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The role of co-crystals in pharmaceutical design

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Polymorphism
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The Importance of Solvates
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Concepts and Nomenclature in Chemical Crystallography
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Principles and Applications of Thermal Analysis
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Polymorphism in the Pharmaceutical Industry
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Supramolecular Synthons in Crystal Engineering—A New Organic Synthesis
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Structure Calculation of an Elastic Hydrogel from Sonication of Rigid Small Molecule Components
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A Red Zwitterionic Co-Crystal of Acetaminophen and 2,4-Pyridinedicarboxylic Acid
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Polymorphie und Thermische Analyse pharmazeutischer Wirkstoffe
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On the polymorphism of pharmaceuticals and other molecular crystals. I
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On the polymorphism of pharmaceuticals and other molecular crystals. II
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�ber die Verwendung von Perjodat zur ma�analytischen Bestimmung von Ketosen (Monosacchariden)
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Use of a Glutaric Acid Cocrystal to Improve Oral Bioavailability of a Low Solubility API
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Cocrystal Formation during Cogrinding and Storage is Mediated by Amorphous Phase
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The role of cocrystals in pharmaceutical science
inferredcites →https://doi.org/10.1016/j.ejps.2009.05.010openalex-snapshot
Formation of indomethacin–saccharin cocrystals using supercritical fluid technology
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Computational prediction of salt and cocrystal structures—Does a proton position matter?
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Synthesis of co-crystals of meloxicam with carboxylic acids by grinding
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Cyclodextrins and their uses: a review
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Diversity in Single- and Multiple-Component Crystals. The Search for and Prevalence of Polymorphs and Cocrystals
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Cocrystal Systems of Pharmaceutical Interest: 2010
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Polymorphs, Salts, and Cocrystals: What’s in a Name?
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Applying Hot-Stage Microscopy to Co-Crystal Screening: A Study of Nicotinamide with Seven Active Pharmaceutical Ingredients
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Recent Advances in Understanding the Mechanism of Cocrystal Formation via Grinding
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Designing Co-Crystals of Pharmaceutically Relevant Compounds That Crystallize with Z′ > 1
inferredcites →https://doi.org/10.1021/cg801039jopenalex-snapshot
Solubility Advantage of Pharmaceutical Cocrystals
inferredcites →https://doi.org/10.1021/cg900873topenalex-snapshot
A Survey of Cocrystals Reported Prior to 2000
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Hydrogen bond directed cocrystallization and molecular recognition properties of acyclic imides
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Hydrogen bond-directed cocrystallization and molecular recognition properties of diarylureas
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Physics and Chemistry of the Organic Solid State.
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Crystal Engineering Approach To Forming Cocrystals of Amine Hydrochlorides with Organic Acids. Molecular Complexes of Fluoxetine Hydrochloride with Benzoic, Succinic, and Fumaric Acids
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Using Cocrystals To Systematically Modulate Aqueous Solubility and Melting Behavior of an Anticancer Drug
inferredcites →https://doi.org/10.1021/mp060126oopenalex-snapshot
Cocrystal or Salt: Does It Really Matter?
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The Salt−Cocrystal Continuum: The Influence of Crystal Structure on Ionization State
inferredcites →https://doi.org/10.1021/mp070001zopenalex-snapshot
An Overview of Pharmaceutical Cocrystals as Intellectual Property
inferredcites →https://doi.org/10.1021/mp070012sopenalex-snapshot
Hierarchy of Supramolecular Synthons: Persistent Hydroxyl···Pyridine Hydrogen Bonds in Cocrystals That Contain a Cyano Acceptor
inferredcites →https://doi.org/10.1023/a:1016241927429openalex-snapshot
Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations
inferredcites →https://doi.org/10.1023/a:1025622809025openalex-snapshot
Inclusion of the Antidepressant Paroxetine in β-cyclodextrin
inferredcites →https://doi.org/10.1038/nature10125openalex-snapshot
Modular and predictable assembly of porous organic molecular crystals
inferredcites →https://doi.org/10.1038/nature11395openalex-snapshot
Room-temperature ferroelectricity in supramolecular networks of charge-transfer complexes
inferredcites →https://doi.org/10.1038/nbt722openalex-snapshot
Hybrid insulin cocrystals for controlled release delivery
inferredcites →https://doi.org/10.1039/9781849733502openalex-snapshot
Pharmaceutical Salts and Co-crystals
inferredcites →https://doi.org/10.1039/a604311jopenalex-snapshot
A novel class of phenol–pyridine co-crystals for second harmonic generation
inferredcites →https://doi.org/10.1039/b207369mopenalex-snapshot
Mechanochemistry and co-crystal formation: effect of solvent on reaction kineticsElectronic supplementary information (ESI) available for PXRD profiles showing the grinding results for CTA + Bipy with and without solvent as well as CTA + 2fPh with different solvents. See…
inferredcites →https://doi.org/10.1039/b207493aopenalex-snapshot
Unexpected solid–solid reaction upon preparation of KBr pellets and its exploitation in supramolecular cation complexation
inferredcites →https://doi.org/10.1039/b315687gopenalex-snapshot
Crystal and co-crystal: a second opinion
inferredcites →https://doi.org/10.1039/b402150aopenalex-snapshot
Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?
inferredcites →https://doi.org/10.1039/b504487aopenalex-snapshot
Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug
inferredcites →https://doi.org/10.1039/b505883jopenalex-snapshot
Building co-crystals with molecular sense and supramolecular sensibility
inferredcites →https://doi.org/10.1039/b516057jopenalex-snapshot
NMR studies of organic polymorphs & solvates
inferredcites →https://doi.org/10.1039/b803866jopenalex-snapshot
Current directions in co-crystal growth
inferredcites →https://doi.org/10.1039/b815174aopenalex-snapshot
The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome
inferredcites →https://doi.org/10.1039/c0cc02701dopenalex-snapshot
From unexpected reactions to a new family of ionic co-crystals: the case of barbituric acid with alkali bromides and caesium iodide
inferredcites →https://doi.org/10.1039/c0ce00052copenalex-snapshot
Mapping out the synthetic landscape for re-crystallization, co-crystallization and salt formation
inferredcites →https://doi.org/10.1039/c1cc10762copenalex-snapshot
Which, if any, hydrates will crystallise? Predicting hydrate formation of two dihydroxybenzoic acids
inferredcites →https://doi.org/10.1039/c1cs15171aopenalex-snapshot
Mechanochemistry: opportunities for new and cleaner synthesis
inferredcites →https://doi.org/10.1039/c2ce06659aopenalex-snapshot
Supramolecular constructs and thermodynamic stability of four polymorphs and a co-crystal of pentobarbital (nembutal)
inferredcites →https://doi.org/10.1039/c2nj40093fopenalex-snapshot
How good are the crystallisation methods for co-crystals? A comparative study of piroxicam
inferredcites →https://doi.org/10.1080/713738904openalex-snapshot
Recent Advances in the Opportunities for Solving Molecular Crystal Structures Directly from Powder Diffraction Data
inferredcites →https://doi.org/10.1081/e-esmcopenalex-snapshot
Encyclopedia of Supramolecular Chemistry
inferredcites →https://doi.org/10.1093/acprof:oso/9780199236565.001.0001openalex-snapshot
Polymorphism in Molecular Crystals
inferredcites →https://doi.org/10.1107/s0108768100001452openalex-snapshot
2′,3′-Didehydro-3′-deoxythymidine N-methyl-2-pyrrolidone solvate (D4T·NMPO)
inferredcites →https://doi.org/10.1107/s0108768193009504openalex-snapshot
Structures of two binary n-alkane solid solutions
inferredcites →https://doi.org/10.1107/s0108768197008446openalex-snapshot
Crystal Engineering: Strategies and Architectures
inferredcites →https://doi.org/10.1107/s1600536807045680openalex-snapshot
Ornidazole hemihydrate
inferredcites →https://doi.org/10.1515/zpch-1941-18820openalex-snapshot
Thermische Analyse im heizbaren Mikroskop
inferredcites →https://doi.org/10.1557/mrs2006.206openalex-snapshot
Pharmaceutical Cocrystals: An Emerging Approach to Physical Property Enhancement
inferredcites →https://doi.org/10.3390/w2030333openalex-snapshot
X-ray and Neutron Diffraction in the Study of Organic Crystalline Hydrates

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Opportunities and Challenges in Applying Solid‐State NMR Spectroscopy in Organic Mechanochemistry
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Disappearing Polymorphs Revisited
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Phenanthrene Purification: Comparison of Zone Melting and Co‐Crystallization
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Molecular Basis for the Mechanical Response of Sulfa Drug Crystals
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Cocrystals “Divorce and Marriage”: When a Binary System Meets an Active Multifunctional Synthon in a Ball Mill
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Mechanochemical Transformations of Pharmaceutical Cocrystals: Polymorphs and Coformer Exchange
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Interplay of Halogen and Hydrogen Bonding through Co–Crystallization in Pharmacologically Active Dihydropyrimidines: Insights from Crystal Structure and Energy Framework
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Scalability of Pharmaceutical Co‐Crystal Formation by Mechanochemistry in Batch
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Changes in the proportions of an active pharmaceutical through cocrystals
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Unsymmetrical Bipyrrole‐Derived β‐Tetraalkylporphycenes and C–H···Br–C Interaction Induced 2D Arrays of the 2:1 Supramolecular Sandwich Complex of Their cis‐/trans‐Dibromo Isomers
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The Future of Structural Chemistry Nucleates in the Present
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Computational predictions of cocrystal formation: A benchmark study of 28 assemblies comparing five methods from high‐throughput to advanced models
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An Investigation of Indomethacin–Nicotinamide Cocrystal Formation Induced by Thermal Stress in the Solid or Liquid State
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Cocrystalline Solids of Telaprevir with Enhanced Oral Absorption
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Understanding the Formation of Novel Hydrated Gallic Acid-Creatinine Molecular Salt: Crystal Structure, Hirshfeld Surface and DFT Studies
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The Effects of Humidity on Spontaneous Cocrystallization: A Survey of Diacid Cocrystals with Caffeine, Theophylline, and Nicotinamide
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Crystal and Molecular Structures of Three Co-crystals from 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione and Carboxylic Acids
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Transferability of cocrystallization propensities between aromatic and heteroaromatic amides
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Simultaneous screening and detection of pharmaceutical co-crystals by the one-step DSC–FTIR microspectroscopic technique
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Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method
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Cocrystal solubility product analysis – Dual concentration-pH mass action model not dependent on explicit solubility equations
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Recent Developments in the Crystallization Process: Toward the Pharmaceutical Industry
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Measurement and correlation for the solubilities of cinnarizine, pentoxifylline, and piracetam in supercritical carbon dioxide
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Continuous, one-step synthesis of pharmaceutical cocrystals via hot melt extrusion from neat to matrix-assisted processing – State of the art
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Multicomponent ionic crystals of diltiazem with dicarboxylic acids toward understanding the structural aspects driving the drug-release
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Combined anti-solvent and cooling method of manufacturing indomethacin–saccharin (IMC–SAC) co-crystal powders
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Thermodynamic analysis and molecular simulation of solid–liquid phase equilibrium of isoprenaline hydrochloride in eleven pure solvents at saturation
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Solubility determination, Hansen solubility parameter, molecular simulation and thermodynamic properties of 2-anilino-6-(dibutylamino)-3-methylfluoran in four binary solvent mixtures from 283.15 K to 323.15 K
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Dual-drug co-crystal synthesis for synergistic in vitro effect of three key first-line antiretroviral drugs
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Gas anti-solvent processing of a new sulfamethoxazole−l-malic acid cocrystal
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Solid-state NMR studies of theophylline co-crystals with dicarboxylic acids
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The protonation transformation between the mycophenolic acid-2,4,6-triaminopyrimidine hydrated salt and cocrystal: A Thermodynamic Perspective
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Crystal myth
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Solid-state loading of organic molecular materials within mesoporous silica matrix: Application to ibuprofen
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dl-isoprenaline hydrochloride solubility in four binary solvents at saturation: Thermodynamic analysis, Hansen solubility parameters and molecular simulation
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Studies on the synthesis, structural characterization, Hirshfeld analysis and stability of apovincamine (API) and its co-crystal (terephthalic acid: Apovincamine=1:2)
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Novel Isoniazid cocrystals with aromatic carboxylic acids: Crystal engineering, spectroscopy and thermochemical investigations
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Structural insights into salts and a salt polymorph of nitrogen containing small organic molecules
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A preformulation co-crystal screening case study: Polymorphic co-crystals of an imidazopyridazine antimalarial drug lead with the coformer succinic acid
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Structural elucidation, theoretical insights and thermal properties of three novel multicomponent molecular forms of gallic acid with hydroxypyridines
inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.128587openalex-snapshot
Study on the self-assembly behaviors based on aromatic carboxylic acids and dibenzo-diaza-crown ether salts
inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.129388openalex-snapshot
Isoniazid-Gentisic acid cocrystallization: Solubility, Stability, Dissolution rate, Antioxidant and Flowability Properties Studies
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.132340openalex-snapshot
Synthesis and structural characterization of two novel olanzapine cocrystals with decreased or enhanced dissolution rate
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.133256openalex-snapshot
Noncovalent-bonded 2D-3D supramolecular adducts from 6-methylpyridine-3-carboxamide and carboxylic acids
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.136942openalex-snapshot
Molecular structures of eight hydrogen bond-mediated minoxidil adducts from different aryl acids
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.137386openalex-snapshot
Solid state synthesis of zwitterionic cocrystal 5-fluorouracil L-phenylalanine explicated via structural, spectroscopy, quantum chemicals, Hirshfeld and docking analysis
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.140328openalex-snapshot
Regulating the physical and chemical properties of gefitinib and its positional isomer through salt formation
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.143028openalex-snapshot
Structural elucidation of unforeseen salt hydrate of gliclazide for enhanced solubility and dissolution rate
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.143071openalex-snapshot
Pyrimethamine as a building block for 8 multicomponent crystals: Preparation, spectral, structural diversity, synthons investigation
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.145400openalex-snapshot
Structural and computational insights into ternary cocrystals of succinimide with 3-nitrophthalic acid and urea
inferred← citeshttps://doi.org/10.1016/j.pcrysgrow.2016.07.001openalex-snapshot
Spring and parachute: How cocrystals enhance solubility
inferred← citeshttps://doi.org/10.1016/j.poly.2022.115848openalex-snapshot
Structural elucidation and cytotoxicity profile of neocuproine-Cu(II) and Cu(I)-based chemotherapeutic agents: Effect of picric acid-derived cocrystals
inferred← citeshttps://doi.org/10.1016/j.proche.2014.10.079openalex-snapshot
Pharmaceutical Cocrystals
inferred← citeshttps://doi.org/10.1016/j.ssnmr.2014.11.002openalex-snapshot
NMR crystallography of ezetimibe co-crystals
inferred← citeshttps://doi.org/10.1016/j.tifs.2021.01.035openalex-snapshot
Cocrystallization: A tool to modulate physicochemical and biological properties of food-relevant polyphenols
inferred← citeshttps://doi.org/10.1016/j.tips.2018.10.006openalex-snapshot
Pharmaceutical Cocrystal Drug Products: An Outlook on Product Development
inferred← citeshttps://doi.org/10.1016/j.xphs.2016.08.029openalex-snapshot
The Crystal Structure and Behavior of Fenamic Acid-Acridine Complex Under High Pressure
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.02.014openalex-snapshot
Improved Stability of Tuberculosis Drug Fixed-Dose Combination Using Isoniazid-Caffeic Acid and Vanillic Acid Cocrystal
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.03.014openalex-snapshot
Polymorphs of Curcumin and Its Cocrystals With Cinnamic Acid
inferred← citeshttps://doi.org/10.1016/j.xphs.2020.03.017openalex-snapshot
Polymorphs of DP-VPA Solid Solutions and Their Physicochemical Properties
inferred← citeshttps://doi.org/10.1016/j.xphs.2021.08.009openalex-snapshot
Zaltoprofen/4,4′-Bipyridine: A Case Study to Demonstrate the Potential of Differential Scanning Calorimetry (DSC) in the Pharmaceutical Field
inferred← citeshttps://doi.org/10.1016/j.xphs.2022.08.031openalex-snapshot
Mechanistic Study on Transformation of Coamorphous Baicalein-Nicotinamide to Its Cocrystal Form
inferred← citeshttps://doi.org/10.1017/9781139026949.002openalex-snapshot
Crystals and Crystal Growth
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b01112openalex-snapshot
Triboluminescence from Pharmaceutical Formulations
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c00149openalex-snapshot
Discovery of New Proxyphylline-Based Chiral Cocrystals: Solid State Landscape and Dehydration Mechanism
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c00266openalex-snapshot
Enhanced Aqueous Solubility of the Solid Forms of a BCS Class-II Anti-Tuberculosis Drug, Prothionamide
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c00490openalex-snapshot
Cocrystal Polymorphs and Solvates of the Anti-Trypanosoma cruzi Drug Benznidazole with Improved Dissolution Performance
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c00900openalex-snapshot
Natural Antimicrobials Meet a Synthetic Antibiotic: Carvacrol/Thymol and Ciprofloxacin Cocrystals as a Promising Solid-State Route to Activity Enhancement
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c01153openalex-snapshot
Temozolomide–Hesperetin Drug–Drug Cocrystal with Optimized Performance in Stability, Dissolution, and Tabletability
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c01427openalex-snapshot
Advanced Methodologies for Pharmaceutical Salt Synthesis
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c00216openalex-snapshot
Solvent Effect on the Preparation of Ionic Cocrystals of dl -Amino Acids with Lithium Chloride: Conglomerate versus Racemate Formation
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c00643openalex-snapshot
Self-Assemblies of Solvates, Ionic Cocrystals, and a Salt Based on 4-{[(4-Nitrophenyl)carbamoyl]amino}-N-(pyrimidin-2-yl)benzene-1-sulfonamide: Study in the Solid and Solution States
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c00768openalex-snapshot
Analysis of Weak Interactions in Crystals of Fenamic Acids–Ethacridine Complexes
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c01408openalex-snapshot
A Review on Co-crystals of Herbal Bioactives for Solubility Enhancement: Preparation Methods and Characterization Techniques
inferred← citeshttps://doi.org/10.1021/acs.cgd.1c01435openalex-snapshot
Inhibition of the Antibiotic Activity of Cephalosporines by Co-Crystallization with Thymol
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c00262openalex-snapshot
On the Mechanism of Cocrystal Mechanochemical Reaction via Low Melting Eutectic: A Time-Resolved In Situ Monitoring Investigation
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c00639openalex-snapshot
Preference of High-Nitrogen-Content Compounds to Form Hydrates and the Tandem Contacts of Azide Groups
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c00896openalex-snapshot
Directional Self-Assembly of Ofloxacin and Syringic Acid: The First Salt Cocrystal of Ofloxacin with Phenolic Acid Displays Superior In Vitro/Vivo Biopharmaceutical Property and Enhanced Antibacterial Activity
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c00904openalex-snapshot
Multivariate Analysis of a Highly Effective Drug Combination Tablet Containing the Antiepileptic Drug Gabapentin to Enhance Pharmaceutical Properties with a Multicomponent Crystal Strategy
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c00996openalex-snapshot
Isomeric Coformer Responsive Conformational Adjustment to Recuperate Stability, Solubility, and In Vitro Permeation Behavior of Drug Molecular Salts
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c01142openalex-snapshot
Crystallographic and Computational Analysis of the Solid-Form Landscape of Three Structurally Related Imidazolidine-2,4-dione Active Pharmaceutical Ingredients: Nitrofurantoin, Furazidin, and Dantrolene
inferred← citeshttps://doi.org/10.1021/acs.cgd.2c01256openalex-snapshot
Syntheses, Structures, and Magnetic Properties of Novel [3×1 + 2×1] Pentanuclear Zinc(II)-Lanthanide(III) Cocrystal Complexes: Slow Magnetic Relaxation Behavior of the Dy(III) Analogue
inferred← citeshttps://doi.org/10.1021/acs.cgd.3c00042openalex-snapshot
Conjugation of a Silver-Based Coordination Polymer with Curcumin: A New Case of an Inorganic Polymeric Co-crystal
inferred← citeshttps://doi.org/10.1021/acs.cgd.3c00615openalex-snapshot
Exploring the Co-Crystallization Landscape of One-Dimensional Coordination Polymers Using a Molecular Electrostatic Potential-Driven Approach
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b00700openalex-snapshot
In Situ Monitoring of Antisolvent Cocrystallization by Combining Near-Infrared and Raman Spectroscopies
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b00840openalex-snapshot
Supramolecular Gel Control of Cisplatin Crystallization: Identification of a New Solvate Form Using a Cisplatin-Mimetic Gelator
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b01320openalex-snapshot
New Multicomponent Sulfadimethoxine Crystal Forms: Sulfonamides as Participants in Supramolecular Interactions
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b01619openalex-snapshot
Crystal Engineering of Pharmaceutical Co-crystals: “NMR Crystallography” of Niclosamide Co-crystals
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00245openalex-snapshot
Enhancing the Oral Bioavailability of an Antiviral Drug Acyclovir by Crystal Engineering of Novel Pharmaceutical Cocrystals
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00555openalex-snapshot
Special Issue: Multi-Component Pharmaceutical Solids
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00704openalex-snapshot
Deciphering the Structural Dynamics and Attributes of Cocrystals Engineered from 2-Amino, 5-Nitrobenzoic Acid with Neutral Coformers: A Synergistic Experimental and Computational Exploration
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00735openalex-snapshot
Piracetam and Oxiracetam Afford Molecular, Cocrystalline, and Ionic Cocrystalline Solid Solutions
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00755openalex-snapshot
Cocrystal Engineering-Based Strategies for Enhancing the Permeability of Poorly Permeable APIs
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c01287openalex-snapshot
Unraveling the Impact of Fluorine Positioning in Crystal Packing: Halogen-Bonded Cocrystals of 4-Styrylpyridines with Pentafluoroiodobenzene
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00010openalex-snapshot
Drug Molecule Diflunisal Forms Crystalline Inclusion Complexes with Multiple Types of Linear Polymers
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00032openalex-snapshot
Chloral Hydrate Polymorphs and Cocrystal Revisited: Solving Two Pharmaceutical Cold Cases
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00200openalex-snapshot
Solvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00321openalex-snapshot
Heterometallic Copper(II)–Tin(II/IV) Salts, Cocrystals, and Salt Cocrystals: Selectivity and Structural Diversity Depending on Ligand Substitution and the Metal Oxidation State
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00491openalex-snapshot
Caffeine Co-Crystal Mechanics Evaluated with a Combined Structural and Spectroscopic Approach
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00544openalex-snapshot
Expanding the Pyridine–Formic Acid Cocrystal Landscape under Extreme Conditions
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00552openalex-snapshot
Improving the Membrane Permeability of 5-Fluorouracil via Cocrystallization
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01164openalex-snapshot
Catalytic Effect of Solvent Vapors on the Spontaneous Formation of Caffeine–Malonic Acid Cocrystal
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01399openalex-snapshot
Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01426openalex-snapshot
Ionic Cocrystals of Racemic and Enantiopure Histidine: An Intriguing Case of Homochiral Preference
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01578openalex-snapshot
Dissolution Behavior of the Crystalline Inclusion Complex Formed by the Drug Diflunisal and Poly(ε-caprolactone)
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01669openalex-snapshot
Are Oxygen and Sulfur Atoms Structurally Equivalent in Organic Crystals?
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00322openalex-snapshot
Epalrestat–Cytosine Cocrystal and Salt Structures: Attempt To Control E,Z → Z,Z Isomerization
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00606openalex-snapshot
Molecular Salts of the Antidepressant Venlafaxine: An Effective Route to Solubility Properties Modifications
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00684openalex-snapshot
Stable Cocrystals and Salts of the Antineoplastic Drug Apatinib with Improved Solubility in Aqueous Solution
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00933openalex-snapshot
Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b01049openalex-snapshot
Investigation into the Structures and Properties of Multicomponent Crystals Formed from a Series of 7-Chloroquinolines and Aromatic Acids
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b01298openalex-snapshot
Cocrystals, Salts, and Supramolecular Gels of Nonsteroidal Anti-Inflammatory Drug Niflumic Acid
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00145openalex-snapshot
Colossal Positive and Negative Axial Thermal Expansion Induced by Scissor-like Motion of a Two-Dimensional Hydrogen Bonded Network in an Organic Salt
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00931openalex-snapshot
Engineering a Remedy to Improve Phase Stability of Famotidine under Physiological pH Environments
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b01195openalex-snapshot
Novel Pharmaceutical Cocrystals and Salts of Bumetanide
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b01253openalex-snapshot
Calorimetric Determination of Cocrystal Thermodynamic Stability: Sulfamethazine–Salicylic Acid Case Study
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b01310openalex-snapshot
5-Fluorouracil Cocrystals with Lipophilic Hydroxy-2-Naphthoic Acids: Crystal Structures, Theoretical Computations, and Permeation Studies
inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00987openalex-snapshot
Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs
inferred← citeshttps://doi.org/10.1021/acs.jcim.6c01386openalex-snapshot
A Multimodal Semi-Supervised Learning Framework for Pharmaceutical Cocrystals Prediction
inferred← citeshttps://doi.org/10.1021/acs.jctc.2c00343openalex-snapshot
A Hybrid Machine Learning Approach for Structure Stability Prediction in Molecular Co-crystal Screenings
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01234openalex-snapshot
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine…
inferred← citeshttps://doi.org/10.1021/acs.joc.0c00220openalex-snapshot
Bringing a Molecular Plus One: Synergistic Binding Creates Guest-Mediated Three-Component Complexes
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.4c00393openalex-snapshot
Highly Soluble Dacarbazine Multicomponent Crystals Less Prone to Photodegradation
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.9b00377openalex-snapshot
Molecular Interpretation of the Compaction Performance and Mechanical Properties of Caffeine Cocrystals: A Polymorphic Study
inferred← citeshttps://doi.org/10.1021/acs.oprd.2c00314openalex-snapshot
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing
inferred← citeshttps://doi.org/10.1021/acs.oprd.5b00279openalex-snapshot
Recrystallizing Primidone through Supercritical Antisolvent Precipitation
inferred← citeshttps://doi.org/10.1021/acs.oprd.6c00052openalex-snapshot
Systematic Scale-Up of Mechanochemical Paracetamol–Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies
inferred← citeshttps://doi.org/10.1021/acsabm.2c00404openalex-snapshot
Comparison of Antimicrobial and Antibiofilm Activity of Proflavine Co-crystallized with Silver, Copper, Zinc, and Gallium Salts
inferred← citeshttps://doi.org/10.1021/acschemneuro.1c00312openalex-snapshot
Novel Co-crystal of Pentoxifylline and Protocatechuic Acid Relieves Allodynia in Rat Models of Peripheral Neuropathic Pain and CRPS by Alleviating Local Tissue Hypoxia
inferred← citeshttps://doi.org/10.1021/acssuschemeng.2c01257openalex-snapshot
Dispensing Essential Oil Components through Cocrystallization: Sustainable and Smart Materials for Food Preservation and Agricultural Applications
inferred← citeshttps://doi.org/10.1021/acssuschemeng.9b04576openalex-snapshot
Designing a Palette of Cocrystals Based on Essential Oil Constituents for Agricultural Applications
inferred← citeshttps://doi.org/10.1021/cg400638gopenalex-snapshot
Ketoconazole Salt and Co-crystals with Enhanced Aqueous Solubility
inferred← citeshttps://doi.org/10.1021/cg401061topenalex-snapshot
Diversity in Itraconazole Cocrystals with Aliphatic Dicarboxylic Acids of Varying Chain Length
inferred← citeshttps://doi.org/10.1021/cg401660hopenalex-snapshot
Insight into the Mechanism of Formation of Channel Hydrates via Templating
inferred← citeshttps://doi.org/10.1021/cg4018807openalex-snapshot
Structural Insights into Proton Conduction in Gallic Acid–Isoniazid Cocrystals
inferred← citeshttps://doi.org/10.1021/cg500345aopenalex-snapshot
A Twist in Cocrystals of Salts: Changes in Packing and Chloride Coordination Lead to Opposite Trends in the Biopharmaceutical Performance of Fluoroquinolone Hydrochloride Cocrystals
inferred← citeshttps://doi.org/10.1021/cg501009copenalex-snapshot
Cocrystallization of Nutraceuticals
inferred← citeshttps://doi.org/10.1021/cg5014329openalex-snapshot
Cyclic Interconversion among Molecular Salts via Neat Grinding and Related Photoluminescence Properties
inferred← citeshttps://doi.org/10.1021/cr500564zopenalex-snapshot
Packing Problems: High Z ′ Crystal Structures and Their Relationship to Cocrystals, Inclusion Compounds, and Polymorphism
inferred← citeshttps://doi.org/10.1021/ja403264copenalex-snapshot
Crystal Engineering: From Molecule to Crystal
inferred← citeshttps://doi.org/10.1021/jp503256kopenalex-snapshot
Mechanochemical Synthesis of Bumetanide–4-Aminobenzoic Acid Molecular Cocrystals: A Facile and Green Approach to Drug Optimization
inferred← citeshttps://doi.org/10.1021/jp5123008openalex-snapshot
NMR Study of BA/FBA Cocrystal Confined Within Mesoporous Silica Nanoparticles Employing Thermal Solid Phase Transformation
inferred← citeshttps://doi.org/10.1021/jz501699hopenalex-snapshot
Monitoring Cocrystal Formation via In Situ Solid-State NMR
inferred← citeshttps://doi.org/10.1021/mp5004652openalex-snapshot
Pharmaceutical Cocrystals of Diflunisal and Diclofenac with Theophylline
inferred← citeshttps://doi.org/10.1038/s41598-017-04980-3openalex-snapshot
High Pressure Spectroscopic Investigation on Proton Transfer in Squaric Acid and 4,4′-Bipyridine Co-crystal
inferred← citeshttps://doi.org/10.1038/s42003-022-03776-0openalex-snapshot
A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
inferred← citeshttps://doi.org/10.1039/bk9781782621737-00719openalex-snapshot
Crystal Engineering: State of the Art and Open Challenges
inferred← citeshttps://doi.org/10.1039/c3ce42415dopenalex-snapshot
Crystal engineering of homochiral molecular organization of naproxen in cocrystals and their thermal phase transformation studies
inferred← citeshttps://doi.org/10.1039/c3ce42457jopenalex-snapshot
Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing
inferred← citeshttps://doi.org/10.1039/c3cs60224aopenalex-snapshot
Supramolecular gel phase crystallization: orthogonal self-assembly under non-equilibrium conditions
inferred← citeshttps://doi.org/10.1039/c3sc51419fopenalex-snapshot
The curious case of (caffeine)·(benzoic acid): how heteronuclear seeding allowed the formation of an elusive cocrystal
inferred← citeshttps://doi.org/10.1039/c4cc00159aopenalex-snapshot
Co-crystal formation between poly(ethylene glycol) and a small molecular drug griseofulvin
inferred← citeshttps://doi.org/10.1039/c4ce00127copenalex-snapshot
Pharmaceutical co-crystals – are we there yet?
inferred← citeshttps://doi.org/10.1039/c4ce00316kopenalex-snapshot
Knowledge-based approaches to co-crystal design
inferred← citeshttps://doi.org/10.1039/c4ce00666fopenalex-snapshot
Structural and physicochemical aspects of hydrochlorothiazide co-crystals
inferred← citeshttps://doi.org/10.1039/c4ce01150copenalex-snapshot
2 : 1 5-Fluorocytosine–acesulfame CAB cocrystal and 1 : 1 5-fluorocytosine–acesulfame salt hydrate with enhanced stability against hydration
inferred← citeshttps://doi.org/10.1039/c4ce02044hopenalex-snapshot
Pharmaceutical cocrystals of the anti-tuberculosis drug pyrazinamide with dicarboxylic and tricarboxylic acids
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