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Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy

https://doi.org/10.3390/molecules25204831

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inferredcites →https://doi.org/10.1016/j.cmet.2016.08.011openalex-snapshot

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

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inferredcites →https://doi.org/10.1016/j.cmet.2016.12.018openalex-snapshot

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

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HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

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TGF-β and kynurenines as the key to infectious tolerance

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3‐Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

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Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

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Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2+/− Mice

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Stress responses in stromal cells and tumor homeostasis

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Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

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Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?

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Cancer Stem Cells: Current Status and Evolving Complexities

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Cancer Stem Cells: The Architects of the Tumor Ecosystem

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Nutrient transporters: the Achilles’ heel of anabolism

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The Warburg Effect: How Does it Benefit Cancer Cells?

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Inhibition of Tumor-associated Fatty Acid Synthase Hyperactivity Induces Synergistic Chemosensitization of HER-2/neu-Overexpressing Human Breast Cancer Cells to Docetaxel (taxotere)

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Hallmarks of cancer stem cell metabolism

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Metabolism addiction in pancreatic cancer

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T-cell exhaustion in the tumor microenvironment

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Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

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Fatty acid carbon is essential for dNTP synthesis in endothelial cells

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Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

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TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

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Targeting mitochondria metabolism for cancer therapy

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Landscape of the mitochondrial Hsp90 metabolome in tumours

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Tumour-associated mutant p53 drives the Warburg effect

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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

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Srebp-controlled glucose metabolism is essential for NK cell functional responses

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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

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Metabolic control of epigenetics in cancer

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Mitochondria and cancer

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Dissecting tumour pathophysiology using intravital microscopy

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Cancer metabolism: a therapeutic perspective

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The diverse functions of the PD1 inhibitory pathway

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Molecular and cellular insights into T cell exhaustion

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PI3K pathway alterations in cancer: variations on a theme

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Molecular mechanisms of cisplatin resistance

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Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

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Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells

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TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

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Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

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Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

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Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

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An inhibitor of oxidative phosphorylation exploits cancer vulnerability

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Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro

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Vascular endothelial growth factor signaling requires glycine to promote angiogenesis

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Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer

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PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer

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Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

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Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin

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The role of amino acid transporters in inherited and acquired diseases

inferredcites →https://doi.org/10.1042/bj20151120openalex-snapshot

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

inferredcites →https://doi.org/10.1053/j.gastro.2008.07.016openalex-snapshot

PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity

inferredcites →https://doi.org/10.1053/j.seminoncol.2013.04.016openalex-snapshot

Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?

inferredcites →https://doi.org/10.1053/j.seminoncol.2017.10.004openalex-snapshot

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

inferredcites →https://doi.org/10.1073/pnas.0605251103openalex-snapshot

A2A adenosine receptor protects tumors from antitumor T cells

inferredcites →https://doi.org/10.1073/pnas.0810199105openalex-snapshot

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

inferredcites →https://doi.org/10.1073/pnas.1206360109openalex-snapshot

Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response

inferredcites →https://doi.org/10.1073/pnas.1317577110openalex-snapshot

Phenformin enhances the therapeutic benefit of BRAF V600E inhibition in melanoma

inferredcites →https://doi.org/10.1073/pnas.1409844111openalex-snapshot

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

inferredcites →https://doi.org/10.1073/pnas.1620164114openalex-snapshot

Stromal cues regulate the pancreatic cancer epigenome and metabolome

inferredcites →https://doi.org/10.1073/pnas.1620433114openalex-snapshot

Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

inferredcites →https://doi.org/10.1073/pnas.1700600114openalex-snapshot

Metabolic origins of spatial organization in the tumor microenvironment

inferredcites →https://doi.org/10.1073/pnas.94.13.6658openalex-snapshot

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

inferredcites →https://doi.org/10.1074/jbc.c000023200openalex-snapshot

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

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Molecular approaches to potentiate cisplatin responsiveness in carcinoma therapeutics

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HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

inferredcites →https://doi.org/10.1084/jem.20100637openalex-snapshot

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients

inferredcites →https://doi.org/10.1084/jem.20112741openalex-snapshot

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

inferredcites →https://doi.org/10.1084/jem.20121015openalex-snapshot

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

inferredcites →https://doi.org/10.1084/jem.20131916openalex-snapshot

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

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Differential Toxic Mechanisms of 2-Deoxy-D-Glucose versus 2-Fluorodeoxy-D -Glucose in Hypoxic and Normoxic Tumor Cells

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Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

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CTLA-4 and PD-1 Pathways

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MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

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Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid

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MYC ‐induced cytidine metabolism regulates survival and drug resistance via cGas‐STING pathway in mantle cell lymphoma

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A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer

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Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

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FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner

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Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

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Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment

inferred← citeshttps://doi.org/10.3389/fonc.2022.1025397openalex-snapshot

Development and validation of prognostic models for colon adenocarcinoma based on combined immune-and metabolism-related genes

inferred← citeshttps://doi.org/10.3389/fonc.2022.1046630openalex-snapshot

Effects of metabolic cancer therapy on tumor microenvironment

inferred← citeshttps://doi.org/10.3389/fonc.2022.1089320openalex-snapshot

Immunoregulatory framework and the role of miRNA in the pathogenesis of NSCLC – A systematic review

inferred← citeshttps://doi.org/10.3389/fonc.2022.808290openalex-snapshot

Serum Abnormal Metabolites for Evaluating Therapeutic Response and Prognosis of Patients With Multiple Myeloma

inferred← citeshttps://doi.org/10.3389/fonc.2023.1063051openalex-snapshot

Enhancement of immune surveillance in breast cancer by targeting hypoxic tumor endothelium: Can it be an immunological switch point?

inferred← citeshttps://doi.org/10.3389/fonc.2025.1540643openalex-snapshot

Exosomes: their role and therapeutic potential in overcoming drug resistance of gastrointestinal cancers

inferred← citeshttps://doi.org/10.3389/fonc.2026.1708878openalex-snapshot

Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming

inferred← citeshttps://doi.org/10.3390/antiox12061302openalex-snapshot

Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open

inferred← citeshttps://doi.org/10.3390/app152111576openalex-snapshot

The Dual Role of Metformin: Repurposing an Antidiabetic Drug for Cancer Therapy

inferred← citeshttps://doi.org/10.3390/biom15101376openalex-snapshot

Unveiling Metabolic Signatures as Potential Biomarkers in Common Cancers: Insights from Lung, Breast, Colorectal, Liver, and Gastric Tumours

inferred← citeshttps://doi.org/10.3390/biomedicines12030591openalex-snapshot

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma or a Metaphor for Heterogeneity: From Single-Cell Analysis to Whole-Body Imaging

inferred← citeshttps://doi.org/10.3390/cancers14215345openalex-snapshot

Metabolic Plasticity of Cancer Stem Cells in Response to Microenvironmental Cues

inferred← citeshttps://doi.org/10.3390/cancers14215442openalex-snapshot

Role of CAR T Cell Metabolism for Therapeutic Efficacy

inferred← citeshttps://doi.org/10.3390/cancers15010005openalex-snapshot

The Emerging Role of Tumor Microenvironmental Stimuli in Regulating Metabolic Rewiring of Liver Cancer Stem Cells

inferred← citeshttps://doi.org/10.3390/cancers15235657openalex-snapshot

Role of Vitamin C in Targeting Cancer Stem Cells and Cellular Plasticity

inferred← citeshttps://doi.org/10.3390/cancers16173028openalex-snapshot

ASCT2 Regulates Fatty Acid Metabolism to Trigger Glutamine Addiction in Basal-like Breast Cancer

inferred← citeshttps://doi.org/10.3390/cancers16173082openalex-snapshot

Cisplatin Resistance and Metabolism: Simplification of Complexity

inferred← citeshttps://doi.org/10.3390/cells14060403openalex-snapshot

Cross-Talk Between Cancer and Its Cellular Environment—A Role in Cancer Progression

inferred← citeshttps://doi.org/10.3390/ijms22041565openalex-snapshot

The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia

inferred← citeshttps://doi.org/10.3390/ijms22126262openalex-snapshot

Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy

inferred← citeshttps://doi.org/10.3390/ijms22179507openalex-snapshot

More Than Meets the Eye Regarding Cancer Metabolism

inferred← citeshttps://doi.org/10.3390/ijms23073745openalex-snapshot

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities

inferred← citeshttps://doi.org/10.3390/ijms24097771openalex-snapshot

Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma

inferred← citeshttps://doi.org/10.3390/ijms241411816openalex-snapshot

Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression

inferred← citeshttps://doi.org/10.3390/ijms25115691openalex-snapshot

Ovarian Cancer Cell-Conditioning Medium Induces Cancer-Associated Fibroblast Phenoconversion through Glucose-Dependent Inhibition of Autophagy

inferred← citeshttps://doi.org/10.3390/ijms25179463openalex-snapshot

From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies

inferred← citeshttps://doi.org/10.3390/ijms262411893openalex-snapshot

Microenvironmental and Molecular Pathways Driving Dormancy Escape in Bone Metastases

inferred← citeshttps://doi.org/10.3390/life15020202openalex-snapshot

A Pilot Study on Qualitative Metabolomics to Characterize Lewis Lung Carcinoma in Mice

inferred← citeshttps://doi.org/10.3390/metabo12121214openalex-snapshot

Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer

inferred← citeshttps://doi.org/10.3390/nu18040679openalex-snapshot

A Global Perspective on Metabolic Dysfunction-Associated Steatotic Liver Disease: From Molecular Mechanisms to Therapeutic Strategy Innovation

inferred← citeshttps://doi.org/10.3390/pharmaceutics15112610openalex-snapshot

Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance

inferred← citeshttps://doi.org/10.34172/ajmb.2524openalex-snapshot

Proteomic Alterations and Metabolic Pathway Modulations Induced by Methyl Methane Sulfonate Treatment in Response to DNA Damage

inferred← citeshttps://doi.org/10.3892/ijo.2022.5369openalex-snapshot

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation

inferred← citeshttps://doi.org/10.3892/mmr.2024.13255openalex-snapshot

Research progress in the metabolic reprogramming of hepatocellular carcinoma (Review)

inferred← citeshttps://doi.org/10.55563/clinexprheumatol/hhbqejopenalex-snapshot

The pathogenic role of metabolism in Sjögren's syndrome

inferred← citeshttps://doi.org/10.56294/saludcyt20251644openalex-snapshot

Development of a risk model for bcr-free prognosis in prostate cancer patients linked to nucleotide metabolism

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298899openalex-snapshot

Additional file 1 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298902openalex-snapshot

Additional file 2 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298905openalex-snapshot

Additional file 3 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298908openalex-snapshot

Additional file 4 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298911openalex-snapshot

Additional file 5 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298914openalex-snapshot

Additional file 6 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298917openalex-snapshot

Additional file 7 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298920openalex-snapshot

Additional file 8 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.23298923openalex-snapshot

Additional file 9 of Group-specific cellular metabolism in Medulloblastoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.24112960openalex-snapshot

Additional file 1 of Characterization of the effect of pomegranate crude extract, and its post-harvesting preservation procedures, on redox tone, cellular growth and metabolic profile of MDA-MB-231 cell line

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181103openalex-snapshot

Additional file 1 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181106openalex-snapshot

Additional file 2 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181109openalex-snapshot

Additional file 3 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181115openalex-snapshot

Additional file 4 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181118openalex-snapshot

Additional file 5 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181121openalex-snapshot

Additional file 6 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181124openalex-snapshot

Additional file 7 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.24181127openalex-snapshot

Additional file 8 of Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

inferred← citeshttps://doi.org/10.6084/m9.figshare.25770354openalex-snapshot

Additional file 1 of Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686413openalex-snapshot

Additional file 1 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686416openalex-snapshot

Additional file 2 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686419openalex-snapshot

Additional file 3 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686422openalex-snapshot

Additional file 4 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686425openalex-snapshot

Additional file 5 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686428openalex-snapshot

Additional file 6 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686431openalex-snapshot

Additional file 7 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686434openalex-snapshot

Additional file 8 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686437openalex-snapshot

Additional file 9 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686440openalex-snapshot

Additional file 10 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.6084/m9.figshare.26686443openalex-snapshot

Additional file 11 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics

inferred← citeshttps://doi.org/10.70675/9e290f7fz176bz4249zba2aze5e67eeff324openalex-snapshot

HVEM : une nouvelle cible prometteuse d'immunothérapie anti-cancéreuse

inferred← citeshttps://doi.org/10.70675/b81c167azcc23z4977z90f0z0ff71e3da7c4openalex-snapshot

Characterizing and targeting the microenviromental changes in PIK3CA related overgrowth syndromes

inferred← citeshttps://doi.org/10.7717/peerj.21400openalex-snapshot

The metabolic escape: how tumor metabolic reprogramming drives drug resistance

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