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Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

https://doi.org/10.1101/2023.02.14.528574

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A Physiological Perspective on the Use of Imaging to Assess the In Vivo Delivery of Therapeutics

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A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Transthyretin Amyloidosis

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Identification of tissue sites for increased albumin degradation in sarcoma-bearing mice

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Elevated uptake of low density lipoproteins by human lung cancer tissue in vivo

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Design of compounds having enhanced tumour uptake, using serum albumin as a carrier—part II. In vivo studies

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Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

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Harnessing albumin as a carrier for cancer therapies

inferredcites →https://doi.org/10.1016/j.biomaterials.2010.05.027openalex-snapshot

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

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Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes

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Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers

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Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA

inferredcites →https://doi.org/10.1016/j.jconrel.2008.05.010openalex-snapshot

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

inferredcites →https://doi.org/10.1016/j.jconrel.2014.03.057openalex-snapshot

EPR: Evidence and fallacy

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To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

inferredcites →https://doi.org/10.1016/j.jconrel.2019.03.028openalex-snapshot

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

inferredcites →https://doi.org/10.1016/j.jsb.2006.08.015openalex-snapshot

Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin

inferredcites →https://doi.org/10.1016/j.omtn.2016.12.011openalex-snapshot

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

inferredcites →https://doi.org/10.1016/j.omtn.2018.09.002openalex-snapshot

An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo

inferredcites →https://doi.org/10.1016/j.semcancer.2003.09.015openalex-snapshot

Oncogenic Ras and its role in tumor cell invasion and metastasis

inferredcites →https://doi.org/10.1016/j.stemcr.2018.01.005openalex-snapshot

A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells

inferredcites →https://doi.org/10.1016/j.ymthe.2017.05.009openalex-snapshot

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

inferredcites →https://doi.org/10.1016/j.ymthe.2021.02.015openalex-snapshot

Centyrin ligands for extrahepatic delivery of siRNA

inferredcites →https://doi.org/10.1016/s0021-9258(17)37571-3openalex-snapshot

Albondin-mediated capillary permeability to albumin. Differential role of receptors in endothelial transcytosis and endocytosis of native and modified albumins.

inferredcites →https://doi.org/10.1016/s0021-9258(18)35799-5openalex-snapshot

Preferential interaction of albumin-binding proteins, gp30 and gp18, with conformationally modified albumins. Presence in many cells and tissues with a possible role in catabolism.

inferredcites →https://doi.org/10.1016/s0021-9258(18)53212-9openalex-snapshot

High affinity binding, endocytosis, and degradation of conformationally modified albumins. Potential role of gp30 and gp18 as novel scavenger receptors.

inferredcites →https://doi.org/10.1016/s0021-9258(19)41721-3openalex-snapshot

Long chain fatty acid binding to human plasma albumin.

inferredcites →https://doi.org/10.1016/s0026-895x(25)12512-1openalex-snapshot

Effects of Fatty Acids on Two Specific Drug Binding Sites on Human Serum Albumin

inferredcites →https://doi.org/10.1016/s1040-8428(97)00015-2openalex-snapshot

Plasma protein (albumin) catabolism by the tumor itself—implications for tumor metabolism and the genesis of cachexia

inferredcites →https://doi.org/10.1021/acs.accounts.9b00228openalex-snapshot

Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures

inferredcites →https://doi.org/10.1021/acs.bioconjchem.6b00437openalex-snapshot

Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?

inferredcites →https://doi.org/10.1021/acs.biomac.5b00550openalex-snapshot

Cholesterol Modified Self-Assemblies and Their Application to Nanomedicine

inferredcites →https://doi.org/10.1021/acs.jmedchem.5b00726openalex-snapshot

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

inferredcites →https://doi.org/10.1021/bc800278eopenalex-snapshot

siRNA Conjugate Delivery Systems

inferredcites →https://doi.org/10.1021/jacs.7b02917openalex-snapshot

Development of DNA Nanostructures for High-Affinity Binding to Human Serum Albumin

inferredcites →https://doi.org/10.1021/jacs.9b13524openalex-snapshot

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

inferredcites →https://doi.org/10.1021/jm049167jopenalex-snapshot

Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

inferredcites →https://doi.org/10.1021/jm070861jopenalex-snapshot

Structure−Activity and Protraction Relationship of Long-Acting Glucagon-like Peptide-1 Derivatives: Importance of Fatty Acid Length, Polarity, and Bulkiness

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Nile Red and DCM Fluorescence Anisotropy Studies in C12E7/DPPC Mixed Systems

inferredcites →https://doi.org/10.1021/jp0704822openalex-snapshot

Effect of Unsaturation in Fatty Acids on the Main Characteristics of Langmuir Monolayers

inferredcites →https://doi.org/10.1038/cddis.2014.561openalex-snapshot

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

inferredcites →https://doi.org/10.1038/nature12138openalex-snapshot

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

inferredcites →https://doi.org/10.1038/nature12978openalex-snapshot

Structure-based programming of lymph-node targeting in molecular vaccines

inferredcites →https://doi.org/10.1038/nature19830openalex-snapshot

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

inferredcites →https://doi.org/10.1038/nbt.1560openalex-snapshot

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

inferredcites →https://doi.org/10.1038/nbt1339openalex-snapshot

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

inferredcites →https://doi.org/10.1038/ncb2488openalex-snapshot

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

inferredcites →https://doi.org/10.1038/s42003-021-02564-6openalex-snapshot

The multiple mechanisms of MCL1 in the regulation of cell fate

inferredcites →https://doi.org/10.1039/c1cs15038copenalex-snapshot

Hybrid lipid oligonucleotide conjugates: synthesis, self-assemblies and biomedical applications

inferredcites →https://doi.org/10.1073/pnas.1621240114openalex-snapshot

Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

inferredcites →https://doi.org/10.1080/10717544.2016.1267821openalex-snapshot

A tumor-targeting cRGD-EGFR siRNA conjugate and its anti-tumor effect on glioblastoma in vitro and in vivo

inferredcites →https://doi.org/10.1089/nat.2018.0725openalex-snapshot

Improving siRNA Delivery In Vivo Through Lipid Conjugation

inferredcites →https://doi.org/10.1091/mbc.e15-01-0028openalex-snapshot

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

inferredcites →https://doi.org/10.1093/nar/gkaa595openalex-snapshot

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

inferredcites →https://doi.org/10.1093/nar/gkx818openalex-snapshot

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

inferredcites →https://doi.org/10.1093/nar/gky1232openalex-snapshot

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

inferredcites →https://doi.org/10.1093/nar/gky745openalex-snapshot

Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs

inferredcites →https://doi.org/10.1093/nar/gkz354openalex-snapshot

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

inferredcites →https://doi.org/10.1158/0008-5472.can-14-2211openalex-snapshot

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

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Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer

inferredcites →https://doi.org/10.1158/1535-7163.mct-14-0928openalex-snapshot

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor

inferredcites →https://doi.org/10.1182/blood-2018-06-859405openalex-snapshot

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

inferredcites →https://doi.org/10.1186/s13045-020-01007-9openalex-snapshot

MCL-1 inhibitors, fast-lane development of a new class of anti-cancer agents

inferredcites →https://doi.org/10.1186/s13045-021-01079-1openalex-snapshot

Targeting MCL-1 in cancer: current status and perspectives

inferredcites →https://doi.org/10.18632/aging.204207openalex-snapshot

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells

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Receptor mediated uptake of paclitaxel from a synthetic high density lipoprotein nanocarrier

inferredcites →https://doi.org/10.3892/ijo.11.3.497openalex-snapshot

Enhanced albumin uptake by rat tumors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Engineering approaches for RNA-based and cell-based osteoarthritis therapies

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Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

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