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Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.cell.2010.02.024openalex-snapshot
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
inferredcites →https://doi.org/10.1016/j.cell.2012.07.032openalex-snapshot
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
inferredcites →https://doi.org/10.1016/j.cell.2013.05.016openalex-snapshot
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
inferredcites →https://doi.org/10.1016/j.celrep.2015.10.072openalex-snapshot
Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation
inferredcites →https://doi.org/10.1016/j.cub.2004.08.017openalex-snapshot
Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates
inferredcites →https://doi.org/10.1016/j.immuni.2009.04.014openalex-snapshot
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
inferredcites →https://doi.org/10.1016/j.immuni.2009.10.010openalex-snapshot
The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
inferredcites →https://doi.org/10.1016/j.immuni.2010.06.002openalex-snapshot
Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways
inferredcites →https://doi.org/10.1016/j.immuni.2011.03.017openalex-snapshot
Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division
inferredcites →https://doi.org/10.1016/j.immuni.2011.09.021openalex-snapshot
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
inferredcites →https://doi.org/10.1016/j.immuni.2011.12.007openalex-snapshot
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
inferredcites →https://doi.org/10.1016/j.immuni.2012.06.021openalex-snapshot
T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
inferredcites →https://doi.org/10.1016/j.immuni.2013.09.015openalex-snapshot
T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
inferredcites →https://doi.org/10.1016/j.it.2014.11.005openalex-snapshot
Regulation of T cells by mTOR: the known knowns and the known unknowns
inferredcites →https://doi.org/10.1038/nature08097openalex-snapshot
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
inferredcites →https://doi.org/10.1038/nature08155openalex-snapshot
mTOR regulates memory CD8 T-cell differentiation
inferredcites →https://doi.org/10.1038/ni.2005openalex-snapshot
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
inferredcites →https://doi.org/10.1038/ni.2556openalex-snapshot
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
inferredcites →https://doi.org/10.1038/ni.2842openalex-snapshot
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
inferredcites →https://doi.org/10.1038/ni.2867openalex-snapshot
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
inferredcites →https://doi.org/10.1038/ni1268openalex-snapshot
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
inferredcites →https://doi.org/10.1038/ni889openalex-snapshot
Lineage relationship and protective immunity of memory CD8 T cell subsets
inferredcites →https://doi.org/10.1038/nri3307openalex-snapshot
Transcriptional control of effector and memory CD8+ T cell differentiation
inferredcites →https://doi.org/10.1038/nri3701openalex-snapshot
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
inferredcites →https://doi.org/10.1038/sj.onc.1201990openalex-snapshot
Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway
inferredcites →https://doi.org/10.1038/srep19182openalex-snapshot
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8+ T Lymphocyte Fates
inferredcites →https://doi.org/10.1073/pnas.1221740110openalex-snapshot
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
inferredcites →https://doi.org/10.1074/jbc.273.49.32437openalex-snapshot
Identification and Characterization of a Membrane Protein (y+L Amino Acid Transporter-1) That Associates with 4F2hc to Encode the Amino Acid Transport Activity y+L
inferredcites →https://doi.org/10.1074/jbc.m302777200openalex-snapshot
CD98 and Intracellular Adhesion Molecule I Regulate the Activity of Amino Acid Transporter LAT-2 in Polarized Intestinal Epithelia
inferredcites →https://doi.org/10.1074/jbc.m309999200openalex-snapshot
AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression
inferredcites →https://doi.org/10.1084/jem.20112607openalex-snapshot
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
inferredcites →https://doi.org/10.1126/science.1139393openalex-snapshot
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
inferredcites →https://doi.org/10.1126/science.1166831openalex-snapshot
Secondary Replicative Function of CD8 + T Cells That Had Developed an Effector Phenotype
inferredcites →https://doi.org/10.1126/science.1207056openalex-snapshot
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase
inferredcites →https://doi.org/10.1146/annurev-immunol-032712-095956openalex-snapshot
Metabolic Regulation of T Lymphocytes
inferredcites →https://doi.org/10.1172/jci69589openalex-snapshot
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
inferredcites →https://doi.org/10.1172/jci77746openalex-snapshot
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
inferredcites →https://doi.org/10.1371/journal.pone.0121710openalex-snapshot
Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition
inferredcites →https://doi.org/10.4049/jimmunol.0903627openalex-snapshot
Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Targeted Localization of the Mother Centrosome in CD8 T Cells Undergoing Asymmetric Cell Division Promotes Memory Formation
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Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology
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CD8 T‐cell diversification: Asymmetric cell division and its functional implications
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MiR‐15a/16 deficiency enhances anti‐tumor immunity of glioma‐infiltrating CD8+ T cells through targeting mTOR
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Immunometabolism Governs T Cell Immunity
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Memory T Cell Responses
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The Fate Choice Between Effector and Memory T Cell Lineages: Asymmetry, Signal Integration, and Feedback to Create Bistability
inferred← citeshttps://doi.org/10.1016/bs.ai.2018.02.002openalex-snapshot
Chemokines: Critical Regulators of Memory T Cell Development, Maintenance, and Function
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Sexual dimorphism in immunometabolism and autoimmunity: Impact on personalized medicine
inferred← citeshttps://doi.org/10.1016/j.canlet.2017.08.033openalex-snapshot
Metabolic reprogramming and apoptosis sensitivity: Defining the contours of a T cell response
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A metabolic switch to memory CAR T cells: Implications for cancer treatment
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216267openalex-snapshot
Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancer
inferred← citeshttps://doi.org/10.1016/j.cell.2017.02.004openalex-snapshot
mTOR Signaling in Growth, Metabolism, and Disease
inferred← citeshttps://doi.org/10.1016/j.cell.2017.04.004openalex-snapshot
Metabolic Instruction of Immunity
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The PI3K Pathway in Human Disease
inferred← citeshttps://doi.org/10.1016/j.cell.2021.02.021openalex-snapshot
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
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Stem cell-like memory T cells: A perspective from the dark side
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.10.032openalex-snapshot
CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.12.087openalex-snapshot
Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.07.032openalex-snapshot
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112468openalex-snapshot
Asymmetric cell division safeguards memory CD8 T cell development
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.115127openalex-snapshot
Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117848openalex-snapshot
Calibration of CAR signaling promotes asymmetric cell division to direct CAR-T cell fate and antitumor potency
inferred← citeshttps://doi.org/10.1016/j.clim.2022.108987openalex-snapshot
SLC7A5 expression is up-regulated in peripheral blood T and B lymphocytes of systemic lupus erythematosus patients, associating with renal damage
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.06.004openalex-snapshot
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.06.016openalex-snapshot
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.01.008openalex-snapshot
mTOR Is Key to T Cell Transdifferentiation
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.06.010openalex-snapshot
Amino Assets: How Amino Acids Support Immunity
inferred← citeshttps://doi.org/10.1016/j.coi.2017.03.011openalex-snapshot
Metabolic reprograming of anti-tumor immunity
inferred← citeshttps://doi.org/10.1016/j.coi.2017.04.004openalex-snapshot
The role of AMPK in T cell metabolism and function
inferred← citeshttps://doi.org/10.1016/j.coi.2017.04.005openalex-snapshot
mTOR signaling in the differentiation and function of regulatory and effector T cells
inferred← citeshttps://doi.org/10.1016/j.coi.2017.06.002openalex-snapshot
Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate
inferred← citeshttps://doi.org/10.1016/j.coi.2018.01.002openalex-snapshot
The regulation of lymphocyte activation and proliferation
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2020.02.004openalex-snapshot
Plasticity in T-cell mitochondrial metabolism: A necessary peacekeeper during the troubled times of persistent HIV-1 infection
inferred← citeshttps://doi.org/10.1016/j.devcel.2018.01.017openalex-snapshot
The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis
inferred← citeshttps://doi.org/10.1016/j.immuni.2017.03.012openalex-snapshot
Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency
inferred← citeshttps://doi.org/10.1016/j.immuni.2017.04.009openalex-snapshot
Metabolic Regulation of the Immune Humoral Response
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MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells
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CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs
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Understanding Subset Diversity in T Cell Memory
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Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis
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The endogenous antigen-specific CD8+ T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments
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More TOR: The expanding role of mTOR in regulating immune responses
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Coupling and uncoupling cell cycle and metabolism in CD8+ T cells
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L-type amino acid transporter 1 as a target for inflammatory disease and cancer immunotherapy
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Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation
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Age-related diseases, therapies and gut microbiome: A new frontier for healthy aging
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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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Natural killer cell metabolism
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Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity
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The memory of the fatty acid system
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Nutrient sensing, signal transduction and immune responses
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Polarization and asymmetry in T cell metabolism
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Metabolic pathways in T cell activation and lineage differentiation
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Lymphocyte Fate and Metabolism: A Clonal Balancing Act
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An immunological panacea for cancer-related cachexia
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Amino acid metabolism-mediated immune cell fate and function in pigs
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Metabolic control of asyMYCtric division
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Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing
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Mitochondria are the powerhouses of immunity
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T memory stem cells in health and disease
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Epigenetic control of CD8+ T cell differentiation
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The fellowship of regulatory and tissue-resident memory cells
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B cell memory: from generation to reactivation: a multipronged defense wall against pathogens
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Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure
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Metabolic signaling in T cells
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DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8+ T cells
inferred← citeshttps://doi.org/10.1038/s41423-022-00879-wopenalex-snapshot
Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models
inferred← citeshttps://doi.org/10.1038/s41423-025-01299-2openalex-snapshot
CCR2+ monocytes promote memory CD8+ T-cell differentiation via membrane-bound TGF-β
inferred← citeshttps://doi.org/10.1038/s41467-017-00348-3openalex-snapshot
The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
inferred← citeshttps://doi.org/10.1038/s41467-020-15413-7openalex-snapshot
TNIK signaling imprints CD8+ T cell memory formation early after priming
inferred← citeshttps://doi.org/10.1038/s41467-021-22954-yopenalex-snapshot
Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
inferred← citeshttps://doi.org/10.1038/s41467-021-24619-2openalex-snapshot
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
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Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging
inferred← citeshttps://doi.org/10.1038/s41556-018-0217-xopenalex-snapshot
Metabolism as a guiding force for immunity
inferred← citeshttps://doi.org/10.1038/s41556-025-01835-2openalex-snapshot
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment
inferred← citeshttps://doi.org/10.1038/s41556-025-01841-4openalex-snapshot
Mitochondrial asymmetry shifts T cell fate
inferred← citeshttps://doi.org/10.1038/s41568-020-0273-yopenalex-snapshot
Metabolism of immune cells in cancer
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The quest to slow ageing through drug discovery
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Metabolic coordination of T cell quiescence and activation
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Redox regulation of immunometabolism
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CD8+ T cell metabolism in infection and cancer
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The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
inferred← citeshttps://doi.org/10.1038/s41586-024-07862-7openalex-snapshot
Fate induction in CD8 CAR T cells through asymmetric cell division
inferred← citeshttps://doi.org/10.1038/s41590-018-0045-yopenalex-snapshot
Metabolic exhaustion in infection, cancer and autoimmunity
inferred← citeshttps://doi.org/10.1038/s41590-026-02548-wopenalex-snapshot
Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor costimulatory domains
inferred← citeshttps://doi.org/10.1038/s41598-018-35463-8openalex-snapshot
Baculovirus as an efficient vector for gene delivery into mosquitoes
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Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection
inferred← citeshttps://doi.org/10.1038/s44318-026-00891-0openalex-snapshot
KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution
inferred← citeshttps://doi.org/10.1038/s44319-025-00536-zopenalex-snapshot
Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms
inferred← citeshttps://doi.org/10.1063/5.0166848openalex-snapshot
Mechanical forces amplify TCR mechanotransduction in T cell activation and function
inferred← citeshttps://doi.org/10.1073/pnas.1808320115openalex-snapshot
Lack of Sprouty 1 and 2 enhances survival of effector CD8 + T cells and yields more protective memory cells
inferred← citeshttps://doi.org/10.1073/pnas.2317658121openalex-snapshot
Sustained AhR activity programs memory fate of early effector CD8 + T cells
inferred← citeshttps://doi.org/10.1084/jem.20161046openalex-snapshot
CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions
inferred← citeshttps://doi.org/10.1084/jem.20170697openalex-snapshot
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells
inferred← citeshttps://doi.org/10.1084/jem.20180397openalex-snapshot
Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome
inferred← citeshttps://doi.org/10.1084/jem.20221839openalex-snapshot
Nutrients: Signal 4 in T cell immunity
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Fatty acid metabolism in T-cell function and differentiation
inferred← citeshttps://doi.org/10.1093/jimmun/vkag206openalex-snapshot
Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion
inferred← citeshttps://doi.org/10.1093/jleuko/qiag106openalex-snapshot
The pentose phosphate pathway in immunotherapy
inferred← citeshttps://doi.org/10.1093/lifemeta/loac038openalex-snapshot
Lipid metabolism in tumor-infiltrating T cells: mechanisms and applications
inferred← citeshttps://doi.org/10.1097/cm9.0000000000002989openalex-snapshot
Metabolic plasticity of T cell fate decision
inferred← citeshttps://doi.org/10.1097/tp.0000000000001951openalex-snapshot
Navigating T-Cell Immunometabolism in Transplantation
inferred← citeshttps://doi.org/10.1101/2021.09.10.458880openalex-snapshot
Role of mitotic diffusion barriers in regulating the asymmetric division of activated CD8 T cells
inferred← citeshttps://doi.org/10.1101/2022.11.30.518569openalex-snapshot
Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy
inferred← citeshttps://doi.org/10.1101/2024.01.29.577412openalex-snapshot
Inheritance of old mitochondria controls early CD8 + T cell fate commitment and is regulated by autophagy
inferred← citeshttps://doi.org/10.1101/2024.03.21.586160openalex-snapshot
Hierarchal Single-Cell Lineage Tracing Reveals Differential Fate Commitment of Cd8 T-Cell Clones in Response to Acute Infection
inferred← citeshttps://doi.org/10.1101/2025.04.10.648158openalex-snapshot
Enhance Memory CD8 + T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness
inferred← citeshttps://doi.org/10.1101/2025.11.14.688504openalex-snapshot
CD4⁺ T cells confer transplantable rejuvenation via Rivers of telomeres
inferred← citeshttps://doi.org/10.1101/cshperspect.a037044openalex-snapshot
Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages
inferred← citeshttps://doi.org/10.1101/cshperspect.a037770openalex-snapshot
Metabolic Control of Memory T-Cell Generation and Stemness
inferred← citeshttps://doi.org/10.1101/cshperspect.a037796openalex-snapshot
Area under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets
inferred← citeshttps://doi.org/10.1101/cshperspect.a037937openalex-snapshot
A Regenerative Perspective on Successful and Failed T-Cell Immunity
inferred← citeshttps://doi.org/10.1111/cas.15719openalex-snapshot
Lenvatinib enhances antitumor immunity by promoting the infiltration of TCF1 + CD8 + T cells in HCC via blocking VEGFR2
inferred← citeshttps://doi.org/10.1111/cei.13308openalex-snapshot
T cell metabolism in chronic viral infection
inferred← citeshttps://doi.org/10.1111/febs.14125openalex-snapshot
Metabolic rewiring in mutant Kras lung cancer
inferred← citeshttps://doi.org/10.1111/febs.14454openalex-snapshot
Understanding lymphocyte metabolism for use in cancer immunotherapy
inferred← citeshttps://doi.org/10.1111/imcb.12274openalex-snapshot
The metabolic spectrum of memory T cells
inferred← citeshttps://doi.org/10.1111/imm.12655openalex-snapshot
T‐cell metabolism governing activation, proliferation and differentiation; a modular view
inferred← citeshttps://doi.org/10.1111/imr.12640openalex-snapshot
Generation of memory B cells and their reactivation
inferred← citeshttps://doi.org/10.1111/imr.12655openalex-snapshot
Fatty acid metabolism in CD 8 + T cell memory: Challenging current concepts
inferred← citeshttps://doi.org/10.1111/imr.12796openalex-snapshot
mTOR and other effector kinase signals that impact T cell function and activity
inferred← citeshttps://doi.org/10.1111/imr.12845openalex-snapshot
mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions
inferred← citeshttps://doi.org/10.1111/imr.12851openalex-snapshot
Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism
inferred← citeshttps://doi.org/10.1111/sji.70067openalex-snapshot
Beyond Energy Fuel: Ketone Bodies as Multifaceted Modulators of T Cell and Anti‐Tumour Immunity
inferred← citeshttps://doi.org/10.1126/sciadv.ade0718openalex-snapshot
Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8 + T cell cytotoxicity and proliferation
inferred← citeshttps://doi.org/10.1126/science.aar3932openalex-snapshot
An evolutionary perspective on immunometabolism
inferred← citeshttps://doi.org/10.1126/sciimmunol.aav1730openalex-snapshot
Modulation of asymmetric cell division as a mechanism to boost CD8 + T cell memory
inferred← citeshttps://doi.org/10.1126/sciimmunol.abh4271openalex-snapshot
Persistent CAD activity in memory CD8 + T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
inferred← citeshttps://doi.org/10.1126/sciimmunol.adj7238openalex-snapshot
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics
inferred← citeshttps://doi.org/10.1126/sciimmunol.adn4958openalex-snapshot
A metabolic pacer ensures smooth running of the lymphocyte activation race
inferred← citeshttps://doi.org/10.1146/annurev-immunol-042617-053019openalex-snapshot
Unraveling the Complex Interplay Between T Cell Metabolism and Function
inferred← citeshttps://doi.org/10.1152/ajpregu.00209.2018openalex-snapshot
Bridging angiogenesis and immune evasion in the hypoxic tumor microenvironment
inferred← citeshttps://doi.org/10.1152/physrev.00018.2019openalex-snapshot
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-20-1540openalex-snapshot
Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-21-0459openalex-snapshot
Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited
inferred← citeshttps://doi.org/10.1159/000542578openalex-snapshot
Immunometabolic Targets in CD8+ T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1172/jci.insight.167829openalex-snapshot
TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy
inferred← citeshttps://doi.org/10.1172/jci.insight.93814openalex-snapshot
High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells
inferred← citeshttps://doi.org/10.1172/jci128075openalex-snapshot
Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells
inferred← citeshttps://doi.org/10.1172/jci148546openalex-snapshot
Targeting memory T cell metabolism to improve immunity
inferred← citeshttps://doi.org/10.1172/jci192731openalex-snapshot
Immune regeneration: implications for cancer immunotherapy and beyond
inferred← citeshttps://doi.org/10.1172/jci90895openalex-snapshot
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification
inferred← citeshttps://doi.org/10.1182/blood.2019003257openalex-snapshot
Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes
inferred← citeshttps://doi.org/10.1182/bloodadvances.2024014822openalex-snapshot
Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model
inferred← citeshttps://doi.org/10.1186/s12943-021-01486-5openalex-snapshot
Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
inferred← citeshttps://doi.org/10.1186/s40364-026-00903-5openalex-snapshot
Semaphorins: from CD8⁺ T cells to cancer immunotherapy
inferred← citeshttps://doi.org/10.1189/jlb.1mr0216-074ropenalex-snapshot
Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs
inferred← citeshttps://doi.org/10.1360/n972016-00797openalex-snapshot
Progress on whether generation and maintenance of memory T cells require chronic exposure to antigens
inferred← citeshttps://doi.org/10.1371/journal.pbio.3001983openalex-snapshot
Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection
inferred← citeshttps://doi.org/10.1371/journal.pone.0175549openalex-snapshot
Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation
inferred← citeshttps://doi.org/10.1371/journal.pone.0237646openalex-snapshot
Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor
inferred← citeshttps://doi.org/10.15212/hod-2022-0009openalex-snapshot
T-cell engineering strategies for tumors with low antigen density, and T-cell survival in the immunosuppressive tumor microenvironment of relapsed/refractory diffuse large B-cell lymphoma
inferred← citeshttps://doi.org/10.1523/jneurosci.3619-17.2018openalex-snapshot
mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation
inferred← citeshttps://doi.org/10.1615/critrevimmunol.2016017164openalex-snapshot
Metabolic Factors that Contribute to Lupus Pathogenesis
inferred← citeshttps://doi.org/10.1681/asn.0000000716openalex-snapshot
Mechanistic Target of Rapamycin Inhibitors and Vaccine Response in Kidney Transplant Recipients
inferred← citeshttps://doi.org/10.17650/2313-805x-2017-4-3-21-26openalex-snapshot
Metabolic aspects of adoptive immunotherapy of tumors
inferred← citeshttps://doi.org/10.20900/immunometab20210007openalex-snapshot
Diverse Roles of Akt in T cells
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9268813/v1openalex-snapshot
The MLL1–MENIN complex preserves CD8 T cell memory through a TOX–BTLA-TCF1 axis
inferred← citeshttps://doi.org/10.2174/1568009618666181015150138openalex-snapshot
Targeting Strategies for Glucose Metabolic Pathways and T Cells in Colorectal Cancer
inferred← citeshttps://doi.org/10.31274/etd-20210609-3openalex-snapshot
Modulation of adaptive immunity through acute exercise, metabolism-targeting pharmacological agents, and chronic exercise training
inferred← citeshttps://doi.org/10.3389/fcell.2018.00122openalex-snapshot
mTOR Regulation of Glycolytic Metabolism in T Cells
inferred← citeshttps://doi.org/10.3389/fcell.2023.1191774openalex-snapshot
Modulation of T cell function and survival by the tumor microenvironment
inferred← citeshttps://doi.org/10.3389/fendo.2023.1216193openalex-snapshot
Low glucose availability potentiates the effects of metformin on model T cell activation and exhaustion markers in vitro
inferred← citeshttps://doi.org/10.3389/fimmu.2017.00270openalex-snapshot
Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01311openalex-snapshot
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections
inferred← citeshttps://doi.org/10.3389/fimmu.2018.00053openalex-snapshot
Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses
inferred← citeshttps://doi.org/10.3389/fimmu.2018.00339openalex-snapshot
Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01381openalex-snapshot
CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01740openalex-snapshot
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02181openalex-snapshot
Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02826openalex-snapshot
Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01400openalex-snapshot
Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00812openalex-snapshot
Deciphering Natural Killer Cell Homeostasis
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01517openalex-snapshot
Metabolic Pathways in Alloreactive T Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2021.635862openalex-snapshot
Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens
inferred← citeshttps://doi.org/10.3389/fimmu.2021.677036openalex-snapshot
How Does B Cell Antigen Presentation Affect Memory CD4 T Cell Differentiation and Longevity?
inferred← citeshttps://doi.org/10.3389/fimmu.2021.684197openalex-snapshot
Mesenchymal Stem Cell Protects Injured Renal Tubular Epithelial Cells by Regulating mTOR-Mediated Th17/Treg Axis
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1090429openalex-snapshot
Manipulating T-cell metabolism to enhance immunotherapy in solid tumor
inferred← citeshttps://doi.org/10.3389/fimmu.2022.827461openalex-snapshot
mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2022.886822openalex-snapshot
Immunometabolism – The Role of Branched-Chain Amino Acids
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1104771openalex-snapshot
T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1301378openalex-snapshot
Asymmetric T-cell division: insights from cutting-edge experimental techniques and implications for immunotherapy
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1548234openalex-snapshot
Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1688995openalex-snapshot
Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy
inferred← citeshttps://doi.org/10.3389/fonc.2018.00315openalex-snapshot
Immuno-Oncology: Emerging Targets and Combination Therapies
inferred← citeshttps://doi.org/10.3389/fphys.2018.00879openalex-snapshot
Simulation of Stimulation: Cytokine Dosage and Cell Cycle Crosstalk Driving Timing-Dependent T Cell Differentiation
inferred← citeshttps://doi.org/10.3390/cells11223554openalex-snapshot
Advances in T Cells Based on Inflammation in Metabolic Diseases
inferred← citeshttps://doi.org/10.3390/diseases9030057openalex-snapshot
Synthetic mRNAs; Their Analogue Caps and Contribution to Disease
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