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Effect of Detergent on “Promiscuous” Inhibitors
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/0076-6879(90)82020-3openalex-snapshot
[18] Detergents: An overview
inferredcites →https://doi.org/10.1016/0076-6879(90)82021-sopenalex-snapshot
[19] Solubilization of native membrane proteins
inferredcites →https://doi.org/10.1016/s0169-409x(00)00129-0openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
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Recognizing molecules with drug-like properties
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Crystallographic Structure of a Phosphonate Derivative of the Enterobacter cloacae P99 Cephalosporinase: Mechanistic Interpretation of a .beta.-Lactamase Transition-State Analog
inferredcites →https://doi.org/10.1021/jm010533yopenalex-snapshot
A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening
inferredcites →https://doi.org/10.1021/jm015507eopenalex-snapshot
Simple Selection Criteria for Drug-like Chemical Matter
inferredcites →https://doi.org/10.1021/jm020427bopenalex-snapshot
Kinase Inhibitors: Not Just for Kinases Anymore
inferredcites →https://doi.org/10.1042/bj2280241openalex-snapshot
The β-lactamase of Enterobacter cloacae P99. Chemical properties, N-terminal sequence and interaction with 6β-halogenopenicillanates
inferredcites →https://doi.org/10.1073/pnas.90.23.11257openalex-snapshot
Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors
inferred← citeshttps://doi.org/10.1021/jm200022gopenalex-snapshot
Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH) Phosphatase
inferred← citeshttps://doi.org/10.1021/jm201243popenalex-snapshot
Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry
inferred← citeshttps://doi.org/10.1021/jm301008nopenalex-snapshot
Rules for Identifying Potentially Reactive or Promiscuous Compounds
inferred← citeshttps://doi.org/10.1021/jm700952vopenalex-snapshot
Surface Plasmon Resonance Based Assay for the Detection and Characterization of Promiscuous Inhibitors
inferred← citeshttps://doi.org/10.1021/jm800762uopenalex-snapshot
Novel Naphthalene-N-sulfonyl- d -glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme,
inferred← citeshttps://doi.org/10.1021/jm801605ropenalex-snapshot
Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding
inferred← citeshttps://doi.org/10.1021/jm900314jopenalex-snapshot
Identification of Inhibitors of Checkpoint Kinase 1 through Template Screening
inferred← citeshttps://doi.org/10.1021/jm900776mopenalex-snapshot
Novel Inhibitors of Dengue Virus Methyltransferase: Discovery by in Vitro-Driven Virtual Screening on a Desktop Computer Grid
inferred← citeshttps://doi.org/10.1021/jm9009229openalex-snapshot
Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series
inferred← citeshttps://doi.org/10.1021/jm901070copenalex-snapshot
Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease
inferred← citeshttps://doi.org/10.1021/jm901137jopenalex-snapshot
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
inferred← citeshttps://doi.org/10.1038/nchembio718openalex-snapshot
High-throughput assays for promiscuous inhibitors
inferred← citeshttps://doi.org/10.1038/nprot.2006.77openalex-snapshot
A detergent-based assay for the detection of promiscuous inhibitors
inferred← citeshttps://doi.org/10.1038/s41467-018-02956-zopenalex-snapshot
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors
inferred← citeshttps://doi.org/10.1038/s41557-019-0234-9openalex-snapshot
Computational advances in combating colloidal aggregation in drug discovery
inferred← citeshttps://doi.org/10.1038/s41596-021-00612-3openalex-snapshot
Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities
inferred← citeshttps://doi.org/10.1038/s41598-018-26577-0openalex-snapshot
Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors
inferred← citeshttps://doi.org/10.1038/sj.onc.1210729openalex-snapshot
A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D
inferred← citeshttps://doi.org/10.1039/b616314aopenalex-snapshot
Stability and equilibria of promiscuous aggregates in high protein milieus
inferred← citeshttps://doi.org/10.1039/c5cp01980jopenalex-snapshot
Investigating the molecular and aggregated states of a drug molecule rutaecarpine using spectroscopy, microscopy, crystallography and computational studies
inferred← citeshttps://doi.org/10.1039/c6lc01072eopenalex-snapshot
Monitoring few molecular binding events in scalable confined aqueous compartments by raster image correlation spectroscopy (CADRICS)
inferred← citeshttps://doi.org/10.1039/c8cp03404dopenalex-snapshot
Self-assembly and biological activities of ionic liquid crystals derived from aromatic amino acids
inferred← citeshttps://doi.org/10.1039/c9nj00703bopenalex-snapshot
A new efficient domino approach for the synthesis of coumarin-pyrazolines as antimicrobial agents targeting bacterial d -alanine- d -alanine ligase
inferred← citeshttps://doi.org/10.1039/c9ra06466dopenalex-snapshot
Resonant waveguide grating based assays for colloidal aggregate detection and promiscuity characterization in natural products
inferred← citeshttps://doi.org/10.1039/d6md00502kopenalex-snapshot
Rhodanine and 2,4-dioxothiazolidine-based amides: synthesis and evaluation as dual-action cholinesterase inhibitors and antioxidants
inferred← citeshttps://doi.org/10.1055/s-0034-1383061openalex-snapshot
How to Translate a Bioassay Into a Screening Assay for Natural Products: General Considerations and Implementation of Antimicrobial Screens
inferred← citeshttps://doi.org/10.1073/pnas.0805820105openalex-snapshot
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei
inferred← citeshttps://doi.org/10.1073/pnas.1102376108openalex-snapshot
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
inferred← citeshttps://doi.org/10.1074/jbc.m113.503474openalex-snapshot
Structural Determinants of Tau Aggregation Inhibitor Potency
inferred← citeshttps://doi.org/10.1074/jbc.m501100200openalex-snapshot
High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase
inferred← citeshttps://doi.org/10.1080/17576180.2025.2580287openalex-snapshot
Development of a fit-for-purpose semi-homogeneous competitive ELISA for total PEG quantitation in a PEGylated molecule
inferred← citeshttps://doi.org/10.1089/adt.2010.0345openalex-snapshot
Validation of an Optical Microplate Label-Free Platform in the Screening of Chemical Libraries for Direct Binding to a Nuclear Receptor
inferred← citeshttps://doi.org/10.1093/bioinformatics/btp380openalex-snapshot
A survey of across-target bioactivity results of small molecules in PubChem
inferred← citeshttps://doi.org/10.1093/nar/gkae424openalex-snapshot
ChemFH: an integrated tool for screening frequent false positives in chemical biology and drug discovery
inferred← citeshttps://doi.org/10.1093/toxsci/kfl092openalex-snapshot
Nature of the Binding Interaction for 50 Structurally Diverse Chemicals with Rat Estrogen Receptors
inferred← citeshttps://doi.org/10.1096/fj.09-143743openalex-snapshot
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights
inferred← citeshttps://doi.org/10.1101/2023.10.14.562361openalex-snapshot
Selective Smurf1 E3 ligase inhibitors that prevent transthiolation
inferred← citeshttps://doi.org/10.1107/s0907444911018610openalex-snapshot
Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of theYersinia pestisprotein tyrosine phosphatase YopH
inferred← citeshttps://doi.org/10.1109/iembs.2009.5333796openalex-snapshot
A method for identifying small molecule aggregators using photonic crystal biosensor microplates
inferred← citeshttps://doi.org/10.1111/cbdd.13787openalex-snapshot
Gallotannins are non‐specific inhibitors of α‐amylase: Aggregates are the active species taking part in inhibition
inferred← citeshttps://doi.org/10.1111/tra.12119openalex-snapshot
Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis
inferred← citeshttps://doi.org/10.11606/t.46.2016.tde-10082016-115529openalex-snapshot
Modelos de virtual Screening de inibidores da cruzaína: desenvolvimento e validação experimental
inferred← citeshttps://doi.org/10.11606/t.9.2021.tde-06072021-104351openalex-snapshot
Inibidores de Desmetilase Lisina-Específica 1 (LSD1) como candidatos a agentes antineoplásicos
inferred← citeshttps://doi.org/10.1177/1087057105281173openalex-snapshot
Experimental Screening of Dihydrofolate Reductase Yields a “Test Set” of 50,000 Small Molecules for a Computational Data-Mining and Docking Competition
inferred← citeshttps://doi.org/10.1177/1087057106290992openalex-snapshot
Identification of Small-Molecule Inhibitors of Protein Kinase B (PKB/AKT) in an AlphaScreen™ High-Throughput Screen
inferred← citeshttps://doi.org/10.1177/1087057106294094openalex-snapshot
A Microfluidics-Based Mobility Shift Assay to Discover New Tyrosine Phosphatase Inhibitors
inferred← citeshttps://doi.org/10.1177/1087057107304113openalex-snapshot
A Simple Assay for Detection of Small-Molecule Redox Activity
inferred← citeshttps://doi.org/10.1177/1087057109332597openalex-snapshot
New High-Throughput Fluorimetric Assay for Discovering Inhibitors of UDP-N-Acetylmuramyl-l-Alanine: d-Glutamate (MurD) Ligase
inferred← citeshttps://doi.org/10.1177/1087057109336586openalex-snapshot
Efficient Elimination of Nonstoichiometric Enzyme Inhibitors from HTS Hit Lists
inferred← citeshttps://doi.org/10.1177/1087057110376537openalex-snapshot
Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors of the Cell Cycle–Regulated Nek2 Kinase
inferred← citeshttps://doi.org/10.1177/1087057111417712openalex-snapshot
A Continuous, Fluorescent, High-Throughput Assay for Human Dimethylarginine Dimethylaminohydrolase-1
inferred← citeshttps://doi.org/10.1177/1087057111421525openalex-snapshot
Case Studies of Minimizing Nonspecific Inhibitors in HTS Campaigns That Use Assay-Ready Plates
inferred← citeshttps://doi.org/10.1177/1087057113492851openalex-snapshot
A Label-Free LC/MS/MS-Based Enzymatic Activity Assay for the Detection of Genuine Caspase Inhibitors and SAR Development
inferred← citeshttps://doi.org/10.1177/1087057113494805openalex-snapshot
Human Rhinovirus VPg Uridylylation AlphaScreen for High-Throughput Screening
inferred← citeshttps://doi.org/10.1177/1087057113518069openalex-snapshot
Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry
inferred← citeshttps://doi.org/10.1177/2472555218757180openalex-snapshot
Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds
inferred← citeshttps://doi.org/10.1177/2472555218818786openalex-snapshot
Perspective on Antibacterial Lead Identification Challenges and the Role of Hypothesis-Driven Strategies
inferred← citeshttps://doi.org/10.1371/journal.pone.0034806openalex-snapshot
The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone
inferred← citeshttps://doi.org/10.1371/journal.pone.0038086openalex-snapshot
Application of Consensus Scoring and Principal Component Analysis for Virtual Screening against β-Secretase (BACE-1)
inferred← citeshttps://doi.org/10.1371/journal.pone.0078877openalex-snapshot
A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation
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