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Preclinical Dose Number and Its Application in Understanding Drug Absorption Risk and Formulation Design for Preclinical Species
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
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Computational Oral Absorption Simulation for Low‐Solubility Compounds
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Effect of gastric pH on the pharmacokinetics of a bcs class II compound in dogs: Utilization of an artificial stomach and duodenum dissolution model and gastroplus,™ simulations to predict absorption
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Optimizing the “Drug-Like” Properties of Leads in Drug Discovery
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Case History — Use of ADME Studies for Optimization of Drug Candidates
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Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization
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Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure
inferredcites →https://doi.org/10.1007/bf02854912openalex-snapshot
Discovery pharmaceutics—Challenges and opportunities
inferredcites →https://doi.org/10.1007/s11095-007-9236-1openalex-snapshot
Predicting Effect of Food on Extent of Drug Absorption Based on Physicochemical Properties
inferredcites →https://doi.org/10.1016/j.bmcl.2009.08.045openalex-snapshot
Using the Golden Triangle to optimize clearance and oral absorption
inferredcites →https://doi.org/10.1016/j.ejps.2005.08.011openalex-snapshot
A strategy for preclinical formulation development using GastroPlus™ as pharmacokinetic simulation tool and a statistical screening design applied to a dog study
inferredcites →https://doi.org/10.1016/j.ejps.2009.04.009openalex-snapshot
Temperature and solvent effects in the solubility of some pharmaceutical compounds: Measurements and modeling
inferredcites →https://doi.org/10.1021/jm1002638openalex-snapshot
Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates
inferredcites →https://doi.org/10.1021/mp100157sopenalex-snapshot
A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling
inferredcites →https://doi.org/10.1021/mp200452ropenalex-snapshot
Identification of Suitable Formulations for High Dose Oral Studies in Rats Using In Vitro Solubility Measurements, the Maximum Absorbable Dose Model, and Historical Data Sets
inferredcites →https://doi.org/10.1023/a:1018947113238openalex-snapshot
Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model
inferredcites →https://doi.org/10.1023/a:1025084527878openalex-snapshot
Predicting oral absorption of drugs: a case study with a novel class of antimicrobial agents.
inferredcites →https://doi.org/10.1177/00970002042006005openalex-snapshot
A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals
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Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs
inferredcites →https://doi.org/10.1208/s12249-013-0030-6openalex-snapshot
Use of Preclinical Dog Studies and Absorption Modeling to Facilitate Late Stage Formulation Bridging for a BCS II Drug Candidate
inferredcites →https://doi.org/10.2133/dmpk.22.225openalex-snapshot
Solubility and Dissolution Profile Assessment in Drug Discovery
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Systematic Screening and Investigation of Solid‐State Landscapes
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A Retrospective Analysis of Preclinical and Clinical Pharmacokinetics from Administration of Long-Acting Aqueous Suspensions
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Drug discovery: Standing on the shoulders of giants
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Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase
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Discovery solubility measurement and assessment of small molecules with drug development in mind
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Enabling lead optimization with a focus on optimal dose selection by utilizing multi-parametric data visualization techniques
inferred← citeshttps://doi.org/10.1016/j.ejpb.2019.06.010openalex-snapshot
In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.10.003openalex-snapshot
Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2016.02.033openalex-snapshot
Application of in vitro transmucosal permeability, dose number, and maximum absorbable dose for biopharmaceutics assessment during early drug development for intraoral delivery
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.121298openalex-snapshot
Lamotrigine therapy in patients after bariatric surgery: Potentially hampered solubility and dissolution
inferred← citeshttps://doi.org/10.1016/j.xphs.2017.05.025openalex-snapshot
Automated Supersaturation Stability Assay to Differentiate Poorly Soluble Compounds in Drug Discovery
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Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?
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Vehicle effect on in-vitro and in-vivo performance of spray-dried dispersions
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01687openalex-snapshot
Dose Number as a Tool to Guide Lead Optimization for Orally Bioavailable Compounds in Drug Discovery
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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease
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Flexibility in Drug Product Development: A Perspective
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.6b01118openalex-snapshot
Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species
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Impact of Gut Microbiota-Mediated Bile Acid Metabolism on the Solubilization Capacity of Bile Salt Micelles and Drug Solubility
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Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes
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Strategy for Extending Half-life in Drug Design and Its Significance
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