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Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jps.21592openalex-snapshot
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inferredcites →https://doi.org/10.1007/978-1-4757-9021-4openalex-snapshot
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
inferredcites →https://doi.org/10.1016/0378-5173(86)90055-4openalex-snapshot
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inferredcites →https://doi.org/10.1016/0378-5173(94)00311-ropenalex-snapshot
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inferredcites →https://doi.org/10.1016/0378-5173(94)90104-xopenalex-snapshot
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inferredcites →https://doi.org/10.1016/j.addr.2005.09.018openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ejpb.2006.09.011openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ijpharm.2007.05.049openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.vascn.2006.02.006openalex-snapshot
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inferredcites →https://doi.org/10.1016/s0169-409x(00)00118-6openalex-snapshot
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inferredcites →https://doi.org/10.1016/s0169-409x(96)00487-5openalex-snapshot
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inferredcites →https://doi.org/10.1016/s0378-5173(00)00614-1openalex-snapshot
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inferredcites →https://doi.org/10.1016/s1359-6446(04)03171-xopenalex-snapshot
Application of formulation technologies in lead candidate selection and optimization
inferredcites →https://doi.org/10.1016/s1367-5931(03)00055-3openalex-snapshot
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inferredcites →https://doi.org/10.1021/jm000407eopenalex-snapshot
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inferredcites →https://doi.org/10.1021/jm0303812openalex-snapshot
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inferredcites →https://doi.org/10.1038/nrd1721openalex-snapshot
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inferredcites →https://doi.org/10.3109/9781420084733openalex-snapshot
Preclinical Drug Development

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/9781118873922.ch11openalex-snapshot
Analytical Chemistry and Toxicology Formulations
inferred← citeshttps://doi.org/10.1002/9781118907894.ch1openalex-snapshot
Introduction
inferred← citeshttps://doi.org/10.1002/9781118907894.ch2openalex-snapshot
Lead Identification/Optimization
inferred← citeshttps://doi.org/10.1002/9781118907894.ch3openalex-snapshot
Oral Drug Formulation Development in Pharmaceutical Lead Selection Stage
inferred← citeshttps://doi.org/10.1002/9781119097440.ch5openalex-snapshot
FORMULATIONS, ROUTES, AND DOSAGE REGIMENS
inferred← citeshttps://doi.org/10.1002/9781119264408.ch1openalex-snapshot
Solid‐State Properties and Pharmaceutical Development
inferred← citeshttps://doi.org/10.1002/9781119264408.ch24openalex-snapshot
Quality by Design
inferred← citeshttps://doi.org/10.1002/9781119755883.ch6openalex-snapshot
FORMULATIONS, ROUTES, AND DOSAGE REGIMENS
inferred← citeshttps://doi.org/10.1002/9781394159338.ch11openalex-snapshot
Molecular Simulation
inferred← citeshttps://doi.org/10.1002/9781394254484.ch01openalex-snapshot
Solid‐State Properties and Pharmaceutical Development
inferred← citeshttps://doi.org/10.1002/9781394254484.ch26openalex-snapshot
Quality by Design
inferred← citeshttps://doi.org/10.1002/9783527801756.ch12openalex-snapshot
Early Drug Development: From a Drug Candidate to the Clinic
inferred← citeshttps://doi.org/10.1002/chin.201046236openalex-snapshot
ChemInform Abstract: Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates
inferred← citeshttps://doi.org/10.1002/cmdc.201000405openalex-snapshot
Solid‐State Perturbation for Solubility Improvement: A Proof of Concept
inferred← citeshttps://doi.org/10.1002/jps.23257openalex-snapshot
A rapid approach to the preliminary assessment of the physical stability of pharmaceutical hydrates
inferred← citeshttps://doi.org/10.1002/jps.24088openalex-snapshot
Physicochemical Properties, Form, and Formulation Selection Strategy for a Biopharmaceutical Classification System Class II Preclinical Drug Candidate
inferred← citeshttps://doi.org/10.1002/jps.24294openalex-snapshot
Advancing Drug Discovery: A Pharmaceutics Perspective
inferred← citeshttps://doi.org/10.1002/jps.24541openalex-snapshot
Amorphous Solid Dispersions: Utilization and Challenges in Drug Discovery and Development
inferred← citeshttps://doi.org/10.1007/978-1-4939-1399-2_7openalex-snapshot
Strategies and Methods for Drug Candidate Phase Optimization in Discovery Space
inferred← citeshttps://doi.org/10.1007/s11095-014-1463-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11095-024-03737-8openalex-snapshot
Accelerated Development of Pharmaceuticals Past, Present, and Future
inferred← citeshttps://doi.org/10.1016/b978-0-12-417205-0.00031-6openalex-snapshot
Improving the Water-Solubility of Compounds by Molecular Modification to Disrupt Crystal Packing
inferred← citeshttps://doi.org/10.1016/j.addr.2019.05.008openalex-snapshot
Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms
inferred← citeshttps://doi.org/10.1016/j.cie.2022.108974openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ddtec.2012.03.006openalex-snapshot
Optimizing the physical form – opportunities and limitations
inferred← citeshttps://doi.org/10.1016/j.drudis.2011.11.007openalex-snapshot
Bridging solubility between drug discovery and development
inferred← citeshttps://doi.org/10.1016/j.drudis.2012.03.016openalex-snapshot
Progressing preclinical drug candidates: strategies on preclinical safety studies and the quest for adequate exposure
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.05.014openalex-snapshot
NIPTE: a multi-university partnership supporting academic drug development
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.06.046openalex-snapshot
Synthesis and evaluation of N -heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents
inferred← citeshttps://doi.org/10.1016/j.ejpb.2023.01.008openalex-snapshot
Solid-state properties of Nifurtimox. Preparation, analytical characterization, and stability of an amorphous phase
inferred← citeshttps://doi.org/10.1016/j.ejps.2013.10.015openalex-snapshot
Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.07.018openalex-snapshot
A preformulation evaluation of a photosensitive surface active compound, explaining concentration dependent degradation
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.12.043openalex-snapshot
AI-directed formulation strategy design initiates rational drug development
inferred← citeshttps://doi.org/10.1016/j.jpba.2013.01.016openalex-snapshot
Evaluating MISER chromatography for a rapid formulation screen
inferred← citeshttps://doi.org/10.1016/j.molliq.2021.118352openalex-snapshot
Solubility of baclofen in some neat and mixed solvents at different temperatures
inferred← citeshttps://doi.org/10.1016/j.rinphs.2011.09.001openalex-snapshot
Oral bioavailability of a poorly aqueous drug from three different SBE7-β-cyclodextrin based formulations in beagle dogs
inferred← citeshttps://doi.org/10.1016/j.techfore.2021.120698openalex-snapshot
How pharmaceutical innovation evolves: The path from science to technological development to marketable drugs
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.02.011openalex-snapshot
Evaluating Spray Drying and Co-Precipitation as Manufacturing Processes for Amorphous Solid Dispersions of a Low Tg API
inferred← citeshttps://doi.org/10.1016/s1773-2247(14)50002-0openalex-snapshot
Nanotechnologies in Drug Delivery - An Industrial Perspective
inferred← citeshttps://doi.org/10.1021/acs.cgd.0c00313openalex-snapshot
Salts and Cocrystal of Etodolac: Advantage of Solubility, Dissolution, and Permeability
inferred← citeshttps://doi.org/10.1021/acs.oprd.5b00279openalex-snapshot
Recrystallizing Primidone through Supercritical Antisolvent Precipitation
inferred← citeshttps://doi.org/10.1021/cg300878jopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jm101356popenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/mp200452ropenalex-snapshot
Identification of Suitable Formulations for High Dose Oral Studies in Rats Using In Vitro Solubility Measurements, the Maximum Absorbable Dose Model, and Historical Data Sets
inferred← citeshttps://doi.org/10.1021/mp400176yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/mp500504qopenalex-snapshot
Preclinical Dose Number and Its Application in Understanding Drug Absorption Risk and Formulation Design for Preclinical Species
inferred← citeshttps://doi.org/10.1021/op200026fopenalex-snapshot
Coupling Polymorphism/Solvatomorphism and Physical Stability Evaluation with Early Salt Synthesis Optimization of an Investigational Drug
inferred← citeshttps://doi.org/10.1021/tx3000522openalex-snapshot
Introduction: Use of Radioactive Compounds in Drug Discovery and Development
inferred← citeshttps://doi.org/10.1039/9781849733502-00110openalex-snapshot
Role of Co-crystals in the Pharmaceutical Development Continuum
inferred← citeshttps://doi.org/10.1039/9781849733557-00079openalex-snapshot
The Learning and Evolution of Medicinal Chemistry against Kinase Targets
inferred← citeshttps://doi.org/10.1039/c0md00214copenalex-snapshot
Activation energies for the decomposition of pharmaceuticals and their application to predicting hydrolytic stability in drug discovery
inferred← citeshttps://doi.org/10.1039/c6md00138fopenalex-snapshot
On the utility of coupling polarised light microscopy to a solubility assay in drug discovery
inferred← citeshttps://doi.org/10.1124/pr.112.005660openalex-snapshot
Strategies to Address Low Drug Solubility in Discovery and Development
inferred← citeshttps://doi.org/10.1146/annurev-chembioeng-061010-114224openalex-snapshot
Crystal Polymorphism in Chemical Process Development
inferred← citeshttps://doi.org/10.1208/s12249-017-0849-3openalex-snapshot
Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing the Design and Selection of Optimal Drug Candidates
inferred← citeshttps://doi.org/10.1208/s12249-021-02106-7openalex-snapshot
Salts and Polymorph Screens for Bedaquiline
inferred← citeshttps://doi.org/10.1248/cpb.c18-00644openalex-snapshot
Preparation of Amorphous Composite Particles of Drugs with Ursodeoxycholic Acid as Preclinical Formulations
inferred← citeshttps://doi.org/10.1517/17460441.2014.960839openalex-snapshot
Novel tactics for designing water-soluble molecules in drug discovery
inferred← citeshttps://doi.org/10.3109/03639045.2011.589452openalex-snapshot
Preformulation evaluation of AZD1305, an oxabispidine intended for oral and intravenous treatment
inferred← citeshttps://doi.org/10.3109/03639045.2012.662507openalex-snapshot
Early pharmaceutical evaluation of a crystalline and hygroscopic GABAB receptor agonist
inferred← citeshttps://doi.org/10.3109/10717544.2014.898714openalex-snapshot
Rational formulation strategy from drug discovery profiling to human proof of concept
inferred← citeshttps://doi.org/10.3389/fphar.2011.00044openalex-snapshot
Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO® Micro Infusion Pump: Programmable, Refillable, and Implantable
inferred← citeshttps://doi.org/10.3390/molecules26010182openalex-snapshot
Molecular Simulation and Statistical Learning Methods toward Predicting Drug–Polymer Amorphous Solid Dispersion Miscibility, Stability, and Formulation Design
inferred← citeshttps://doi.org/10.3390/pharmaceutics12040342openalex-snapshot
Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates
inferred← citeshttps://doi.org/10.3390/pharmaceutics13091328openalex-snapshot
Exploring Taxifolin Polymorphs: Insights on Hydrate and Anhydrous Forms
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