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A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome

https://doi.org/10.1021/acschembio.6b01075
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00253-009-2219-xopenalex-snapshot
Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering
inferredcites →https://doi.org/10.1016/j.cbpa.2007.12.008openalex-snapshot
Unearthing the roots of the terpenome
inferredcites →https://doi.org/10.1016/j.molp.2014.12.002openalex-snapshot
The Application of Synthetic Biology to Elucidation of Plant Mono-, Sesqui-, and Diterpenoid Metabolism
inferredcites →https://doi.org/10.1016/j.phytochem.2006.10.016openalex-snapshot
Functional characterization of the rice kaurene synthase-like gene family
inferredcites →https://doi.org/10.1016/j.phytochem.2011.11.004openalex-snapshot
Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism
inferredcites →https://doi.org/10.1016/j.phytochem.2014.04.005openalex-snapshot
Biochemical characterization of the castor bean ent -kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization
inferredcites →https://doi.org/10.1021/cr050286wopenalex-snapshot
Structural Biology and Chemistry of the Terpenoid Cyclases
inferredcites →https://doi.org/10.1021/ja071158nopenalex-snapshot
A Modular Approach for Facile Biosynthesis of Labdane-Related Diterpenes
inferredcites →https://doi.org/10.1021/ja710524wopenalex-snapshot
Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch
inferredcites →https://doi.org/10.1038/ja.2016.39openalex-snapshot
General base-general acid catalysis by terpenoid cyclases
inferredcites →https://doi.org/10.1039/c0cc02960bopenalex-snapshot
Electrostatic effects on (di)terpene synthase product outcome
inferredcites →https://doi.org/10.1039/c0np00019aopenalex-snapshot
Two rings in them all: The labdane-related diterpenoids
inferredcites →https://doi.org/10.1073/pnas.0611454104openalex-snapshot
Following evolution's lead to a single residue switch for diterpene synthase product outcome
inferredcites →https://doi.org/10.1104/pp.15.01727openalex-snapshot
A Tandem Array of ent -Kaurene Synthases in Maize with Roles in Gibberellin and More Specialized Metabolism
inferredcites →https://doi.org/10.1111/j.1365-313x.2011.04520.xopenalex-snapshot
The family of terpene synthases in plants: a mid‐size family of genes for specialized metabolism that is highly diversified throughout the kingdom
inferredcites →https://doi.org/10.1146/annurev-arplant-050213-035705openalex-snapshot
To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism
inferredcites →https://doi.org/10.1271/bbb.60044openalex-snapshot
Characterization of a Rice Gene Family Encoding Type-A Diterpene Cyclases
inferredcites →https://doi.org/10.1351/pac-con-09-09-37openalex-snapshot
Trinuclear metal clusters in catalysis by terpenoid synthases
inferredcites →https://doi.org/10.3389/fpls.2016.01765openalex-snapshot
Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent-Kaurene Synthases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A pair of threonines mark ent-kaurene synthases for phytohormone biosynthesis
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Organic Synthesis with Isomerases
inferred← citeshttps://doi.org/10.1002/cplu.202300676openalex-snapshot
Recent Developments in the Syntheses of C‐20‐Oxygenated ent ‐Kaurane Diterpenoids
inferred← citeshttps://doi.org/10.1007/s11101-017-9513-5openalex-snapshot
Plant diterpenoid metabolism for manufacturing the biopharmaceuticals of tomorrow: prospects and challenges
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14624-4openalex-snapshot
Biosynthesis of Diterpenoid Natural Products
inferred← citeshttps://doi.org/10.1016/j.apsb.2022.02.013openalex-snapshot
Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.03.057openalex-snapshot
An alternative splicing alters the product outcome of a class I terpene synthase in Isodon rubescens
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.108142openalex-snapshot
Between scents and sterols: Cyclization of labdane-related diterpenes as model systems for enzymatic control of carbocation cascades
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111410openalex-snapshot
Structural diversity of isoprene synthases in mosses from multiple terpenoid synthase lineages
inferred← citeshttps://doi.org/10.1016/j.jsb.2019.04.010openalex-snapshot
The structure of (E)-biformene synthase provides insights into the biosynthesis of bacterial bicyclic labdane-related diterpenoids
inferred← citeshttps://doi.org/10.1016/j.plantsci.2024.112046openalex-snapshot
ApCPS2 contributes to medicinal diterpenoid biosynthesis and defense against insect herbivore in Andrographis paniculata
inferred← citeshttps://doi.org/10.1016/j.plantsci.2024.112080openalex-snapshot
Functional identification of specialized diterpene synthases from Chamaecyparis obtusa and C. obtusa var. formosana to illustrate the putative evolution of diterpene synthases in Cupressaceae
inferred← citeshttps://doi.org/10.1016/j.ymben.2019.06.008openalex-snapshot
Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00137openalex-snapshot
Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases
inferred← citeshttps://doi.org/10.1021/acscatal.3c01486openalex-snapshot
Discovery of Class I Diterpene Cyclases Producing a Tetracyclic Cephalotene Skeleton in Plum Yews
inferred← citeshttps://doi.org/10.1021/acscatal.3c03047openalex-snapshot
Decoding Catalysis by Terpene Synthases
inferred← citeshttps://doi.org/10.1021/acscatal.3c05918openalex-snapshot
From Functional Plasticity of Two Diterpene Synthases (IrTPS2/IrKSL3a) to Enzyme Evolution
inferred← citeshttps://doi.org/10.1021/acscatal.4c05274openalex-snapshot
Unexpected Main-Chain-Mediated and Neutral-Intermediate-Involved Catalytic Reaction in a High-Fidelity ent-Neoabietadiene Synthase
inferred← citeshttps://doi.org/10.1021/acscatal.8b00121openalex-snapshot
Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase
inferred← citeshttps://doi.org/10.1021/acssynbio.6c00190openalex-snapshot
Diterpene Synthases as Gatekeepers of Bioactive Diterpenoids: A Resource for Discovery and Engineering toward Efficient Synthesis
inferred← citeshttps://doi.org/10.1021/jacs.0c10214openalex-snapshot
Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase
inferred← citeshttps://doi.org/10.1039/d3np00052dopenalex-snapshot
Biosynthesis of fungal terpenoids
inferred← citeshttps://doi.org/10.1039/d4cc05785fopenalex-snapshot
Engineering terpene synthases and their substrates for the biocatalytic production of terpene natural products and analogues
inferred← citeshttps://doi.org/10.1039/d5np00066aopenalex-snapshot
Engineering class I terpene synthases for skeletal diversity: strategies and applications
inferred← citeshttps://doi.org/10.1074/jbc.ra118.006025openalex-snapshot
A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae)
inferred← citeshttps://doi.org/10.1093/bbb/zbad146openalex-snapshot
Characterization of diterpene synthase genes in Brachypodium distachyon, a monocotyledonous model plant, provides evolutionary insight into their multiple homologs in cereals
inferred← citeshttps://doi.org/10.1093/jxb/erz211openalex-snapshot
Transcriptome analysis reveals novel enzymes for apo-carotenoid biosynthesis in saffron and allows construction of a pathway for crocetin synthesis in yeast
inferred← citeshttps://doi.org/10.1093/plphys/kiac056openalex-snapshot
Diterpene synthases fromLeonurus japonicuselucidate epoxy-bridge formation of spiro-labdane diterpenoids
inferred← citeshttps://doi.org/10.1101/2023.05.26.542545openalex-snapshot
Exploration of an enzyme-product mapping approach for plant-derived diterpene synthases
inferred← citeshttps://doi.org/10.1111/tpj.14513openalex-snapshot
Biochemical characterization of diterpene synthases of Taiwania cryptomerioides expands the known functional space of specialized diterpene metabolism in gymnosperms
inferred← citeshttps://doi.org/10.1186/s40643-026-01094-5openalex-snapshot
Engineered microorganisms unlock a new era of diterpenoid biomanufacturing: recent advances and future perspectives
inferred← citeshttps://doi.org/10.1371/journal.pone.0176507openalex-snapshot
Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
inferred← citeshttps://doi.org/10.20944/preprints202309.0431.v1openalex-snapshot
AlphaFold2 Empowers Product Specificity Analysis in Plant-derived Diterpene Synthases
inferred← citeshttps://doi.org/10.31274/td-20240329-820openalex-snapshot
Transcending eons; evolutionary and mechanistic insight into plant Class I Diterpene synthases
inferred← citeshttps://doi.org/10.3389/fchem.2018.00101openalex-snapshot
Insights Into the Bifunctional Aphidicolan-16-ß-ol Synthase Through Rapid Biomolecular Modeling Approaches
inferred← citeshttps://doi.org/10.3389/fpls.2018.01542openalex-snapshot
Functional Characterization of Two Class II Diterpene Synthases Indicates Additional Specialized Diterpenoid Pathways in Maize (Zea mays)
inferred← citeshttps://doi.org/10.3389/fpls.2019.01166openalex-snapshot
Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity
inferred← citeshttps://doi.org/10.3390/biom14010120openalex-snapshot
Sequence-Structure Analysis Unlocking the Potential Functional Application of the Local 3D Motifs of Plant-Derived Diterpene Synthases
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