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An Integrated In-Silico-In-Chemico-In-Vitro (Isiciv) Approach to Identify Biomarkers to Predict the Skin Sensitization Potential of Phytochemicals

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Allergic Contact Dermatitis
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Activation of the Nrf2/antioxidant response pathway increases IL-8 expression
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The OECD QSAR Toolbox Starts Its Second Decade
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Induction of skin sensitization is augmented in Nrf2-deficient mice
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Biomarkers, oxidative stress and autophagy in skin aging
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THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers
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Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT)
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Phenotypic alterations and cytokine production in THP-1 cells in response to allergens
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Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes
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Toxicogenomics in the assessment of immunotoxicity
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Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers
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Genome-Wide Transcriptional Responses to Acrolein
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Use and misuse of the gene ontology annotations
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Identification of Gene Expression Changes Induced by Chemical Allergens in Dendritic Cells: Opportunities for Skin Sensitization Testing
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A Skin-Like Cytochrome P450 Cocktail Activates Prohaptens to Contact Allergenic Metabolites
inferredcites →https://doi.org/10.1080/10629361003773955openalex-extracted
Prediction of skin sensitization potential using D-optimal design and GA-kNN classification methods
inferredcites →https://doi.org/10.1080/15287390801989168openalex-extracted
Sensitization Assays: Monocyte-Derived Dendritic Cells Versus a Monocytic Cell Line (THP-1)
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BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks
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The Gene Ontology (GO) database and informatics resource
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STITCH: interaction networks of chemicals and proteins
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The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers
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Allergic Skin Inflammation Induced by Chemical Sensitizers Is Controlled by the Transcription Factor Nrf2
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Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
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Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System
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Herbal Treatment for Dermatologic Disorders
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Prediction of Chemical-Protein Interactions Network with Weighted Network-Based Inference Method
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The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety
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Understanding and using sensitivity, specificity and predictive values
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