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Genome-Wide Transcriptional Responses to Acrolein
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jbt.10007openalex-snapshot
Extensive protein carbonylation precedes acrolein‐mediated cell death in mouse hepatocytes
inferredcites →https://doi.org/10.1002/jcp.10140openalex-snapshot
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
inferredcites →https://doi.org/10.1002/jnr.20863openalex-snapshot
Acrolein‐mediated mechanisms of neuronal death
inferredcites →https://doi.org/10.1002/mnfr.200700412openalex-snapshot
Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease
inferredcites →https://doi.org/10.1007/s11010-007-9411-zopenalex-snapshot
Induction of COX-2 by acrolein in rat lung epithelial cells
inferredcites →https://doi.org/10.1016/0197-0186(94)00173-ropenalex-snapshot
Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc
inferredcites →https://doi.org/10.1016/0891-5849(91)90192-6openalex-snapshot
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
inferredcites →https://doi.org/10.1016/j.bbamcr.2004.11.007openalex-snapshot
The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway
inferredcites →https://doi.org/10.1016/j.cellsig.2006.10.014openalex-snapshot
P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells
inferredcites →https://doi.org/10.1016/j.fct.2006.06.016openalex-snapshot
Sugars as tobacco ingredient: Effects on mainstream smoke composition
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2006.12.009openalex-snapshot
Activation of the death receptor pathway of apoptosis by the aldehyde acrolein
inferredcites →https://doi.org/10.1016/j.tiv.2007.12.018openalex-snapshot
Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: Influence of nucleophilic culture media constituents
inferredcites →https://doi.org/10.1016/j.yexcr.2007.04.032openalex-snapshot
Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis
inferredcites →https://doi.org/10.1016/s0006-2952(99)00301-9openalex-snapshot
Regulation of metallothionein gene expression by oxidative stress and metal ions
inferredcites →https://doi.org/10.1016/s0009-2797(01)00295-2openalex-snapshot
Acrolein-induced cell death: a caspase-influenced decision between apoptosis and oncosis/necrosis
inferredcites →https://doi.org/10.1016/s0300-483x(97)00086-3openalex-snapshot
Relationships between cell density, glutathione and proliferation of A549 human lung adenocarcinoma cells treated with acrolein
inferredcites →https://doi.org/10.1016/s0378-4274(02)00055-3openalex-snapshot
Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
inferredcites →https://doi.org/10.1016/s0891-5849(03)00107-2openalex-snapshot
Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells
inferredcites →https://doi.org/10.1021/bi0264723openalex-snapshot
Mutagenesis by Acrolein-Derived Propanodeoxyguanosine Adducts in Human Cells
inferredcites →https://doi.org/10.1021/tx050211nopenalex-snapshot
Alterations in Gene Expression Induced by the Lipid Peroxidation Product, 4-Hydroxy-2-nonenal
inferredcites →https://doi.org/10.1021/tx050321uopenalex-snapshot
Endogenous Reactive Intermediates as Modulators of Cell Signaling and Cell Death
inferredcites →https://doi.org/10.1021/tx700192eopenalex-snapshot
Intermolecular Protein Cross-Linking During Acrolein Toxicity: Efficacy of Carbonyl Scavengers as Inhibitors of Heat Shock Protein-90 Cross-Linking in A549 Cells
inferredcites →https://doi.org/10.1038/nature02661openalex-snapshot
Gene regulation and DNA damage in the ageing human brain
inferredcites →https://doi.org/10.1038/ng0498-382openalex-snapshot
Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies
inferredcites →https://doi.org/10.1038/sj.cdd.4400818openalex-snapshot
Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2
inferredcites →https://doi.org/10.1038/sj.onc.1206222openalex-snapshot
EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
inferredcites →https://doi.org/10.1038/sj.onc.1209601openalex-snapshot
p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction
inferredcites →https://doi.org/10.1042/bj20050196openalex-snapshot
MSKs are required for the transcription of the nuclear orphan receptors Nur77 , Nurr1 and Nor1 downstream of MAPK signalling
inferredcites →https://doi.org/10.1073/pnas.0401168101openalex-snapshot
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
inferredcites →https://doi.org/10.1073/pnas.0607031103openalex-snapshot
Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair
inferredcites →https://doi.org/10.1073/pnas.0732111100openalex-snapshot
A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells
inferredcites →https://doi.org/10.1073/pnas.88.22.9984openalex-snapshot
Zinc transfer from transcription factor IIIA fingers to thionein clusters.
inferredcites →https://doi.org/10.1073/pnas.95.7.3489openalex-snapshot
Control of zinc transfer between thionein, metallothionein, and zinc proteins
inferredcites →https://doi.org/10.1074/jbc.274.14.9200openalex-snapshot
Acrolein Causes Inhibitor κB-independent Decreases in Nuclear Factor κB Activation in Human Lung Adenocarcinoma (A549) Cells
inferredcites →https://doi.org/10.1074/jbc.m008900200openalex-snapshot
Evaluation of the Mutagenic Potential of the Principal DNA Adduct of Acrolein
inferredcites →https://doi.org/10.1074/jbc.m500107200openalex-snapshot
Activation of Nur77 by Selected 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes Induces Apoptosis through Nuclear Pathways
inferredcites →https://doi.org/10.1084/jem.20021842openalex-snapshot
Orphan Nuclear Receptor Nur77 Is Involved in Caspase-independent Macrophage Cell Death
inferredcites →https://doi.org/10.1093/jn/134.1.57openalex-snapshot
Identification of Genes Responsive to Intracellular Zinc Depletion in the Human Colon Adenocarcinoma Cell Line HT-29
inferredcites →https://doi.org/10.1093/toxsci/57.1.6openalex-snapshot
The Molecular Effects of Acrolein
inferredcites →https://doi.org/10.1093/toxsci/kfm127openalex-snapshot
Neurotoxic Mechanisms of Electrophilic Type-2 Alkenes: Soft Soft Interactions Described by Quantum Mechanical Parameters
inferredcites →https://doi.org/10.1111/j.1365-2443.2008.01177.xopenalex-snapshot
ERK5 is involved in TCR‐induced apoptosis through the modification of Nur77
inferredcites →https://doi.org/10.1111/j.1742-4658.2006.05428.xopenalex-snapshot
Aldehydes release zinc from proteins. A pathway from oxidative stress/lipid peroxidation to cellular functions of zinc
inferredcites →https://doi.org/10.1126/science.289.5482.1159openalex-snapshot
Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3
inferredcites →https://doi.org/10.1128/aem.00526-06openalex-snapshot
Old Yellow Enzymes Protect against Acrolein Toxicity in the Yeast Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1152/ajpcell.00043.2003openalex-snapshot
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
inferredcites →https://doi.org/10.1152/ajplung.00265.2007openalex-snapshot
Early growth response factor-1 in acute lung injury
inferredcites →https://doi.org/10.1152/jappl.1992.72.2.555openalex-snapshot
Smoke aldehyde component influences pulmonary edema
inferredcites →https://doi.org/10.1158/0008-5472.can-07-2528openalex-snapshot
Lack of Mutagenicity of Acrolein-Induced DNA Adducts in Mouse and Human Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-1567openalex-snapshot
Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors
inferredcites →https://doi.org/10.1161/atvbaha.106.132837openalex-snapshot
Acrolein Induces Cyclooxygenase-2 and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
inferredcites →https://doi.org/10.1165/ajrcmb.23.3.4112openalex-snapshot
Transcription of krox-20/egr-2 Is Upregulated after Exposure to Fibrous Particles and Adhesion in Rat Alveolar Macrophages
inferredcites →https://doi.org/10.1165/rcmb.2006-0106ocopenalex-snapshot
Cigarette Smoke Stimulates Matrix Metalloproteinase-2 Activity via EGR-1 in Human Lung Fibroblasts
inferredcites →https://doi.org/10.1167/iovs.06-0248openalex-snapshot
Acrolein, a Toxicant in Cigarette Smoke, Causes Oxidative Damage and Mitochondrial Dysfunction in RPE Cells: Protection by ( R )-α-Lipoic Acid
inferredcites →https://doi.org/10.1189/jlb.0907625openalex-snapshot
Cigarette smoke stimulates the production of chemokines in mast cells
inferredcites →https://doi.org/10.1200/jco.2005.08.127openalex-snapshot
EGR1 Predicts PTEN and Survival in Patients With Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1210/me.16.7.1638openalex-snapshot
Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways
inferredcites →https://doi.org/10.1242/jcs.113.20.3603openalex-snapshot
The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins
inferredcites →https://doi.org/10.2174/138955708783955953openalex-snapshot
Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4822668openalex-extracted
An Integrated In-Silico-In-Chemico-In-Vitro (Isiciv) Approach to Identify Biomarkers to Predict the Skin Sensitization Potential of Phytochemicals
inferred← citeshttps://doi.org/10.1002/mnfr.201100182openalex-snapshot
Protein modification by acrolein: Relevance to pathological conditions and inhibition by aldehyde sequestering agents
inferred← citeshttps://doi.org/10.1002/pro.495openalex-snapshot
Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics
inferred← citeshttps://doi.org/10.1007/978-1-4471-5553-9_10openalex-snapshot
Everyday Toxicology II: Tobacco
inferred← citeshttps://doi.org/10.1007/978-1-61737-995-6_3openalex-snapshot
Tobacco Smoke Carcinogens and Lung Cancer
inferred← citeshttps://doi.org/10.1007/s00125-018-4707-yopenalex-snapshot
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
inferred← citeshttps://doi.org/10.1007/s00232-014-9651-2openalex-snapshot
Vocal Fold Ion Transport and Mucin Expression Following Acrolein Exposure
inferred← citeshttps://doi.org/10.1007/s13206-012-6309-yopenalex-snapshot
Differentially-expressed genes associated with glycophosphatidylinositol (GPI)-anchored proteins by diabetes-related toxic substances in human endothelial cells
inferred← citeshttps://doi.org/10.1007/s13273-011-0017-xopenalex-snapshot
Genome-wide analysis of gene expression by crotonaldehyde in human umbilical vein endothelial cells
inferred← citeshttps://doi.org/10.1016/bs.acc.2014.09.001openalex-snapshot
Biomarkers of Tobacco Smoke Exposure
inferred← citeshttps://doi.org/10.1016/j.cbi.2009.12.006openalex-snapshot
Toxicity of smoke extracts towards A549 lung cells: Role of acrolein and suppression by carbonyl scavengers
inferred← citeshttps://doi.org/10.1016/j.cbi.2017.08.018openalex-snapshot
19p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese
inferred← citeshttps://doi.org/10.1016/j.envint.2020.105943openalex-snapshot
The multiplex interactions and molecular mechanism on genotoxicity induced by formaldehyde and acrolein mixtures on human bronchial epithelial BEAS-2B cells
inferred← citeshttps://doi.org/10.1016/j.jprot.2011.05.039openalex-snapshot
Proteomic profiling of acrolein adducts in human lung epithelial cells
inferred← citeshttps://doi.org/10.1016/j.lfs.2009.05.012openalex-snapshot
Proteomic profiling of rat lung epithelial cells induced by acrolein
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.10.004openalex-snapshot
An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena
inferred← citeshttps://doi.org/10.1016/j.phyplu.2024.100650openalex-snapshot
An integrated In-Silico-In-Chemico-In-Vitro (iSiCiV) Approach to identify biomarkers to predict the skin sensitisation potential of phytochemicals
inferred← citeshttps://doi.org/10.1016/j.taap.2013.05.029openalex-snapshot
Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity
inferred← citeshttps://doi.org/10.1016/j.tips.2014.10.011openalex-snapshot
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection
inferred← citeshttps://doi.org/10.1016/j.tiv.2013.02.003openalex-snapshot
In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells
inferred← citeshttps://doi.org/10.1016/j.tiv.2017.09.016openalex-snapshot
Inflammatory effects of acrolein, crotonaldehyde and hexanal vapors on human primary bronchial epithelial cells cultured at air-liquid interface
inferred← citeshttps://doi.org/10.1016/j.tox.2014.02.010openalex-snapshot
Airborne acrolein induces keratin-8 (Ser-73) hyperphosphorylation and intermediate filament ubiquitination in bronchiolar lung cell monolayers
inferred← citeshttps://doi.org/10.1016/j.tox.2021.153083openalex-snapshot
Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses
inferred← citeshttps://doi.org/10.1016/j.toxlet.2010.05.005openalex-snapshot
Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde
inferred← citeshttps://doi.org/10.1016/j.toxlet.2012.06.003openalex-snapshot
Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.0c00146openalex-snapshot
Albumin Protects Lung Cells against Acrolein Cytotoxicity and Acrolein-Adducted Albumin Increases Heme Oxygenase 1 Transcripts
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00310openalex-snapshot
Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00490openalex-snapshot
In Vitro Toxicity and Chemical Characterization of Aerosol Derived from Electronic Cigarette Humectants Using a Newly Developed Exposure System
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c06538openalex-snapshot
Cytotoxicity of a Novel Compound Produced in Foods via the Reaction of Amino Acids with Acrolein along with Formaldehyde
inferred← citeshttps://doi.org/10.1021/tx100056mopenalex-snapshot
Applying Tobacco Carcinogen and Toxicant Biomarkers in Product Regulation and Cancer Prevention
inferred← citeshttps://doi.org/10.1021/tx300264xopenalex-snapshot
Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
inferred← citeshttps://doi.org/10.1021/tx8004136openalex-snapshot
A New Hammer in the Redox Toolbox: High-Purity Peroxynitrite for Cell Signaling and Toxicology Studies
inferred← citeshttps://doi.org/10.1038/nrc2674openalex-snapshot
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers
inferred← citeshttps://doi.org/10.1038/s44303-025-00096-wopenalex-snapshot
Aldehydic load as an objective imaging biomarker of mild traumatic brain injury
inferred← citeshttps://doi.org/10.1039/c4em00465eopenalex-snapshot
Application of chemical vapor generation systems to deliver constant gas concentrations for in vitro exposure to volatile organic compounds
inferred← citeshttps://doi.org/10.1039/c4tx00213jopenalex-snapshot
In vitro effects of low-level aldehyde exposures on human umbilical vein endothelial cells
inferred← citeshttps://doi.org/10.1074/jbc.m113.476630openalex-snapshot
Cigarette Smoke Component Acrolein Modulates Chromatin Assembly by Inhibiting Histone Acetylation
inferred← citeshttps://doi.org/10.1093/carcin/bgs026openalex-snapshot
Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers
inferred← citeshttps://doi.org/10.1093/toxsci/kfp228openalex-snapshot
The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers
inferred← citeshttps://doi.org/10.1093/toxsci/kfu165openalex-snapshot
Tissue Sensitivity of the Rat Upper and Lower Extrapulmonary Airways to the Inhaled Electrophilic Air Pollutants Diacetyl and Acrolein
inferred← citeshttps://doi.org/10.1093/toxsci/kfv327openalex-snapshot
Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation
inferred← citeshttps://doi.org/10.1111/febs.13999openalex-snapshot
Regulation of the mammalian heat shock factor 1
inferred← citeshttps://doi.org/10.1111/j.1471-4159.2009.06395.xopenalex-snapshot
Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury
inferred← citeshttps://doi.org/10.1111/j.1749-6632.2012.06531.xopenalex-snapshot
Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1155/2013/690545openalex-snapshot
Regulation of NF-B-Induced Inflammatory Signaling by Lipid Peroxidation-Derived Aldehydes
inferred← citeshttps://doi.org/10.1158/1055-9965.epi-09-1291openalex-snapshot
Elevated Levels of Volatile Organic Carcinogen and Toxicant Biomarkers in Chinese Women Who Regularly Cook at Home
inferred← citeshttps://doi.org/10.1159/000350141openalex-snapshot
The Uremic Toxin Acrolein Promotes Suicidal Erythrocyte Death
inferred← citeshttps://doi.org/10.1164/rccm.201001-0120ocopenalex-snapshot
Macrophage Migration Inhibitory Factor Promotes Tumor Growth in the Context of Lung Injury and Repair
inferred← citeshttps://doi.org/10.1177/0192623309345691openalex-snapshot
Activation of Calcitonin Gene-Related Peptide Receptor during Ozone Inhalation Contributes to Airway Epithelial Injury and Repair
inferred← citeshttps://doi.org/10.1186/1465-9921-13-92openalex-snapshot
Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene
inferred← citeshttps://doi.org/10.1201/b16661-3openalex-snapshot
Cellular Mechanisms of Cytokine Activation
inferred← citeshttps://doi.org/10.1369/0022155412459759openalex-snapshot
High-throughput, Quantitative Analysis of Acrolein-derived DNA Adducts in Human Oral Cells by Immunohistochemistry
inferred← citeshttps://doi.org/10.2174/157019311797440263openalex-snapshot
Mechanism of Oxidative Broncho-Epithelial Cell Damage with Reference to Gas Phase Cigarette Smoke
inferred← citeshttps://doi.org/10.2500/aap.2014.35.3748openalex-snapshot
The role of zinc, copper, plasma glutathione peroxidase enzyme, and vitamins in the development of allergic diseases in early childhood: The Polish mother and child cohort study
inferred← citeshttps://doi.org/10.3109/02656736.2011.627408openalex-snapshot
Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1382655openalex-snapshot
Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung
inferred← citeshttps://doi.org/10.3389/ftox.2023.1280230openalex-snapshot
Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats
inferred← citeshttps://doi.org/10.3390/ijms18030652openalex-snapshot
Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure
inferred← citeshttps://doi.org/10.5041/rmmj.10251openalex-snapshot
Acrolein—an α,ß-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects
inferred← citeshttps://doi.org/10.6064/2012/606104openalex-snapshot
The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
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