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Modulation of asymmetric cell division as a mechanism to boost CD8 + T cell memory

https://doi.org/10.1126/sciimmunol.aav1730
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/eji.1830200227openalex-snapshot
T cell receptor (TcR) β chain transgenic mice: Studies on allelic exclusion and on the TcR+ γ/δ population
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Exploring Functional In Vivo Consequences of the Selective Genetic Ablation of mTOR Signaling in T Helper Lymphocytes
inferredcites →https://doi.org/10.1016/0092-8674(94)90140-6openalex-snapshot
A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
inferredcites →https://doi.org/10.1016/0166-0934(91)90018-uopenalex-snapshot
Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates
inferredcites →https://doi.org/10.1016/j.cell.2016.05.035openalex-snapshot
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
inferredcites →https://doi.org/10.1016/j.cell.2017.04.004openalex-snapshot
Metabolic Instruction of Immunity
inferredcites →https://doi.org/10.1016/j.celrep.2015.12.095openalex-snapshot
Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner
inferredcites →https://doi.org/10.1016/j.cmet.2008.10.002openalex-snapshot
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
inferredcites →https://doi.org/10.1016/j.immuni.2007.08.007openalex-snapshot
Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection
inferredcites →https://doi.org/10.1016/j.immuni.2007.10.012openalex-snapshot
A Single Naive CD8+ T Cell Precursor Can Develop into Diverse Effector and Memory Subsets
inferredcites →https://doi.org/10.1016/j.immuni.2007.12.016openalex-snapshot
Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell Memory
inferredcites →https://doi.org/10.1016/j.immuni.2011.03.017openalex-snapshot
Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division
inferredcites →https://doi.org/10.1016/j.immuni.2012.06.021openalex-snapshot
T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
inferredcites →https://doi.org/10.1016/j.immuni.2016.07.021openalex-snapshot
T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections
inferredcites →https://doi.org/10.1016/j.immuni.2016.11.009openalex-snapshot
CD8 + T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections
inferredcites →https://doi.org/10.1016/j.it.2014.11.005openalex-snapshot
Regulation of T cells by mTOR: the known knowns and the known unknowns
inferredcites →https://doi.org/10.1016/j.it.2015.09.004openalex-snapshot
Asymmetric Cell Division in T Lymphocyte Fate Diversification
inferredcites →https://doi.org/10.1016/j.smim.2016.10.002openalex-snapshot
Polarization and asymmetry in T cell metabolism
inferredcites →https://doi.org/10.1016/s1074-7613(04)00106-2openalex-snapshot
Activation-Induced Polarized Recycling Targets T Cell Antigen Receptors to the Immunological Synapse
inferredcites →https://doi.org/10.1038/nature02284openalex-snapshot
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
inferredcites →https://doi.org/10.1038/nature08097openalex-snapshot
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
inferredcites →https://doi.org/10.1038/nature08155openalex-snapshot
mTOR regulates memory CD8 T-cell differentiation
inferredcites →https://doi.org/10.1038/nature17442openalex-snapshot
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
inferredcites →https://doi.org/10.1038/nature25144openalex-snapshot
Effector CD8 T cells dedifferentiate into long-lived memory cells
inferredcites →https://doi.org/10.1038/ni.2556openalex-snapshot
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
inferredcites →https://doi.org/10.1038/ni.2842openalex-snapshot
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
inferredcites →https://doi.org/10.1038/ni.3438openalex-snapshot
Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation
inferredcites →https://doi.org/10.1038/ni.3688openalex-snapshot
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing
inferredcites →https://doi.org/10.1038/nri2888openalex-snapshot
Metabolism, migration and memory in cytotoxic T cells
inferredcites →https://doi.org/10.1038/nri3307openalex-snapshot
Transcriptional control of effector and memory CD8+ T cell differentiation
inferredcites →https://doi.org/10.1038/nri3734openalex-snapshot
Lymphocyte fate specification as a deterministic but highly plastic process
inferredcites →https://doi.org/10.1038/nrm3025openalex-snapshot
mTOR: from growth signal integration to cancer, diabetes and ageing
inferredcites →https://doi.org/10.1073/pnas.0801497105openalex-snapshot
Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade
inferredcites →https://doi.org/10.1073/pnas.1213480110openalex-snapshot
ICAM-1–dependent tuning of memory CD8 T-cell responses following acute infection
inferredcites →https://doi.org/10.1073/pnas.94.8.3909openalex-snapshot
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes
inferredcites →https://doi.org/10.1074/jbc.m805186200openalex-snapshot
FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells
inferredcites →https://doi.org/10.1084/jem.160.2.521openalex-snapshot
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.
inferredcites →https://doi.org/10.1084/jem.20091175openalex-snapshot
One naive T cell, multiple fates in CD8+ T cell differentiation
inferredcites →https://doi.org/10.1084/jem.20112607openalex-snapshot
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
inferredcites →https://doi.org/10.1093/bioinformatics/btp616openalex-snapshot
edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
inferredcites →https://doi.org/10.1093/bioinformatics/btt656openalex-snapshot
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
inferredcites →https://doi.org/10.1093/nar/gkt214openalex-snapshot
The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
inferredcites →https://doi.org/10.1111/j.1432-2277.2011.01384.xopenalex-snapshot
T-lymphocyte homeostasis and function in infant baboons: implications for transplantation
inferredcites →https://doi.org/10.1126/science.1070238openalex-snapshot
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
inferredcites →https://doi.org/10.1126/science.1139393openalex-snapshot
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
inferredcites →https://doi.org/10.1126/science.aah6499openalex-snapshot
The epigenetic control of stemness in CD8 + T cell fate commitment
inferredcites →https://doi.org/10.1146/annurev-immunol-020711-075024openalex-snapshot
Regulation of Immune Responses by mTOR
inferredcites →https://doi.org/10.1158/0008-5472.can-05-3405openalex-snapshot
A Novel Small-Molecule Inhibitor of Protein Kinase Cι Blocks Transformed Growth of Non–Small-Cell Lung Cancer Cells
inferredcites →https://doi.org/10.1182/blood-2007-06-097576openalex-snapshot
In vivo transformation of mouse conventional CD8α+ dendritic cells leads to progressive multisystem histiocytosis
inferredcites →https://doi.org/10.18632/oncotarget.3812openalex-snapshot
A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion
inferredcites →https://doi.org/10.4049/jimmunol.0903627openalex-snapshot
Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms
inferredcites →https://doi.org/10.4049/jimmunol.1200176openalex-snapshot
Cutting Edge: Asymmetric Memory T Cell Division in Response to Rechallenge
inferredcites →https://doi.org/10.4049/jimmunol.1401652openalex-snapshot
Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by Protein Kinase Cζ and Protein Kinase Cλ/ι
inferredcites →https://doi.org/10.7554/elife.28329openalex-snapshot
Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4692176openalex-extracted
Targeted Localization of the Mother Centrosome in CD8 T Cells Undergoing Asymmetric Cell Division Promotes Memory Formation
inferred← citeshttps://doi.org/10.1002/eji.202250225openalex-snapshot
CD8 T‐cell diversification: Asymmetric cell division and its functional implications
inferred← citeshttps://doi.org/10.1007/978-3-031-06566-8_9openalex-snapshot
PI3K Isoforms in CD8+ T Cell Development and Function
inferred← citeshttps://doi.org/10.1007/s00294-020-01074-yopenalex-snapshot
Asymmetric cell division and replicative aging: a new perspective from the spindle poles
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2023.02.011openalex-snapshot
Polarity in immune cells
inferred← citeshttps://doi.org/10.1016/j.apsb.2023.02.017openalex-snapshot
Berberine improves central memory formation of CD8+ T cells: Implications for design of natural product-based vaccines
inferred← citeshttps://doi.org/10.1016/j.cellimm.2020.104273openalex-snapshot
Stem cell-like memory T cells: A perspective from the dark side
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108078openalex-snapshot
Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112468openalex-snapshot
Asymmetric cell division safeguards memory CD8 T cell development
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112548openalex-snapshot
Linking asymmetric cell division, CD8+ T cell fate, and signal strength
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113155openalex-snapshot
Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.115127openalex-snapshot
Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117848openalex-snapshot
Calibration of CAR signaling promotes asymmetric cell division to direct CAR-T cell fate and antitumor potency
inferred← citeshttps://doi.org/10.1016/j.immuni.2023.01.029openalex-snapshot
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection
inferred← citeshttps://doi.org/10.1016/j.immuni.2025.06.010openalex-snapshot
More TOR: The expanding role of mTOR in regulating immune responses
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108666openalex-snapshot
IL-15 boosts activated HBV core-specific CD8+ progenitor cells via metabolic rebalancing in persistent HBV infection
inferred← citeshttps://doi.org/10.1016/j.it.2023.05.004openalex-snapshot
Quantitating CD8+ T cell memory development
inferred← citeshttps://doi.org/10.1016/j.jtct.2025.12.988openalex-snapshot
Optimal Avidity of the Immune Synapse and Mitochondrial Repair Trigger Asymmetrical Cell Division and CAR T Cell Persistence – Review
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.04.016openalex-snapshot
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
inferred← citeshttps://doi.org/10.1016/j.plantsci.2025.112433openalex-snapshot
Root-derived small peptides: Key regulators of plant development, stress resilience, and nutrient acquisition
inferred← citeshttps://doi.org/10.1016/j.xcrm.2026.102990openalex-snapshot
CD8+ stem cell-like memory T cells: Unveiling the potential for next-generation vaccination strategies
inferred← citeshttps://doi.org/10.1038/s41375-025-02601-xopenalex-snapshot
Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport
inferred← citeshttps://doi.org/10.1038/s41467-021-22954-yopenalex-snapshot
Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
inferred← citeshttps://doi.org/10.1038/s41556-025-01835-2openalex-snapshot
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment
inferred← citeshttps://doi.org/10.1038/s41577-019-0223-7openalex-snapshot
Precursor exhausted T cells: key to successful immunotherapy?
inferred← citeshttps://doi.org/10.1038/s41577-020-0307-4openalex-snapshot
Clonal expansion of innate and adaptive lymphocytes
inferred← citeshttps://doi.org/10.1038/s41577-020-0381-7openalex-snapshot
Immunometabolism and HIV-1 pathogenesis: food for thought
inferred← citeshttps://doi.org/10.1038/s41577-021-00574-3openalex-snapshot
CD8+ T cell differentiation and dysfunction in cancer
inferred← citeshttps://doi.org/10.1038/s41586-024-07862-7openalex-snapshot
Fate induction in CD8 CAR T cells through asymmetric cell division
inferred← citeshttps://doi.org/10.1038/s41590-026-02559-7openalex-snapshot
Costimulation drives CAR-T cell division fate
inferred← citeshttps://doi.org/10.1038/s41596-019-0249-0openalex-snapshot
Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds
inferred← citeshttps://doi.org/10.1038/s44319-025-00536-zopenalex-snapshot
Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms
inferred← citeshttps://doi.org/10.1098/rsif.2022.0629openalex-snapshot
Why are cell populations maintained via multiple compartments?
inferred← citeshttps://doi.org/10.1098/rsos.251979openalex-snapshot
A stochastic model of T cell expansion in micro-rod scaffolds and its continuum limit: importance of IL-2 loading and scaffold structure
inferred← citeshttps://doi.org/10.1101/2020.11.01.364224openalex-snapshot
CD4+ T cell subsets present stable relationships in their T cell receptor repertoires
inferred← citeshttps://doi.org/10.1101/2021.09.10.458880openalex-snapshot
Role of mitotic diffusion barriers in regulating the asymmetric division of activated CD8 T cells
inferred← citeshttps://doi.org/10.1101/2023.10.04.560863openalex-snapshot
Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer
inferred← citeshttps://doi.org/10.1101/2024.01.29.577412openalex-snapshot
Inheritance of old mitochondria controls early CD8 + T cell fate commitment and is regulated by autophagy
inferred← citeshttps://doi.org/10.1111/imcb.12274openalex-snapshot
The metabolic spectrum of memory T cells
inferred← citeshttps://doi.org/10.1111/imm.13537openalex-snapshot
Asymmetric T cell division of GAD65 specific naive T cells contribute to an early divergence in the differentiation fate into memory T cell subsets
inferred← citeshttps://doi.org/10.1111/imr.12796openalex-snapshot
mTOR and other effector kinase signals that impact T cell function and activity
inferred← citeshttps://doi.org/10.1111/imr.13203openalex-snapshot
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections
inferred← citeshttps://doi.org/10.1111/sji.12983openalex-snapshot
T cell fate mapping and lineage tracing technologies probing clonal aspects underlying the generation of CD8 T cell subsets
inferred← citeshttps://doi.org/10.1126/sciadv.aba5130openalex-snapshot
Mapping bilayer thickness in the ER membrane
inferred← citeshttps://doi.org/10.1126/sciadv.abo5871openalex-snapshot
The evolving role of tissue-resident memory T cells in infections and cancer
inferred← citeshttps://doi.org/10.1126/science.abq0225openalex-snapshot
Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning
inferred← citeshttps://doi.org/10.1126/scisignal.adi8753openalex-snapshot
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells
inferred← citeshttps://doi.org/10.1172/jci148546openalex-snapshot
Targeting memory T cell metabolism to improve immunity
inferred← citeshttps://doi.org/10.1172/jci192731openalex-snapshot
Immune regeneration: implications for cancer immunotherapy and beyond
inferred← citeshttps://doi.org/10.1371/journal.pbio.3001983openalex-snapshot
Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection
inferred← citeshttps://doi.org/10.33540/1850openalex-snapshot
Ink Trails
inferred← citeshttps://doi.org/10.3389/fcimb.2021.676183openalex-snapshot
Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1301378openalex-snapshot
Asymmetric T-cell division: insights from cutting-edge experimental techniques and implications for immunotherapy
inferred← citeshttps://doi.org/10.3390/bioengineering12080830openalex-snapshot
Regulation of Tetraspanin CD63 in Chronic Myeloid Leukemia (CML): Single-Cell Analysis of Asymmetric Hematopoietic Stem Cell Division Genes
inferred← citeshttps://doi.org/10.3390/cancers13081922openalex-snapshot
Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.4049/jimmunol.2100633openalex-snapshot
An Updated Model for the Epigenetic Regulation of Effector and Memory CD8+ T Cell Differentiation
inferred← citeshttps://doi.org/10.70322/immune.2025.10005openalex-snapshot
Metabolic Regulation of T Cell Exhaustion
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