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High-Throughput Screening of Drug−Brain Tissue Binding and in Silico Prediction for Assessment of Central Nervous System Drug Delivery
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Blood-Brain Barrier Permeation Models: Discriminating between Potential CNS and Non-CNS Drugs Including P-Glycoprotein Substrates
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Structure−Brain Exposure Relationships
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A method to estimate binding constants at variable protein concentrations
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RELATIONSHIP BETWEEN EXPOSURE AND NONSPECIFIC BINDING OF THIRTY-THREE CENTRAL NERVOUS SYSTEM DRUGS IN MICE
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In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids
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Drug Tissue Distribution: Study Methods and Therapeutic Implications
What points at this work
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Permeability: Blood–Brain Barrier
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Methods for Assessing Brain Binding
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In Silico Prediction of Brain Exposure: Drug Free Fraction, Unbound Brain to Plasma Concentration Ratio and Equilibrium Half-Life
inferred← citeshttps://doi.org/10.2967/jnumed.116.183566openalex-snapshot
Prediction of the Clinical SUV Ratio in Amyloid PET Imaging Using a Biomathematic Modeling Approach Toward the Efficient Development of a Radioligand
inferred← citeshttps://doi.org/10.3109/00498254.2011.618953openalex-snapshot
Associatingin vitrotarget binding andin vivoCNS occupancy of serotonin reuptake inhibitors in rats: The role of free drug concentrations
inferred← citeshttps://doi.org/10.3109/00498254.2014.919430openalex-snapshot
Temporal expression of transporters and receptors in a rat primary co-culture blood–brain barrier model
inferred← citeshttps://doi.org/10.3109/03602532.2012.691099openalex-snapshot
The right compound in the right assay at the right time: an integrated discovery DMPK strategy
inferred← citeshttps://doi.org/10.3389/fnins.2022.1084493openalex-snapshot
Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics
inferred← citeshttps://doi.org/10.3389/fphar.2023.1291246openalex-snapshot
Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates
inferred← citeshttps://doi.org/10.3390/ijms242316956openalex-snapshot
Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution
inferred← citeshttps://doi.org/10.3390/membranes16100315openalex-snapshot
Biomimetic ADME Profiling of Multifunctional Biphenylalkoxyamine-Related Histamine H3 Receptor Ligands with Anti-Alzheimer Potential
inferred← citeshttps://doi.org/10.3390/molecules27123668openalex-snapshot
Prediction Models for Brain Distribution of Drugs Based on Biomimetic Chromatographic Data
inferred← citeshttps://doi.org/10.3390/molecules29061264openalex-snapshot
Experimental and Computational Methods to Assess Central Nervous System Penetration of Small Molecules
inferred← citeshttps://doi.org/10.3390/pharmaceutics12111009openalex-snapshot
Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90
inferred← citeshttps://doi.org/10.3390/pharmaceutics13101542openalex-snapshot
Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems
inferred← citeshttps://doi.org/10.3390/pharmaceutics15112619openalex-snapshot
The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery
inferred← citeshttps://doi.org/10.4155/9781909453883openalex-snapshot
Eliminating Bottlenecks for Efficient Bioanalysis: Practices and Applications in Drug Discovery and Development
inferred← citeshttps://doi.org/10.4155/fseb2013.13.67openalex-snapshot
Tissue analysis and tissue imaging
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