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Novel Cinnamoylated Flavoalkaloids Identified in Tea with Acetylcholinesterase Inhibition Effect

https://doi.org/10.1021/acs.jafc.9b08285
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-0010(20000515)80:7<1033::aid-jsfa595>3.0.co;2-topenalex-snapshot
Chlorogenic acids and other cinnamates - nature, occurrence, dietary burden, absorption and metabolism
inferredcites →https://doi.org/10.1002/(sici)1097-458x(199611)34:11<887::aid-omr995>3.0.co;2-uopenalex-snapshot
1H and13C NMR Assignments of Some Green Tea Polyphenols
inferredcites →https://doi.org/10.1002/jsfa.4184openalex-snapshot
Changes in volatile compounds upon aging and drying in oolong tea production
inferredcites →https://doi.org/10.1016/0003-9861(66)90111-1openalex-snapshot
γ-Methylaminobutyraldehyde, a new intermediate in nicotine biosynthesis
inferredcites →https://doi.org/10.1016/0006-2952(61)90145-9openalex-snapshot
A new and rapid colorimetric determination of acetylcholinesterase activity
inferredcites →https://doi.org/10.1016/0031-9422(93)85370-7openalex-snapshot
Nuclear magnetic resonance studies of 5,7-dihydroxyflavonoids
inferredcites →https://doi.org/10.1016/j.bioorg.2018.10.024openalex-snapshot
A novel bi-functional chalcone inhibits multi-drug resistant Staphylococcus aureus and potentiates the activity of fluoroquinolones
inferredcites →https://doi.org/10.1016/j.fitote.2012.05.006openalex-snapshot
Benzophenone glycosides and epicatechin derivatives from Malania oleifera
inferredcites →https://doi.org/10.1016/j.foodchem.2004.09.013openalex-snapshot
New black tea polyphenol having -ethyl-2-pyrrolidinone moiety derived from tea amino acid theanine: isolation, characterization and partial synthesis
inferredcites →https://doi.org/10.1016/j.foodchem.2013.10.117openalex-snapshot
8-C N-ethyl-2-pyrrolidinone substituted flavan-3-ols as the marker compounds of Chinese dark teas formed in the post-fermentation process provide significant antioxidative activity
inferredcites →https://doi.org/10.1016/j.foodchem.2017.06.011openalex-snapshot
Novel acetylcholinesterase inhibitors from Zijuan tea and biosynthetic pathway of caffeoylated catechin in tea plant
inferredcites →https://doi.org/10.1016/j.foodchem.2018.04.117openalex-snapshot
Contribution of l-theanine to the formation of 2,5-dimethylpyrazine, a key roasted peanutty flavor in Oolong tea during manufacturing processes
inferredcites →https://doi.org/10.1016/j.foodres.2013.01.038openalex-snapshot
Tea: A new perspective on health benefits
inferredcites →https://doi.org/10.1016/j.fshw.2013.03.004openalex-snapshot
Black tea in chemo-prevention of cancer and other human diseases
inferredcites →https://doi.org/10.1016/j.fshw.2015.04.001openalex-snapshot
Tea aroma formation
inferredcites →https://doi.org/10.1016/j.phytochem.2008.01.013openalex-snapshot
Stereochemistry of flavonoidal alkaloids from Dracocephalum rupestre
inferredcites →https://doi.org/10.1016/j.tet.2017.01.068openalex-snapshot
C8-selective biomimetic transformation of 5,7-dihydroxylated flavonoids by an acid-catalysed phenolic Mannich reaction: Synthesis of flavonoid alkaloids with quercetin and (–)-epicatechin skeletons
inferredcites →https://doi.org/10.1016/s0031-9422(00)82304-3openalex-snapshot
Lilaline—a flavonoid alkaloid from Lilium candidum
inferredcites →https://doi.org/10.1016/s0040-4039(00)01170-9openalex-snapshot
Synthesis of amino acids via a three-component reaction of phenols, glyoxylates and amines
inferredcites →https://doi.org/10.1016/s0040-4039(01)88288-5openalex-snapshot
Sythesis of (±) ficine
inferredcites →https://doi.org/10.1016/s0960-894x(00)00314-0openalex-snapshot
Antitumor promoting activities of 3-O-acyl-(−)-epigallocatechins
inferredcites →https://doi.org/10.1021/acs.jafc.7b00239openalex-snapshot
Novel Acylated Flavonol Tetraglycoside with Inhibitory Effect on Lipid Accumulation in 3T3-L1 Cells from Lu’an GuaPian Tea and Quantification of Flavonoid Glycosides in Six Major Processing Types of Tea
inferredcites →https://doi.org/10.1021/acs.jafc.7b06044openalex-snapshot
Novel Theaflavin-Type Chlorogenic Acid Derivatives Identified in Black Tea
inferredcites →https://doi.org/10.1021/acs.jafc.8b00650openalex-snapshot
Novel Flavoalkaloids from White Tea with Inhibitory Activity against the Formation of Advanced Glycation End Products
inferredcites →https://doi.org/10.1021/acs.jafc.8b02038openalex-snapshot
Metabolomics Investigation Reveals That 8-C N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols Are Potential Marker Compounds of Stored White Teas
inferredcites →https://doi.org/10.1021/acs.jafc.8b02266openalex-snapshot
Flavoalkaloids with a Pyrrolidinone Ring from Chinese Ancient Cultivated Tea Xi-Gui
inferredcites →https://doi.org/10.1021/acs.jafc.9b01365openalex-snapshot
Two Pairs of Isomerically New Phenylpropanoidated Epicatechin Gallates with Neuroprotective Effects on H2O2-Injured SH-SY5Y Cells from Zijuan Green Tea and Their Changes in Fresh Tea Leaves Collected from Different Months and Final Product
inferredcites →https://doi.org/10.1021/cr60156a002openalex-snapshot
The Strecker Degradation of α-Amino Acids.
inferredcites →https://doi.org/10.1021/jf000986wopenalex-snapshot
Carbohydrate and Amino Acid Degradation Pathways in l -Methionine/ d -[13C] Glucose Model Systems
inferredcites →https://doi.org/10.1021/jf800986sopenalex-snapshot
New Phenolic Components and Chromatographic Profiles of Green and Fermented Teas
inferredcites →https://doi.org/10.1021/np100523sopenalex-snapshot
Catechin Derivatives from Parapiptadenia rigida with in Vitro Wound-Healing Properties
inferredcites →https://doi.org/10.1021/np50023a015openalex-snapshot
A One-Step Synthesis of Ficine and Isoficine
inferredcites →https://doi.org/10.1039/c2fo30093aopenalex-snapshot
Black tea: chemical analysis and stability
inferredcites →https://doi.org/10.1055/s-2004-818923openalex-snapshot
Antimicrobial Activity of 3-O-Acyl-(-)-epicatechin and 3-O-Acyl-(+)-catechin derivatives
inferredcites →https://doi.org/10.1074/jbc.m112.403071openalex-snapshot
Purification and Characterization of a Novel Galloyltransferase Involved in Catechin Galloylation in the Tea Plant (Camellia sinensis)
inferredcites →https://doi.org/10.1080/10286020802361198openalex-snapshot
Two new flavonoid alkaloids fromSenecio argunensis
inferredcites →https://doi.org/10.1093/jxb/erw053openalex-snapshot
Identification of UDP-glycosyltransferases involved in the biosynthesis of astringent taste compounds in tea ( Camellia sinensis )
inferredcites →https://doi.org/10.1146/annurev-anchem-071114-040110openalex-snapshot
Structure Determination of Natural Products by Mass Spectrometry
inferredcites →https://doi.org/10.1186/s12870-014-0243-1openalex-snapshot
TMDB: A literature-curated database for small molecular compounds found from tea
inferredcites →https://doi.org/10.3945/ajcn.113.058263openalex-snapshot
Interactions of black tea polyphenols with human gut microbiota: implications for gut and cardiovascular health

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Microorganisms Associate to Flavor Conversion During Storage in White Tea
inferred← citeshttps://doi.org/10.1002/fsn3.72464openalex-snapshot
Anti‐Browning and Prebiotic Effects of White Tea Extract on Fresh‐Cut Lotus Root
inferred← citeshttps://doi.org/10.1016/b978-0-443-45844-6.00013-5openalex-snapshot
Natural anti-AChE compounds for Alzheimer's disease therapy
inferred← citeshttps://doi.org/10.1016/j.bse.2024.104876openalex-snapshot
Extraction of phenolic compounds from Acinos rotundifolius pers. And evaluation of bioactivities
inferred← citeshttps://doi.org/10.1016/j.fbio.2024.103765openalex-snapshot
Identification, anti-Alzheimer's disease and antiaging activities of cinnamoylated flavoalkaloids from green tea
inferred← citeshttps://doi.org/10.1016/j.fitote.2024.106099openalex-snapshot
Flavonoidal alkaloids: Emerging targets for drug discovery from Nature's bounty
inferred← citeshttps://doi.org/10.1016/j.foodchem.2020.127864openalex-snapshot
Detection and quantification of flavoalkaloids in different tea cultivars and during tea processing using UPLC-TOF-MS/MS
inferred← citeshttps://doi.org/10.1016/j.foodchem.2023.135643openalex-snapshot
Novel methylated flavoalkaloids from Echa 1 green tea inhibit fat accumulation and enhance stress resistance in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.139932openalex-snapshot
Dynamic changes and correlation analysis of microorganisms and flavonoids/ amino acids during white tea storage
inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.140510openalex-snapshot
Unraveling anti-aging mystery of green tea in C. elegans: Chemical truth and multiple mechanisms
inferred← citeshttps://doi.org/10.1016/j.foodchem.2025.145311openalex-snapshot
Natural guanidine alkaloids in tea (Camellia sinensis): Identification, quantification and α-glucosidase inhibitory activity of cis- and trans-cinnamoylagmatines
inferred← citeshttps://doi.org/10.1016/j.jff.2025.106673openalex-snapshot
Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star”
inferred← citeshttps://doi.org/10.1016/j.lwt.2021.110963openalex-snapshot
Identification and quantification of hydroxycinnamoylated catechins in tea by targeted UPLC-MS using synthesized standards and their potential use in discrimination of tea varieties
inferred← citeshttps://doi.org/10.1016/j.phymed.2021.153853openalex-snapshot
Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays
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N-ethyl-2-pyrrolidinone substitution enhances binding affinity between tea flavoalkaloids and human serum albumin: Greatly influenced by esterization
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Synthetic-free compounds as the potential glycation inhibitors performed in in vitro chemical models: Molecular mechanisms and structure requirements
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L-theanine–polyphenol noncovalent synergies: Emerging strategies for taste modulation, bioactivity delivery, and functional food innovation
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c00964openalex-snapshot
Discovery and Targeted Isolation of Phenylpropanoid-Substituted Ester-Catechins Using UPLC-Q/TOF-HRMS/MS-Based Molecular Networks: Implication of the Reaction Mechanism among Polyphenols during Green Tea Processing
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c06608openalex-snapshot
Novel Flavonol Alkaloids in Green Tea: Synthesis, Detection, and Anti-Alzheimer’s Disease Effect in a Transgenic Caenorhabditis elegans CL4176 Model
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c04943openalex-snapshot
Advances and Outlook of Tea Polyphenol Chemistry: A Review
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00691openalex-snapshot
Computationally Assisted Structural Revision of Flavoalkaloids with a Seven-Membered Ring: Aquiledine, Isoaquiledine, and Cheliensisine
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.4c01359openalex-snapshot
Secondary Metabolites of the Lichen Lethariella cladonioides and Their Neuroprotective Potential
inferred← citeshttps://doi.org/10.1021/acs.joc.2c00387openalex-snapshot
Synthesis of Pyrrolidin-5-one-2-carboxamides through Cyclization of N-Substituted-2-alleneamides
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New Dihydropyrrole-Substituted Epicatechins from Sun-Dried Dongting-Biluochun Tea Leaves and Their Inhibitory Activities on Acetylcholinesterase
inferred← citeshttps://doi.org/10.1039/d2fo01795dopenalex-snapshot
Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways
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Updates on the chemistry, processing characteristics, and utilization of tea flavonoids in last two decades (2001-2021)
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Novel Mannich based derivatives of isoliquiritigenin and liquiritigenin, bioactive constituents of Glycyrrhiza glabra , as potent antimalarial agents
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Recent Advances in N ‐Ethyl‐2‐Pyrrolidinone‐Substituted Flavanols (EPSFs), Novel Bioactive Components in Tea: Chemical Structure, Formation Mechanism, and Potential Health Benefits
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Biocompatible green tea extract‐stabilised zinc nanoparticles encapsulated by poly(butyl‐2‐cyanoacrylate) with control release profile and antioxidative capacity
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Metabolomics in quality formation and characterisation of tea products: a review
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Naturally Occurring Cholinesterase Inhibitors from Plants, Fungi, Algae, and Animals: A Review of the Most Effective Inhibitors Reported in 2012-2022
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Food‐derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
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Electronic Sensor Technologies in Monitoring Quality of Tea: A Review
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Recent Advances in Analytical Methods for Determination of Polyphenols in Tea: A Comprehensive Review
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Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases
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Extraction and Purification of Catechins from Tea Leaves: An Overview of Methods, Advantages, and Disadvantages
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Treatment of alcohol dependence with drug antagonists of the stress response
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