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T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/0167-5699(89)90307-1openalex-snapshot
The thymus selects the useful, neglects the useless and destroys the harmful
inferredcites →https://doi.org/10.1016/j.cub.2004.08.017openalex-snapshot
Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates
inferredcites →https://doi.org/10.1016/j.immuni.2006.06.009openalex-snapshot
T Cells with Low Avidity for a Tissue-Restricted Antigen Routinely Evade Central and Peripheral Tolerance and Cause Autoimmunity
inferredcites →https://doi.org/10.1016/j.immuni.2007.07.010openalex-snapshot
Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor
inferredcites →https://doi.org/10.1016/j.immuni.2007.12.016openalex-snapshot
Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell Memory
inferredcites →https://doi.org/10.1016/j.immuni.2010.12.017openalex-snapshot
Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination
inferredcites →https://doi.org/10.1016/j.immuni.2011.03.017openalex-snapshot
Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division
inferredcites →https://doi.org/10.1016/s0092-8674(00)00120-3openalex-snapshot
Signaling Takes Shape in the Immune System
inferredcites →https://doi.org/10.1016/s1074-7613(00)80092-8openalex-snapshot
The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery
inferredcites →https://doi.org/10.1016/s1074-7613(00)80093-xopenalex-snapshot
Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts
inferredcites →https://doi.org/10.1016/s1074-7613(00)80461-6openalex-snapshot
The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells
inferredcites →https://doi.org/10.1038/35005508openalex-snapshot
Selecting and maintaining a diverse T-cell repertoire
inferredcites →https://doi.org/10.1038/356063a0openalex-snapshot
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
inferredcites →https://doi.org/10.1038/46218openalex-snapshot
Selecting and maintaining a diverse T-cell repertoire
inferredcites →https://doi.org/10.1038/nature05269openalex-snapshot
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
inferredcites →https://doi.org/10.1038/nature07657openalex-snapshot
Complete but curtailed T-cell response to very low-affinity antigen
inferredcites →https://doi.org/10.1038/nature08944openalex-snapshot
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
inferredcites →https://doi.org/10.1038/ni908openalex-snapshot
T cell fitness determined by signal strength
inferredcites →https://doi.org/10.1038/ni912openalex-snapshot
Dynamic programming of CD8+ T lymphocyte responses
inferredcites →https://doi.org/10.1038/nm1114openalex-snapshot
TCR affinity and negative regulation limit autoimmunity
inferredcites →https://doi.org/10.1038/nri1461openalex-snapshot
Immune responses to Listeria monocytogenes
inferredcites →https://doi.org/10.1073/pnas.0909945107openalex-snapshot
CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses
inferredcites →https://doi.org/10.1073/pnas.1011556107openalex-snapshot
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate
inferredcites →https://doi.org/10.1073/pnas.221458898openalex-snapshot
Formation of supramolecular activation clusters on fresh ex vivo CD8 + T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells
inferredcites →https://doi.org/10.1084/jem.150.6.1323openalex-snapshot
B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.
inferredcites →https://doi.org/10.1084/jem.186.12.2057openalex-snapshot
CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity
inferredcites →https://doi.org/10.1084/jem.20011612openalex-snapshot
Uncoupling of Proliferative Potential and Gain of Effector Function by CD8+ T Cells Responding to Self-Antigens
inferredcites →https://doi.org/10.1084/jem.20031873openalex-snapshot
T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes
inferredcites →https://doi.org/10.1084/jem.20051018openalex-snapshot
CD4 T cells integrate signals delivered during successive DC encounters in vivo
inferredcites →https://doi.org/10.1084/jem.20070254openalex-snapshot
A constant affinity threshold for T cell tolerance
inferredcites →https://doi.org/10.1084/jem.20070841openalex-snapshot
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells
inferredcites →https://doi.org/10.1084/jem.20111485openalex-snapshot
Self-reactive human CD4 T cell clones form unusual immunological synapses
inferredcites →https://doi.org/10.1126/science.1139393openalex-snapshot
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
inferredcites →https://doi.org/10.1126/science.274.5293.1707openalex-snapshot
Induction of Autoimmune Diabetes by Oral Administration of Autoantigen
inferredcites →https://doi.org/10.1182/blood-2010-06-292748openalex-snapshot
T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool
inferredcites →https://doi.org/10.1242/jcs.02898openalex-snapshot
The PAR-aPKC system: lessons in polarity
inferredcites →https://doi.org/10.2337/diab.43.4.529openalex-snapshot
Protection Against Adoptive Transfer of Autoimmune Diabetes Mediated Through Very Late Antigen-4 Integrin
inferredcites →https://doi.org/10.2353/ajpath.2007.060142openalex-snapshot
Islet β-Cell-Specific T Cells Can Use Different Homing Mechanisms to Infiltrate and Destroy Pancreatic Islets
inferredcites →https://doi.org/10.4049/jimmunol.0903627openalex-snapshot
Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms
inferredcites →https://doi.org/10.4049/jimmunol.172.9.5420openalex-snapshot
Helper Requirements for Generation of Effector CTL to Islet β Cell Antigens
inferredcites →https://doi.org/10.4049/jimmunol.173.4.2222openalex-snapshot
Cutting Edge: LFA-1 Integrin-Dependent T Cell Adhesion Is Regulated by Both Ag Specificity and Sensitivity
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4692176openalex-extracted
Targeted Localization of the Mother Centrosome in CD8 T Cells Undergoing Asymmetric Cell Division Promotes Memory Formation
inferred← citeshttps://doi.org/10.1002/bies.201600156openalex-snapshot
Aurora‐A shines on T cell activation through the regulation of Lck
inferred← citeshttps://doi.org/10.1002/bies.202000024openalex-snapshot
Why the Outcome of Anti‐Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers
inferred← citeshttps://doi.org/10.1002/cm.21434openalex-snapshot
New dimensions of asymmetric division in vertebrates
inferred← citeshttps://doi.org/10.1002/eji.201545909openalex-snapshot
Opposing effects of actin signaling and LFA‐1 on establishing the affinity threshold for inducing effector T‐cell responses in mice
inferred← citeshttps://doi.org/10.1002/eji.201646475openalex-snapshot
Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection
inferred← citeshttps://doi.org/10.1002/eji.202250009openalex-snapshot
Single‐cell fate mapping reveals widespread clonal ignorance of low‐affinity T cells exposed to systemic infection
inferred← citeshttps://doi.org/10.1002/eji.202250225openalex-snapshot
CD8 T‐cell diversification: Asymmetric cell division and its functional implications
inferred← citeshttps://doi.org/10.1002/eji.70085openalex-snapshot
Differential Regulation of TCR‐Induced ZFP36 and ZFP36L1 Expression by Cyclosporin A in CD8 + T Cells
inferred← citeshttps://doi.org/10.1002/wsbm.1475openalex-snapshot
Single‐cell analysis of CD8 T lymphocyte diversity during adaptive immunity
inferred← citeshttps://doi.org/10.1007/978-1-4939-3302-0_5openalex-snapshot
The Analysis of Cell Cycle, Proliferation, and Asymmetric Cell Division by Imaging Flow Cytometry
inferred← citeshttps://doi.org/10.1007/978-1-4939-6881-7_23openalex-snapshot
Imaging Asymmetric T Cell Division
inferred← citeshttps://doi.org/10.1007/978-3-030-57204-4_9openalex-snapshot
Inferring Differentiation Order in Adaptive Immune Responses from Population-Level Data
inferred← citeshttps://doi.org/10.1007/978-3-319-14463-4_11openalex-snapshot
Immunological Synapse Formation: Cell Polarity During T Cell–APC Interaction
inferred← citeshttps://doi.org/10.1007/978-3-319-14463-4_4openalex-snapshot
The Scribble–Dlg–Lgl Module in Cell Polarity Regulation
inferred← citeshttps://doi.org/10.1007/978-4-431-55381-6_3openalex-snapshot
Gangliosides and T-Cell Immunity
inferred← citeshttps://doi.org/10.1007/s00294-020-01074-yopenalex-snapshot
Asymmetric cell division and replicative aging: a new perspective from the spindle poles
inferred← citeshttps://doi.org/10.1007/s12307-013-0143-1openalex-snapshot
T Cell Avidity and Tumor Immunity: Problems and Solutions
inferred← citeshttps://doi.org/10.1016/b978-0-12-374279-7.14012-3openalex-snapshot
CD8 T Cell Memory to Pathogens
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00243-1openalex-snapshot
The Role of Asymmetric T Cell Fates in Controlling Memory Formation
inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00292-1openalex-snapshot
Memory T Cell Responses
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2016.06.004openalex-snapshot
Orchestrating Lymphocyte Polarity in Cognate Immune Cell–Cell Interactions
inferred← citeshttps://doi.org/10.1016/j.cell.2013.04.007openalex-snapshot
Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection
inferred← citeshttps://doi.org/10.1016/j.cell.2013.04.026openalex-snapshot
Dwelling on T Cell Fate Decisions
inferred← citeshttps://doi.org/10.1016/j.cell.2014.08.042openalex-snapshot
Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.02.010openalex-snapshot
Implications of non-canonical G-protein signaling for the immune system
inferred← citeshttps://doi.org/10.1016/j.celrep.2013.07.008openalex-snapshot
Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.08.056openalex-snapshot
Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.01.008openalex-snapshot
Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112468openalex-snapshot
Asymmetric cell division safeguards memory CD8 T cell development
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112548openalex-snapshot
Linking asymmetric cell division, CD8+ T cell fate, and signal strength
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.115127openalex-snapshot
Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117848openalex-snapshot
Calibration of CAR signaling promotes asymmetric cell division to direct CAR-T cell fate and antitumor potency
inferred← citeshttps://doi.org/10.1016/j.coi.2018.01.002openalex-snapshot
The regulation of lymphocyte activation and proliferation
inferred← citeshttps://doi.org/10.1016/j.ebiom.2025.106107openalex-snapshot
Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells
inferred← citeshttps://doi.org/10.1016/j.imlet.2019.03.009openalex-snapshot
Mechanisms of polarized cell-cell communication of T lymphocytes
inferred← citeshttps://doi.org/10.1016/j.immuni.2013.07.014openalex-snapshot
Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection
inferred← citeshttps://doi.org/10.1016/j.immuni.2013.08.008openalex-snapshot
Generating CD8 T Cell Heterogeneity: Attack of the Clones
inferred← citeshttps://doi.org/10.1016/j.immuni.2013.10.007openalex-snapshot
Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation
inferred← citeshttps://doi.org/10.1016/j.it.2014.02.006openalex-snapshot
Single cell behavior in T cell differentiation
inferred← citeshttps://doi.org/10.1016/j.it.2014.09.008openalex-snapshot
TCR signal quantity and quality in CD4+ T cell differentiation
inferred← citeshttps://doi.org/10.1016/j.it.2015.09.004openalex-snapshot
Asymmetric Cell Division in T Lymphocyte Fate Diversification
inferred← citeshttps://doi.org/10.1016/j.it.2016.06.005openalex-snapshot
What Scales the T Cell Response?
inferred← citeshttps://doi.org/10.1016/j.it.2021.09.004openalex-snapshot
Staggered starts in the race to T cell activation
inferred← citeshttps://doi.org/10.1016/j.jim.2014.07.012openalex-snapshot
Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3+ Treg cells
inferred← citeshttps://doi.org/10.1016/j.jtct.2025.12.988openalex-snapshot
Optimal Avidity of the Immune Synapse and Mitochondrial Repair Trigger Asymmetrical Cell Division and CAR T Cell Persistence – Review
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.04.016openalex-snapshot
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
inferred← citeshttps://doi.org/10.1016/j.molimm.2020.01.023openalex-snapshot
Non-coding RNAs in CD8 T cell biology
inferred← citeshttps://doi.org/10.1016/j.smim.2013.10.015openalex-snapshot
MicroRNAs in T helper cell differentiation and plasticity
inferred← citeshttps://doi.org/10.1016/j.tcb.2013.09.005openalex-snapshot
Immune synapse: conductor of orchestrated organelle movement
inferred← citeshttps://doi.org/10.1038/cr.2017.42openalex-snapshot
Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor
inferred← citeshttps://doi.org/10.1038/icb.2015.82openalex-snapshot
Lethal giant larvae‐1 deficiency enhances the CD8+ effector T‐cell response to antigen challenge in vivo
inferred← citeshttps://doi.org/10.1038/ncomms11389openalex-snapshot
Aurora A drives early signalling and vesicle dynamics during T-cell activation
inferred← citeshttps://doi.org/10.1038/ncomms13540openalex-snapshot
T-cell stimuli independently sum to regulate an inherited clonal division fate
inferred← citeshttps://doi.org/10.1038/ncomms2796openalex-snapshot
Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
inferred← citeshttps://doi.org/10.1038/ncomms7301openalex-snapshot
Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation
inferred← citeshttps://doi.org/10.1038/ni.2710openalex-snapshot
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
inferred← citeshttps://doi.org/10.1038/ni.3031openalex-snapshot
Molecular regulation of effector and memory T cell differentiation
inferred← citeshttps://doi.org/10.1038/ni.3386openalex-snapshot
Control of T cell antigen reactivity via programmed TCR downregulation
inferred← citeshttps://doi.org/10.1038/ni.3438openalex-snapshot
Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation
inferred← citeshttps://doi.org/10.1038/nri3734openalex-snapshot
Lymphocyte fate specification as a deterministic but highly plastic process
inferred← citeshttps://doi.org/10.1038/s41418-019-0410-xopenalex-snapshot
T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate
inferred← citeshttps://doi.org/10.1038/s41423-022-00879-wopenalex-snapshot
Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models
inferred← citeshttps://doi.org/10.1038/s41423-025-01299-2openalex-snapshot
CCR2+ monocytes promote memory CD8+ T-cell differentiation via membrane-bound TGF-β
inferred← citeshttps://doi.org/10.1038/s41467-023-42455-4openalex-snapshot
Interferon-γ couples CD8+ T cell avidity and differentiation during infection
inferred← citeshttps://doi.org/10.1038/s41467-025-61627-yopenalex-snapshot
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells
inferred← citeshttps://doi.org/10.1038/s41556-025-01835-2openalex-snapshot
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment
inferred← citeshttps://doi.org/10.1038/s41586-023-06218-xopenalex-snapshot
Origin and evolutionary malleability of T cell receptor α diversity
inferred← citeshttps://doi.org/10.1038/s41590-018-0160-9openalex-snapshot
T cell cytolytic capacity is independent of initial stimulation strength
inferred← citeshttps://doi.org/10.1038/s41590-023-01697-6openalex-snapshot
A type 1 immunity-restricted promoter of the IL−33 receptor gene directs antiviral T-cell responses
inferred← citeshttps://doi.org/10.1038/s44319-025-00536-zopenalex-snapshot
Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms
inferred← citeshttps://doi.org/10.1042/ebc20220247openalex-snapshot
T-cell response to checkpoint blockade immunotherapies: from fundamental mechanisms to treatment signatures
inferred← citeshttps://doi.org/10.1073/pnas.1213480110openalex-snapshot
ICAM-1–dependent tuning of memory CD8 T-cell responses following acute infection
inferred← citeshttps://doi.org/10.1073/pnas.1402724111openalex-snapshot
Optimal T-cell receptor affinity for inducing autoimmunity
inferred← citeshttps://doi.org/10.1073/pnas.1403271111openalex-snapshot
Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation
inferred← citeshttps://doi.org/10.1073/pnas.2318599121openalex-snapshot
How persistent infection overcomes peripheral tolerance mechanisms to cause T cell–mediated autoimmune disease
inferred← citeshttps://doi.org/10.1083/jcb.201502053openalex-snapshot
Asymmetric cell division during T cell development controls downstream fate
inferred← citeshttps://doi.org/10.1083/jcb.201609072openalex-snapshot
A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation
inferred← citeshttps://doi.org/10.1083/jcb.202104093openalex-snapshot
Signal strength controls the rate of polarization within CTLs during killing
inferred← citeshttps://doi.org/10.1084/jem.20150304openalex-snapshot
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance
inferred← citeshttps://doi.org/10.1084/jem.20151990openalex-snapshot
Recent thymic emigrants are tolerized in the absence of inflammation
inferred← citeshttps://doi.org/10.1084/jem.20160553openalex-snapshot
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation
inferred← citeshttps://doi.org/10.1084/jem.20201966openalex-snapshot
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion
inferred← citeshttps://doi.org/10.1084/jem.20220679openalex-snapshot
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection
inferred← citeshttps://doi.org/10.1093/protein/gzab034openalex-snapshot
Immortalization and functional screening of natively paired human T cell receptor repertoires
inferred← citeshttps://doi.org/10.1098/rsos.251979openalex-snapshot
A stochastic model of T cell expansion in micro-rod scaffolds and its continuum limit: importance of IL-2 loading and scaffold structure
inferred← citeshttps://doi.org/10.1101/2021.09.10.458880openalex-snapshot
Role of mitotic diffusion barriers in regulating the asymmetric division of activated CD8 T cells
inferred← citeshttps://doi.org/10.1101/2023.01.24.525203openalex-snapshot
Multimodal characterization of antigen-specific CD8 + T cells across SARS-CoV-2 vaccination and infection
inferred← citeshttps://doi.org/10.1101/2024.01.29.577412openalex-snapshot
Inheritance of old mitochondria controls early CD8 + T cell fate commitment and is regulated by autophagy
inferred← citeshttps://doi.org/10.1101/2024.11.26.625263openalex-snapshot
Identification of a Highly Functional Effector CD8 + T Cell Program after Transplantation in Mice and Humans
inferred← citeshttps://doi.org/10.1101/2025.08.28.672860openalex-snapshot
LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice
inferred← citeshttps://doi.org/10.1101/2025.09.24.678222openalex-snapshot
Differential regulation of TCR-induced ZFP36 and ZFP36L1 expression by cyclosporin A in CD8+ T cells
inferred← citeshttps://doi.org/10.1101/456392openalex-snapshot
Multifaceted influence of pre-mitotic cytotoxicity of primed CD8 T cells on immunity and infection
inferred← citeshttps://doi.org/10.1101/cshperspect.a041592openalex-snapshot
T Cell Differentiation in Autoimmune Type 1 Diabetes
inferred← citeshttps://doi.org/10.1111/cei.12570openalex-snapshot
T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells
inferred← citeshttps://doi.org/10.1111/imm.12420openalex-snapshot
Visualization of granzyme B‐expressing CD 8 T cells during primary and secondary immune responses to Listeria monocytogenes
inferred← citeshttps://doi.org/10.1111/imm.13537openalex-snapshot
Asymmetric T cell division of GAD65 specific naive T cells contribute to an early divergence in the differentiation fate into memory T cell subsets
inferred← citeshttps://doi.org/10.1111/imm.13804openalex-snapshot
T cell‐intrinsic PKD3 fine‐tunes differentiation into CD8 + central memory T cells and CD8 single positive thymocyte development
inferred← citeshttps://doi.org/10.1111/imr.12042openalex-snapshot
The role of mi RNA s in mast cells and other innate immune cells
inferred← citeshttps://doi.org/10.1111/imr.12107openalex-snapshot
The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse
inferred← citeshttps://doi.org/10.1111/imr.12130openalex-snapshot
Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation
inferred← citeshttps://doi.org/10.1111/imr.12131openalex-snapshot
Design and development of therapies using chimeric antigen receptor‐expressing T cells
inferred← citeshttps://doi.org/10.1111/imr.70168openalex-snapshot
Structural T‐Cell Receptor Analysis in the Age of Machine Learning
inferred← citeshttps://doi.org/10.1126/sciimmunol.aav1730openalex-snapshot
Modulation of asymmetric cell division as a mechanism to boost CD8 + T cell memory
inferred← citeshttps://doi.org/10.1126/sciimmunol.abj0789openalex-snapshot
Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling
inferred← citeshttps://doi.org/10.1126/scisignal.2005477openalex-snapshot
Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8 + T cells
inferred← citeshttps://doi.org/10.1126/scitranslmed.aaf1278openalex-snapshot
Direct measurement of T cell receptor affinity and sequence from naïve antiviral T cells
inferred← citeshttps://doi.org/10.1146/annurev-immunol-032414-112014openalex-snapshot
T Cell Fate at the Single-Cell Level
inferred← citeshttps://doi.org/10.1146/annurev-immunol-042617-053344openalex-snapshot
Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response
inferred← citeshttps://doi.org/10.1146/annurev-immunol-051116-052155openalex-snapshot
Immune Responses to Retroviruses
inferred← citeshttps://doi.org/10.1161/circresaha.114.301137openalex-snapshot
Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis
inferred← citeshttps://doi.org/10.1182/blood-2013-06-504100openalex-snapshot
Trick to treat: tricking the thymus to treat cancer
inferred← citeshttps://doi.org/10.1186/s12974-019-1684-0openalex-snapshot
MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries
inferred← citeshttps://doi.org/10.1189/jlb.1mr0216-074ropenalex-snapshot
Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs
inferred← citeshttps://doi.org/10.13028/m27883openalex-snapshot
Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation
inferred← citeshttps://doi.org/10.13028/mjvg-ne97openalex-snapshot
TCR Signal Strength Controls Dynamic NFAT Activation Threshold and Graded IRF4 Expression in CD8+ T Cells
inferred← citeshttps://doi.org/10.1371/journal.pbio.3001983openalex-snapshot
Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection
inferred← citeshttps://doi.org/10.1371/journal.pbio.3002465openalex-snapshot
Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity
inferred← citeshttps://doi.org/10.1371/journal.pone.0077537openalex-snapshot
The Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0091926openalex-snapshot
Geometrically Controlled Asymmetric Division of CD4+ T Cells Studied by Immunological Synapse Arrays
inferred← citeshttps://doi.org/10.1371/journal.pone.0099885openalex-snapshot
Normalized Polarization Ratios for the Analysis of Cell Polarity
inferred← citeshttps://doi.org/10.1371/journal.pone.0121710openalex-snapshot
Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition
inferred← citeshttps://doi.org/10.1371/journal.pone.0149582openalex-snapshot
Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses
inferred← citeshttps://doi.org/10.15252/embj.201798518openalex-snapshot
Strong homeostatic TCR signals induce formation of self‐tolerant virtual memory CD8 T cells
inferred← citeshttps://doi.org/10.15252/embr.202050785openalex-snapshot
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance
inferred← citeshttps://doi.org/10.15252/embr.202254969openalex-snapshot
Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response
inferred← citeshttps://doi.org/10.1615/critrevimmunol.2014010373openalex-snapshot
CD4 T-Cell Memory Generation and Maintenance
inferred← citeshttps://doi.org/10.2174/1573395509666131126231209openalex-snapshot
Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection
inferred← citeshttps://doi.org/10.26508/lsa.202201503openalex-snapshot
Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage
inferred← citeshttps://doi.org/10.3389/fcvm.2023.1205475openalex-snapshot
Hypertensive heart disease: risk factors, complications and mechanisms
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00031openalex-snapshot
The smallest unit: effector and memory CD8+ T cell differentiation on the single cell level
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00227openalex-snapshot
Antigen and Transforming Growth Factor Beta Receptors Contribute to Long Term Functional and Phenotypic Heterogeneity of Memory CD8 T Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00264openalex-snapshot
Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis
inferred← citeshttps://doi.org/10.3389/fimmu.2014.00026openalex-snapshot
Polarized Cells, Polarized Views: Asymmetric Cell Division in Hematopoietic Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2015.00468openalex-snapshot
Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response
inferred← citeshttps://doi.org/10.3389/fimmu.2016.00076openalex-snapshot
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2016.00421openalex-snapshot
Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination
inferred← citeshttps://doi.org/10.3389/fimmu.2018.00760openalex-snapshot
Cytomegalovirus-Specific CD8+ T-Cells With Different T-Cell Receptor Affinities Segregate T-Cell Phenotypes and Correlate With Chronic Graft-Versus-Host Disease in Patients Post-Hematopoietic Stem Cell Transplantation
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01290openalex-snapshot
T Cell Receptor–Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103+ Memory Status of CD8 T Cells in the Brain
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01274openalex-snapshot
CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01887openalex-snapshot
Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00624openalex-snapshot
Regulation of T Helper Cell Fate by TCR Signal Strength
inferred← citeshttps://doi.org/10.3389/fimmu.2020.615371openalex-snapshot
The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes
inferred← citeshttps://doi.org/10.3389/fimmu.2021.635862openalex-snapshot
Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1009198openalex-snapshot
Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections
inferred← citeshttps://doi.org/10.3389/fimmu.2022.949423openalex-snapshot
Divide and Conquer: Phenotypic and Temporal Heterogeneity Within CD8+ T Cell Responses
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1085895openalex-snapshot
Regulator of G-protein signaling 1 critically supports CD8+ TRM cell-mediated intestinal immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1301378openalex-snapshot
Asymmetric T-cell division: insights from cutting-edge experimental techniques and implications for immunotherapy
inferred← citeshttps://doi.org/10.3390/cells10081882openalex-snapshot
Tissue-Resident T Cells in Chronic Relapsing–Remitting Intestinal Disorders
inferred← citeshttps://doi.org/10.3390/ijms21217969openalex-snapshot
Relationship of 2D Affinity to T Cell Functional Outcomes
inferred← citeshttps://doi.org/10.3390/jdb3040129openalex-snapshot
Cell Fate Decision Making through Oriented Cell Division
inferred← citeshttps://doi.org/10.3390/vaccines12050483openalex-snapshot
Tuberculosis Vaccines and T Cell Immune Memory
inferred← citeshttps://doi.org/10.3410/f.733651067.793549172openalex-snapshot
Faculty Opinions recommendation of T cell cytolytic capacity is independent of initial stimulation strength.
inferred← citeshttps://doi.org/10.3934/molsci.2016.4.585openalex-snapshot
Role of actin cytoskeleton at multiple levels of T cell activation
inferred← citeshttps://doi.org/10.4049/jimmunol.1300424openalex-snapshot
Phenotypic CD8+ T Cell Diversification Occurs before, during, and after the First T Cell Division
inferred← citeshttps://doi.org/10.4049/jimmunol.1300905openalex-snapshot
Cutting Edge: The Signals for the Generation of T Cell Memory Are Qualitatively Different Depending on TCR Ligand Strength
inferred← citeshttps://doi.org/10.4049/jimmunol.1401652openalex-snapshot
Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by Protein Kinase Cζ and Protein Kinase Cλ/ι
inferred← citeshttps://doi.org/10.4049/jimmunol.1401870openalex-snapshot
Cutting Edge: CD8+ Recent Thymic Emigrants Exhibit Increased Responses to Low-Affinity Ligands and Improved Access to Peripheral Sites of Inflammation
inferred← citeshttps://doi.org/10.4049/jimmunol.1403145openalex-snapshot
Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence
inferred← citeshttps://doi.org/10.4049/jimmunol.1500639openalex-snapshot
Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity
inferred← citeshttps://doi.org/10.4049/jimmunol.1501053openalex-snapshot
A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology
inferred← citeshttps://doi.org/10.4161/21645515.2014.973314openalex-snapshot
To affinity and beyond: Harnessing the T Cell receptor for cancer immunotherapy
inferred← citeshttps://doi.org/10.64898/2026.06.24.734351openalex-snapshot
T cell receptor-ligand affinity quantitatively tunes transcriptome remodelling in vivo inversely regulating cell division and interferon response
inferred← citeshttps://doi.org/10.70675/12363b3fz08c5z4f59zbb0bz16e5b97d5a12openalex-snapshot
Rôle de la protéine Pleckstrin dans la génération de lymphocytes T CD8 mémoires et la mise en place d'une immunité tissulaire
inferred← citeshttps://doi.org/10.70675/9b9c23c9z39f9z40ccza4f0zc74757786c3dopenalex-snapshot
Étude de la répartition asymétrique des molécules lytiques et métaboliques dans la division des lymphocytes T CD8+ humains
inferred← citeshttps://doi.org/10.7554/elife.53948openalex-snapshot
Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling
inferred← citeshttps://doi.org/10.7554/elife.79342openalex-snapshot
Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2
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