
Experimental glioma with high bHLH expression harbor increased replicative stress and are sensitive toward ATR inhibition
inferred← citeshttps://doi.org/10.1093/stmcls/sxac008openalex-snapshot
Sirt1 Protects Subventricular Zone-Derived Neural Stem Cells from DNA Double-Strand Breaks and Contributes to Olfactory Function Maintenance in Aging Mice
inferred← citeshttps://doi.org/10.1097/bs9.0000000000000029openalex-snapshot
Inflamm-aging of hematopoietic stem cells
inferred← citeshttps://doi.org/10.1101/2019.12.23.887687openalex-snapshot
Zebrafish dazl regulates cystogenesis upstream of the meiotic transition and germline stem cell specification and independent of meiotic checkpoints
inferred← citeshttps://doi.org/10.1101/2020.10.27.355388openalex-snapshot
Cell size is a determinant of stem cell potential during aging
inferred← citeshttps://doi.org/10.1101/2023.05.08.539818openalex-snapshot
Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer
inferred← citeshttps://doi.org/10.1101/2025.10.11.681821openalex-snapshot
Machine learning-based definition of cellular senescence reveals pro-senescence potential implication in lung adenocarcinoma
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