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Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor

https://doi.org/10.1210/en.2004-0965

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/mgme.2000.3106openalex-snapshot

Correlation of Farnesoid X Receptor Coactivator Recruitment and Cholesterol 7α-Hydroxylase Gene Repression by Bile Acids

inferredcites →https://doi.org/10.1016/0092-8674(95)90530-8openalex-snapshot

Identification of a nuclear receptor that is activated by farnesol metabolites

inferredcites →https://doi.org/10.1016/j.febslet.2004.04.026openalex-snapshot

The farnesoid X receptor induces very low density lipoprotein receptor gene expression

inferredcites →https://doi.org/10.1016/s0016-5085(03)00896-5openalex-snapshot

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

inferredcites →https://doi.org/10.1016/s0021-9258(17)31420-5openalex-snapshot

Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.

inferredcites →https://doi.org/10.1016/s0021-9258(18)34426-0openalex-snapshot

Rapid changes in the concentration of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney. Effects of insulin and cyclic AMP.

inferredcites →https://doi.org/10.1016/s0021-9258(18)48115-xopenalex-snapshot

Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.

inferredcites →https://doi.org/10.1016/s0092-8674(00)00062-3openalex-snapshot

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

inferredcites →https://doi.org/10.1016/s0168-8227(87)80041-4openalex-snapshot

Cholesterol biosynthesis in nonketotic diabetics before and during insulin therapy

inferredcites →https://doi.org/10.1016/s1047-2797(01)00260-5openalex-snapshot

Hyperinsulinemia, Dyslipidemia, and Obesity as Risk Factors for Hospitalized Gallbladder Disease

inferredcites →https://doi.org/10.1016/s1097-2765(00)00050-2openalex-snapshot

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

inferredcites →https://doi.org/10.1016/s1097-2765(00)00051-4openalex-snapshot

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

inferredcites →https://doi.org/10.1016/s1097-2765(03)00104-7openalex-snapshot

A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

inferredcites →https://doi.org/10.1021/jm0002127openalex-snapshot

Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR

inferredcites →https://doi.org/10.1038/305549a0openalex-snapshot

Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

inferredcites →https://doi.org/10.1038/nm1044openalex-snapshot

PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

inferredcites →https://doi.org/10.1038/nm898openalex-snapshot

Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null mice

inferredcites →https://doi.org/10.1042/bj2460237openalex-snapshot

Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis

inferredcites →https://doi.org/10.1056/nejm197706162962401openalex-snapshot

Effects of Diabetes Mellitus on Cholesterol Metabolism in Man

inferredcites →https://doi.org/10.1073/pnas.0830671100openalex-snapshot

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

inferredcites →https://doi.org/10.1074/jbc.273.42.27320openalex-snapshot

Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene

inferredcites →https://doi.org/10.1074/jbc.274.23.15982openalex-snapshot

Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway

inferredcites →https://doi.org/10.1074/jbc.274.24.16741openalex-snapshot

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

inferredcites →https://doi.org/10.1074/jbc.274.42.29749openalex-snapshot

Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

inferredcites →https://doi.org/10.1074/jbc.m007998200openalex-snapshot

The Farnesoid X-activated Receptor Mediates Bile Acid Activation of Phospholipid Transfer Protein Gene Expression

inferredcites →https://doi.org/10.1074/jbc.m011610200openalex-snapshot

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

inferredcites →https://doi.org/10.1074/jbc.m109326200openalex-snapshot

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

inferredcites →https://doi.org/10.1074/jbc.m207187200openalex-snapshot

Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo

inferredcites →https://doi.org/10.1074/jbc.m210208200openalex-snapshot

Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis

inferredcites →https://doi.org/10.1074/jbc.m305079200openalex-snapshot

Coordinated Control of Cholesterol Catabolism to Bile Acids and of Gluconeogenesis via a Novel Mechanism of Transcription Regulation Linked to the Fasted-to-fed Cycle

inferredcites →https://doi.org/10.1074/jbc.m314322200openalex-snapshot

Bile Acids Regulate Gluconeogenic Gene Expression via Small Heterodimer Partner-mediated Repression of Hepatocyte Nuclear Factor 4 and Foxo1

inferredcites →https://doi.org/10.1093/emboj/19.5.989openalex-snapshot

Differential regulation of gene expression by insulin and IGF‐1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

inferredcites →https://doi.org/10.1111/j.1432-1033.1980.tb06078.xopenalex-snapshot

Glucocorticoid‐Dependent Induction of mRNA Coding for Phosphoenolpyruvate Carboxykinase (GTP) in Rat Kidney

inferredcites →https://doi.org/10.1126/science.1072891openalex-snapshot

A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR

inferredcites →https://doi.org/10.1126/science.1079817openalex-snapshot

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

inferredcites →https://doi.org/10.1126/science.284.5418.1362openalex-snapshot

Identification of a Nuclear Receptor for Bile Acids

inferredcites →https://doi.org/10.1126/science.284.5418.1365openalex-snapshot

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

inferredcites →https://doi.org/10.1152/ajpendo.00253.2003openalex-snapshot

Novel concepts in insulin regulation of hepatic gluconeogenesis

inferredcites →https://doi.org/10.1172/jci0214505openalex-snapshot

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

inferredcites →https://doi.org/10.1172/jci115997openalex-snapshot

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

inferredcites →https://doi.org/10.1172/jci14505openalex-snapshot

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

inferredcites →https://doi.org/10.1194/jlr.c200014-jlr200openalex-snapshot

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

inferredcites →https://doi.org/10.1210/en.140.7.3140openalex-snapshot

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter

inferredcites →https://doi.org/10.1210/me.16.7.1590openalex-snapshot

The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor

inferredcites →https://doi.org/10.1210/me.2002-0120openalex-snapshot

Bile Acids Induce the Expression of the Human Peroxisome Proliferator-Activated Receptor α Gene via Activation of the Farnesoid X Receptor

inferredcites →https://doi.org/10.1210/mend.15.10.0712openalex-snapshot

Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

inferredcites →https://doi.org/10.2337/diabetes.53.4.890openalex-snapshot

Glucose Regulates the Expression of the Farnesoid X Receptor in Liver

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Discovery of 12β-Oxygenated Oleanolic Acid Alkyl Esters as Potent and Selective FXR Antagonists Exhibiting Hyperglycemia Amelioration in Vivo

inferred← citeshttps://doi.org/10.1002/9780470140505.ch2openalex-snapshot

Organic Cation Transporters

inferred← citeshttps://doi.org/10.1002/9780470409107.ch10openalex-snapshot

Beyond PXR and CAR, Regulation of Xenobiotic Metabolism by other Nuclear Receptors

inferred← citeshttps://doi.org/10.1002/cphy.c120023openalex-snapshot

Bile Acid Metabolism and Signaling

inferred← citeshttps://doi.org/10.1002/elps.201300017openalex-snapshot

Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes

inferred← citeshttps://doi.org/10.1002/hep.20919openalex-snapshot

Glucagon and cAMP inhibit cholesterol 7α‐hydroxylase (CYP7a1) gene expression in human hepatocytes

inferred← citeshttps://doi.org/10.1002/hep.26896openalex-snapshot

The Hunt for Treatment Options of Fatty Liver Continues: Effects of Retinoic Acid on Hepatic Steatosis Reveal Novel Transcriptional Interactions of Nuclear Receptors

inferred← citeshttps://doi.org/10.1002/hep.28709openalex-snapshot

Bile acids and nonalcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1002/hsr2.243openalex-snapshot

Bile acids during pregnancy: Trimester variations and associations with glucose homeostasis

inferred← citeshttps://doi.org/10.1002/j.2040-4603.2013.tb00517.xopenalex-snapshot

Bile Acid Metabolism and Signaling

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TRB3 mediates homocysteine‐induced inhibition of endothelial cell proliferation

inferred← citeshttps://doi.org/10.1002/minf.200900009openalex-snapshot

Target Profile Prediction: Cross‐Activation of Peroxisome Proliferator‐Activated Receptor (PPAR) and Farnesoid X Receptor (FXR)

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Nutritional lipidomics: Molecular metabolism, analytics, and diagnostics

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Bile Acids: At the Crossroads of Sterol, Fat and Carbohydrate Metabolism

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Nonsteroidal FXR Ligands: Current Status and Clinical Applications

inferred← citeshttps://doi.org/10.1007/164_2019_236openalex-snapshot

Bile Acid-Activated Receptors: A Review on FXR and Other Nuclear Receptors

inferred← citeshttps://doi.org/10.1007/978-1-4020-6252-0_3openalex-snapshot

Activation of a G-protein coupled receptor by conjugated bile acids in primary hepatocytes and liver: effects on glucose metabolism

inferred← citeshttps://doi.org/10.1007/978-1-60327-963-5_3openalex-snapshot

Management of Dyslipidemia

inferred← citeshttps://doi.org/10.1007/978-3-319-20433-8_1openalex-snapshot

Use of Combination Statin and Bile Acid Sequestrant Therapy to Treat Dyslipidemia

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Management of Dyslipidemia

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Bile Acids and Metabolic Syndrome

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Nuclear Receptor Regulation

inferred← citeshttps://doi.org/10.1007/978-90-481-3303-1_12openalex-snapshot

Fxr

inferred← citeshttps://doi.org/10.1007/s00011-014-0780-yopenalex-snapshot

Role of farnesoid X receptor in inflammation and resolution

inferred← citeshttps://doi.org/10.1007/s00018-007-7280-yopenalex-snapshot

Lipid sensing and lipid sensors

inferred← citeshttps://doi.org/10.1007/s00018-013-1387-0openalex-snapshot

Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

inferred← citeshttps://doi.org/10.1007/s00044-012-0359-5openalex-snapshot

Identification of liver X receptor and farnesoid X receptor dual agonists from Tithonia diversifolia

inferred← citeshttps://doi.org/10.1007/s00360-017-1112-7openalex-snapshot

Histone methylation in the freeze-tolerant wood frog (Rana sylvatica)

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Gut microbiota functions: metabolism of nutrients and other food components

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The relative abundance of fecal bacterial species belonging to the Firmicutes and Bacteroidetes phyla is related to plasma levels of bile acids in young adults

inferred← citeshttps://doi.org/10.1007/s11427-023-2353-0openalex-snapshot

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

inferred← citeshttps://doi.org/10.1007/s11883-015-0500-2openalex-snapshot

FXR Agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease

inferred← citeshttps://doi.org/10.1007/s11892-011-0187-xopenalex-snapshot

Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes

inferred← citeshttps://doi.org/10.1007/s11892-020-01329-5openalex-snapshot

The Physiological Importance of Bile Acid Structure and Composition on Glucose Homeostasis

inferred← citeshttps://doi.org/10.1007/s12272-016-0812-yopenalex-snapshot

Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function

inferred← citeshttps://doi.org/10.1016/b978-0-08-046884-6.00213-xopenalex-snapshot

Convergence of Multiple Nuclear Receptor Signaling

inferred← citeshttps://doi.org/10.1016/b978-0-12-386456-7.02009-8openalex-snapshot

The Gut Microbiota and Effects on Metabolism

inferred← citeshttps://doi.org/10.1016/b978-0-12-394316-3.00004-1openalex-snapshot

The SLC10 Carrier Family

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Influence of the Human Gut Microbiome on the Metabolic Phenotype

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The pathophysiology of gut–liver connection

inferred← citeshttps://doi.org/10.1016/b978-0-443-16098-1.00008-4openalex-snapshot

Role of the gallbladder in our metabolism and immune system

inferred← citeshttps://doi.org/10.1016/b978-0-443-18979-1.00013-7openalex-snapshot

Obesity, gut bacteria, and the epigenetic control of metabolic disease

inferred← citeshttps://doi.org/10.1016/j.acthis.2007.08.001openalex-snapshot

Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray

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Integrating bile acid metabolism into precision nutrition strategies for improved swine performance

inferred← citeshttps://doi.org/10.1016/j.apsb.2015.01.004openalex-snapshot

Bile acid nuclear receptor FXR and digestive system diseases

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The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications

inferred← citeshttps://doi.org/10.1016/j.bbadis.2010.01.002openalex-snapshot

The bile acid sensor FXR regulates insulin transcription and secretion

inferred← citeshttps://doi.org/10.1016/j.bbadis.2010.12.006openalex-snapshot

Nuclear bile acid receptor FXR in the hepatic regeneration

inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.10.003openalex-snapshot

Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism

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FXR in liver physiology: Multiple faces to regulate liver metabolism

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Nuclear receptors and nonalcoholic fatty liver disease

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Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice

inferred← citeshttps://doi.org/10.1016/j.bbrc.2005.01.141openalex-snapshot

Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

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Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A mice

inferred← citeshttps://doi.org/10.1016/j.bbrc.2008.02.031openalex-snapshot

Relationship between circadian oscillations of Rev-erbα expression and intracellular levels of its ligand, heme

inferred← citeshttps://doi.org/10.1016/j.bcp.2013.01.001openalex-snapshot

FXR-dependent and -independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver

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Bile acids: From digestion to cancers

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Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo

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Hepatoprotective effect of Typhaneoside on non-alcoholic fatty liver disease via farnesoid X receptor in vivo and in vitro

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Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

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Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists

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Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: Role of the chirality on the biological activity

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Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists

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Triterpenes from Alisma orientalis act as farnesoid X receptor agonists

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Cryptochinones from Cryptocarya chinensis act as farnesoid X receptor agonists

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Stress response and adaptation: A new molecular toolkit for the 21st century

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Molecular cloning and characterization of farnesoid X receptor from large yellow croaker ( Larimichthys crocea ) and the effect of dietary CDCA on the expression of inflammatory genes in intestine and spleen

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How to modulate FXR activity to treat the Metabolic Syndrome

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Targeting the gut microbiota-bile acid axis: Therapeutic strategies for cholestatic liver disease and metabolic dysfunction-associated steatotic liver disease

inferred← citeshttps://doi.org/10.1016/j.febslet.2005.06.033openalex-snapshot

Transient impairment of the adaptive response to fasting in FXR‐deficient mice

inferred← citeshttps://doi.org/10.1016/j.febslet.2007.03.047openalex-snapshot

T0901317 is a potent PXR ligand: Implications for the biology ascribed to LXR

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FXR signaling in metabolic disease

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The nuclear receptor FXR is expressed in pancreatic β‐cells and protects human islets from lipotoxicity

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Protective and ameliorating effects of probiotics against diet-induced obesity: A review

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Biology of the Microbiome 2

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Mitigation of oxidative stress-induced aging by extracellular polysaccharides from Lactiplantibacillus plantarum R6-1 from Sayram ketteki

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Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate

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Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets

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Biological functions and pharmacological behaviors of bile acids in metabolic diseases

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Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity

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The interaction of hepatic lipid and glucose metabolism in liver diseases

inferred← citeshttps://doi.org/10.1016/j.jhep.2013.01.020openalex-snapshot

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis

inferred← citeshttps://doi.org/10.1016/j.jhep.2018.06.022openalex-snapshot

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

inferred← citeshttps://doi.org/10.1016/j.jhep.2024.09.032openalex-snapshot

Bile acid metabolism and signalling in liver disease

inferred← citeshttps://doi.org/10.1016/j.jlr.2025.100954openalex-snapshot

Serum cholic acid and cecal Faecalibaculum increase in a male-specific manner in a murine hepatocellular carcinoma model

inferred← citeshttps://doi.org/10.1016/j.lfs.2008.04.006openalex-snapshot

Guggulsterone blocks IL-1β-mediated inflammatory responses by suppressing NF-κB activation in fibroblast-like synoviocytes

inferred← citeshttps://doi.org/10.1016/j.lfs.2024.123042openalex-snapshot

Blockade of forkhead box protein O1 signaling alleviates primary sclerosing cholangitis-induced sarcopenia in mice model

inferred← citeshttps://doi.org/10.1016/j.mam.2017.01.006openalex-snapshot

Bile acids and their receptors

inferred← citeshttps://doi.org/10.1016/j.mam.2017.04.004openalex-snapshot

The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

inferred← citeshttps://doi.org/10.1016/j.mce.2008.02.001openalex-snapshot

Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic β cells from cytokine toxicity

inferred← citeshttps://doi.org/10.1016/j.mce.2008.10.020openalex-snapshot

Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

inferred← citeshttps://doi.org/10.1016/j.mce.2012.05.010openalex-snapshot

FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice

inferred← citeshttps://doi.org/10.1016/j.mce.2021.111191openalex-snapshot

Long noncoding RNAs-a new dimension in the molecular architecture of the bile acid/FXR pathway

inferred← citeshttps://doi.org/10.1016/j.metabol.2018.03.016openalex-snapshot

HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter

inferred← citeshttps://doi.org/10.1016/j.molmed.2007.06.001openalex-snapshot

Targeting farnesoid X receptor for liver and metabolic disorders

inferred← citeshttps://doi.org/10.1016/j.nut.2022.111631openalex-snapshot

Genetic reprogramming of remnant duodenum may contribute to type 2 diabetes improvement after Roux-en-Y gastric bypass

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Interactions between gut microbiota and non-alcoholic liver disease: The role of microbiota-derived metabolites

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Bile acids and their receptors in metabolic disorders

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Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress

inferred← citeshttps://doi.org/10.1016/j.taap.2009.11.022openalex-snapshot

Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)

inferred← citeshttps://doi.org/10.1016/j.tem.2006.07.004openalex-snapshot

Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy

inferred← citeshttps://doi.org/10.1016/j.tem.2011.07.002openalex-snapshot

Hepatic FXR: key regulator of whole-body energy metabolism

inferred← citeshttps://doi.org/10.1016/j.tem.2014.03.007openalex-snapshot

Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization

inferred← citeshttps://doi.org/10.1016/j.tibs.2006.08.002openalex-snapshot

FXR, a multipurpose nuclear receptor

inferred← citeshttps://doi.org/10.1016/j.tips.2007.03.002openalex-snapshot

FXR: a promising target for the metabolic syndrome?

inferred← citeshttps://doi.org/10.1016/j.tips.2009.08.001openalex-snapshot

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

inferred← citeshttps://doi.org/10.1016/j.tox.2011.06.012openalex-snapshot

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01017openalex-snapshot

Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor

inferred← citeshttps://doi.org/10.1021/acs.jproteome.3c00244openalex-snapshot

Proteomic Serum Profiling of Holstein Friesian Cows with Different Pathological Forms of Bovine Paratuberculosis Reveals Changes in the Acute-Phase Response and Lipid Metabolism

inferred← citeshttps://doi.org/10.1021/jm0582221openalex-snapshot

Farnesoid X Receptor: From Structure to Potential Clinical Applications

inferred← citeshttps://doi.org/10.1021/jm060294kopenalex-snapshot

Back Door Modulation of the Farnesoid X Receptor: Design, Synthesis, and Biological Evaluation of a Series of Side Chain Modified Chenodeoxycholic Acid Derivatives

inferred← citeshttps://doi.org/10.1038/aps.2014.116openalex-snapshot

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

inferred← citeshttps://doi.org/10.1038/cr.2008.289openalex-snapshot

FXR: a metabolic regulator and cell protector

inferred← citeshttps://doi.org/10.1038/ijo.2013.230openalex-snapshot

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

inferred← citeshttps://doi.org/10.1038/ncomms2924openalex-snapshot

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

inferred← citeshttps://doi.org/10.1038/nrd2619openalex-snapshot

Targeting bile-acid signalling for metabolic diseases

inferred← citeshttps://doi.org/10.1038/nsmb1344openalex-snapshot

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ

inferred← citeshttps://doi.org/10.1038/s41575-021-00566-7openalex-snapshot

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

inferred← citeshttps://doi.org/10.1038/s41586-023-06990-wopenalex-snapshot

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

inferred← citeshttps://doi.org/10.1038/sj.emboj.7601049openalex-snapshot

Endocrine functions of bile acids

inferred← citeshttps://doi.org/10.1038/sj.jcbfm.9600444openalex-snapshot

Gender-Specific Response to Isoflurane Preconditioning in Focal Cerebral Ischemia

inferred← citeshttps://doi.org/10.1039/c2mt20017aopenalex-snapshot

A systems approach implicates nuclear receptor targeting in the Atp7b−/− mouse model of Wilson's disease

inferred← citeshttps://doi.org/10.1042/bj20130609openalex-snapshot

Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes

inferred← citeshttps://doi.org/10.1053/j.gastro.2017.01.055openalex-snapshot

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

inferred← citeshttps://doi.org/10.1073/pnas.0506982103openalex-snapshot

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

inferred← citeshttps://doi.org/10.1073/pnas.1006734107openalex-snapshot

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

inferred← citeshttps://doi.org/10.1074/jbc.m111.248203openalex-snapshot

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

inferred← citeshttps://doi.org/10.1074/jbc.m501931200openalex-snapshot

The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition

inferred← citeshttps://doi.org/10.1074/jbc.m510258200openalex-snapshot

The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice

inferred← citeshttps://doi.org/10.1074/jbc.m605815200openalex-snapshot

Insulin Regulation of Cholesterol 7α-Hydroxylase Expression in Human Hepatocytes

inferred← citeshttps://doi.org/10.1074/jbc.m606779200openalex-snapshot

Farnesoid X Receptor Agonist Reduces Serum Asymmetric Dimethylarginine Levels through Hepatic Dimethylarginine Dimethylaminohydrolase-1 Gene Regulation

inferred← citeshttps://doi.org/10.1080/00015458.2016.1215953openalex-snapshot

The expanding role of the bile acid receptor farnesoid X in the intestine and its potential clinical implications

inferred← citeshttps://doi.org/10.1080/10286020.2014.964689openalex-snapshot

Lepidozenolide from the liverwortLepidozia faurianaacts as a farnesoid X receptor agonist

inferred← citeshttps://doi.org/10.1080/10408398.2023.2173719openalex-snapshot

Pectin mediates the mechanism of host blood glucose regulation through intestinal flora

inferred← citeshttps://doi.org/10.1080/13543776.2018.1459569openalex-snapshot

Farnesoid X receptor modulators 2014-present: a patent review

inferred← citeshttps://doi.org/10.1080/13543784.2017.1385760openalex-snapshot

Beneficial effects of bile acid receptor agonists in pulmonary disease models

inferred← citeshttps://doi.org/10.1080/14656566.2022.2112945openalex-snapshot

Colesevelam – a bile acid sequestrant for treating hypercholesterolemia and improving hyperglycemia

inferred← citeshttps://doi.org/10.1080/14728222.2019.1559825openalex-snapshot

The farnesoid X receptor: a potential target for expanding the therapeutic arsenal against kidney disease

inferred← citeshttps://doi.org/10.1080/17460441.2021.1916465openalex-snapshot

The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1080/19768354.2014.987318openalex-snapshot

Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

inferred← citeshttps://doi.org/10.1089/met.2010.0096openalex-snapshot

Bile Acid Sequestrants: Glucose-Lowering Mechanisms

inferred← citeshttps://doi.org/10.1089/ten.tec.2010.0012openalex-snapshot

A Comparative Study of Genome-Wide Transcriptional Profiles of Primary Hepatocytes in Collagen Sandwich and Monolayer Cultures

inferred← citeshttps://doi.org/10.1096/fj.11-195701openalex-snapshot

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition

inferred← citeshttps://doi.org/10.1097/fjc.0b013e31817ffe5aopenalex-snapshot

Reducing Cardiovascular Complications of Type 2 Diabetes by Targeting Multiple Risk Factors

inferred← citeshttps://doi.org/10.1097/hc9.0000000000000213openalex-snapshot

Hepatic farnesoid X receptor is necessary to facilitate ductular reaction and expression of heme biosynthetic genes

inferred← citeshttps://doi.org/10.1097/maj.0000000000000593openalex-snapshot

Farnesoid X Receptor Expression Reduced in Obese Rat Model With Insulin Resistance

inferred← citeshttps://doi.org/10.1097/mjt.0b013e31815a69fcopenalex-snapshot

The ‘Forgotten’ Bile Acid Sequestrants: Is Now a Good Time to Remember?

inferred← citeshttps://doi.org/10.1097/mol.0b013e32834f0ef3openalex-snapshot

Bile acid sequestrants

inferred← citeshttps://doi.org/10.1101/2021.09.16.460588openalex-snapshot

Deletion of serine palmitoyl transferase 2 in hepatocytes impairs ceramide/sphingomyelin balance, prevents obesity and leads to liver damage in mice

inferred← citeshttps://doi.org/10.1101/2024.10.29.620968openalex-snapshot

Robust fine-mapping in the presence of linkage disequilibrium mismatch

inferred← citeshttps://doi.org/10.1111/apt.15314openalex-snapshot

Review article: emerging role of the gut microbiome in the progression of nonalcoholic fatty liver disease and potential therapeutic implications

inferred← citeshttps://doi.org/10.1111/j.1440-1827.2009.02435.xopenalex-snapshot

Decreased protein and gene expression of hepatic cholesterol 7a‐hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats

inferred← citeshttps://doi.org/10.1111/j.1463-1326.2008.00903.xopenalex-snapshot

Novel pathways for glycaemic control in type 2 diabetes: focus on bile acid modulation

inferred← citeshttps://doi.org/10.1111/j.1474-9726.2008.00387.xopenalex-snapshot

Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings

inferred← citeshttps://doi.org/10.1124/dmd.112.048694openalex-snapshot

Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases

inferred← citeshttps://doi.org/10.1124/jpet.110.166892openalex-snapshot

Cholestyramine Reverses Hyperglycemia and Enhances Glucose-Stimulated Glucagon-Like Peptide 1 Release in Zucker Diabetic Fatty Rats

inferred← citeshttps://doi.org/10.1124/jpet.112.196519openalex-snapshot

Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice

inferred← citeshttps://doi.org/10.1124/jpet.114.214650openalex-snapshot

Semisynthetic Bile Acid FXR and TGR5 Agonists: Physicochemical Properties, Pharmacokinetics, and Metabolism in the Rat

inferred← citeshttps://doi.org/10.1124/mol.107.039099openalex-snapshot

Regulation of Human 3α-Hydroxysteroid Dehydrogenase (AKR1C4) Expression by the Liver X Receptor α

inferred← citeshttps://doi.org/10.1124/mol.108.048538openalex-snapshot

The Selective Alzheimer’s Disease Indicator-1 Gene (Seladin-1/DHCR24) Is a Liver X Receptor Target Gene

inferred← citeshttps://doi.org/10.1124/pr.113.008201openalex-snapshot

Bile Acid Signaling in Metabolic Disease and Drug Therapy

inferred← citeshttps://doi.org/10.1136/gutjnl-2015-310904openalex-snapshot

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

inferred← citeshttps://doi.org/10.1146/annurev-biochem-081308-165917openalex-snapshot

Sterol Regulation of Metabolism, Homeostasis, and Development

inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010715-103209openalex-snapshot

Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

inferred← citeshttps://doi.org/10.1146/annurev-physiol-021909-135917openalex-snapshot

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

inferred← citeshttps://doi.org/10.1146/annurev.physiol.68.033104.152158openalex-snapshot

LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism

inferred← citeshttps://doi.org/10.1152/ajpendo.00061.2011openalex-snapshot

Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways

inferred← citeshttps://doi.org/10.1152/ajpendo.00323.2011openalex-snapshot

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes

inferred← citeshttps://doi.org/10.1152/ajpendo.90748.2008openalex-snapshot

Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?

inferred← citeshttps://doi.org/10.1152/ajpgi.00223.2019openalex-snapshot

Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy

inferred← citeshttps://doi.org/10.1152/ajpgi.90546.2008openalex-snapshot

LXRα activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins

inferred← citeshttps://doi.org/10.1152/ajprenal.00404.2009openalex-snapshot

The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria

inferred← citeshttps://doi.org/10.1152/physiol.00007.2012openalex-snapshot

Orphan Nuclear Receptors and the Regulation of Nutrient Metabolism: Understanding Obesity

inferred← citeshttps://doi.org/10.1152/physrev.00010.2008openalex-snapshot

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

inferred← citeshttps://doi.org/10.1155/2012/754067openalex-snapshot

Bile Acid Signaling in Liver Metabolism and Diseases

inferred← citeshttps://doi.org/10.1155/2014/751859openalex-snapshot

Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes

inferred← citeshttps://doi.org/10.1158/0008-5472.c.6494070openalex-snapshot

Data from The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression

inferred← citeshttps://doi.org/10.1158/0008-5472.c.6494070.v1openalex-snapshot

Data from The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression

inferred← citeshttps://doi.org/10.1158/0008-5472.can-06-2399openalex-snapshot

The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression

inferred← citeshttps://doi.org/10.1159/000149779openalex-snapshot

Farnesoid X Receptor Induces GLUT4 Expression Through FXR Response Element in the GLUT4 Promoter

inferred← citeshttps://doi.org/10.1159/000341485openalex-snapshot

Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats

inferred← citeshttps://doi.org/10.11606/d.9.2022.tde-15032023-095506openalex-snapshot

Efeitos do D-limoneno no metabolismo de ácidos biliares em camundongos C57/B16

inferred← citeshttps://doi.org/10.1161/atvbaha.109.197897openalex-snapshot

A Role of the Bile Salt Receptor FXR in Atherosclerosis

inferred← citeshttps://doi.org/10.1172/jci25604openalex-snapshot

Farnesoid X receptor is essential for normal glucose homeostasis

inferred← citeshttps://doi.org/10.1172/jci88893openalex-snapshot

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

inferred← citeshttps://doi.org/10.1185/030079907x210525openalex-snapshot

Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus

inferred← citeshttps://doi.org/10.1186/s12864-015-2054-7openalex-snapshot

Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

inferred← citeshttps://doi.org/10.1186/s40104-025-01275-wopenalex-snapshot

Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows

inferred← citeshttps://doi.org/10.1186/s40104-026-01474-zopenalex-snapshot

Taurolithocholic acid alleviates hepatic glycolipid dysregulation in low-birth-weight piglets by activating HNF4α and FXR

inferred← citeshttps://doi.org/10.1194/jlr.m004929openalex-snapshot

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via Gαi-protein-coupled receptors and the AKT pathway

inferred← citeshttps://doi.org/10.1194/jlr.m005546openalex-snapshot

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms

inferred← citeshttps://doi.org/10.1194/jlr.m500390-jlr200openalex-snapshot

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

inferred← citeshttps://doi.org/10.1194/jlr.r024794openalex-snapshot

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

inferred← citeshttps://doi.org/10.1201/9781420045390.sec2openalex-snapshot

Alpha-Keto Acid Dehydrogenase Complexes and Glycine Cleavage System

inferred← citeshttps://doi.org/10.1210/clinem/dgaa940openalex-snapshot

Plasma Bile Acids More Closely Align With Insulin Resistance, Visceral and Hepatic Adiposity Than Total Adiposity

inferred← citeshttps://doi.org/10.1210/clinem/dgab531openalex-snapshot

Circulating Bile Acid Profiles: A Need for Further Examination

inferred← citeshttps://doi.org/10.1210/en.2004-1595openalex-snapshot

Farnesoid X Receptor: A New Player in Glucose Metabolism?

inferred← citeshttps://doi.org/10.1210/me.2007-0025openalex-snapshot

A Common Polymorphism in the Bile Acid Receptor Farnesoid X Receptor Is Associated with Decreased Hepatic Target Gene Expression

inferred← citeshttps://doi.org/10.1210/me.2009-0212openalex-snapshot

Minireview: Nuclear Receptor-Controlled Steroid Hormone Synthesis and Metabolism

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