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The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers

https://doi.org/10.1093/toxsci/kfp228
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1099-1263(200005/06)20:3<221::aid-jat651>3.0.co;2-#openalex-snapshot
Characterization in mice of the immunological properties of five allergenic acid anhydrides
inferredcites →https://doi.org/10.1002/eji.200526116openalex-snapshot
Activation of the Nrf2/antioxidant response pathway increases IL-8 expression
inferredcites →https://doi.org/10.1002/jat.1146openalex-snapshot
A future approach to measuring relative skin sensitising potency: a proposal
inferredcites →https://doi.org/10.1006/bbrc.2000.2311openalex-snapshot
HSP70 Induction in the Brain Following Ethanol Administration in the Rat: Regulation by Glutathione Redox State
inferredcites →https://doi.org/10.1006/taap.2002.9473openalex-snapshot
Cytokine Production Induced by Low-Molecular-Weight Chemicals as a Function of the Stimulation Index in a Modified Local Lymph Node Assay: An Approach to Discriminate Contact Sensitizers from Respiratory Sensitizers
inferredcites →https://doi.org/10.1007/s10695-008-9299-xopenalex-snapshot
Induction of phase II enzymes and hsp70 genes by copper sulfate through the electrophile-responsive element (EpRE): insights obtained from a transgenic zebrafish model carrying an orthologous EpRE sequence of mammalian origin
inferredcites →https://doi.org/10.1007/s11064-008-9775-9openalex-snapshot
Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity
inferredcites →https://doi.org/10.1016/j.canlet.2005.11.050openalex-snapshot
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (−/−) mice
inferredcites →https://doi.org/10.1016/j.jaci.2008.01.016openalex-snapshot
Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells
inferredcites →https://doi.org/10.1016/j.molmed.2004.09.003openalex-snapshot
Nrf2–Keap1 defines a physiologically important stress response mechanism
inferredcites →https://doi.org/10.1016/j.smim.2006.12.002openalex-snapshot
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
inferredcites →https://doi.org/10.1016/j.taap.2006.12.026openalex-snapshot
Assessment of the U937 cell line for the detection of contact allergens
inferredcites →https://doi.org/10.1016/j.taap.2008.03.014openalex-snapshot
A cell-based in vitro alternative to identify skin sensitizers by gene expression
inferredcites →https://doi.org/10.1016/j.taap.2009.05.001openalex-snapshot
Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1
inferredcites →https://doi.org/10.1016/j.taap.2009.06.003openalex-snapshot
Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde
inferredcites →https://doi.org/10.1016/j.tiv.2005.10.012openalex-snapshot
Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT)
inferredcites →https://doi.org/10.1016/j.tiv.2005.10.014openalex-snapshot
Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT) II. An inter-laboratory study of the h-CLAT
inferredcites →https://doi.org/10.1016/j.tox.2008.10.014openalex-snapshot
Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: Identification of discriminating genetic markers and pathway analysis
inferredcites →https://doi.org/10.1016/j.toxlet.2004.02.002openalex-snapshot
Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen
inferredcites →https://doi.org/10.1016/j.toxlet.2006.10.012openalex-snapshot
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice
inferredcites →https://doi.org/10.1016/j.toxlet.2007.12.003openalex-snapshot
Analysis of differential gene expression in auricular lymph nodes draining skin exposed to sensitizers and irritants
inferredcites →https://doi.org/10.1016/s0278-6915(01)00130-2openalex-snapshot
Local lymph node assay — validation, conduct and use in practice
inferredcites →https://doi.org/10.1016/s0887-2333(03)00148-6openalex-snapshot
Dendritic cells and skin sensitisation hazard assessment
inferredcites →https://doi.org/10.1021/tx049688+openalex-snapshot
Selective Haptenation of Cellular or Extracellular Protein by Chemical Allergens: Association with Cytokine Polarization
inferredcites →https://doi.org/10.1021/tx049758copenalex-snapshot
A Conjugated Diene Identified as a Prohapten: Contact Allergenic Activity and Chemical Reactivity of Proposed Epoxide Metabolites
inferredcites →https://doi.org/10.1021/tx050217copenalex-snapshot
The Role of Keap1 in Cellular Protective Responses
inferredcites →https://doi.org/10.1021/tx060102oopenalex-snapshot
Mechanistic Applicability Domains for Non-Animal Based Prediction of Toxicological Endpoints. QSAR Analysis of the Schiff Base Applicability Domain for Skin Sensitization
inferredcites →https://doi.org/10.1021/tx700024wopenalex-snapshot
Mechanistic Applicability Domain Classification of a Local Lymph Node Assay Dataset for Skin Sensitization
inferredcites →https://doi.org/10.1021/tx8001934openalex-snapshot
Genome-Wide Transcriptional Responses to Acrolein
inferredcites →https://doi.org/10.1021/tx8003906openalex-snapshot
Covalent Modification of Lysine Residues by Allyl Isothiocyanate in Physiological Conditions: Plausible Transformation of Isothiocyanate from Thiol to Amine
inferredcites →https://doi.org/10.1021/tx800431xopenalex-snapshot
High Throughput Kinetic Profiling Approach for Covalent Binding to Peptides: Application to Skin Sensitization Potency of Michael Acceptor Electrophiles
inferredcites →https://doi.org/10.1038/nrmicro1068openalex-snapshot
LPS, TLR4 and infectious disease diversity
inferredcites →https://doi.org/10.1038/sj.jid.5700319openalex-snapshot
Identification of Gene Expression Changes Induced by Chemical Allergens in Dendritic Cells: Opportunities for Skin Sensitization Testing
inferredcites →https://doi.org/10.1038/sj.jid.5700638openalex-snapshot
A Skin-Like Cytochrome P450 Cocktail Activates Prohaptens to Contact Allergenic Metabolites
inferredcites →https://doi.org/10.1038/sj.jid.5700819openalex-snapshot
Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity
inferredcites →https://doi.org/10.1073/pnas.0307301101openalex-snapshot
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
inferredcites →https://doi.org/10.1074/jbc.271.9.4805openalex-snapshot
Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols
inferredcites →https://doi.org/10.1074/jbc.m211898200openalex-snapshot
Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway
inferredcites →https://doi.org/10.1074/jbc.m605391200openalex-snapshot
PCAF Modulates PTEN Activity
inferredcites →https://doi.org/10.1084/jem.20070509openalex-snapshot
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
inferredcites →https://doi.org/10.1093/toxsci/kfh213openalex-snapshot
Development of a Peptide Reactivity Assay for Screening Contact Allergens
inferredcites →https://doi.org/10.1093/toxsci/kfm064openalex-snapshot
Quantification of Chemical Peptide Reactivity for Screening Contact Allergens: A Classification Tree Model Approach
inferredcites →https://doi.org/10.1093/toxsci/kfm259openalex-snapshot
Skin Sensitizers Induce Antioxidant Response Element Dependent Genes: Application to the In Vitro Testing of the Sensitization Potential of Chemicals
inferredcites →https://doi.org/10.1093/toxsci/kfm299openalex-snapshot
Nonanimal Alternatives for Skin Sensitization: A Step Forward?
inferredcites →https://doi.org/10.1093/toxsci/kfn194openalex-snapshot
LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential
inferredcites →https://doi.org/10.1093/toxsci/kfn204openalex-snapshot
Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing
inferredcites →https://doi.org/10.1093/toxsci/kfn243openalex-snapshot
HMOX1 and NQO1 Genes are Upregulated in Response to Contact Sensitizers in Dendritic Cells and THP-1 Cell Line: Role of the Keap1/Nrf2 Pathway
inferredcites →https://doi.org/10.1093/toxsci/kfn247openalex-snapshot
Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA)
inferredcites →https://doi.org/10.1093/toxsci/kfp030openalex-snapshot
Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment
inferredcites →https://doi.org/10.1124/mol.105.019794openalex-snapshot
Induction of AKR1C2 by Phase II Inducers: Identification of a Distal Consensus Antioxidant Response Element Regulated by NRF2
inferredcites →https://doi.org/10.1158/0008-5472.can-08-1107openalex-snapshot
PTEN Acetylation Modulates Its Interaction with PDZ Domain
inferredcites →https://doi.org/10.1159/000235108openalex-snapshot
Influence of Glutathione Conjugation on the Immunogenicity of Dinitrophenyl Derivatives in the Rat
inferredcites →https://doi.org/10.1189/jlb.0604352openalex-snapshot
IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis
inferredcites →https://doi.org/10.2131/jts.33.51openalex-snapshot
Role of MAPK signaling pathway in the activation of dendritic type cell line, THP-1, induced by DNCB and NiSO4
inferredcites →https://doi.org/10.4049/jimmunol.182.1.675openalex-snapshot
Heat Shock Proteins HSP27 and HSP70 Are Present in the Skin and Are Important Mediators of Allergic Contact Hypersensitivity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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An Integrated In-Silico-In-Chemico-In-Vitro (Isiciv) Approach to Identify Biomarkers to Predict the Skin Sensitization Potential of Phytochemicals
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Immunotoxicogenomics: A Systems Approach
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NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products
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Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice
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Systemic drugs inducing non‐immediate cutaneous adverse reactions and contact sensitizers evoke similar responses in THP‐1 cells
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Application of Spectro‐DPRA, KeratinoSens™ and h‐CLAT to estimation of the skin sensitization potential of cosmetics ingredients
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Identification of Contact Allergens by In Vitro Cell Culture-Based Methods
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The KeratinoSens™ Assay for Skin Sensitization Screening
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Proteomics Testing for Sensitization Potency Using the Sensiderm™ TMT-SRM 10-Plex Assay
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Identification of Contact Allergens by In Vitro Cell Culture-Based Methods
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Predictive Tests for Irritants and Allergens: Human, Animal, and In Vitro Tests
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Identification of Contact Allergens by In Vitro Cell Culture–Based Methods
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Besonderheiten von Haptenen und Allergenen bei Spättypreaktionen
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Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
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Non-animal test methods for predicting skin sensitization potentials
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Induction of skin sensitization is augmented in Nrf2-deficient mice
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Xenobiotic metabolizing enzyme activities in cells used for testing skin sensitization in vitro
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Reporter cell lines for skin sensitization testing
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Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy
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Contact dermatitis: in pursuit of sensitizer’s molecular targets through proteomics
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State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies
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The role of transcription factor Nrf2 in skin cells metabolism
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Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis
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Verbraucherschutz und Risikobewertung — allergieauslösende Substanzen in Verbraucherprodukten
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Consumer protection and risk assessment: sensitising substances in consumer products
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Chemical Sensitization
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The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress
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Transcriptomics and Epigenomics
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The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress
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Medical device testing
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Immunotoxicogenomics: A potential approach for comprehending toxicity mechanisms and enhancing risk assessment
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MitoQ for vitiligo by mitigating PARP1 translocation aberrations: Network pharmacology and experimental validation
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Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2
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Assessment of antibacterial properties and skin irritation potential of anodized aluminum impregnated with various quaternary ammonium
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Comparison of the molecular topologies of stress-activated transcription factors HSF1, AP-1, NRF2, and NF-κB in their induction kinetics of HMOX1
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Probabilistic prediction of human skin sensitiser potency for use in next generation risk assessment
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A purified Feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway
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Perspectives and strategies of alternative methods used in the risk assessment of personal care products
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Nature and kinetics of redox imbalance triggered by respiratory and skin chemical sensitizers on the human monocytic cell line THP-1
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Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro
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Evaluation of the sensitizing potential of antibiotics in vitro using the human cell lines THP-1 and MUTZ-LC and primary monocyte‐derived dendritic cells
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Application of ARE-reporter systems in drug discovery and safety assessment
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The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories
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The GARD assay for assessment of chemical skin sensitizers
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Proteomic allergen–peptide/protein interaction assay for the identification of human skin sensitizers
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Applicability of a keratinocyte gene signature to predict skin sensitizing potential
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Application of the acquired knowledge and implementation of the Sens-it-iv toolbox for identification and classification of skin and respiratory sensitizers
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Potential of in vitro reconstituted 3D human airway epithelia (MucilAir™) to assess respiratory sensitizers
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The sensitivity of the KeratinoSens™ assay to evaluate plant extracts: A pilot study
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Gene expressions changes in bronchial epithelial cells: Markers for respiratory sensitizers and exploration of the NRF2 pathway
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Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation
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Development of an in vitro test to identify respiratory sensitizers in bronchial epithelial cells using gene expression profiling
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From genome-wide arrays to tailor-made biomarker readout – Progress towards routine analysis of skin sensitizing chemicals with GARD
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Intra- and inter-laboratory reproducibility and predictivity of the HaCaSens assay: A skin sensitization test using human keratinocytes, HaCaT
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Predicting skin sensitizers with confidence — Using conformal prediction to determine applicability domain of GARD
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Optimization and validation of a method to identify skin sensitization hazards using IL-1 α and IL-6 secretion from HaCaT
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In vitro measurement of skin sensitization hazard of mixtures and finished products: Results obtained with the SENS-IS assays
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Skin sensitisation testing in practice: Applying a stacking meta model to cosmetic ingredients
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Sensitization effect of thimerosal is mediated in vitro via reactive oxygen species and calcium signaling
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Chemical respiratory allergy: Reverse engineering an adverse outcome pathway
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An integrated in silico-in vitro investigation to assess the skin sensitization potential of 4-Octylphenol
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Optimizing the cutoff for the identification of skin sensitizers by the HaCaSens assay: Introducing an ROC-analysis-based cutoff approach
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Skin sensitizing effects of sulfur mustard and other alkylating agents in accordance to OECD guidelines
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Application of an in vitro reconstructed human skin coculture with THP-1 on cosmetics in skin sensitization
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Toxicity characterization of urban stormwater with bioanalytical tools
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Bioanalytical and chemical evaluation of disinfection by-products in swimming pool water
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Evaluating the sensitization potential of surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach
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Assessment of the skin sensitising potency of the lower alkyl methacrylate esters
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Binary test battery with KeratinoSens™ and h-CLAT as part of a bottom-up approach for skin sensitization hazard prediction
inferred← citeshttps://doi.org/10.1016/j.yrtph.2017.09.023openalex-snapshot
In chemico, in vitro and in vivo comparison of the skin sensitizing potential of eight unsaturated and one saturated lipid compounds
inferred← citeshttps://doi.org/10.1016/j.yrtph.2019.01.001openalex-snapshot
The use of Genomic Allergen Rapid Detection (GARD) assays to predict the respiratory and skin sensitising potential of e-liquids
inferred← citeshttps://doi.org/10.1016/j.yrtph.2019.104445openalex-snapshot
The 21st Century movement within the area of skin sensitization assessment: From the animal context towards current human-relevant in vitro solutions
inferred← citeshttps://doi.org/10.1016/j.yrtph.2020.104688openalex-snapshot
Skin sensitization in silico protocol
inferred← citeshttps://doi.org/10.1021/tx1002707openalex-snapshot
Chemical Basis for the Extreme Skin Sensitization Potency of (E)-4-(Ethoxymethylene)-2-phenyloxazol-5(4H)-one
inferred← citeshttps://doi.org/10.1021/tx200196sopenalex-snapshot
Structure–Activity Relationship between the in Vivo Skin Sensitizing Potency of Analogues of Phenyl Glycidyl Ether and the Induction of Nrf2-Dependent Luciferase Activity in the KeratinoSens in Vitro Assay
inferred← citeshttps://doi.org/10.1021/tx2003678openalex-snapshot
Relating Skin Sensitizing Potency to Chemical Reactivity: Reactive Michael Acceptors Inhibit NF-κB Signaling and Are Less Sensitizing than SNAr- and SN2- Reactive Chemicals
inferred← citeshttps://doi.org/10.1021/tx300472dopenalex-snapshot
Development of an in Vitro Dendritic Cell-Based Test for Skin Sensitizer Identification
inferred← citeshttps://doi.org/10.1038/s41598-023-45598-yopenalex-snapshot
Toxicological investigation of lilial
inferred← citeshttps://doi.org/10.1038/srep21203openalex-snapshot
Peptide Reactivity of Isothiocyanates – Implications for Skin Allergy
inferred← citeshttps://doi.org/10.1039/9781849737920-00215openalex-snapshot
In Vitro Toxicology Models for Acute Eye and Skin Irritation Assessment
inferred← citeshttps://doi.org/10.1039/9781849737920-00244openalex-snapshot
Skin Sensitization Testing
inferred← citeshttps://doi.org/10.1039/9781849737920-00265openalex-snapshot
Integrated Approaches to Safety Testing: General Principles and Skin Sensitization as Test Case
inferred← citeshttps://doi.org/10.1039/c2em30506bopenalex-snapshot
Water quality assessment using the AREc32 reporter gene assay indicative of the oxidative stress response pathway
inferred← citeshttps://doi.org/10.1039/c3tx50027fopenalex-snapshot
High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds
inferred← citeshttps://doi.org/10.1039/c7tx00272fopenalex-snapshot
Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway
inferred← citeshttps://doi.org/10.1039/c9an02514fopenalex-snapshot
Development of a chromophore-solid phase peptide reaction assay (C-SPRA) for assessing skin sensitization in vitro
inferred← citeshttps://doi.org/10.1071/en14054openalex-snapshot
Chemical and bioanalytical assessment of coal seam gas associated water
inferred← citeshttps://doi.org/10.1080/26415275.2023.2223223openalex-snapshot
Biological aspects of modern dental composites
inferred← citeshttps://doi.org/10.1089/aivt.2017.0010openalex-snapshot
An Adverse Outcome Pathway for Sensitization of the Respiratory Tract by Low-Molecular-Weight Chemicals: Building Evidence to Support the Utility of In Vitro and In Silico Methods in a Regulatory Context
inferred← citeshttps://doi.org/10.1089/aivt.2017.0023openalex-snapshot
Alternative Integrated Testing for Skin Sensitization: Assuring Consumer Safety
inferred← citeshttps://doi.org/10.1093/toxres/tfab101openalex-snapshot
A new cytometry-based method reveals an accumulation of Nrf2 in dendritic cells exposed to two respiratory sensitizers
inferred← citeshttps://doi.org/10.1093/toxsci/kfab055openalex-snapshot
Critical Evaluation of Low-Molecular Weight Respiratory Sensitizers and Their Protein Reactivity Potential Toward Lysine Residues
inferred← citeshttps://doi.org/10.1093/toxsci/kfq182openalex-snapshot
Keratinocyte Gene Expression Profiles Discriminate Sensitizing and Irritating Compounds
inferred← citeshttps://doi.org/10.1093/toxsci/kfq346openalex-snapshot
Chemical Allergy: Translating Biology into Hazard Characterization
inferred← citeshttps://doi.org/10.1093/toxsci/kfr237openalex-snapshot
An In Vitro Test to Screen Skin Sensitizers Using a Stable THP-1–Derived IL-8 Reporter Cell Line, THP-G8
inferred← citeshttps://doi.org/10.1093/toxsci/kfs205openalex-snapshot
The Direct Peptide Reactivity Assay: Selectivity of Chemical Respiratory Allergens
inferred← citeshttps://doi.org/10.1093/toxsci/kft075openalex-snapshot
Reactivity of Chemical Sensitizers Toward Amino Acids In Cellulo Plays a Role in the Activation of the Nrf2-ARE Pathway in Human Monocyte Dendritic Cells and the THP-1 Cell Line
inferred← citeshttps://doi.org/10.1093/toxsci/kft160openalex-snapshot
Utility of Rat Liver S9 Fractions to Study Skin-Sensitizing Prohaptens in a Modified KeratinoSens Assay
inferred← citeshttps://doi.org/10.1093/toxsci/kfu046openalex-snapshot
Genomic Allergen Rapid Detection In-House Validation—A Proof of Concept
inferred← citeshttps://doi.org/10.1093/toxsci/kfv109openalex-snapshot
A Dose-Response Modeling Approach Shows That Effects From Mixture Exposure to the Skin Sensitizers Isoeugenol and Cinnamal Are in Line With Dose Addition and Not With Synergism
inferred← citeshttps://doi.org/10.1093/toxsci/kfz108openalex-snapshot
Validation of the GARD™skin Assay for Assessment of Chemical Skin Sensitizers: Ring Trial Results of Predictive Performance and Reproducibility
inferred← citeshttps://doi.org/10.1096/fj.202601575ropenalex-snapshot
Intranasal Administration of Isoeugenol Improves Memory Deficits in APP / PS1 Old Mice—A Role Beyond Nrf2 Activation?
inferred← citeshttps://doi.org/10.1097/aci.0000000000000092openalex-snapshot
New findings in allergic contact dermatitis
inferred← citeshttps://doi.org/10.1111/cod.14073openalex-snapshot
Regulation of the immune response to contact sensitizers by Nrf2
inferred← citeshttps://doi.org/10.1111/cod.14682openalex-snapshot
In vitro characterisation of a novel rubber contact allergen in protective gloves
inferred← citeshttps://doi.org/10.1111/ics.12165openalex-snapshot
Photoprotection in changing times – UV filter efficacy and safety, sensitization processes and regulatory aspects
inferred← citeshttps://doi.org/10.1111/j.1398-9995.2011.02652.xopenalex-snapshot
Mechanisms of chemical-induced innate immunity in allergic contact dermatitis
inferred← citeshttps://doi.org/10.1111/j.1600-0625.2012.01471.xopenalex-snapshot
Contact dermatitis: from pathomechanisms to immunotoxicology
inferred← citeshttps://doi.org/10.1155/omcl/7695056openalex-snapshot
Targeting NRF2 With Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders
inferred← citeshttps://doi.org/10.1177/026119291604400515openalex-snapshot
The Adverse Outcome Pathway for Skin Sensitisation: Moving Closer to Replacing Animal Testing
inferred← citeshttps://doi.org/10.1186/s40824-020-00194-3openalex-snapshot
Synthesis and characterization of conductive flexible cellulose carbon nanohorn sheets for human tissue applications
inferred← citeshttps://doi.org/10.1371/journal.pone.0118808openalex-snapshot
Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature
inferred← citeshttps://doi.org/10.14573/altex.1406091openalex-snapshot
Consensus report on the future of animal-free systemic toxicity testing
inferred← citeshttps://doi.org/10.14573/altex.1411011openalex-snapshot
Integrated testing strategies (ITS) for safety assessment
inferred← citeshttps://doi.org/10.14573/altex.1608081openalex-snapshot
From in vivo to in vitro: The medical device testing paradigm shift
inferred← citeshttps://doi.org/10.14573/altex.1701101openalex-snapshot
The GARD platform for potency assessment of skin sensitizing chemicals
inferred← citeshttps://doi.org/10.14573/altex.1701101sopenalex-snapshot
The GARD platform for potency assessment of skin sensitizing chemicals_suppl
inferred← citeshttps://doi.org/10.14573/altex.1701121openalex-snapshot
Evaluation of the GARD assay in a blind Cosmetics Europe study
inferred← citeshttps://doi.org/10.14573/altex.1701121sopenalex-snapshot
Evaluation of the GARD assay in a blind Cosmetics Europe study_suppl
inferred← citeshttps://doi.org/10.14573/altex.1701311openalex-snapshot
Adaptation of the KeratinoSens™ skin sensitization test to animal-product-free cell culture
inferred← citeshttps://doi.org/10.14573/altex.2008142openalex-snapshot
Sensitization potential of medical devices detected by in vitro and in vivo methods
inferred← citeshttps://doi.org/10.1517/17425255.2015.1048222openalex-snapshot
Detecting reactive drug metabolites for reducing the potential for drug toxicity
inferred← citeshttps://doi.org/10.1586/17469872.2013.814882openalex-snapshot
In vitroapproaches to the identification and characterization of skin sensitizers
inferred← citeshttps://doi.org/10.1787/9789264221444-enopenalex-snapshot
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
inferred← citeshttps://doi.org/10.1787/9789264229778-fropenalex-snapshot
Essai n° 442D: Sensibilisation cutanée in vitro
inferred← citeshttps://doi.org/10.1787/9789264229822-enopenalex-snapshot
Test No. 442D: In Vitro Skin Sensitisation
inferred← citeshttps://doi.org/10.1787/9789264279285-enopenalex-snapshot
Guidance Document on the Reporting of Defined Approaches and Individual Information Sources to be Used within Integrated Approaches to Testing and Assessment (IATA) for Skin Sensitisation
inferred← citeshttps://doi.org/10.2131/jts.46.235openalex-snapshot
Enhancing between-facility reproducibility of the SH test as an in vitro skin sensitization test by the improved test method
inferred← citeshttps://doi.org/10.2139/ssrn.4025899openalex-snapshot
Nrf2 Pathway Involvement in the Beneficial Skin Effects of Moderate Ionic Osmotic Stress – the Case of the Dead Sea Water
inferred← citeshttps://doi.org/10.2174/1389200223666220517114004openalex-snapshot
Dermatokinetics: Advances and Experimental Models, Focus on Skin Metabolism
inferred← citeshttps://doi.org/10.2174/1871530323666230413081128openalex-snapshot
New Approach Methodologies in Immunotoxicology: Challenges and Opportunities
inferred← citeshttps://doi.org/10.23860/diss-chen-yi-tzai-2014openalex-snapshot
MOLECULAR INTERACTION IN CARBOXYLESTERASES-BASED CATALYSIS: ONTOGENIC EXPRESSION AND INDUCTION THROUGH A NOVEL ELEMENT
inferred← citeshttps://doi.org/10.26481/dis.20150211jsopenalex-snapshot
Application of omics to immunotoxicology : from mechanisms of action to alternative testing strategies
inferred← citeshttps://doi.org/10.26481/dis.20181116sdopenalex-snapshot
Towards a testing strategy for the identification of respiratory sensitizing chemicals
inferred← citeshttps://doi.org/10.2788/52914openalex-snapshot
EURL ECVAM Recommendation on the KeratinoSensTM assay for skin sensitisation testing
inferred← citeshttps://doi.org/10.3109/00498254.2012.754112openalex-snapshot
Chemical reactivity and biological activity of chalcones and other α,β-unsaturated carbonyl compounds
inferred← citeshttps://doi.org/10.3109/10408440903524262openalex-snapshot
Non-animal sensitization testing: State-of-the-art
inferred← citeshttps://doi.org/10.3109/10408444.2014.940445openalex-snapshot
A critical appraisal of the process of regulatory implementation of novelin vivoandin vitromethods for chemical hazard and risk assessment
inferred← citeshttps://doi.org/10.32388/luxm7wopenalex-snapshot
Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01004openalex-snapshot
Nrf2 Involvement in Chemical-Induced Skin Innate Immunity
inferred← citeshttps://doi.org/10.3389/fphar.2015.00094openalex-snapshot
In vitro methods for hazard assessment of industrial chemicals – opportunities and challenges
inferred← citeshttps://doi.org/10.3389/fphar.2016.00053openalex-snapshot
Evaluation of a High-Throughput Peptide Reactivity Format Assay for Assessment of the Skin Sensitization Potential of Chemicals
inferred← citeshttps://doi.org/10.3389/ftox.2024.1331803openalex-snapshot
Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers
inferred← citeshttps://doi.org/10.3390/cancers15041208openalex-snapshot
Evaluation of Delayed-Type Hypersensitivity to Antineoplastic Drugs—An Overview
inferred← citeshttps://doi.org/10.3390/cosmetics4030030openalex-snapshot
Alternative Methods to Animal Testing for the Safety Evaluation of Cosmetic Ingredients: An Overview
inferred← citeshttps://doi.org/10.3390/ijms21207791openalex-snapshot
Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models
inferred← citeshttps://doi.org/10.3390/nu9121371openalex-snapshot
Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin
inferred← citeshttps://doi.org/10.3390/ph15091111openalex-snapshot
Evaluation of Antineoplastic Delayed-Type Hypersensitivity Skin Reactions In Vitro
inferred← citeshttps://doi.org/10.3390/pharmaceutics12090815openalex-snapshot
Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic
inferred← citeshttps://doi.org/10.3390/toxics10120740openalex-snapshot
Alternative Methods for Skin-Sensitization Assessment
inferred← citeshttps://doi.org/10.3390/toxics11120973openalex-snapshot
Application of an Antioxidant Response Element–Nuclear Factor Erythroid 2 Luciferase Assay for Assessing the Skin Sensitization Potential of Agrochemicals
inferred← citeshttps://doi.org/10.3390/toxics9070167openalex-snapshot
Comparative Cytotoxicity Study of PM2.5 and TSP Collected from Urban Areas
inferred← citeshttps://doi.org/10.4155/tde.15.58openalex-snapshot
In Vitro Methods for Screening Transdermal Formulations
inferred← citeshttps://doi.org/10.4161/hv.25813openalex-snapshot
Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme’s performance in gene immunization
inferred← citeshttps://doi.org/10.5772/28337openalex-snapshot
Keratinocytes, Innate Immunity and Allergic Contact Dermatitis - Opportunities for the Development of In Vitro Assays to Predict the Sensitizing Potential of Chemicals
inferred← citeshttps://doi.org/10.58837/chula.the.2021.302openalex-snapshot
Antioxidant activity of thunbergia laurifolia lindl. Ethanolic extract in keratinocytes
inferred← citeshttps://doi.org/10.70675/0958a7daze8d7z4adaz9db4z01df5bdd3bc8openalex-snapshot
Evaluation in vitro de la sensibilisation cutanée aux xénobiotiques : Pertinence d’un modèle de co-culture épiderme reconstruit humain/cellules THP-1
inferred← citeshttps://doi.org/10.70675/158fdf52zf391z4345za623z1930dc13404dopenalex-snapshot
L'apport de l'étude des mécanismes intracellulaires pour l'évaluation du pouvoir sensibilisant de substances industrielles
inferred← citeshttps://doi.org/10.70675/458a3786zfb6dz4c63z958fz93ab685b0b5dopenalex-snapshot
Étude du métabolisme cutané des xénobiotiques dans un contexte d’évaluation du risque pour l’Homme
inferred← citeshttps://doi.org/10.70675/693ee815z010ez466fz8803zaa33a2ff2105openalex-snapshot
Nouvelles applications des nanoparticules organiques : de la vectorisation d'un mélange d'actifs à travers la peau jusqu'au développement d'un test diagnostique in vitro de l'allergie aux parfums
inferred← citeshttps://doi.org/10.70675/a019e3ccz77b1z4f0dz8000z6c13a5462c44openalex-snapshot
Rôle du facteur de transcription Nrf2 dans la régulation des fonctions du neutrophile in vitro et dans l’allergie cutanée
inferred← citeshttps://doi.org/10.70675/f5a0d4a4zaf90z4900z9845z57eb9260f964openalex-snapshot
Rôle du facteur de transcription Nrf2 dans le contrôle de l'allergie cutanée en réponse aux molécules allergisantes
inferred← citeshttps://doi.org/10.70675/fed3e8c8z64c2z4e1ez81a9z054e2d240b5fopenalex-snapshot
Rôle de la CK2 dans l’activation de la réponse immunitaire induite par les molécules allergisantes et son lien avec Nrf2
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