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ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

https://doi.org/10.1083/jcb.201008076

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.20204openalex-snapshot

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

inferredcites →https://doi.org/10.1016/j.dnarep.2006.09.002openalex-snapshot

Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1

inferredcites →https://doi.org/10.1016/j.febslet.2004.11.029openalex-snapshot

Replication of damaged DNA by translesion synthesis in human cells

inferredcites →https://doi.org/10.1016/j.molcel.2009.12.039openalex-snapshot

Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination

inferredcites →https://doi.org/10.1016/s1097-2765(01)00278-7openalex-snapshot

The Y-Family of DNA Polymerases

inferredcites →https://doi.org/10.1016/s1097-2765(04)00259-xopenalex-snapshot

Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA

inferredcites →https://doi.org/10.1038/21447openalex-snapshot

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

inferredcites →https://doi.org/10.1038/emboj.2010.205openalex-snapshot

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

inferredcites →https://doi.org/10.1038/nature00991openalex-snapshot

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

inferredcites →https://doi.org/10.1038/nature01965openalex-snapshot

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

inferredcites →https://doi.org/10.1038/nature02352openalex-snapshot

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

inferredcites →https://doi.org/10.1038/nature09196openalex-snapshot

Structure and mechanism of human DNA polymerase η

inferredcites →https://doi.org/10.1038/nrm1781openalex-snapshot

Suffering in silence: the tolerance of DNA damage

inferredcites →https://doi.org/10.1038/sj.emboj.7600383openalex-snapshot

Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

inferredcites →https://doi.org/10.1038/sj.emboj.7601178openalex-snapshot

Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin

inferredcites →https://doi.org/10.1073/pnas.0802727105openalex-snapshot

Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

inferredcites →https://doi.org/10.1073/pnas.0808589105openalex-snapshot

Human DNA polymerase η activity and translocation is regulated by phosphorylation

inferredcites →https://doi.org/10.1073/pnas.0809844105openalex-snapshot

Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase η in translesion DNA synthesis

inferredcites →https://doi.org/10.1073/pnas.72.1.219openalex-snapshot

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.

inferredcites →https://doi.org/10.1074/jbc.m211838200openalex-snapshot

Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells

inferredcites →https://doi.org/10.1091/mbc.e08-07-0724openalex-snapshot

Effect of Proliferating Cell Nuclear Antigen Ubiquitination and Chromatin Structure on the Dynamic Properties of the Y-family DNA Polymerases

inferredcites →https://doi.org/10.1093/emboj/19.12.3100openalex-snapshot

Mechanisms of accurate translesion synthesis by human DNA polymerase η

inferredcites →https://doi.org/10.1093/nar/gkq403openalex-snapshot

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts

inferredcites →https://doi.org/10.1101/gad.13.2.152openalex-snapshot

A role for ATR in the DNA damage-induced phosphorylation of p53

inferredcites →https://doi.org/10.1101/gad.1793409openalex-snapshot

Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast

inferredcites →https://doi.org/10.1101/gad.187501openalex-snapshot

Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

inferredcites →https://doi.org/10.1111/j.1365-2443.2006.00974.xopenalex-snapshot

A human DNA polymerase η complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin‐bound fraction of cells undergoing replication fork arrest

inferredcites →https://doi.org/10.1126/science.1120615openalex-snapshot

Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

inferredcites →https://doi.org/10.1126/science.285.5425.263openalex-snapshot

hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum

inferredcites →https://doi.org/10.1146/annurev.biochem.74.082803.133250openalex-snapshot

EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function

inferredcites →https://doi.org/10.1186/1748-717x-4-51openalex-snapshot

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3185110openalex-extracted

Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis and Cancer Etiology

inferred← citeshttps://doi.org/10.1002/em.21741openalex-snapshot

Regulation of the specialized DNA polymerase eta: Revisiting the biological relevance of its PCNA‐ and ubiquitin‐binding motifs

inferred← citeshttps://doi.org/10.1002/em.22176openalex-snapshot

Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

inferred← citeshttps://doi.org/10.1002/em.22359openalex-snapshot

Regulation of translesion DNA synthesis in mammalian cells

inferred← citeshttps://doi.org/10.1007/978-4-431-55873-6_16openalex-snapshot

Signaling of DNA Replication Stress Through the ATR Checkpoint

inferred← citeshttps://doi.org/10.1007/s00294-020-01061-3openalex-snapshot

Regulation of the abundance of Y-family polymerases in the cell cycle of budding yeast in response to DNA damage

inferred← citeshttps://doi.org/10.1007/s11010-025-05291-2openalex-snapshot

Human TLS DNA polymerase: saviors or threats under replication stress?

inferred← citeshttps://doi.org/10.1007/s11538-021-00868-6openalex-snapshot

ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways

inferred← citeshttps://doi.org/10.1016/b978-0-12-819460-7.00130-4openalex-snapshot

DNA repair | XPV Polymerase and the Bypass of Ultraviolet DNA Damage

inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.109707openalex-snapshot

Targeting ATR in Cancer therapy: A drug discovery perspective

inferred← citeshttps://doi.org/10.1016/j.dnarep.2011.07.007openalex-snapshot

The DNA damage checkpoint allows recombination between divergent DNA sequences in budding yeast

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.02.011openalex-snapshot

Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.02.015openalex-snapshot

The steady-state level and stability of TLS polymerase eta are cell cycle dependent in the yeast S. cerevisiae

inferred← citeshttps://doi.org/10.1016/j.febslet.2011.06.005openalex-snapshot

Ubiquitin‐family modifications in the replication of DNA damage

inferred← citeshttps://doi.org/10.1016/j.isci.2018.07.009openalex-snapshot

Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis

inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100570openalex-snapshot

Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skin

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107361openalex-snapshot

Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol η catalyzed DNA synthesis

inferred← citeshttps://doi.org/10.1016/j.mrrev.2014.10.003openalex-snapshot

The fork and the kinase: A DNA replication tale from a CHK1 perspective

inferred← citeshttps://doi.org/10.1016/j.mrrev.2022.108436openalex-snapshot

Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations

inferred← citeshttps://doi.org/10.1016/j.tim.2019.10.008openalex-snapshot

Catching HPV in the Homologous Recombination Cookie Jar

inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00938openalex-snapshot

Rad6/Rad18 Competes with DNA Polymerases η and δ for PCNA Encircling DNA

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.7b00190openalex-snapshot

Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles

inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00046openalex-snapshot

Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle

inferred← citeshttps://doi.org/10.1021/bi500019sopenalex-snapshot

An Overview of Y-Family DNA Polymerases and a Case Study of Human DNA Polymerase η

inferred← citeshttps://doi.org/10.1021/cb400305ropenalex-snapshot

N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases

inferred← citeshttps://doi.org/10.1021/jacs.2c05312openalex-snapshot

Polymerase η Recruits DHX9 Helicase to Promote Replication across Guanine Quadruplex Structures

inferred← citeshttps://doi.org/10.1038/jid.2012.41openalex-snapshot

A UVR-Induced G2-Phase Checkpoint Response to ssDNA Gaps Produced by Replication Fork Bypass of Unrepaired Lesions Is Defective in Melanoma

inferred← citeshttps://doi.org/10.1038/ncomms13326openalex-snapshot

Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

inferred← citeshttps://doi.org/10.1038/ncomms6437openalex-snapshot

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

inferred← citeshttps://doi.org/10.1038/nrm.2017.67openalex-snapshot

The essential kinase ATR: ensuring faithful duplication of a challenging genome

inferred← citeshttps://doi.org/10.1038/nrm3289openalex-snapshot

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

inferred← citeshttps://doi.org/10.1038/nrm3562openalex-snapshot

Regulation of PCNA–protein interactions for genome stability

inferred← citeshttps://doi.org/10.1038/s41467-017-02164-1openalex-snapshot

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

inferred← citeshttps://doi.org/10.1038/s41594-020-0418-4openalex-snapshot

Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart

inferred← citeshttps://doi.org/10.1038/s41598-019-41249-3openalex-snapshot

DNA polymerase ι is acetylated in response to SN2 alkylating agents

inferred← citeshttps://doi.org/10.1073/pnas.1116345109openalex-snapshot

Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA

inferred← citeshttps://doi.org/10.1074/jbc.m111.276113openalex-snapshot

Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase

inferred← citeshttps://doi.org/10.1074/jbc.m111.278994openalex-snapshot

The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere Homeostasis

inferred← citeshttps://doi.org/10.1074/mcp.m115.052167openalex-snapshot

The Functions of Serine 687 Phosphorylation of Human DNA Polymerase η in UV Damage Tolerance

inferred← citeshttps://doi.org/10.1080/10409238.2017.1291576openalex-snapshot

Translesion DNA polymerases in eukaryotes: what makes them tick?

inferred← citeshttps://doi.org/10.1080/10985549.2023.2224199openalex-snapshot

Implications of Translesion DNA Synthesis Polymerases on Genomic Stability and Human Health

inferred← citeshttps://doi.org/10.1091/mbc.e11-10-0829openalex-snapshot

c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks

inferred← citeshttps://doi.org/10.1093/nar/gku1030openalex-snapshot

Polymerase η suppresses telomere defects induced by DNA damaging agents

inferred← citeshttps://doi.org/10.1093/nar/gkv076openalex-snapshot

FF483–484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance

inferred← citeshttps://doi.org/10.1093/nar/gkx619openalex-snapshot

Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle

inferred← citeshttps://doi.org/10.1093/nar/gkz824openalex-snapshot

UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity

inferred← citeshttps://doi.org/10.1093/narcan/zcad005openalex-snapshot

Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy

inferred← citeshttps://doi.org/10.1101/cshperspect.a012708openalex-snapshot

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

inferred← citeshttps://doi.org/10.1101/gad.353474.125openalex-snapshot

Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR

inferred← citeshttps://doi.org/10.1111/cas.15845openalex-snapshot

Emerging strategies for cancer therapy by ATR inhibitors

inferred← citeshttps://doi.org/10.1111/pcmr.12136openalex-snapshot

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma

inferred← citeshttps://doi.org/10.1111/php.13164openalex-snapshot

ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation

inferred← citeshttps://doi.org/10.1146/annurev-genet-121415-121658openalex-snapshot

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

inferred← citeshttps://doi.org/10.1186/1471-2164-13-664openalex-snapshot

An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control

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inferred← citeshttps://doi.org/10.1242/dev.101196openalex-snapshot

TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η

inferred← citeshttps://doi.org/10.1242/jcs.161596openalex-snapshot

ATR suppresses apoptosis after UVB light by controlling both translesion synthesis and alternative tolerance pathways

inferred← citeshttps://doi.org/10.1242/jcs.258637openalex-snapshot

DNA polymerase η is a substrate for calpain: A possible mechanism for pol η retention in UV induced replication foci

inferred← citeshttps://doi.org/10.13025/16394openalex-snapshot

Characterisation of UVA-induced DNA damage responses in human skin cells

inferred← citeshttps://doi.org/10.1371/journal.pgen.1002826openalex-snapshot

Reversal of PCNA Ubiquitylation by Ubp10 in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1371/journal.pone.0036004openalex-snapshot

Evidence for a Rad18-Independent Frameshift Mutagenesis Pathway in Human Cell-Free Extracts

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Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression

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DNA damage kinase signaling: checkpoint and repair at 30 years

inferred← citeshttps://doi.org/10.3123/jemsge.34.63openalex-snapshot

Human DNA Polymerase η and Its Regulatory Mechanisms

inferred← citeshttps://doi.org/10.3123/jemsge.34.89openalex-snapshot

Translesion DNA Synthesis and Hsp90

inferred← citeshttps://doi.org/10.3389/fgene.2016.00105openalex-snapshot

The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers

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DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target

inferred← citeshttps://doi.org/10.3389/fphar.2012.00009openalex-snapshot

Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies

inferred← citeshttps://doi.org/10.3390/genes14010175openalex-snapshot

Nontraditional Roles of DNA Polymerase Eta Support Genome Duplication and Stability

inferred← citeshttps://doi.org/10.3390/genes15101271openalex-snapshot

Canonical and Non-Canonical Roles of Human DNA Polymerase η

inferred← citeshttps://doi.org/10.3390/genes8010019openalex-snapshot

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

inferred← citeshttps://doi.org/10.3390/genes8010024openalex-snapshot

Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases

inferred← citeshttps://doi.org/10.3390/genes9080416openalex-snapshot

Maneuvers on PCNA Rings during DNA Replication and Repair

inferred← citeshttps://doi.org/10.3390/ijms19103255openalex-snapshot

Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress

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The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork

inferred← citeshttps://doi.org/10.3390/pathogens8040267openalex-snapshot

β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage

inferred← citeshttps://doi.org/10.3390/v13081662openalex-snapshot

Beta-Genus Human Papillomavirus 8 E6 Destabilizes the Host Genome by Promoting p300 Degradation

inferred← citeshttps://doi.org/10.4161/cc.26590openalex-snapshot

Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?

inferred← citeshttps://doi.org/10.5772/18616openalex-snapshot

Faithful DNA Replication Requires Regulation of CDK Activity by Checkpoint Kinases

inferred← citeshttps://doi.org/10.70675/2122f712z2f95z45caz8f82za68872f01e3copenalex-snapshot

La voie de dégradation CRL4Cdt2 régule le recrutement des ADN polymérases translésionnelles eta et kappa en foyers nucléaires après endommagements aux UV-C en ciblant pour dégradation les protéines qui contiennent des PIP box spécialisées

inferred← citeshttps://doi.org/10.70675/7894ebf5zbdf7z4147z940ezc553e0ed0e18openalex-snapshot

Regulation of the DNA polymerase zeta in response to genotoxic stress in mammalian cells

inferred← citeshttps://doi.org/10.70675/cf32bcd5z3031z4693z8b1bz62fe76673cccopenalex-snapshot

Caractérisation fonctionnelle de la tolérance aux endommagements de l’ADN des embryons précoces

inferred← citeshttps://doi.org/10.70675/eb51eb1ezc51dz4737zaf38z954d1a68dbeaopenalex-snapshot

Mutations de la voie ATR-CHK1, réponse au stress réplicatif et cancer

inferred← citeshttps://doi.org/10.7554/elife.19788openalex-snapshot

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

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