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X-ray Crystal Structure of a Xanthine Oxidase Complex with the Flavonoid Inhibitor Quercetin

https://doi.org/10.1021/np500320g
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Structural study of quercetin by vibrational and electronic spectroscopies combined with semiempirical calculations
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Purification of highly active milk xanthine oxidase by affinity chromatography on sepharose 4B/folate gel
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Molybdenum-containing hydroxylases
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A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome
inferredcites →https://doi.org/10.1016/j.ejphar.2008.03.008openalex-snapshot
Health effects of quercetin: From antioxidant to nutraceutical
inferredcites →https://doi.org/10.1016/j.jmb.2007.03.062openalex-snapshot
Crystal Structures of Multidrug Binding Protein TtgR in Complex with Antibiotics and Plant Antimicrobials
inferredcites →https://doi.org/10.1016/j.molcel.2010.04.001openalex-snapshot
Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1
inferredcites →https://doi.org/10.1016/s0021-9258(18)91738-2openalex-snapshot
Studies on Milk Xanthine Oxidase
inferredcites →https://doi.org/10.1016/s0021-9258(19)45598-1openalex-snapshot
The Resolution of Active and Inactive Xanthine Oxidase by Affinity Chromatography
inferredcites →https://doi.org/10.1016/s0968-0004(02)02107-2openalex-snapshot
Molybdenum and tungsten in biology
inferredcites →https://doi.org/10.1016/s0969-2126(01)00695-5openalex-snapshot
Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana
inferredcites →https://doi.org/10.1016/s1097-2765(05)00089-4openalex-snapshot
Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
inferredcites →https://doi.org/10.1021/bi401465uopenalex-snapshot
Substrate Orientation and Specificity in Xanthine Oxidase: Crystal Structures of the Enzyme in Complex with Indole-3-acetaldehyde and Guanine
inferredcites →https://doi.org/10.1021/cr400443zopenalex-snapshot
The Mononuclear Molybdenum Enzymes
inferredcites →https://doi.org/10.1021/cr950061topenalex-snapshot
The Mononuclear Molybdenum Enzymes
inferredcites →https://doi.org/10.1021/np8007123openalex-snapshot
Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin
inferredcites →https://doi.org/10.1021/np970237hopenalex-snapshot
Structure−Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers
inferredcites →https://doi.org/10.1038/385602a0openalex-snapshot
Crystal structure of the Src family tyrosine kinase Hck
inferredcites →https://doi.org/10.1038/sj.emboj.7600970openalex-snapshot
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification
inferredcites →https://doi.org/10.1038/sj.mn.7800136openalex-snapshot
The Physiology of Endothelial Xanthine Oxidase: From Urate Catabolism to Reperfusion Injury to Inflammatory Signal Transduction
inferredcites →https://doi.org/10.1042/bj1950753openalex-snapshot
Kinetic and e.p.r. studies on the inhibition of xanthine oxidase by alloxanthine (1 H-pyrazolo [3, 4-d] pyrimidine-4,6-diol)
inferredcites →https://doi.org/10.1073/pnas.0706290104openalex-snapshot
Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols
inferredcites →https://doi.org/10.1073/pnas.262506299openalex-snapshot
Anaerobic enzyme⋅substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase
inferredcites →https://doi.org/10.1073/pnas.97.20.10723openalex-snapshot
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
inferredcites →https://doi.org/10.1074/jbc.274.8.4985openalex-snapshot
Binding of Xanthine Oxidase to Vascular Endothelium
inferredcites →https://doi.org/10.1074/jbc.m110.128561openalex-snapshot
Substrate Orientation and Catalytic Specificity in the Action of Xanthine Oxidase
inferredcites →https://doi.org/10.1074/jbc.m208307200openalex-snapshot
An Extremely Potent Inhibitor of Xanthine Oxidoreductase
inferredcites →https://doi.org/10.1074/jbc.m700364200openalex-snapshot
The Role of Arginine 310 in Catalysis and Substrate Specificity in Xanthine Dehydrogenase from Rhodobacter capsulatus
inferredcites →https://doi.org/10.1074/jbc.m707918200openalex-snapshot
Substrate Orientation in Xanthine Oxidase
inferredcites →https://doi.org/10.1074/jbc.m804517200openalex-snapshot
Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase
inferredcites →https://doi.org/10.1074/jbc.m808114200openalex-snapshot
Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase
inferredcites →https://doi.org/10.1080/15257770802146577openalex-snapshot
Mechanism of Inhibition of Xanthine Oxidoreductase by Allopurinol: Crystal Structure of Reduced Bovine Milk Xanthine Oxidoreductase Bound with Oxipurinol
inferredcites →https://doi.org/10.1093/jb/mvm053openalex-snapshot
Human Xanthine Oxidase Changes its Substrate Specificity to Aldehyde Oxidase Type upon Mutation of Amino Acid Residues in the Active Site: Roles of Active Site Residues in Binding and Activation of Purine Substrate
inferredcites →https://doi.org/10.1096/fasebj.9.11.7649415openalex-snapshot
Xanthine oxidase and xanthine dehydrogenase
inferredcites →https://doi.org/10.1107/s0021889892009944openalex-snapshot
PROCHECK: a program to check the stereochemical quality of protein structures
inferredcites →https://doi.org/10.1110/ps.036186.108openalex-snapshot
Three flavonoids targeting the β‐hydroxyacyl‐acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay
inferredcites →https://doi.org/10.1111/j.1582-4934.2008.00564.xopenalex-snapshot
Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy
inferredcites →https://doi.org/10.1113/jphysiol.2003.055913openalex-snapshot
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
inferredcites →https://doi.org/10.1124/pr.58.1.6openalex-snapshot
Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
inferredcites →https://doi.org/10.1136/annrheumd00512-0010openalex-snapshot
Enzymatic and Metabolic Studies with Allopurinol
inferredcites →https://doi.org/10.1152/ajplung.00007.2008openalex-snapshot
Xanthine oxidoreductase in respiratory and cardiovascular disorders
inferredcites →https://doi.org/10.1158/1535-7163.mct-06-0397openalex-snapshot
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
inferredcites →https://doi.org/10.1161/01.cir.0000041431.57222.afopenalex-snapshot
Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure
inferredcites →https://doi.org/10.1271/bbb.63.1787openalex-snapshot
Inhibition of Xanthine Oxidase by Flavonoids
inferredcites →https://doi.org/10.2174/0929867023371229openalex-snapshot
Progress Towards the Discovery of Xanthine Oxidase Inhibitors
inferredcites →https://doi.org/10.2174/1570161054368607openalex-snapshot
Role of Oxidative-Nitrosative Stress and Downstream Pathways in Various Forms of Cardiomyopathy and Heart Failure
inferredcites →https://doi.org/10.2337/diabetes.51.4.1118openalex-snapshot
Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes
inferredcites →https://doi.org/10.7326/0003-4819-143-7-200510040-00009openalex-snapshot
Pathogenesis of Gout

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A eukaryotic nicotinate-inducible gene cluster: convergent evolution in fungi and bacteria
inferred← citeshttps://doi.org/10.1101/2023.01.11.523536openalex-snapshot
Deep-learning based bioactive peptides generation and screening against Xanthine oxidase
inferred← citeshttps://doi.org/10.1109/icstm.2017.8089213openalex-snapshot
Molecular docking analysis of imidazole derivatives and polybenzimidazole analogs as inhibitors of superoxide dismutase (SOD) and xanthine oxidase (XO)
inferred← citeshttps://doi.org/10.1111/cbdd.13437openalex-snapshot
Natural compounds with xanthine oxidase inhibitory activity: A review
inferred← citeshttps://doi.org/10.1111/cbdd.14109openalex-snapshot
Synthetic heterocyclic derivatives as promising xanthine oxidase inhibitors: An overview
inferred← citeshttps://doi.org/10.1124/dmd.114.061192openalex-snapshot
Inhibition of Human Aldehyde Oxidase Activity by Diet-Derived Constituents: Structural Influence, Enzyme-Ligand Interactions, and Clinical Relevance
inferred← citeshttps://doi.org/10.1142/s0192415x24500733openalex-snapshot
Natural Bioactive Compounds: Emerging Therapies for Hyperuricemia
inferred← citeshttps://doi.org/10.1142/s0219633620400088openalex-snapshot
Xanthine oxidoreductase inhibition – A review of computational aspect
inferred← citeshttps://doi.org/10.1155/2017/5762172openalex-snapshot
Antidepressant Flavonoids and Their Relationship with Oxidative Stress
inferred← citeshttps://doi.org/10.1186/s12906-017-1698-zopenalex-snapshot
Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content
inferred← citeshttps://doi.org/10.1186/s43094-022-00448-yopenalex-snapshot
Xanthine oxidase inhibitory potentials of flavonoid aglycones of Tribulus terrestris: in vivo, in silico and in vitro studies
inferred← citeshttps://doi.org/10.13005/ojc/340362openalex-snapshot
Combination of Tamsulosin with Potassium Citrate Effect on Serum Oxidoreductases in Patients with Nephrolithiasis
inferred← citeshttps://doi.org/10.1371/journal.pone.0202572openalex-snapshot
Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations
inferred← citeshttps://doi.org/10.14710/jksa.25.7.253-263openalex-snapshot
Phenolic Compound in Garlic (Allium sativum) and Black Garlic Potency as Antigout Using Molecular Docking Approach
inferred← citeshttps://doi.org/10.17576/jskm-2018-1601-17openalex-snapshot
Synthesis, Biological Evaluation and Docking Studies of Aurone Derivatives on Xanthine Oxidase Enzyme
inferred← citeshttps://doi.org/10.17576/jsm-2023-5206-03openalex-snapshot
In Vitro and in Silico Study on the Interaction between Apigenin, Kaempferol and 4-Hydroxybenzoic Acid in Xanthine Oxidase Inhibition
inferred← citeshttps://doi.org/10.19080/arr.2019.04.555648openalex-snapshot
The Chemistry of Oxidative Stress and Glycoxidation As Risk Factors for Developing Degenerative Disease
inferred← citeshttps://doi.org/10.2139/ssrn.5749884openalex-snapshot
Acridine-based compounds with promising antimicrobial and antioxidant activities: experimental and computational insight
inferred← citeshttps://doi.org/10.2174/1381612826666200728144605openalex-snapshot
Natural Products and Extracts as Xantine Oxidase Inhibitors - A Hope for Gout Disease?
inferred← citeshttps://doi.org/10.2174/1386207323666200428075224openalex-snapshot
In vitro and in silico Xanthine Oxidase Inhibitory Activity of Selected Phytochemicals Widely Present in Various Edible Plants
inferred← citeshttps://doi.org/10.2174/1568026619666190206122640openalex-snapshot
In Silico and 3D QSAR Studies of Natural Based Derivatives as Xanthine Oxidase Inhibitors
inferred← citeshttps://doi.org/10.2174/1573406415666191004134346openalex-snapshot
Computational Analysis and Synthesis of Syringic Acid Derivatives as Xanthine Oxidase Inhibitors
inferred← citeshttps://doi.org/10.2210/pdb6m8d/pdbopenalex-snapshot
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with diosmetin
inferred← citeshttps://doi.org/10.22159/ajpcr.2017.v10s2.19486openalex-snapshot
IN VITRO AND IN SILICO EVALUATION OF XANTHINE OXIDASE INHIBITORY ACTIVITY OF QUERCETIN CONTAINED IN SONCHUS ARVENSIS LEAF EXTRACT
inferred← citeshttps://doi.org/10.2478/enr-2021-0015openalex-snapshot
Quercetin improves myocardial redox status in rats with type 2 diabetes
inferred← citeshttps://doi.org/10.25077/jsfk.10.1.114-119.2023openalex-snapshot
Nilai IC50 Ekstrak dan Fraksi Daun Benalu Kersen terhadap Enzim Xantin Oksidase
inferred← citeshttps://doi.org/10.26599/fmh.2027.9420159openalex-snapshot
Piper nigrum L. and its main component piperine ameliorate hyperuricemia and hyperuricemia-related renal inflammation through suppressing the JAK2-STAT3-XDH/SOCS3/TNF-α signalling pathway
inferred← citeshttps://doi.org/10.26740/ujc.v10n1.p96-108openalex-snapshot
REVIEW ARTIKEL: ISOLASI DAN PENGUKURAN AKTIVITAS ENZIM XANTIN OKSIDASE
inferred← citeshttps://doi.org/10.29228/jrp.532openalex-snapshot
Molecular docking approach to identify xanthine oxidase inhibitory effect of bioactive compounds in Pogostemon cablin (Blanco) Benth
inferred← citeshttps://doi.org/10.31925/farmacia.2021.6.4openalex-snapshot
PLANT PRODUCTS AND THEIR INHIBITORY ACTIVITY AGAINST XANTHINE OXIDASE
inferred← citeshttps://doi.org/10.32571/ijct.1199221openalex-snapshot
The investigation of the effect of chalcones with benzoic acid on xanthine oxidase activity
inferred← citeshttps://doi.org/10.33263/briac134.327openalex-snapshot
An in silico Molecular Docking and ADME Analysis of Naturally Derived Biomolecules against Xanthine Oxidase: A Novel Lead for Antihyperuricemia Treatment
inferred← citeshttps://doi.org/10.3389/fchem.2025.1518777openalex-snapshot
Design and evaluation of novel triazole derivatives as potential anti-gout inhibitors: a comprehensive molecular modeling study
inferred← citeshttps://doi.org/10.3389/fphar.2025.1576390openalex-snapshot
Chromene flavanones from Dalea boliviana as xanthine oxidase inhibitors: in vitro biological evaluation and molecular docking studies
inferred← citeshttps://doi.org/10.3390/antiox10111822openalex-snapshot
Purification, Identification and Characterization of Antioxidant Peptides from Corn Silk Tryptic Hydrolysate: An Integrated In Vitro-In Silico Approach
inferred← citeshttps://doi.org/10.3390/antiox12091669openalex-snapshot
Exploring the Antioxidant Properties of Caffeoylquinic and Feruloylquinic Acids: A Computational Study on Hydroperoxyl Radical Scavenging and Xanthine Oxidase Inhibition
inferred← citeshttps://doi.org/10.3390/antiox13101184openalex-snapshot
Antidiabetic and Antigout Properties of the Ultrasound-Assisted Extraction of Total Biflavonoids from Selaginella doederleinii Revealed by In Vitro and In Silico Studies
inferred← citeshttps://doi.org/10.3390/antiox7100137openalex-snapshot
Antiradical and Xanthine Oxidase Inhibitory Activity Evaluations of Averrhoa bilimbi L. Leaves and Tentative Identification of Bioactive Constituents through LC-QTOF-MS/MS and Molecular Docking Approach
inferred← citeshttps://doi.org/10.3390/biom15030313openalex-snapshot
Quercetin: Molecular Insights into Its Biological Roles
inferred← citeshttps://doi.org/10.3390/catal13030605openalex-snapshot
Exploring the Potential of Black Soldier Fly Larval Proteins as Bioactive Peptide Sources through in Silico Gastrointestinal Proteolysis: A Cheminformatic Investigation
inferred← citeshttps://doi.org/10.3390/ecsoc-28-20212openalex-snapshot
In Silico Investigation of Two Benzoxanthone-Flavonoids: ADMET Analysis and Xanthine Oxidase Binding
inferred← citeshttps://doi.org/10.3390/ecsoc-29-26723openalex-snapshot
Docking and In Silico ADMET Analysis of Flavone Glucoside Compounds as Antioxidant Agents
inferred← citeshttps://doi.org/10.3390/foods10092191openalex-snapshot
Epicatechin Gallate as Xanthine Oxidase Inhibitor: Inhibitory Kinetics, Binding Characteristics, Synergistic Inhibition, and Action Mechanism
inferred← citeshttps://doi.org/10.3390/foods13152365openalex-snapshot
Structure–Activity Relationships and Changes in the Inhibition of Xanthine Oxidase by Polyphenols: A Review
inferred← citeshttps://doi.org/10.3390/foods14030524openalex-snapshot
In Slico Screening and In Vitro Identification of Hyperuricemia-Inhibiting Peptides from Trachurus japonicus
inferred← citeshttps://doi.org/10.3390/ijms20112681openalex-snapshot
Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme
inferred← citeshttps://doi.org/10.3390/ijms242015391openalex-snapshot
Inhibitory Effect of Quercetin on Oxidative Endogen Enzymes: A Focus on Putative Binding Modes
inferred← citeshttps://doi.org/10.3390/ijms25031798openalex-snapshot
Virtual Screening of Peptide Libraries: The Search for Peptide-Based Therapeutics Using Computational Tools
inferred← citeshttps://doi.org/10.3390/ijms251910426openalex-snapshot
Interaction of Tri-Cyclic Nucleobase Analogs with Enzymes of Purine Metabolism: Xanthine Oxidase and Purine Nucleoside Phosphorylase
inferred← citeshttps://doi.org/10.3390/ijms26010404openalex-snapshot
Theoretical Study of Antioxidant and Prooxidant Potency of Protocatechuic Aldehyde
inferred← citeshttps://doi.org/10.3390/ijms27125353openalex-snapshot
The In Vivo Existence Forms of Engeletin and Their Anti-Hyperuricemia Activity
inferred← citeshttps://doi.org/10.3390/metabo12111031openalex-snapshot
Euclea divinorum Hiern: Chemical Profiling of the Leaf Extract and Its Antioxidant Activity In Silico, In Vitro and in Caenorhabditis elegans Model
inferred← citeshttps://doi.org/10.3390/metabo13010113openalex-snapshot
A Study of the Interaction between Xanthine Oxidase and Its Inhibitors from Chrysanthemum morifolium Using Computational Simulation and Multispectroscopic Methods
inferred← citeshttps://doi.org/10.3390/molecules26237307openalex-snapshot
Natural Xanthine Oxidase Inhibitor 5-O-Caffeoylshikimic Acid Ameliorates Kidney Injury Caused by Hyperuricemia in Mice
inferred← citeshttps://doi.org/10.3390/molecules26237396openalex-snapshot
Computational Screening for the Anticancer Potential of Seed-Derived Antioxidant Peptides: A Cheminformatic Approach
inferred← citeshttps://doi.org/10.3390/molecules31040630openalex-snapshot
Beyond α-Glucosidase and α-Amylase Inhibition: Integrated In Vitro and Multi-Scale In Silico Insights into the Antidiabetic and Antioxidant Mechanisms of Oxalis corniculata L. Aerial Parts
inferred← citeshttps://doi.org/10.3390/ph11030072openalex-snapshot
An Antioxidant Potential, Quantum-Chemical and Molecular Docking Study of the Major Chemical Constituents Present in the Leaves of Curatella americana Linn
inferred← citeshttps://doi.org/10.3390/plants15050708openalex-snapshot
Phytochemical Profiling and Antioxidant Properties of Ziziphus lotus (L.) Fruits Supported by Xanthine Oxidase Inhibition and Molecular Docking
inferred← citeshttps://doi.org/10.36468/pharmaceutical-sciences.863openalex-snapshot
In Vitro and In Silico Study of 5-[(4-Methylpiperazin-1-yl) methyl]dehydrozingerone and 5-(Morpholin-4-ylmethyl) dehydrozingerone as Lipoxygenase and Xanthine Oxidase Inhibitor
inferred← citeshttps://doi.org/10.4155/fmc-2016-0186openalex-snapshot
Quercetin and Derivatives: Useful Tools in Inflammation and Pain Management
inferred← citeshttps://doi.org/10.4236/jbpc.2019.101001openalex-snapshot
In Silico and in Vitro Approach for the Understanding of the Xanthine Oxidase Inhibitory Activity of Uruguayan Tannat Grape Pomace and Propolis Poliphenols
inferred← citeshttps://doi.org/10.47583/ijpsrr.2021.v69i01.036openalex-snapshot
An Overview of a Versatile Compound: Quercetin
inferred← citeshttps://doi.org/10.47583/ijpsrr.2021.v69i01.037openalex-snapshot
Effect of Sodium Fluoride (NaF) Exposure on Heart: Protective Effect of Eugenol with Reference to the Lipid Metabolic Profiles
inferred← citeshttps://doi.org/10.5772/intechopen.82461openalex-snapshot
Medicinal Plants of the Peruvian Amazon: Bioactive Phytochemicals, Mechanisms of Action, and Biosynthetic Pathways
inferred← citeshttps://doi.org/10.7287/peerj.3376v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.3376v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells (v0.1)"
inferred← citeshttps://doi.org/10.7717/peerj.3376openalex-snapshot
Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.