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Farnesoid X Receptor: From Structure to Potential Clinical Applications

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-4419-9034-1openalex-snapshot

Molecular Pathogenesis of Cholestasis

inferredcites →https://doi.org/10.1007/bf00877420openalex-snapshot

Hypolipidemic and antioxidant effects of commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia

inferredcites →https://doi.org/10.1016/0092-8674(88)90552-1openalex-snapshot

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

inferredcites →https://doi.org/10.1016/0092-8674(95)90075-6openalex-snapshot

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

inferredcites →https://doi.org/10.1016/0092-8674(95)90530-8openalex-snapshot

Identification of a nuclear receptor that is activated by farnesol metabolites

inferredcites →https://doi.org/10.1016/0303-7207(94)90294-1openalex-snapshot

Peroxisome proliferator-activated receptors: finding the orphan a home

inferredcites →https://doi.org/10.1016/j.bbrc.2005.01.141openalex-snapshot

Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

inferredcites →https://doi.org/10.1016/j.biochi.2004.11.018openalex-snapshot

Potential regulatory role of the farnesoid X receptor in the metabolic syndrome

inferredcites →https://doi.org/10.1016/j.jhep.2003.11.006openalex-snapshot

Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms

inferredcites →https://doi.org/10.1016/j.jmb.2003.10.033openalex-snapshot

Crystal Structure of the Human Liver X Receptor β Ligand-binding Domain in Complex with a Synthetic Agonist

inferredcites →https://doi.org/10.1016/j.ymgme.2004.07.007openalex-snapshot

T0901317 is a dual LXR/FXR agonist

inferredcites →https://doi.org/10.1016/s0002-9149(01)02221-4openalex-snapshot

Elucidation of the molecular mechanism of action of selective estrogen receptor modulators

inferredcites →https://doi.org/10.1016/s0016-5085(03)00388-3openalex-snapshot

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

inferredcites →https://doi.org/10.1016/s0016-5085(03)00896-5openalex-snapshot

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

inferredcites →https://doi.org/10.1016/s0021-9258(18)92835-8openalex-snapshot

Effect of hydrophobic bile acids on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and mRNA levels in the rat

inferredcites →https://doi.org/10.1016/s0022-2275(20)30272-8openalex-snapshot

Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids

inferredcites →https://doi.org/10.1016/s0022-2275(20)34421-7openalex-snapshot

Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem

inferredcites →https://doi.org/10.1016/s0022-3565(24)38923-2openalex-snapshot

Molecular Mechanisms of Selective Estrogen Receptor Modulator (SERM) Action

inferredcites →https://doi.org/10.1016/s0076-6879(03)64004-8openalex-snapshot

Cell-Free Ligand Binding Assays for Nuclear Receptors

inferredcites →https://doi.org/10.1016/s0076-6879(03)64005-xopenalex-snapshot

Design and Synthesis of Receptor Ligands

inferredcites →https://doi.org/10.1016/s0092-8674(00)00062-3openalex-snapshot

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

inferredcites →https://doi.org/10.1016/s0092-8674(00)80900-9openalex-snapshot

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

inferredcites →https://doi.org/10.1016/s0092-8674(00)81432-4openalex-snapshot

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

inferredcites →https://doi.org/10.1016/s0168-8278(02)00429-4openalex-snapshot

Liver fibrosis – from bench to bedside

inferredcites →https://doi.org/10.1016/s0378-1119(00)00518-7openalex-snapshot

Regulation of cholesterol 7α-hydroxylase gene ( CYP7A1 ) transcription by the liver orphan receptor (LXRα)

inferredcites →https://doi.org/10.1016/s0960-894x(03)00281-6openalex-snapshot

Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR)

inferredcites →https://doi.org/10.1016/s1043-2760(02)00640-9openalex-snapshot

Guggulsterone: an old approach to a new problem

inferredcites →https://doi.org/10.1016/s1043-2760(02)00646-xopenalex-snapshot

Time to consider new brain clock signals

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Hyperinsulinemia, Dyslipidemia, and Obesity as Risk Factors for Hospitalized Gallbladder Disease

inferredcites →https://doi.org/10.1016/s1097-2765(00)00050-2openalex-snapshot

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

inferredcites →https://doi.org/10.1016/s1097-2765(00)00051-4openalex-snapshot

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

inferredcites →https://doi.org/10.1016/s1097-2765(00)80348-2openalex-snapshot

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

inferredcites →https://doi.org/10.1016/s1097-2765(03)00104-7openalex-snapshot

A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

inferredcites →https://doi.org/10.1016/s1097-2765(03)00112-6openalex-snapshot

Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

inferredcites →https://doi.org/10.1016/s1097-2765(03)00133-3openalex-snapshot

Nuclear Receptor Ligands and Cofactor Recruitment

inferredcites →https://doi.org/10.1016/s1388-1981(02)00186-5openalex-snapshot

On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α

inferredcites →https://doi.org/10.1021/jm00016a018openalex-snapshot

Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

inferredcites →https://doi.org/10.1021/jm025529gopenalex-snapshot

6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

inferredcites →https://doi.org/10.1021/jm049182oopenalex-snapshot

Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor. Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding

inferredcites →https://doi.org/10.1021/jm049904bopenalex-snapshot

Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure−Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid

inferredcites →https://doi.org/10.1038/26996openalex-snapshot

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

inferredcites →https://doi.org/10.1038/27001openalex-snapshot

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

inferredcites →https://doi.org/10.1038/340245a0openalex-snapshot

A novel genetic system to detect protein–protein interactions

inferredcites →https://doi.org/10.1038/340246a0openalex-snapshot

An elF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 5OS ribosomal subunit assembly

inferredcites →https://doi.org/10.1038/355446a0openalex-snapshot

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

inferredcites →https://doi.org/10.1038/355449a0openalex-snapshot

Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+

inferredcites →https://doi.org/10.1038/383728a0openalex-snapshot

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

inferredcites →https://doi.org/10.1038/nsb0196-87openalex-snapshot

A canonical structure for the ligand-binding domain of nuclear receptors

inferredcites →https://doi.org/10.1039/b300525aopenalex-snapshot

Discovery and optimization of non-steroidal FXR agonists from natural product-like librariesElectronic supplementary information (ESI) available: schemes describing the synthesis of compounds in Fig. 2, 4, 5, 6 and 7. All final compounds were characterized by 1H NMR spectroscopy and HRMS are…

inferredcites →https://doi.org/10.1042/bj2900685openalex-snapshot

Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes

inferredcites →https://doi.org/10.1042/bj3280393openalex-snapshot

The 3′-untranslated region of the mouse cholesterol 7α-hydroxylase mRNA contains elements responsive to post-transcriptional regulation by bile acids

inferredcites →https://doi.org/10.1053/gast.2001.25503openalex-snapshot

The Orphan Nuclear Receptor, shp, Mediates Bile Acid-Induced Inhibition of the Rat Bile Acid Transporter, ntcp

inferredcites →https://doi.org/10.1053/gast.2002.33666openalex-snapshot

Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro

inferredcites →https://doi.org/10.1053/j.gastro.2004.08.001openalex-snapshot

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

inferredcites →https://doi.org/10.1056/nejm199810223391707openalex-snapshot

Molecular Pathogenesis of Cholestasis

inferredcites →https://doi.org/10.1073/pnas.0400046101openalex-snapshot

Expression and activation of the farnesoid X receptor in the vasculature

inferredcites →https://doi.org/10.1073/pnas.051551698openalex-snapshot

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

inferredcites →https://doi.org/10.1073/pnas.94.15.7909openalex-snapshot

Activation of the orphan receptor RIP14 by retinoids

inferredcites →https://doi.org/10.1073/pnas.94.9.4318openalex-snapshot

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

inferredcites →https://doi.org/10.1074/jbc.272.6.3137openalex-snapshot

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

inferredcites →https://doi.org/10.1074/jbc.274.42.29749openalex-snapshot

Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

inferredcites →https://doi.org/10.1074/jbc.275.14.10638openalex-snapshot

Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor

inferredcites →https://doi.org/10.1074/jbc.275.15.10918openalex-snapshot

Farnesoid X Receptor Responds to Bile Acids and Represses Cholesterol 7α-Hydroxylase Gene (CYP7A1) Transcription

inferredcites →https://doi.org/10.1074/jbc.m006577200openalex-snapshot

Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation

inferredcites →https://doi.org/10.1074/jbc.m007998200openalex-snapshot

The Farnesoid X-activated Receptor Mediates Bile Acid Activation of Phospholipid Transfer Protein Gene Expression

inferredcites →https://doi.org/10.1074/jbc.m011610200openalex-snapshot

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

inferredcites →https://doi.org/10.1074/jbc.m107557200openalex-snapshot

Dehydroepiandrosterone Sulfotransferase Gene Induction by Bile Acid Activated Farnesoid X Receptor

inferredcites →https://doi.org/10.1074/jbc.m110869200openalex-snapshot

The Structural Basis for the Specificity of Retinoid-X Receptor-selective Agonists: New Insights Into the Role of Helix H12

inferredcites →https://doi.org/10.1074/jbc.m111795200openalex-snapshot

FOR, a Novel Orphan Nuclear Receptor Related to Farnesoid X Receptor

inferredcites →https://doi.org/10.1074/jbc.m200474200openalex-snapshot

Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity

inferredcites →https://doi.org/10.1074/jbc.m200824200openalex-snapshot

The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate

inferredcites →https://doi.org/10.1074/jbc.m204887200openalex-snapshot

Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles

inferredcites →https://doi.org/10.1074/jbc.m209323200openalex-snapshot

Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump

inferredcites →https://doi.org/10.1074/jbc.m209505200openalex-snapshot

Natural Structural Variants of the Nuclear Receptor Farnesoid X Receptor Affect Transcriptional Activation

inferredcites →https://doi.org/10.1074/jbc.m209863200openalex-snapshot

Identification of Gene-selective Modulators of the Bile Acid Receptor FXR

inferredcites →https://doi.org/10.1074/jbc.m301302200openalex-snapshot

The Human Apolipoprotein AV Gene Is Regulated by Peroxisome Proliferator-activated Receptor-α and Contains a Novel Farnesoid X-activated Receptor Response Element

inferredcites →https://doi.org/10.1074/jbc.m302128200openalex-snapshot

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

inferredcites →https://doi.org/10.1074/jbc.m302505200openalex-snapshot

Syndecan-1 Expression Is Regulated in an Isoform-specific Manner by the Farnesoid-X Receptor

inferredcites →https://doi.org/10.1074/jbc.m304568200openalex-snapshot

Human Kininogen Gene Is Transactivated by the Farnesoid X Receptor

inferredcites →https://doi.org/10.1074/jbc.m306422200openalex-snapshot

The Farnesoid X Receptor Controls Gene Expression in a Ligand- and Promoter-selective Fashion

inferredcites →https://doi.org/10.1074/jbc.m307145200openalex-snapshot

Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity

inferredcites →https://doi.org/10.1074/jbc.m308094200openalex-snapshot

Apomine, a Novel Hypocholesterolemic Agent, Accelerates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase and Stimulates Low Density Lipoprotein Receptor Activity

inferredcites →https://doi.org/10.1074/jbc.m308321200openalex-snapshot

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

inferredcites →https://doi.org/10.1089/154065803772613462openalex-snapshot

Coactivators in Assay Design for Nuclear Hormone Receptor Drug Discovery

inferredcites →https://doi.org/10.1093/nar/gkg444openalex-snapshot

The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily

inferredcites →https://doi.org/10.1101/gad.1083503openalex-snapshot

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

inferredcites →https://doi.org/10.1101/gad.1138104openalex-snapshot

Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR

inferredcites →https://doi.org/10.1101/gad.844900openalex-snapshot

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

inferredcites →https://doi.org/10.1101/gad.850400openalex-snapshot

Role of LXRs in control of lipogenesis

inferredcites →https://doi.org/10.1124/jpet.103.064329openalex-snapshot

Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor

inferredcites →https://doi.org/10.1124/jpet.104.079665openalex-snapshot

Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis

inferredcites →https://doi.org/10.1124/mi.2.2.78openalex-snapshot

LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing

inferredcites →https://doi.org/10.1124/mol.104.007054openalex-snapshot

The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand

inferredcites →https://doi.org/10.1126/science.1069434openalex-snapshot

Operant Reward Learning in Aplysia : Neuronal Correlates and Mechanisms

inferredcites →https://doi.org/10.1126/science.1072891openalex-snapshot

A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR

inferredcites →https://doi.org/10.1126/science.284.5415.757openalex-snapshot

Orphan Nuclear Receptors: Shifting Endocrinology into Reverse

inferredcites →https://doi.org/10.1126/science.284.5415.760openalex-snapshot

Cryptochromes: Blue Light Receptors for Plants and Animals

inferredcites →https://doi.org/10.1126/science.284.5418.1362openalex-snapshot

Identification of a Nuclear Receptor for Bile Acids

inferredcites →https://doi.org/10.1126/science.284.5418.1365openalex-snapshot

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

inferredcites →https://doi.org/10.1126/science.284.5418.1368openalex-snapshot

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

inferredcites →https://doi.org/10.1126/science.289.5484.1524openalex-snapshot

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

inferredcites →https://doi.org/10.1128/mcb.23.3.864-872.2003openalex-snapshot

Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol

inferredcites →https://doi.org/10.1146/annurev.nutr.23.011702.073102openalex-snapshot

G UGULIPID : A Natural Cholesterol-Lowering Agent

inferredcites →https://doi.org/10.1152/physrev.00027.2002openalex-snapshot

Bile Salt Transporters: Molecular Characterization, Function, and Regulation

inferredcites →https://doi.org/10.1172/jci0214505openalex-snapshot

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

inferredcites →https://doi.org/10.1172/jci14505openalex-snapshot

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

inferredcites →https://doi.org/10.1172/jci18945openalex-snapshot

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

inferredcites →https://doi.org/10.1172/jci21025openalex-snapshot

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

inferredcites →https://doi.org/10.1186/gb-2001-2-8-research0029openalex-snapshot

Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes

inferredcites →https://doi.org/10.1194/jlr.c200014-jlr200openalex-snapshot

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

inferredcites →https://doi.org/10.1194/jlr.m300215-jlr200openalex-snapshot

Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation

inferredcites →https://doi.org/10.1194/jlr.m400102-jlr200openalex-snapshot

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

inferredcites →https://doi.org/10.1194/jlr.m400294-jlr200openalex-snapshot

Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative

inferredcites →https://doi.org/10.1210/edrv-11-2-201openalex-snapshot

Steroid Receptor Family: Structure and Functions

inferredcites →https://doi.org/10.1210/edrv.20.5.0378openalex-snapshot

Orphan Nuclear Receptors: From Gene to Function

inferredcites →https://doi.org/10.1210/en.2004-0965openalex-snapshot

Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor

inferredcites →https://doi.org/10.1210/me.16.7.1590openalex-snapshot

The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor

inferredcites →https://doi.org/10.1210/me.2002-0120openalex-snapshot

Bile Acids Induce the Expression of the Human Peroxisome Proliferator-Activated Receptor α Gene via Activation of the Farnesoid X Receptor

inferredcites →https://doi.org/10.1210/me.9.1.72openalex-snapshot

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors

inferredcites →https://doi.org/10.1210/mend.15.10.0712openalex-snapshot

Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

inferredcites →https://doi.org/10.1210/rp.57.1.295openalex-snapshot

Definition of the Molecular and Cellular Mechanisms Underlying the Tissue-selective Agonist/Antagonist Activities of Selective Estrogen Receptor Modulators

inferredcites →https://doi.org/10.1358/dnp.2004.17.8.863693openalex-snapshot

FXR as a novel therapeutic target for vascular disease

inferredcites →https://doi.org/10.2174/1381612013398185openalex-snapshot

The Nuclear Receptors FXR and LX alpha Potential Targets for the Development of Drugs Affecting Lipid Metabolism and Neoplastic Diseases

inferredcites →https://doi.org/10.2174/138620703106298365openalex-snapshot

Development and Application of Fluorescence Polarization Assays in Drug Discovery

inferredcites →https://doi.org/10.2337/diabetes.53.4.890openalex-snapshot

Glucose Regulates the Expression of the Farnesoid X Receptor in Liver

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4167582openalex-extracted

Discovery of 12β-Oxygenated Oleanolic Acid Alkyl Esters as Potent and Selective FXR Antagonists Exhibiting Hyperglycemia Amelioration in Vivo

inferred← citeshttps://doi.org/10.1002/9780470495018.ch8openalex-snapshot

Interaction of a Biological Response Modifier with Proteins

inferred← citeshttps://doi.org/10.1002/9780470691861.ch3dopenalex-snapshot

Cellular Cholestasis

inferred← citeshttps://doi.org/10.1002/9780470747919.ch43openalex-snapshot

Adaptive Regulation of Hepatocyte Transporters in Cholestasis

inferred← citeshttps://doi.org/10.1002/9783527621460.ch14openalex-snapshot

Ligand Features Essential for Cytochrome P450 Induction

inferred← citeshttps://doi.org/10.1002/9783527673261.ch14openalex-snapshot

Pharmacophore‐Based Methods for Predicting the Inhibition and Induction of Metabolic Enzymes

inferred← citeshttps://doi.org/10.1002/chin.200547239openalex-snapshot

Farnesoid X Receptor: From Structure to Potential Clinical Applications

inferred← citeshttps://doi.org/10.1002/cld.588openalex-snapshot

Novel treatments in primary sclerosing cholangitis

inferred← citeshttps://doi.org/10.1002/hep.22712openalex-snapshot

Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid–induced liver hypertrophy†

inferred← citeshttps://doi.org/10.1002/jbmr.1961openalex-snapshot

Positive regulation of osteogenesis by bile acid through FXR

inferred← citeshttps://doi.org/10.1002/lipd.12125openalex-snapshot

n‐3 Fatty Acids Abrogate Dyslipidemia‐Induced Changes in Bile Acid Uptake, Synthesis, and Transport in Young and Aged Dyslipidemic Rats

inferred← citeshttps://doi.org/10.1002/med.20142openalex-snapshot

Recent and emerging anti‐diabetes targets

inferred← citeshttps://doi.org/10.1002/prot.21661openalex-snapshot

Molecular dynamics simulation study for LRH‐1: Interaction with fragments of SHP and function of phospholipid ligand

inferred← citeshttps://doi.org/10.1002/slct.202200662openalex-snapshot

Design, Synthesis, and Biological Examination of N‐ Phenyl‐6‐fluoro‐4‐hydroxy‐2‐quinolone‐3‐carboxamides as Anticancer Agents

inferred← citeshttps://doi.org/10.1007/978-3-319-19456-1_19-1openalex-snapshot

Lanostanoids from Fungi as Potential Medicinal Agents

inferred← citeshttps://doi.org/10.1007/978-3-319-25001-4_19openalex-snapshot

Lanostanoids from Fungi as Potential Medicinal Agents

inferred← citeshttps://doi.org/10.1007/978-981-13-1571-8_2openalex-snapshot

TGR5 Receptor

inferred← citeshttps://doi.org/10.1007/s00210-025-04061-7openalex-snapshot

Synergistic action of cilnidipine and bexarotene in mitigating cholestatic liver damage: role of FXR signaling cascade

inferred← citeshttps://doi.org/10.1007/s10549-007-9535-6openalex-snapshot

Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation

inferred← citeshttps://doi.org/10.1007/s10593-013-1265-6openalex-snapshot

Methyl trifluoropyruvate N-(pyrimidin-2-yl)imines in cyclocondensation reactions with 1,3-binucleophilic reagents

inferred← citeshttps://doi.org/10.1007/s10822-017-0054-1openalex-snapshot

Blinded evaluation of farnesoid X receptor (FXR) ligands binding using molecular docking and free energy calculations

inferred← citeshttps://doi.org/10.1007/s10822-017-0056-zopenalex-snapshot

Binding affinities of the farnesoid X receptor in the D3R Grand Challenge 2 estimated by free-energy perturbation and docking

inferred← citeshttps://doi.org/10.1007/s11172-010-0061-zopenalex-snapshot

Modification of biologically active amides and amines with fluorine-containing heterocycles 1. Novel fluorine-containing heterocyclic derivatives of streptocide

inferred← citeshttps://doi.org/10.1007/s12291-024-01292-yopenalex-snapshot

Farnesoid X Receptor-Mediated Bile Acids Regulation in Cholestasis

inferred← citeshttps://doi.org/10.1007/s12672-023-00808-xopenalex-snapshot

Delineating the role of nuclear receptors in colorectal cancer, a focused review

inferred← citeshttps://doi.org/10.1016/j.apsb.2015.01.004openalex-snapshot

Bile acid nuclear receptor FXR and digestive system diseases

inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.08.020openalex-snapshot

DAX1 suppresses FXR transactivity as a novel co-repressor

inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.106203openalex-snapshot

Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115606openalex-snapshot

The regulation of tissue-specific farnesoid X receptor on genes and diseases involved in bile acid homeostasis

inferred← citeshttps://doi.org/10.1016/j.bmc.2007.01.046openalex-snapshot

Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist

inferred← citeshttps://doi.org/10.1016/j.bmc.2011.03.004openalex-snapshot

Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine

inferred← citeshttps://doi.org/10.1016/j.bmc.2011.09.039openalex-snapshot

Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum

inferred← citeshttps://doi.org/10.1016/j.bmc.2011.09.056openalex-snapshot

Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation

inferred← citeshttps://doi.org/10.1016/j.bmc.2013.04.069openalex-snapshot

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.08.021openalex-snapshot

Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.03.075openalex-snapshot

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands

inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.01.079openalex-snapshot

3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.09.027openalex-snapshot

Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.07.148openalex-snapshot

Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR)

inferred← citeshttps://doi.org/10.1016/j.cbpb.2017.09.007openalex-snapshot

Molecular cloning and characterization of farnesoid X receptor from large yellow croaker ( Larimichthys crocea ) and the effect of dietary CDCA on the expression of inflammatory genes in intestine and spleen

inferred← citeshttps://doi.org/10.1016/j.dmd.2025.100190openalex-snapshot

Downregulation of hepatic sulfotransferase 1E1 expression associated with decreased expression of multidrug resistance–associated protein 2

inferred← citeshttps://doi.org/10.1016/j.drudis.2018.09.007openalex-snapshot

Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.08.013openalex-snapshot

Some molecular targets for antihyperlipidemic drug research

inferred← citeshttps://doi.org/10.1016/j.jare.2024.10.028openalex-snapshot

Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe

inferred← citeshttps://doi.org/10.1016/j.jfluchem.2006.01.011openalex-snapshot

Fluorine in medicinal chemistry: A review of anti-cancer agents

inferred← citeshttps://doi.org/10.1016/j.jfluchem.2019.05.008openalex-snapshot

Direct C H/C Li coupling of 1,2,4-triazines with C6F5Li followed by aza-Diels-Alder reaction as a pot, atom, and step economy (PASE) approach towards novel fluorinated 2,2′-bipyridine fluorophores

inferred← citeshttps://doi.org/10.1016/j.jhep.2020.07.028openalex-snapshot

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

inferred← citeshttps://doi.org/10.1016/j.jmgm.2006.09.003openalex-snapshot

3D QSAR comparative molecular field analysis on nonsteroidal farnesoid X receptor activators

inferred← citeshttps://doi.org/10.1016/j.livres.2019.05.001openalex-snapshot

The acidic pathway of bile acid synthesis: Not just an alternative pathway

inferred← citeshttps://doi.org/10.1016/j.livres.2021.08.003openalex-snapshot

Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1016/j.mce.2022.111650openalex-snapshot

Immunomodulatory functions of FXR

inferred← citeshttps://doi.org/10.1016/j.molliq.2019.112092openalex-snapshot

Thermodynamics of the aggregation of the bile anions of obeticholic and chenodeoxycholic acids in aqueous solution

inferred← citeshttps://doi.org/10.1016/j.molmed.2007.06.001openalex-snapshot

Targeting farnesoid X receptor for liver and metabolic disorders

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2010.03.005openalex-snapshot

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

inferred← citeshttps://doi.org/10.1016/j.phrs.2019.104333openalex-snapshot

Semisynthetic bile acids: a new therapeutic option for metabolic syndrome

inferred← citeshttps://doi.org/10.1016/j.steroids.2012.01.006openalex-snapshot

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

inferred← citeshttps://doi.org/10.1016/j.tips.2009.08.001openalex-snapshot

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

inferred← citeshttps://doi.org/10.1016/s0065-7743(06)41006-xopenalex-snapshot

Nuclear Hormone Receptor Modulators for the Treatment of Diabetes and Dyslipidemia

inferred← citeshttps://doi.org/10.1016/s1499-3872(14)60307-6openalex-snapshot

Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00831openalex-snapshot

Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c02658openalex-snapshot

Targeted Degradation of Bromodomain-Containing Protein 4 Enabled by Reactive Oxygen Species–Activatable NanoPROTACs as an Efficient Strategy to Reverse Liver Fibrosis in Chronic Liver Injury

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00398openalex-snapshot

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.7b00318openalex-snapshot

Synthesis and Biological Evaluation of a Series of Bile Acid Derivatives as FXR Agonists for Treatment of NASH

inferred← citeshttps://doi.org/10.1021/ci060112vopenalex-snapshot

Recognition of LXXLL by Ligand Binding Domain of the Farnesoid X Receptor in Molecular Dynamics Simulation

inferred← citeshttps://doi.org/10.1021/ci300459kopenalex-snapshot

Unbinding Pathways of GW4064 from Human Farnesoid X Receptor As Revealed by Molecular Dynamics Simulations

inferred← citeshttps://doi.org/10.1021/ci800196hopenalex-snapshot

Molecular Field Analysis and 3D-Quantitative Structure−Activity Relationship Study (MFA 3D-QSAR) Unveil Novel Features of Bile Acid Recognition at TGR5

inferred← citeshttps://doi.org/10.1021/jm060294kopenalex-snapshot

Back Door Modulation of the Farnesoid X Receptor: Design, Synthesis, and Biological Evaluation of a Series of Side Chain Modified Chenodeoxycholic Acid Derivatives

inferred← citeshttps://doi.org/10.1021/jm070633popenalex-snapshot

Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23- and 6,23-Alkyl-Substituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5

inferred← citeshttps://doi.org/10.1021/jm0707931openalex-snapshot

Synthesis, Characterization, and Receptor Interaction Profiles of Enantiomeric Bile Acids

inferred← citeshttps://doi.org/10.1021/jm3002718openalex-snapshot

Discovery and Optimization of 1,3,4-Trisubstituted-pyrazolone Derivatives as Novel, Potent, and Nonsteroidal Farnesoid X Receptor (FXR) Selective Antagonists

inferred← citeshttps://doi.org/10.1021/jm901650uopenalex-snapshot

Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

inferred← citeshttps://doi.org/10.1021/jo2023763openalex-snapshot

Quantitative NMR-Derived Interproton Distances Combined with Quantum Mechanical Calculations of 13C Chemical Shifts in the Stereochemical Determination of Conicasterol F, a Nuclear Receptor Ligand from Theonella swinhoei

inferred← citeshttps://doi.org/10.1021/mp060133copenalex-snapshot

Clinical Hepatotoxicity. Regulation and Treatment with Inducers of Transport and Cofactors

inferred← citeshttps://doi.org/10.1021/mp400575topenalex-snapshot

Structural Requirements of the Human Sodium-Dependent Bile Acid Transporter (hASBT): Role of 3- and 7-OH Moieties on Binding and Translocation of Bile Acids

inferred← citeshttps://doi.org/10.1021/pr8003024openalex-snapshot

Intrinsic Disorder in Nuclear Hormone Receptors

inferred← citeshttps://doi.org/10.1038/aps.2014.116openalex-snapshot

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

inferred← citeshttps://doi.org/10.1038/nrd2619openalex-snapshot

Targeting bile-acid signalling for metabolic diseases

inferred← citeshttps://doi.org/10.1038/s41401-021-00849-4openalex-snapshot

FXR: structures, biology, and drug development for NASH and fibrosis diseases

inferred← citeshttps://doi.org/10.1038/s42003-025-07854-xopenalex-snapshot

Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex

inferred← citeshttps://doi.org/10.1038/s42004-020-00411-zopenalex-snapshot

A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice

inferred← citeshttps://doi.org/10.1038/sj.bjp.0706511openalex-snapshot

Liver X and farnesoid X

inferred← citeshttps://doi.org/10.1038/sj.emboj.7601049openalex-snapshot

Endocrine functions of bile acids

inferred← citeshttps://doi.org/10.1039/9781788015783-00076openalex-snapshot

Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators

inferred← citeshttps://doi.org/10.1042/bj20130609openalex-snapshot

Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes

inferred← citeshttps://doi.org/10.1080/17474124.2020.1797485openalex-snapshot

An insight into primary biliary cholangitis and its recent advances in treatment: semi-synthetic analogs to combat ursodeoxycholic-acid resistance

inferred← citeshttps://doi.org/10.1097/mog.0b013e328324f87eopenalex-snapshot

Farnesoid X receptor agonists in biliary tract disease

inferred← citeshttps://doi.org/10.1101/2024.05.13.593894openalex-snapshot

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

inferred← citeshttps://doi.org/10.1111/j.1365-2567.2012.03554.xopenalex-snapshot

Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway

inferred← citeshttps://doi.org/10.1111/j.1476-5381.2008.00030.xopenalex-snapshot

Nuclear receptors as therapeutic targets in cholestatic liver diseases

inferred← citeshttps://doi.org/10.1111/j.1582-4934.2009.00997.xopenalex-snapshot

FXR an emerging therapeutic target for the treatment of atherosclerosis

inferred← citeshttps://doi.org/10.1111/j.1751-2980.2009.00369.xopenalex-snapshot

Bile acids and insulin resistance: implications for treating nonalcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1111/jgh.16159openalex-snapshot

Intestinal crosstalk between bile acids and microbiota in irritable bowel syndrome

inferred← citeshttps://doi.org/10.1124/dmd.115.064758openalex-snapshot

Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner

inferred← citeshttps://doi.org/10.1152/ajpgi.00370.2011openalex-snapshot

Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice

inferred← citeshttps://doi.org/10.1152/ajpheart.01075.2008openalex-snapshot

Antiatherosclerotic effect of farnesoid X receptor

inferred← citeshttps://doi.org/10.1155/2008/824168openalex-snapshot

Primary sclerosing cholangitis

inferred← citeshttps://doi.org/10.1351/pac200779040615openalex-snapshot

Structural development studies of nuclear receptor ligands

inferred← citeshttps://doi.org/10.1365/s10337-006-0013-9openalex-snapshot

Dominant Factors Affecting the Chromatographic Behaviour of Bile Acids

inferred← citeshttps://doi.org/10.1365/s10337-006-0108-3openalex-snapshot

Dominant Factors Affecting the Chromatographic Behaviour of Bile Acids

inferred← citeshttps://doi.org/10.1517/13543776.16.3.333openalex-snapshot

Potential therapeutic applications of farnesoid X receptor (FXR) modulators

inferred← citeshttps://doi.org/10.1517/13543776.2010.496777openalex-snapshot

Farnesoid X receptor modulators: a patent review

inferred← citeshttps://doi.org/10.1517/14656566.2014.873404openalex-snapshot

Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis

inferred← citeshttps://doi.org/10.1517/14728214.2016.1150999openalex-snapshot

Emerging drugs for the treatment of Primary Biliary Cholangitis

inferred← citeshttps://doi.org/10.1517/14728222.10.3.409openalex-snapshot

FXR: a target for cholestatic syndromes?

inferred← citeshttps://doi.org/10.1586/egh.12.66openalex-snapshot

Altered enterohepatic circulation of bile acids in Crohn’s disease and their clinical significance: a new perspective

inferred← citeshttps://doi.org/10.2217/17460875.1.5.559openalex-snapshot

Molecular mechanisms involved in the regulation of lipid and lipoprotein metabolism by fish oil

inferred← citeshttps://doi.org/10.2217/bmm-2023-0368openalex-snapshot

Emerging Roles of HOTAIR LncRNA in the Pathogenesis and Prognosis of Cardiovascular Diseases

inferred← citeshttps://doi.org/10.2217/fon-2017-0090openalex-snapshot

Clinical significance of farnesoid X receptor expression in thyroid neoplasia

inferred← citeshttps://doi.org/10.25560/41879openalex-snapshot

Investigating Fibroblast Growth Factor 19 expression in primary and secondary bile acid diarrhoea

inferred← citeshttps://doi.org/10.3389/fchem.2018.00140openalex-snapshot

Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening

inferred← citeshttps://doi.org/10.3390/biom13101465openalex-snapshot

Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors

inferred← citeshttps://doi.org/10.3390/biomedicines11102845openalex-snapshot

Overview of Ursolic Acid Potential for the Treatment of Metabolic Disorders, Autoimmune Diseases, and Cancers via Nuclear Receptor Pathways

inferred← citeshttps://doi.org/10.3390/cells10061281openalex-snapshot

Bile Acids Activated Receptors in Inflammatory Bowel Disease

inferred← citeshttps://doi.org/10.3390/diseases8020020openalex-snapshot

Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists

inferred← citeshttps://doi.org/10.3390/ecsoc-29-27271openalex-snapshot

In Silico Study of Obeticholic Acid Analogs as FXR Agonists

inferred← citeshttps://doi.org/10.3390/md10112448openalex-snapshot

Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

inferred← citeshttps://doi.org/10.3390/molecules24224155openalex-snapshot

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

inferred← citeshttps://doi.org/10.3390/ph16050758openalex-snapshot

Structure Optimization of 12β-O-γ-Glutamyl Oleanolic Acid Derivatives Resulting in Potent FXR Antagonist/Modulator for NASH Therapy

inferred← citeshttps://doi.org/10.3748/wjg.15.2097openalex-snapshot

Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

inferred← citeshttps://doi.org/10.4049/jimmunol.0803978openalex-snapshot

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

inferred← citeshttps://doi.org/10.4149/neo_2015_040openalex-snapshot

Elevated Farnesoid X Receptor (FXR) and Retinoid X Receptors (RXRs) expression is associated with less tumor aggressiveness and favourable prognosis in patients with pancreatic adenocarcinoma

inferred← citeshttps://doi.org/10.4149/neo_2017_420openalex-snapshot

High Farnesoid X Receptor (FXR) expression is a strong and independent prognosticator in invasive breast carcinoma

inferred← citeshttps://doi.org/10.4155/fmc.12.41openalex-snapshot

Farnesoid X Receptor: From Medicinal Chemistry To Clinical Applications

inferred← citeshttps://doi.org/10.6092/unibo/amsdottorato/5612openalex-snapshot

New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism.

inferred← citeshttps://doi.org/10.70675/091a31c9z459fz4029z8a0fzcd7f81d42f9bopenalex-snapshot

Structure-function studies of β-lactamases

inferred← citeshttps://doi.org/10.70675/bd16b908zde01z4a9fz9aa5zad9c5670eb37openalex-snapshot

Towards in silico prediction of mutations related to antibiotic resistance

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