On the public citation graph

Application of Computer-Aided Drug Repurposing in the Search of New Cruzipain Inhibitors: Discovery of Amiodarone and Bromocriptine Inhibitory Effects

0 signed · 84 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/9780470977811.ch5openalex-snapshot

Optimization Clustering Techniques

inferredcites →https://doi.org/10.1002/qsar.200390007openalex-snapshot

The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models

inferredcites →https://doi.org/10.1002/wsbm.147openalex-snapshot

Drug repurposing and adverse event prediction using high‐throughput literature analysis

inferredcites →https://doi.org/10.1007/s00436-009-1383-3openalex-snapshot

Perspectives on the Trypanosoma cruzi–host cell receptor interactions

inferredcites →https://doi.org/10.1016/0166-6851(85)90074-xopenalex-snapshot

End products and enzyme levels of aerobic glucose fermentation in trypanosomatids

inferredcites →https://doi.org/10.1016/0167-4838(90)90166-dopenalex-snapshot

Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi

inferredcites →https://doi.org/10.1016/j.bmc.2004.12.053openalex-snapshot

Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

inferredcites →https://doi.org/10.1016/j.bmc.2009.07.068openalex-snapshot

Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents

inferredcites →https://doi.org/10.1016/j.bmc.2010.09.056openalex-snapshot

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents

inferredcites →https://doi.org/10.1016/j.bmcl.2010.10.015openalex-snapshot

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

inferredcites →https://doi.org/10.1016/j.drudis.2011.02.016openalex-snapshot

In silico repositioning of approved drugs for rare and neglected diseases

inferredcites →https://doi.org/10.1016/j.ijantimicag.2011.03.004openalex-snapshot

Antiprotozoal compounds: state of the art and new developments

inferredcites →https://doi.org/10.1016/j.jprot.2009.12.012openalex-snapshot

Proteomics of trypanosomatids of human medical importance

inferredcites →https://doi.org/10.1016/j.pt.2003.09.001openalex-snapshot

Specific chemotherapy of Chagas disease: controversies and advances

inferredcites →https://doi.org/10.1016/s0263-7855(96)00081-1openalex-snapshot

Pharmacological distribution diagrams: A tool for de novo drug design

inferredcites →https://doi.org/10.1016/s0960-894x(02)00189-0openalex-snapshot

CoMFA and HQSAR of acylhydrazide cruzain inhibitors

inferredcites →https://doi.org/10.1016/s0968-0896(02)00427-3openalex-snapshot

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

inferredcites →https://doi.org/10.1016/s0968-0896(98)80022-9openalex-snapshot

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors

inferredcites →https://doi.org/10.1016/s1074-5521(00)00018-1openalex-snapshot

Aryl ureas represent a new class of anti-trypanosomal agents

inferredcites →https://doi.org/10.1021/ci010291aopenalex-snapshot

Toward an Optimal Procedure for Variable Selection and QSAR Model Building

inferredcites →https://doi.org/10.1021/ci100297yopenalex-snapshot

MultiMCS: A Fast Algorithm for the Maximum Common Substructure Problem on Multiple Molecules

inferredcites →https://doi.org/10.1021/ci200528dopenalex-snapshot

Recognizing Pitfalls in Virtual Screening: A Critical Review

inferredcites →https://doi.org/10.1021/ja710254mopenalex-snapshot

Identification of a New Class of Nonpeptidic Inhibitors of Cruzain

inferredcites →https://doi.org/10.1021/jm049092jopenalex-snapshot

Virtual Screening Workflow Development Guided by the “Receiver Operating Characteristic” Curve Approach. Application to High-Throughput Docking on Metabotropic Glutamate Receptor Subtype 4

inferredcites →https://doi.org/10.1021/jm050691fopenalex-snapshot

Amiodarone Has Intrinsic Anti- Trypanosoma c ruzi Activity and Acts Synergistically with Posaconazole

inferredcites →https://doi.org/10.1021/jm100488wopenalex-snapshot

Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors

inferredcites →https://doi.org/10.1021/jm901069aopenalex-snapshot

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

inferredcites →https://doi.org/10.1093/bib/bbr021openalex-snapshot

Drug repositioning for orphan diseases

inferredcites →https://doi.org/10.1093/nar/gkj067openalex-snapshot

DrugBank: a comprehensive resource for in silico drug discovery and exploration

inferredcites →https://doi.org/10.1093/nar/gkq1126openalex-snapshot

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

inferredcites →https://doi.org/10.1126/scitranslmed.3001512openalex-snapshot

The Emergence of Genome-Based Drug Repositioning

inferredcites →https://doi.org/10.1371/journal.pntd.0001023openalex-snapshot

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

inferredcites →https://doi.org/10.1590/s0074-02762002000100001openalex-snapshot

A Critical Review on Chagas Disease Chemotherapy

inferredcites →https://doi.org/10.1590/s0074-02762009000900005openalex-snapshot

Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy

inferredcites →https://doi.org/10.2174/092986709788802971openalex-snapshot

Cruzipain, the Major Cysteine Protease of Trypanosoma cruzi: A Sulfated Glycoprotein Antigen as Relevant Candidate for Vaccine Development and Drug Target. A Review

inferredcites →https://doi.org/10.2174/092986710790226101openalex-snapshot

Chagas Disease: Progress and New Perspectives

inferredcites →https://doi.org/10.2174/092986711795328427openalex-snapshot

Exploring Old Drugs for the Treatment of Hematological Malignancies

inferredcites →https://doi.org/10.2174/157340810794578506openalex-snapshot

Peptidase Inhibitors as a Possible Therapeutic Strategy for Chagas Disease

inferredcites →https://doi.org/10.2174/157340912801619076openalex-snapshot

An Integrated Drug Development Approach Applying Topological Descriptors

inferredcites →https://doi.org/10.2174/157489107779561625openalex-snapshot

An Insight on Targets and Patented Drugs for Chemotherapy of Chagas Disease

inferredcites →https://doi.org/10.4155/fmc.11.92openalex-snapshot

Target Repurposing for Neglected Diseases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/9783527674381.ch1openalex-snapshot

Polypharmacology in Drug Discovery

inferred← citeshttps://doi.org/10.1007/s10822-016-9903-6openalex-snapshot

Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning

inferred← citeshttps://doi.org/10.1007/s10822-017-0039-0openalex-snapshot

Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure–activity relationship studies

inferred← citeshttps://doi.org/10.1016/b978-0-12-813806-9.00014-7openalex-snapshot

The Challenge of Finding New Therapies for Sleeping Sickness

inferred← citeshttps://doi.org/10.1016/b978-0-12-816125-8.00005-5openalex-snapshot

Repurposed Molecules: A New Hope in Tackling Neglected Infectious Diseases

inferred← citeshttps://doi.org/10.1016/b978-0-12-816125-8.00021-3openalex-snapshot

In Silico Modeling of FDA-Approved Drugs for Discovery of Therapies Against Neglected Diseases: A Drug Repurposing Approach

inferred← citeshttps://doi.org/10.1016/b978-1-60805-865-5.50002-2openalex-snapshot

Knowledge-Based Drug Repurposing: A Rational Approach Towards the Identification of Novel Medical Applications of Known Drugs

inferred← citeshttps://doi.org/10.1016/j.drudis.2015.02.004openalex-snapshot

Cruzain inhibitors: efforts made, current leads and a structural outlook of new hits

inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.01.065openalex-snapshot

Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir

inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.03.063openalex-snapshot

An in vitro and in vivo evaluation of new potential trans -sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method

inferred← citeshttps://doi.org/10.1016/j.heliyon.2025.e42750openalex-snapshot

A bibliometric review on in silico drug repurposing: Performance analysis, science mapping and text mining (2000–2023)

inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.141322openalex-snapshot

Predicting and classifying deoxynivalenol in wheat flour using ATR-FTIR spectroscopy and explainable machine learning

inferred← citeshttps://doi.org/10.1017/s0031182020000207openalex-snapshot

Computational approaches for drug discovery against trypanosomatid-caused diseases

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.0c00042openalex-snapshot

Bromocriptine as a Novel Pharmacological Chaperone for Mucopolysaccharidosis IV A

inferred← citeshttps://doi.org/10.1080/21645515.2015.1078044openalex-snapshot

Coadministration of cruzipain and GM-CSF DNAs, a new immunotherapeutic vaccine againstTrypanosoma cruziinfection

inferred← citeshttps://doi.org/10.1111/1440-1681.13678openalex-snapshot

Bromocriptine therapy: Review of mechanism of action, safety and tolerability

inferred← citeshttps://doi.org/10.1186/s12967-016-1007-5openalex-snapshot

Repositioning of bromocriptine for treatment of acute myeloid leukemia

inferred← citeshttps://doi.org/10.1186/s13321-016-0114-xopenalex-snapshot

How frequently do clusters occur in hierarchical clustering analysis? A graph theoretical approach to studying ties in proximity

inferred← citeshttps://doi.org/10.1371/journal.pntd.0007481openalex-snapshot

Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

inferred← citeshttps://doi.org/10.2174/0109298673254864230921090519openalex-snapshot

Discovery of Novel Inhibitors of Cruzain Cysteine Protease of Trypanosoma cruzi

inferred← citeshttps://doi.org/10.2174/0929867325666180926151059openalex-snapshot

The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

inferred← citeshttps://doi.org/10.2174/0929867326666191016114839openalex-snapshot

In Silico Drug Repositioning for Chagas Disease

inferred← citeshttps://doi.org/10.2174/1381612822666160224143008openalex-snapshot

Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease

inferred← citeshttps://doi.org/10.2174/1389450120666190423160804openalex-snapshot

Major Kinds of Drug Targets in Chagas Disease or American Trypanosomiasis

inferred← citeshttps://doi.org/10.2174/138955751503150312120208openalex-snapshot

High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease

inferred← citeshttps://doi.org/10.2174/1389557515666150219145148openalex-snapshot

Multiscale Modelling of Relationships between Protein Classes and Drug Behavior Across all Diseases Using the CANDO Platform

inferred← citeshttps://doi.org/10.2174/1568026616666160216155043openalex-snapshot

The Importance of Bioactivation in Computer-Guided Drug Repositioning. Why the Parent Drug is Not Always Enough

inferred← citeshttps://doi.org/10.2174/1568026618666180509151146openalex-snapshot

Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases

inferred← citeshttps://doi.org/10.2174/1574891x11666161024165304openalex-snapshot

Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period

inferred← citeshttps://doi.org/10.2460/javma.255.3.317openalex-snapshot

Investigation of a combination of amiodarone and itraconazole for treatment of American trypanosomiasis (Chagas disease) in dogs

inferred← citeshttps://doi.org/10.29356/jmcs.v60i3.100openalex-snapshot

One Drug for Multiple Targets: A Computational Perspective

inferred← citeshttps://doi.org/10.3389/fchem.2020.601151openalex-snapshot

Trypanosomatid-Caused Conditions: State of the Art of Therapeutics and Potential Applications of Lipid-Based Nanocarriers

inferred← citeshttps://doi.org/10.3389/fcimb.2018.00173openalex-snapshot

Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

inferred← citeshttps://doi.org/10.3389/fcimb.2022.885268openalex-snapshot

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

inferred← citeshttps://doi.org/10.3389/fphar.2018.01030openalex-snapshot

Repurposing of Bromocriptine for Cancer Therapy

inferred← citeshttps://doi.org/10.3389/fphar.2026.1749345openalex-snapshot

Chagas disease and amiodarone: a bibliometric and systematic review from cell to patient

inferred← citeshttps://doi.org/10.3390/ijms17010113openalex-snapshot

In Silico Insight into Potential Anti-Alzheimer’s Disease Mechanisms of Icariin

inferred← citeshttps://doi.org/10.3390/ijms21124270openalex-snapshot

Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling

inferred← citeshttps://doi.org/10.3390/mol2net-07-11647openalex-snapshot

Virtual screening based on covalent docking and MM-PBSA calculations predict the drugs neratinib, sacubitril, alprostadil, trandolapril, and florbetapir as promising cruzain inhibitors useful against Chagas disease.

inferred← citeshttps://doi.org/10.3390/molecules22061015openalex-snapshot

Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies

inferred← citeshttps://doi.org/10.3390/ph19010182openalex-snapshot

Integrated In Vitro and In Silico Profiling of Piperazinyl Thiosemicarbazone Derivatives Against Trypanosoma cruzi: Stage-Specific Activity and Enzyme Inhibition

inferred← citeshttps://doi.org/10.35537/10915/137336openalex-snapshot

BÚSQUEDA DE NUEVOS FÁRMACOS ANTICHAGÁSICOS INHIBIDORES DE LA TRIPANOTIÓN SINTETASA

inferred← citeshttps://doi.org/10.35537/10915/43315openalex-snapshot

Búsqueda racional de nuevos fármacos antichagásicos inhibidores de la cruzipaína

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.