On the public citation graph
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors
0 signed · 232 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/gcc.20419openalex-snapshot
Effects of ERBB2 amplicon size and genomic alterations of chromosomes 1, 3, and 10 on patient response to trastuzumab in metastatic breast cancer
inferredcites →https://doi.org/10.1016/0076-6879(91)98010-4openalex-snapshot
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation
inferredcites →https://doi.org/10.1016/0306-9877(95)90228-7openalex-snapshot
Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1016/j.ccr.2008.11.003openalex-snapshot
Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
inferredcites →https://doi.org/10.1016/j.ccr.2009.06.006openalex-snapshot
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
inferredcites →https://doi.org/10.1016/j.cell.2006.01.040openalex-snapshot
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2011.09.035openalex-snapshot
Tumor suppressor genes and ROS: complex networks of interactions
inferredcites →https://doi.org/10.1016/j.molcel.2006.07.014openalex-snapshot
Nuclear PtdIns5P as a Transducer of Stress Signaling: An In Vivo Role for PIP4Kbeta
inferredcites →https://doi.org/10.1016/s0960-9822(00)00002-6openalex-snapshot
Tumor spectrum analysis in p53-mutant mice
inferredcites →https://doi.org/10.1016/s0960-9822(01)00501-2openalex-snapshot
Characterization of MTMR3
inferredcites →https://doi.org/10.1016/s0960-9822(03)00132-5openalex-snapshot
Phosphatidylinositol-5-Phosphate Activation and Conserved Substrate Specificity of the Myotubularin Phosphatidylinositol 3-Phosphatases
inferredcites →https://doi.org/10.1038/36621openalex-snapshot
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
inferredcites →https://doi.org/10.1038/msb.2011.81openalex-snapshot
Deep proteome and transcriptome mapping of a human cancer cell line
inferredcites →https://doi.org/10.1038/nature01045openalex-snapshot
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
inferredcites →https://doi.org/10.1038/nature03918openalex-snapshot
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
inferredcites →https://doi.org/10.1038/ncb1699openalex-snapshot
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
inferredcites →https://doi.org/10.1038/sj.onc.1207251openalex-snapshot
Overexpression of the amplified Pip4k2β gene from 17q11–12 in breast cancer cells confers proliferation advantage
inferredcites →https://doi.org/10.1042/bj20100129openalex-snapshot
A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5 P and other phosphoinositides
inferredcites →https://doi.org/10.1056/nejm198710083171509openalex-snapshot
Proto-Oncogenes and Human Cancers
inferredcites →https://doi.org/10.1056/nejm200103153441101openalex-snapshot
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
inferredcites →https://doi.org/10.1074/jbc.270.27.16128openalex-snapshot
The Isolation and Characterization of cDNA Encoding Human and Rat Brain Inositol Polyphosphate 4-Phosphatase
inferredcites →https://doi.org/10.1074/jbc.272.38.23859openalex-snapshot
The cDNA Cloning and Characterization of Inositol Polyphosphate 4-Phosphatase Type II
inferredcites →https://doi.org/10.1074/jbc.274.13.8347openalex-snapshot
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
inferredcites →https://doi.org/10.1093/bioinformatics/btf877openalex-snapshot
Identifying differentially expressed genes using false discovery rate controlling procedures
inferredcites →https://doi.org/10.1093/carcin/bgl132openalex-snapshot
Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers
inferredcites →https://doi.org/10.1096/fj.12-218842openalex-snapshot
PtdIns5 P is an oxidative stress‐induced second messenger that regulates PKB activation
inferredcites →https://doi.org/10.1101/sqb.2011.76.010868openalex-snapshot
Control of Glycolysis through Regulation of PFK1: Old Friends and Recent Additions
inferredcites →https://doi.org/10.1126/science.2470152openalex-snapshot
Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
inferredcites →https://doi.org/10.1126/science.275.5300.665openalex-snapshot
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate
inferredcites →https://doi.org/10.1126/science.296.5573.1655openalex-snapshot
The Phosphoinositide 3-Kinase Pathway
inferredcites →https://doi.org/10.1128/mcb.21.9.3206-3219.2001openalex-snapshot
Immune System Dysfunction and Autoimmune Disease in Mice Lacking Emk (Par-1) Protein Kinase
inferredcites →https://doi.org/10.1128/mcb.22.1.94-104.2002openalex-snapshot
Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death
inferredcites →https://doi.org/10.1128/mcb.24.11.5080-5087.2004openalex-snapshot
Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase β−/− Mice
inferredcites →https://doi.org/10.1136/jmg.2010.078113openalex-snapshot
A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations: Table 1
inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.481openalex-snapshot
PHOSPHOINOSITIDE KINASES
inferredcites →https://doi.org/10.1182/blood-2005-07-2755openalex-snapshot
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis
inferredcites →https://doi.org/10.2202/1544-6115.1027openalex-snapshot
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
inferredcites →https://doi.org/10.4161/cc.7.12.6124openalex-snapshot
Senescence triggered by the loss of the VHL tumor suppressor
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4781335openalex-extracted
The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
inferred← citeshttps://doi.org/10.1002/1873-3468.14237openalex-snapshot
Expanding role of PI5P4Ks in cancer: A promising druggable target
inferred← citeshttps://doi.org/10.1002/1878-0261.12850openalex-snapshot
High‐throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype‐specific serologically relevant biomarkers
inferred← citeshttps://doi.org/10.1002/9781118512074.ch31openalex-snapshot
Neoplasia of the Gastrointestinal Tract
inferred← citeshttps://doi.org/10.1002/ange.202302364openalex-snapshot
Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader
inferred← citeshttps://doi.org/10.1002/anie.202302364openalex-snapshot
Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader
inferred← citeshttps://doi.org/10.1002/chem.202202083openalex-snapshot
Rational Design and Synthesis of D‐galactosyl Lysophospholipids as Selective Substrates and non‐ATP‐competitive Inhibitors of Phosphatidylinositol Phosphate Kinases
inferred← citeshttps://doi.org/10.1002/cne.24956openalex-snapshot
Distribution and localization of phosphatidylinositol 5‐phosphate, 4‐kinase alpha and beta in the brain
inferred← citeshttps://doi.org/10.1002/jcc.27499openalex-snapshot
Enhancing protein‐ligand binding affinity prediction through sequential fusion of graph and convolutional neural networks
inferred← citeshttps://doi.org/10.1002/jcp.25273openalex-snapshot
Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C
inferred← citeshttps://doi.org/10.1007/978-1-4614-6438-9_418-1openalex-snapshot
Phosphatidylinositol 5-Phosphate 4-Kinase
inferred← citeshttps://doi.org/10.1007/978-1-4939-0727-4_28openalex-snapshot
Genomic Applications in Epithelial Ovarian Malignancies
inferred← citeshttps://doi.org/10.1007/978-1-4939-3170-5_1openalex-snapshot
Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format
inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_418openalex-snapshot
Phosphatidylinositol 5-Phosphate 4-Kinase
inferred← citeshttps://doi.org/10.1007/978-3-319-96830-8_32openalex-snapshot
Genomic Applications in Ovarian Cancer
inferred← citeshttps://doi.org/10.1007/978-3-540-47818-8_37openalex-snapshot
1-Phosphatidylinositol-5-phosphate 4-kinase
inferred← citeshttps://doi.org/10.1007/s00018-017-2575-0openalex-snapshot
Molecularly targeted therapies for p53-mutant cancers
inferred← citeshttps://doi.org/10.1007/s00018-025-05825-3openalex-snapshot
The oily nucleus– role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm
inferred← citeshttps://doi.org/10.1007/s11033-026-12389-3openalex-snapshot
PI4K and PIPK families in breast cancer: subtype-specific oncogenic mechanisms and precision therapeutic strategies
inferred← citeshttps://doi.org/10.1007/s12035-025-04860-2openalex-snapshot
N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis
inferred← citeshttps://doi.org/10.1007/s12035-025-05042-wopenalex-snapshot
GPX4 Inhibition Contributes to NLRP3-Mediated Pyroptosis and Cognitive Impairment in Ketamine-Exposed Neonatal Rats
inferred← citeshttps://doi.org/10.1007/s12672-024-01555-3openalex-snapshot
Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma
inferred← citeshttps://doi.org/10.1007/s42764-022-00060-7openalex-snapshot
Proteome profiling of phosphatidylinositol-5-phosphate 4-kinase type 2A and 2B knockdown cells identify modifications in key regulators involved in cell homeostasis and genome integrity
inferred← citeshttps://doi.org/10.1007/s42764-022-00080-3openalex-snapshot
Synthetic lethality in personalized cancer therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.98742-7openalex-snapshot
MAP Kinase Modules in Signaling☆
inferred← citeshttps://doi.org/10.1016/b978-0-12-821567-8.00017-8openalex-snapshot
Small molecules targeting misfolded mutants of p53 as a rescue strategy to improve glioblastoma chemotherapy
inferred← citeshttps://doi.org/10.1016/j.bbalip.2015.02.013openalex-snapshot
Polyphosphoinositide binding domains: Key to inositol lipid biology
inferred← citeshttps://doi.org/10.1016/j.bbalip.2015.02.014openalex-snapshot
PIP4K and the role of nuclear phosphoinositides in tumour suppression
inferred← citeshttps://doi.org/10.1016/j.bbalip.2021.158903openalex-snapshot
Phosphoinositides: Functions in autophagy-related stress responses
inferred← citeshttps://doi.org/10.1016/j.bbalip.2025.159698openalex-snapshot
The multifaceted phosphatidylinositol 5 phosphate 4-kinase proteins: molecular properties and biological functions
inferred← citeshttps://doi.org/10.1016/j.bbalip.2026.159725openalex-snapshot
Nuclear phosphoinositides: An exploration into their regulation, roles and physico-chemical environment
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.03.014openalex-snapshot
Identification of human Phosphatidyl Inositol 5-Phosphate 4-Kinase as an RNA binding protein that is imported into Plasmodium falciparum
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.154404openalex-snapshot
PIP4K2A depletion suppresses AKT signaling and enhances chemotherapy sensitivity in T-cell lymphoblastic lymphoma cells
inferred← citeshttps://doi.org/10.1016/j.bcmd.2015.06.014openalex-snapshot
Differential profile of PIP4K2A expression in hematological malignancies
inferred← citeshttps://doi.org/10.1016/j.cancergen.2019.04.002openalex-snapshot
PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia
inferred← citeshttps://doi.org/10.1016/j.ccell.2024.04.009openalex-snapshot
Understanding the complexity of p53 in a new era of tumor suppression
inferred← citeshttps://doi.org/10.1016/j.ceb.2021.01.012openalex-snapshot
Emerging cell biological functions of phosphatidylinositol 5 phosphate 4 kinase
inferred← citeshttps://doi.org/10.1016/j.cellsig.2018.05.011openalex-snapshot
Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.04.070openalex-snapshot
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.04.084openalex-snapshot
Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116199openalex-snapshot
PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.chembiol.2020.02.003openalex-snapshot
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
inferred← citeshttps://doi.org/10.1016/j.ctrv.2018.09.004openalex-snapshot
Restoring guardianship of the genome: Anticancer drug strategies to reverse oncogenic mutant p53 misfolding
inferred← citeshttps://doi.org/10.1016/j.devcel.2021.04.019openalex-snapshot
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.115027openalex-snapshot
Development of potent and selective degraders of PI5P4Kγ
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176723openalex-snapshot
Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1016/j.enzmictec.2020.109717openalex-snapshot
Autodisplay of human PIP5K1α lipid kinase on Escherichia coli and inhibitor testing
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2014.04.035openalex-snapshot
Cancer cells with irons in the fire
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.145157openalex-snapshot
Non-canonical functions of PIP4K2A and its role in cancer biology: A review
inferred← citeshttps://doi.org/10.1016/j.isci.2026.115952openalex-snapshot
PIP4K2A/2B inhibitor suppresses tumor growth in a xenograft model of NSCLC
inferred← citeshttps://doi.org/10.1016/j.jare.2025.09.024openalex-snapshot
Orthosteric–allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113071openalex-snapshot
A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113110openalex-snapshot
Phosphatidylinositol 4-kinase α suppresses glioblastoma progression by inactivating YAP and PI3K/Akt signaling
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113123openalex-snapshot
Lipid transfer proteins and PI4KIIα initiate nuclear p53-phosphoinositide signaling
inferred← citeshttps://doi.org/10.1016/j.jbior.2014.09.007openalex-snapshot
Exploring phosphatidylinositol 5-phosphate 4-kinase function
inferred← citeshttps://doi.org/10.1016/j.jbior.2015.11.007openalex-snapshot
Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma
inferred← citeshttps://doi.org/10.1016/j.jbior.2016.10.001openalex-snapshot
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis
inferred← citeshttps://doi.org/10.1016/j.jbior.2018.02.003openalex-snapshot
Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases
inferred← citeshttps://doi.org/10.1016/j.jbior.2021.100839openalex-snapshot
Mechanistic roles of mutant p53 governing lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.jbior.2022.100939openalex-snapshot
PIP kinases: A versatile family that demands further therapeutic attention
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.03.009openalex-snapshot
The Basal Transcription Complex Component TAF3 Transduces Changes in Nuclear Phosphoinositides into Transcriptional Output
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.12.011openalex-snapshot
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.molcel.2017.10.026openalex-snapshot
PIP-ing Lipids on Membranes: PTEN Takes the Cake
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.03.037openalex-snapshot
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.08.005openalex-snapshot
Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease
inferred← citeshttps://doi.org/10.1016/j.molimm.2020.12.023openalex-snapshot
Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages
inferred← citeshttps://doi.org/10.1016/j.mtbio.2026.102805openalex-snapshot
CS-NO releasing hydrogel protects against neuron apoptosis and inflammation through suppressing the HIF-1α and MAPK pathway in stroke
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2016.01.014openalex-snapshot
Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs
inferred← citeshttps://doi.org/10.1016/j.physrep.2019.12.004openalex-snapshot
Computational network biology: Data, models, and applications
inferred← citeshttps://doi.org/10.1016/j.redox.2019.101381openalex-snapshot
Acetaldehyde induces phosphorylation of dynamin-related protein 1 and mitochondrial dysfunction via elevating intracellular ROS and Ca2+ levels
inferred← citeshttps://doi.org/10.1016/j.sajb.2024.08.037openalex-snapshot
Exploring natural resources: Plumbagin as a potent anticancer agent
inferred← citeshttps://doi.org/10.1016/j.tcb.2015.04.001openalex-snapshot
Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation
inferred← citeshttps://doi.org/10.1016/j.tibs.2016.04.003openalex-snapshot
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.tips.2019.09.006openalex-snapshot
Combating Human Pathogens and Cancer by Targeting Phosphoinositides and Their Metabolism
inferred← citeshttps://doi.org/10.1016/j.tranon.2025.102420openalex-snapshot
Downregulation of PIP4K2C inhibits the breast cancer cell proliferation, migration and invasion
inferred← citeshttps://doi.org/10.1016/j.trecan.2016.05.009openalex-snapshot
The Hidden Conundrum of Phosphoinositide Signaling in Cancer
inferred← citeshttps://doi.org/10.1016/j.virol.2023.05.004openalex-snapshot
Activation of p53-regulated pro-survival signals and hypoxia-independent mitochondrial targeting of TIGAR by human papillomavirus E6 oncoproteins
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b01692openalex-snapshot
Use of Multiple Cryoprotectants to Improve Diffraction Quality from Protein Crystals
inferred← citeshttps://doi.org/10.1021/acs.jcim.3c00543openalex-snapshot
Hit Identification Driven by Combining Artificial Intelligence and Computational Chemistry Methods: A PI5P4K-β Case Study
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00227openalex-snapshot
Discovery and Structure–Activity Relationship Study of ( Z )‑5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5‑Phosphate 4‑Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01245openalex-snapshot
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01819openalex-snapshot
Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01693openalex-snapshot
The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules
inferred← citeshttps://doi.org/10.1021/acschembio.5b00368openalex-snapshot
Chemoproteomics Reveals Novel Protein and Lipid Kinase Targets of Clinical CDK4/6 Inhibitors in Lung Cancer
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.9b00402openalex-snapshot
Structure–Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors
inferred← citeshttps://doi.org/10.1038/nature15740openalex-snapshot
Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples
inferred← citeshttps://doi.org/10.1038/onc.2014.399openalex-snapshot
Antitumor mechanisms when pRb and p53 are genetically inactivated
inferred← citeshttps://doi.org/10.1038/onc.2014.77openalex-snapshot
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival
inferred← citeshttps://doi.org/10.1038/onc.2015.388openalex-snapshot
The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain
inferred← citeshttps://doi.org/10.1038/s41392-020-00358-6openalex-snapshot
Development of synthetic lethality in cancer: molecular and cellular classification
inferred← citeshttps://doi.org/10.1038/s41408-022-00747-wopenalex-snapshot
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
inferred← citeshttps://doi.org/10.1038/s41467-017-00750-xopenalex-snapshot
MANF regulates hypothalamic control of food intake and body weight
inferred← citeshttps://doi.org/10.1038/s41467-017-02287-5openalex-snapshot
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
inferred← citeshttps://doi.org/10.1038/s41467-018-05805-1openalex-snapshot
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
inferred← citeshttps://doi.org/10.1038/s41467-023-37064-0openalex-snapshot
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
inferred← citeshttps://doi.org/10.1038/s41467-025-63290-9openalex-snapshot
Axial nephron fate switching demonstrates a plastic system tunable on demand
inferred← citeshttps://doi.org/10.1038/s41556-019-0297-2openalex-snapshot
A nuclear phosphoinositide kinase complex regulates p53
inferred← citeshttps://doi.org/10.1038/s41568-025-00810-1openalex-snapshot
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities
inferred← citeshttps://doi.org/10.1038/s41573-022-00582-5openalex-snapshot
Beyond PI3Ks: targeting phosphoinositide kinases in disease
inferred← citeshttps://doi.org/10.1038/s41589-023-01284-8openalex-snapshot
Deep thermal profiling for detection of functional proteoform groups
inferred← citeshttps://doi.org/10.1038/s41598-024-64823-wopenalex-snapshot
LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1038/s44318-024-00085-6openalex-snapshot
Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer
inferred← citeshttps://doi.org/10.1038/srep19649openalex-snapshot
Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression
inferred← citeshttps://doi.org/10.1039/d3md00039gopenalex-snapshot
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor
inferred← citeshttps://doi.org/10.1039/d3md00355hopenalex-snapshot
The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)
inferred← citeshttps://doi.org/10.1042/bcj20160069openalex-snapshot
Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]
inferred← citeshttps://doi.org/10.1042/bcj20180022openalex-snapshot
Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids
inferred← citeshttps://doi.org/10.1042/bj20141333openalex-snapshot
The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site
inferred← citeshttps://doi.org/10.1042/bsr20182210openalex-snapshot
Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes
inferred← citeshttps://doi.org/10.1042/bst20150238openalex-snapshot
Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle
inferred← citeshttps://doi.org/10.1055/s-0042-1751280openalex-snapshot
Bacterial-Type Long-Chain Polyphosphates Bind Human Proteins in the Phosphatidylinositol Signaling Pathway
inferred← citeshttps://doi.org/10.1073/pnas.1405801111openalex-snapshot
The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer
inferred← citeshttps://doi.org/10.1073/pnas.1522112113openalex-snapshot
Mechanism of substrate specificity of phosphatidylinositol phosphate kinases
inferred← citeshttps://doi.org/10.1073/pnas.1522478113openalex-snapshot
In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P 2 to impact mTORC2 and Akt signaling
inferred← citeshttps://doi.org/10.1073/pnas.1600934113openalex-snapshot
Deletion of the gene Pip4k2c , a novel phosphatidylinositol kinase, results in hyperactivation of the immune system
inferred← citeshttps://doi.org/10.1073/pnas.2002486118openalex-snapshot
Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells
inferred← citeshttps://doi.org/10.1073/pnas.2010053118openalex-snapshot
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity
inferred← citeshttps://doi.org/10.1073/pnas.2217971121openalex-snapshot
MTM1-mediated production of phosphatidylinositol 5-phosphate fuels the formation of podosome-like protrusions regulating myoblast fusion
inferred← citeshttps://doi.org/10.1074/jbc.m116.736041openalex-snapshot
Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6
inferred← citeshttps://doi.org/10.1080/15384047.2026.2692173openalex-snapshot
A preliminary characterization of PI4K/PIPK alterations across solid tumors: an exploratory framework for prognostic and therapeutic stratification
inferred← citeshttps://doi.org/10.1080/23808993.2019.1644164openalex-snapshot
Precision medicine for TP53-mutated acute myeloid leukemia
inferred← citeshttps://doi.org/10.1084/jem.20172170openalex-snapshot
PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma
inferred← citeshttps://doi.org/10.1093/bib/bbz167openalex-snapshot
Cooperative driver pathway discovery via fusion of multi-relational data of genes, miRNAs and pathways
inferred← citeshttps://doi.org/10.1093/nar/gkw491openalex-snapshot
Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants
inferred← citeshttps://doi.org/10.1093/pcmedi/pbad015openalex-snapshot
Genetic factors for differentiated thyroid cancer in French Polynesia: new candidate loci
inferred← citeshttps://doi.org/10.1096/fj.202100457rropenalex-snapshot
Thermal proteome profiling identifies PIP4K2A and ZADH2 as off‐targets of Polo‐like kinase 1 inhibitor volasertib
inferred← citeshttps://doi.org/10.1097/md.0000000000003542openalex-snapshot
Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility
inferred← citeshttps://doi.org/10.1101/2019.12.27.889394openalex-snapshot
Oxygen-generated spatial distribution of cell population links to p53 status
inferred← citeshttps://doi.org/10.1101/2021.12.10.472157openalex-snapshot
Proteome Microarray Screening Identifies Human Polyphosphate-Binding Proteins in the Phosphatidylinositol Signaling Pathway
inferred← citeshttps://doi.org/10.1101/2022.03.25.485814openalex-snapshot
PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1
inferred← citeshttps://doi.org/10.1101/2022.06.10.495491openalex-snapshot
Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers
inferred← citeshttps://doi.org/10.1101/2025.11.24.690171openalex-snapshot
Phosphatidylinositol 5 phosphate 4 kinase regulates phosphatidylinositol 3,4 bisphosphate levels in vivo
inferred← citeshttps://doi.org/10.1101/333153openalex-snapshot
Phosphatidylinositol 5 phosphate 4-kinase regulates plasma-membrane PIP 3 turnover and insulin sensitivity in Drosophila
inferred← citeshttps://doi.org/10.1111/1759-7714.12294openalex-snapshot
Translational progress on tumor biomarkers
inferred← citeshttps://doi.org/10.1111/febs.13739openalex-snapshot
Structural reverse genetics study of the PI 5P4Kβ–nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells
inferred← citeshttps://doi.org/10.1111/febs.15127openalex-snapshot
Phosphoinositides in autophagy: current roles and future insights
inferred← citeshttps://doi.org/10.1111/febs.17393openalex-snapshot
PI 5 P 4 K inhibitors: promising opportunities and challenges
inferred← citeshttps://doi.org/10.1126/sciadv.1600925openalex-snapshot
The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing
inferred← citeshttps://doi.org/10.1126/sciadv.ade8641openalex-snapshot
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
inferred← citeshttps://doi.org/10.1126/sciadv.aeb8658openalex-snapshot
Noncanonical PI(4,5)P 2 coordinates lysosome positioning through cholesterol trafficking
inferred← citeshttps://doi.org/10.1126/scisignal.2005013openalex-snapshot
2013: Signaling Breakthroughs of the Year
inferred← citeshttps://doi.org/10.1126/scisignal.2005191openalex-snapshot
PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
inferred← citeshttps://doi.org/10.1126/scitranslmed.aax3772openalex-snapshot
PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma
inferred← citeshttps://doi.org/10.1146/annurev-cancerbio-042016-073434openalex-snapshot
Synthetic Lethality in Cancer Therapeutics
inferred← citeshttps://doi.org/10.1146/annurev-med-050913-022545openalex-snapshot
Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors
inferred← citeshttps://doi.org/10.1155/2022/6813017openalex-snapshot
Semaglutide Protects against 6‐OHDA Toxicity by Enhancing Autophagy and Inhibiting Oxidative Stress
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-21-0500openalex-snapshot
Synthetic Lethality in Ovarian Cancer
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-26-0063openalex-snapshot
Kinase Plasticity with Vandetanib Treatment Enhances Sensitivity to Tamoxifen in Estrogen Receptor–Positive Breast Cancer
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-19-0144openalex-snapshot
Identification of TP53RK-Binding Protein (TPRKB) Dependency in TP53 -Deficient Cancers
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-24-0290openalex-snapshot
Loss of PI5P4Kα Slows the Progression of a Pten Mutant Basal Cell Model of Prostate Cancer
inferred← citeshttps://doi.org/10.1167/iovs.16-19405openalex-snapshot
Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases
inferred← citeshttps://doi.org/10.1177/1533034615604798openalex-snapshot
Anticancer Opportunity Created by Loss of Tumor Suppressor Genes
inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot
The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
inferred← citeshttps://doi.org/10.1186/s13045-020-00956-5openalex-snapshot
Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
inferred← citeshttps://doi.org/10.1186/s13045-021-01169-0openalex-snapshot
Targeting mutant p53 for cancer therapy: direct and indirect strategies
inferred← citeshttps://doi.org/10.1186/s40170-020-00234-5openalex-snapshot
Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function
inferred← citeshttps://doi.org/10.1242/jcs.260943openalex-snapshot
Adaptations of membrane trafficking in cancer and tumorigenesis
inferred← citeshttps://doi.org/10.12688/f1000research.16679.1openalex-snapshot
Recent advances in understanding phosphoinositide signaling in the nervous system
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1004497openalex-snapshot
A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1006888openalex-snapshot
Predicting synthetic lethal interactions using conserved patterns in protein interaction networks
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1007701openalex-snapshot
Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes
inferred← citeshttps://doi.org/10.1515/jib-2017-0027openalex-snapshot
Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics
inferred← citeshttps://doi.org/10.15252/embr.201643030openalex-snapshot
Drugging the addict: non‐oncogene addiction as a target for cancer therapy
inferred← citeshttps://doi.org/10.1530/erc-16-0228openalex-snapshot
Synthetic lethality: the road to novel therapies for breast cancer
inferred← citeshttps://doi.org/10.2217/epi-2017-0104openalex-snapshot
The Correlation Analysis of miRNAs and Target Genes in Metastasis of Cervical Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.26508/lsa.202301920openalex-snapshot
PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
inferred← citeshttps://doi.org/10.3389/978-2-83250-838-1openalex-snapshot
Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume II
inferred← citeshttps://doi.org/10.3389/fbioe.2015.00172openalex-snapshot
Prediction of Genetic Interactions Using Machine Learning and Network Properties
inferred← citeshttps://doi.org/10.3389/fcell.2021.791758openalex-snapshot
Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P2 Come to the Surface
inferred← citeshttps://doi.org/10.3389/fcell.2022.903994openalex-snapshot
When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response
inferred← citeshttps://doi.org/10.3389/fcell.2023.1297355openalex-snapshot
Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention
inferred← citeshttps://doi.org/10.3389/fgene.2018.00721openalex-snapshot
Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid Cancers
inferred← citeshttps://doi.org/10.3389/fonc.2023.1323897openalex-snapshot
Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer
inferred← citeshttps://doi.org/10.3390/ani15030342openalex-snapshot
Deciphering the Population Characteristics of Leiqiong Cattle Using Whole-Genome Sequencing Data
inferred← citeshttps://doi.org/10.3390/biom12020264openalex-snapshot
Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration
inferred← citeshttps://doi.org/10.3390/biom13091297openalex-snapshot
Regulation of Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes
inferred← citeshttps://doi.org/10.3390/cancers16061180openalex-snapshot
PIP4K2B Protein Regulation by NSD1 in HPV-Negative Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/cells11050794openalex-snapshot
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
inferred← citeshttps://doi.org/10.3390/genes10040312openalex-snapshot
Novel Molecular Signatures in the PIP4K/PIP5K Family of Proteins Specific for Different Isozymes and Subfamilies Provide Important Insights into the Evolutionary Divergence of this Protein Family
inferred← citeshttps://doi.org/10.3390/ijms20092080openalex-snapshot
Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage
inferred← citeshttps://doi.org/10.3390/ijms21072320openalex-snapshot
Using Phosphatidylinositol Phosphorylation as Markers for Hyperglycemic Related Breast Cancer
inferred← citeshttps://doi.org/10.3390/kinasesphosphatases4010005openalex-snapshot
Kinase Chemical Probes and Beyond
inferred← citeshttps://doi.org/10.3390/ph14090942openalex-snapshot
The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.3410/f.734825371.793574126openalex-snapshot
Faculty Opinions recommendation of Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids.
inferred← citeshttps://doi.org/10.6084/m9.figshare.13364550openalex-snapshot
Additional file 8 of Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function
inferred← citeshttps://doi.org/10.64898/2025.12.03.692006openalex-snapshot
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates sugar homeostasis in Drosophila
inferred← citeshttps://doi.org/10.70675/ff8ec5a0z1358z4abdzac6az4cc19fb4f41eopenalex-snapshot
Signalisation et implication des phosphoinositides dans la myopathie myotubulaire liée à l'X
inferred← citeshttps://doi.org/10.7150/jca.9794openalex-snapshot
Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer
inferred← citeshttps://doi.org/10.7150/thno.55856openalex-snapshot
Synthesis of RNA-based gene regulatory devices for redirecting cellular signaling events mediated by p53
inferred← citeshttps://doi.org/10.7150/thno.81847openalex-snapshot
Role of p53 in breast cancer progression: An insight into p53 targeted therapy
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.