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Drug repurposing and adverse event prediction using high‐throughput literature analysis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Serious Adverse Drug Events Reported to the Food and Drug Administration, 1998-2005
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Toward discovery support systems: A replication, re-examination, and extension of Swanson's work on literature-based discovery of a connection between Raynaud's and fish oil
inferredcites →https://doi.org/10.1002/(sici)1097-4571(1999)50:7<574::aid-asi3>3.0.co;2-qopenalex-snapshot
Literature-based discovery by lexical statistics
inferredcites →https://doi.org/10.1002/0471250953.bi1407s23openalex-snapshot
PharmGKB: An Integrated Resource of Pharmacogenomic Data and Knowledge
inferredcites →https://doi.org/10.1002/asi.10389openalex-snapshot
Text mining: Generating hypotheses from MEDLINE
inferredcites →https://doi.org/10.1002/asi.1104openalex-snapshot
Using concepts in literature‐based discovery: Simulating Swanson's Raynaud–fish oil and migraine–magnesium discoveries
inferredcites →https://doi.org/10.1007/978-3-540-68690-3_2openalex-snapshot
The Place of Literature-Based Discovery in Contemporary Scientific Practice
inferredcites →https://doi.org/10.1007/s00228-008-0475-9openalex-snapshot
Pharmacovigilance: methods, recent developments and future perspectives
inferredcites →https://doi.org/10.1007/s10072-010-0307-4openalex-snapshot
Non-pharmacological approach to migraine prophylaxis: part II
inferredcites →https://doi.org/10.1016/0002-9343(89)90261-1openalex-snapshot
Fish-oil dietary supplementation in patients with Raynaud's phenomenon: A double-blind, controlled, prospective study
inferredcites →https://doi.org/10.1016/0300-483x(95)03190-qopenalex-snapshot
Computer prediction of possible toxic action from chemical structure: an update on the DEREK system
inferredcites →https://doi.org/10.1016/j.jbi.2005.11.010openalex-snapshot
Using statistical and knowledge-based approaches for literature-based discovery
inferredcites →https://doi.org/10.1016/j.jbi.2007.05.001openalex-snapshot
Validating discovery in literature-based discovery
inferredcites →https://doi.org/10.1016/j.patbio.2008.10.004openalex-snapshot
Interaction networks: From protein functions to drug discovery. A review
inferredcites →https://doi.org/10.1016/j.yrtph.2008.12.009openalex-snapshot
Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans. Part A: Use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities
inferredcites →https://doi.org/10.1016/j.yrtph.2009.01.007openalex-snapshot
Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities
inferredcites →https://doi.org/10.1016/j.yrtph.2009.01.009openalex-snapshot
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities
inferredcites →https://doi.org/10.1016/j.yrtph.2009.11.006openalex-snapshot
Prediction of drug-related cardiac adverse effects in humans—A: Creation of a database of effects and identification of factors affecting their occurrence
inferredcites →https://doi.org/10.1016/s0167-6296(02)00126-1openalex-snapshot
The price of innovation: new estimates of drug development costs
inferredcites →https://doi.org/10.1016/s1383-5718(00)00167-4openalex-snapshot
Prediction of the genotoxicity of aromatic and heteroaromatic amines using electrotopological state indices
inferredcites →https://doi.org/10.1021/pr0340227openalex-snapshot
Analysis of Genomic and Proteomic Data Using Advanced Literature Mining
inferredcites →https://doi.org/10.1023/a:1021954808804openalex-snapshot
Hypothesis generation guided by co-word clustering
inferredcites →https://doi.org/10.1038/446358bopenalex-snapshot
Experts call for active surveillance of drug safety
inferredcites →https://doi.org/10.1038/msb.2009.98openalex-snapshot
A side effect resource to capture phenotypic effects of drugs
inferredcites →https://doi.org/10.1038/nrd1468openalex-snapshot
Drug repositioning: identifying and developing new uses for existing drugs
inferredcites →https://doi.org/10.1038/nrd2265openalex-snapshot
High-throughput electronic biology: mining information for drug discovery
inferredcites →https://doi.org/10.1038/nrg1768openalex-snapshot
Literature mining for the biologist: from information retrieval to biological discovery
inferredcites →https://doi.org/10.1093/bioinformatics/btg421openalex-snapshot
Knowledge discovery by automated identification and ranking of implicit relationships
inferredcites →https://doi.org/10.1093/bioinformatics/bti273openalex-snapshot
Online Predicted Human Interaction Database
inferredcites →https://doi.org/10.1093/nar/30.1.163openalex-snapshot
PharmGKB: the Pharmacogenetics Knowledge Base
inferredcites →https://doi.org/10.1093/nar/gki033openalex-snapshot
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
inferredcites →https://doi.org/10.1093/nar/gki072openalex-snapshot
Reactome: a knowledgebase of biological pathways
inferredcites →https://doi.org/10.1093/nar/gkj028openalex-snapshot
GLIDA: GPCR-ligand database for chemical genomic drug discovery
inferredcites →https://doi.org/10.1093/nar/gkj067openalex-snapshot
DrugBank: a comprehensive resource for in silico drug discovery and exploration
inferredcites →https://doi.org/10.1093/nar/gkj102openalex-snapshot
From genomics to chemical genomics: new developments in KEGG
inferredcites →https://doi.org/10.1093/nar/gkl999openalex-snapshot
BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities
inferredcites →https://doi.org/10.1093/nar/gkm862openalex-snapshot
SuperTarget and Matador: resources for exploring drug-target relationships
inferredcites →https://doi.org/10.1093/nar/gkn580openalex-snapshot
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks
inferredcites →https://doi.org/10.1093/nar/gkp937openalex-snapshot
STITCH 2: an interaction network database for small molecules and proteins
inferredcites →https://doi.org/10.1126/science.1069492openalex-snapshot
Systems Biology: A Brief Overview
inferredcites →https://doi.org/10.1126/science.1169920openalex-snapshot
Repurposing with a Difference
inferredcites →https://doi.org/10.1142/s0219720010004732openalex-snapshot
COMPUTATIONAL APPROACHES FOR DRUG REPOSITIONING AND COMBINATION THERAPY DESIGN
inferredcites →https://doi.org/10.1155/2010/426479openalex-snapshot
Literature-Based Discovery of IFN- γ and Vaccine-Mediated Gene Interaction Networks
inferredcites →https://doi.org/10.1177/0192623308329286openalex-snapshot
A Comparative Analysis of Acute-phase Proteins as Inflammatory Biomarkers in Preclinical Toxicology Studies: Implications for Preclinical to Clinical Translation
inferredcites →https://doi.org/10.1177/107385840000600408openalex-snapshot
The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?
inferredcites →https://doi.org/10.1186/1471-2105-11-s9-s7openalex-snapshot
Mining multi-item drug adverse effect associations in spontaneous reporting systems
inferredcites →https://doi.org/10.1197/jamia.m1158openalex-snapshot
Generating Hypotheses by Discovering Implicit Associations in the Literature: A Case Report of a Search for New Potential Therapeutic Uses for Thalidomide
inferredcites →https://doi.org/10.1212/wnl.46.2.583openalex-snapshot
Indomethacin and Alzheimer's disease
inferredcites →https://doi.org/10.1212/wnl.47.3.809openalex-snapshot
Linking estrogen to Alzheimer's disease
inferredcites →https://doi.org/10.1353/pbm.1986.0087openalex-snapshot
Fish Oil, Raynaud's Syndrome, and Undiscovered Public Knowledge
inferredcites →https://doi.org/10.1353/pbm.1988.0009openalex-snapshot
Migraine and Magnesium: Eleven Neglected Connections
inferredcites →https://doi.org/10.1371/journal.pbio.0030134openalex-snapshot
Systematic Association of Genes to Phenotypes by Genome and Literature Mining
inferredcites →https://doi.org/10.1371/journal.pcbi.1000450openalex-snapshot
Building Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts
inferredcites →https://doi.org/10.1371/journal.pcbi.1000943openalex-snapshot
Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases
inferredcites →https://doi.org/10.1377/hlthaff.25.2.420openalex-snapshot
Estimating The Cost Of New Drug Development: Is It Really $802 Million?
inferredcites →https://doi.org/10.1517/17460440903322234openalex-snapshot
Building a drug–target network and its applications
inferredcites →https://doi.org/10.1590/s0036-46652006000200011openalex-snapshot
Treatment of chronic hepatitis C in non-responsive patients with pegylated interferon associated with ribavirin and thalidomide: report of six cases of total remission
inferredcites →https://doi.org/10.2165/00019053-200422002-00003openalex-snapshot
Are the Economics of Pharmaceutical Research and Development Changing?
inferredcites →https://doi.org/10.2174/1570163054064675openalex-snapshot
Challenges of Target/Compound Data Integration from Disease to Chemistry: A Case Study of Dihydrofolate Reductase Inhibitors
inferredcites →https://doi.org/10.2217/14622416.8.11.1521openalex-snapshot
Literature-Based Compound Profiling: Application to Toxicogenomics
inferredcites →https://doi.org/10.3233/978-1-60750-939-4-68openalex-snapshot
Improving Literature Based Discovery Support by Genetic Knowledge Integration
inferredcites →https://doi.org/10.3844/ajptsp.2008.193.200openalex-snapshot
Proposal for the Development of Adverse Drug Reaction Prediction Model
inferredcites →https://doi.org/10.7861/clinmedicine.9-5-486openalex-snapshot
Modern methods of pharmacovigilance: detecting adverse effects of drugs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches
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Systematic Drug Repurposing Through Text Mining
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A Practical Guide for Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology
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In Silico Drug Repositioning for COVID-19: Progress and Challenges
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Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
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Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics
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Prospective adverse event risk evaluation in clinical trials
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Drug repurposing: a promising drug discovery strategy for the treatment of emerging epidemic infectious disease
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Biclustering high-frequency MeSH terms based on the co-occurrence of distinct semantic types in a MeSH tree
inferred← citeshttps://doi.org/10.1007/s11192-020-03811-zopenalex-snapshot
Scientometric analysis and knowledge mapping of literature-based discovery (1986–2020)
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Artificial intelligence for next-generation anxiolytic drug discovery: current trends, challenges, and future perspectives
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RNAi Validation of Pancreatic Cancer Antigens Identified by Cell Surface Proteomics
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Systems and Network Pharmacology Strategies for Pancreatic Ductal Adenocarcinoma Therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12283-8openalex-snapshot
Drug Repurposing Review
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Drug Repurposing for Epigenetic Targets Guided by Computational Methods
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Molecular Docking: A Structure-Based Approach for Drug Repurposing
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Application of In Silico Drug Repurposing in Infectious Diseases
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Rediscovering and repurposing natural microbial macromolecules through computational approaches
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Knowledge-Based Drug Repurposing: A Rational Approach Towards the Identification of Novel Medical Applications of Known Drugs
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Drug repurposing for neurodegenerative diseases
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Biomarker identification for statin sensitivity of cancer cell lines
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Targeting calciumopathy for neuroprotection: focus on calcium channels Cav1, Orai1 and P2X7
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theraTRACE®: a mechanism unbiased in vivo platform for phenotypic screening and drug repositioning
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Cheminformatic/bioinformatic analysis of large corporate databases: Application to drug repurposing
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Literature analysis for systematic drug repurposing: a case study from Biovista
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Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram)
inferred← citeshttps://doi.org/10.1016/j.drudis.2012.06.015openalex-snapshot
Opportunities in systems biology to discover mechanisms and repurpose drugs for CNS diseases
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Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir
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Artificial Intelligence in Pharmaceutical Sciences
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MultiGML: Multimodal graph machine learning for prediction of adverse drug events
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An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms
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Identifying plausible adverse drug reactions using knowledge extracted from the literature
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Literature Based Discovery: Models, methods, and trends
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Adverse drug event detection using reason assignments in FDA drug labels
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An In Silico investigation for acyclovir and its derivatives to fight the COVID-19: Molecular docking, DFT calculations, ADME and td-Molecular dynamics simulations
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A computational study on the role of water and conformational fluctuations in Hsp90 in response to inhibitors
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SARS-CoV-2 replication and drug discovery
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Tumor deconstruction as a tool for advanced drug screening and repositioning
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Turning liabilities into opportunities: Off-target based drug repurposing in cancer
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Tozasertib Analogues as Inhibitors of Necroptotic Cell Death
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Repurposing of Drugs Is a Viable Approach to Develop Therapeutic Strategies against Central Nervous System Related Pathogenic Amoebae
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Fingerprinting CANDO: Increased Accuracy with Structure- and Ligand-Based Shotgun Drug Repurposing
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Several New Diverse Anticonvulsant Agents Discovered in a Virtual Screening Campaign Aimed at Novel Antiepileptic Drugs to Treat Refractory Epilepsy
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Application of Computer-Aided Drug Repurposing in the Search of New Cruzipain Inhibitors: Discovery of Amiodarone and Bromocriptine Inhibitory Effects
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Lipophilic Hydroxytyrosol Esters: Fatty Acid Conjugates for Potential Topical Administration
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Novel Data-Mining Methodologies for Adverse Drug Event Discovery and Analysis
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Predicting High‐Throughput Screening Results With Scalable Literature‐Based Discovery Methods
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Drug repurposing for Alzheimer’s disease and other neurodegenerative disorders
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Finding the most promising indications for novel treatments in oncology
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Recent advances in biomedical literature mining
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Drug interaction networks: an introduction to translational and clinical applications
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‘RE:fine drugs’: an interactive dashboard to access drug repurposing opportunities
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Binary Relation Extraction from Biomedical Literature using Dependency Trees and SVMs
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Prediction Of User Ratings For Drug Side Effects Using Deep Neural Network With Contextual Co-occurrence Based Word-Embedding Vector
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An Analytical Review of Computational Drug Repurposing
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Review of Natural Language Processing in Pharmacology
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Data-Driven Prediction of Drug Effects and Interactions
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Accessibility of trial reports for drugs stalling in development: a systematic assessment of registered trials
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Investigating Multiview and Multitask Learning Frameworks for Predicting Drug-Disease Associations
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Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing
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Combination of Deep Recurrent Neural Networks and Conditional Random Fields for Extracting Adverse Drug Reactions from User Reviews
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A Review: Treatment of Alzheimer’s Disease Discovered in Repurposed Agents
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Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity
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Optimising chemical named entity recognition with pre-processing analytics, knowledge-rich features and heuristics
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Identifying Novel Drug Indications through Automated Reasoning
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Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling
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How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
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Novel models for assessing blood–brain barrier drug permeation
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Orphan drug approvals in Europe since 2001: an analysis by indication
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From depression to neurodegeneration and heart failure: re-examining the potential of MAO inhibitors
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Strategies for potentiation of ethionamide and folate antagonists againstMycobacterium tuberculosis
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In Silico Study for Acyclovir and Its Derivatives Against Mpro of nCoV: Temperature Dependent Molecular Dynamics Simulations
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Recent Advances in Drug Repurposing for Parkinson’s Disease
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Anti-Cancer Potential of Some Commonly Used Drugs
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Is There a Relationship Between Sweet Taste and Seizures? Anticonvulsant and Proconvulsant Effects of Non-Nutritive Sweeteners
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High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease
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Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery
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Understanding Drug Repurposing From the Perspective of Biomedical Entities and Their Evolution: Bibliographic Research Using Aspirin
inferred← citeshttps://doi.org/10.2196/21169openalex-snapshot
The Anatomy of the SARS-CoV-2 Biomedical Literature: Introducing the CovidX Network Algorithm for Drug Repurposing Recommendation
inferred← citeshttps://doi.org/10.2196/resprot.5621openalex-snapshot
Using Social Media Data to Identify Potential Candidates for Drug Repurposing: A Feasibility Study
inferred← citeshttps://doi.org/10.2337/dc14-2515openalex-snapshot
Hypothyroidism Is a Risk Factor for New-Onset Diabetes: A Cohort Study
inferred← citeshttps://doi.org/10.26717/bjstr.2019.17.002975openalex-snapshot
Briefly about Anticancer Properties of Statins
inferred← citeshttps://doi.org/10.29219/fnr.v65.7549openalex-snapshot
Evaluation of Colocasia esculenta Schott in anti-cancerous properties with proximity extension assays
inferred← citeshttps://doi.org/10.3389/fbioe.2019.00156openalex-snapshot
SemNet: Using Local Features to Navigate the Biomedical Concept Graph
inferred← citeshttps://doi.org/10.3389/fonc.2020.595351openalex-snapshot
Repurposing Individualized Nutritional Intervention as a Therapeutic Component to Prevent the Adverse Effects of Radiotherapy in Patients With Cervical Cancer
inferred← citeshttps://doi.org/10.3389/fphar.2018.00583openalex-snapshot
DeCoST: A New Approach in Drug Repurposing From Control System Theory
inferred← citeshttps://doi.org/10.3389/frma.2021.644614openalex-snapshot
PubMed-Scale Chemical Concept Embeddings Reconstruct Physical Protein Interaction Networks
inferred← citeshttps://doi.org/10.3389/frma.2021.644728openalex-snapshot
Using Literature Based Discovery to Gain Insights Into the Metabolomic Processes of Cardiac Arrest
inferred← citeshttps://doi.org/10.3390/ijms241612876openalex-snapshot
A Re-Purposing Strategy: Sub-Lethal Concentrations of an Eicosanoid Derived from the Omega-3-Polyunsaturated Fatty Acid Resolvin D1 Affect Dual Species Biofilms
inferred← citeshttps://doi.org/10.3390/ijms25073747openalex-snapshot
Integrated Computational Approaches for Drug Design Targeting Cruzipain
inferred← citeshttps://doi.org/10.35537/10915/100890openalex-snapshot
Tamizado virtual aplicado a la búsqueda de nuevos fármacos antiepilépticos activos en el modelo de 6 Hz
inferred← citeshttps://doi.org/10.35537/10915/137336openalex-snapshot
BÚSQUEDA DE NUEVOS FÁRMACOS ANTICHAGÁSICOS INHIBIDORES DE LA TRIPANOTIÓN SINTETASA
inferred← citeshttps://doi.org/10.35537/10915/43315openalex-snapshot
Búsqueda racional de nuevos fármacos antichagásicos inhibidores de la cruzipaína
inferred← citeshttps://doi.org/10.35537/10915/51575openalex-snapshot
Topología molecular aplicada a la búsqueda de nuevos fármacos para el tratamiento de la epilepsia refractaria
inferred← citeshttps://doi.org/10.5599/admet.2772openalex-snapshot
Leveraging machine learning models in evaluating ADMET properties for drug discovery and development
inferred← citeshttps://doi.org/10.7232/jkiie.2014.40.3.325openalex-snapshot
Development of an Evaluation Method for a Driver's Cognitive Workload Using ECG Signal
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