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Landmark Alzheimer’s drug approval confounds research community

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Topoisomerase I inhibition yields a CD74high/MHChigh human microglial subtype with enhanced Aβ uptake
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Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells – In vitro models simulating Alzheimer's disease pathology
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Integrated bioinformatics, network pharmacology, molecular docking, and molecular dynamics simulation to explore the potential pharmacological mechanism of Erigeron breviscapus (Vant.) Hand-Mazz regulating ferroptosis for the treatment of Alzheimer's disease
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Gamma connectivity predicts response to intermittent theta burst stimulation in Alzheimer’s disease: a randomized controlled trial
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AD and its comorbidities: An obstacle to develop a clinically efficient treatment?
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A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism
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Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease
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Targeting complement in neurodegeneration: challenges, risks, and strategies
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Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's disease
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Role of melatonin in Alzheimer’s disease: From preclinical studies to novel melatonin-based therapies
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Alzheimer's disease outlook: controversies and future directions
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Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer’s Disease Validated in a Mouse Model Expressing Human APOE3/APOE4
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Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential
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Memantine-Derived Schiff Bases as Transdermal Prodrug Candidates
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One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine
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Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78–94
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Nonlocal models in the analysis of brain neurodegenerative protein dynamics with application to Alzheimer’s disease
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Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans
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Stratifying Alzheimer’s disease by patient-specific genetic signatures reveals cognition-linked and cross-disease heterogeneity
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Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease
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Belimumab for the treatment of pediatric patients with lupus nephritis
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A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)
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Current treatments for dementias
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An Integrated Molecular Atlas of Alzheimer’s Disease
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A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
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A Rapid in vivo Pipeline to Identify Small Molecule Inhibitors of Amyloid Aggregation
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Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer’s disease
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Therapeutic potential of a modified Mediterranean ketogenic diet in reversing the peripheral lipid signature of Alzheimer’s disease
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Heteroscedastic Personalized Regression Unveils Genetic Basis of Alzheimer’s Disease Stratified by Cognitive Level
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A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer’s disease
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Toward a holistic model of Alzheimer’s How Not to Study a Disease: The Story of Alzheimer’s Karl Herrup MIT Press, 2021. 272 pp.
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Aducanumab for Alzheimer’s disease?
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FDA’s dilemma with the aducanumab approval: public pressure and hope, surrogate markers and efficacy, and possible next steps
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Aducanumab Therapy to Treat Alzheimer’s Disease: A Narrative Review
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Diabetes Mellitus-related Pathogeny: A Precipitating Factor for Alzheimer’s Disease—An Insight on Repurposing Diabetes Pharmacological Treatments in Alzheimer’s Disease
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Reporting of comorbidities and health status of participants in clinical trials testing amyloid- and tau-targeting monoclonal antibodies for Alzheimer's disease: A systematic review
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Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
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Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer’s disease
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Tau fibril with membrane lipids: Insight from computational modeling and simulations
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Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?
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Blocking the FAM19A5-LRRC4B complex enhances neurite growth and synapse assembly.
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Role of Aducanumab in the Treatment of Alzheimer’s Disease: Challenges and Opportunities
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Recent Advancements in the Treatment of Alzheimer’s Disease: A Multitarget-directed Ligand Approach
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Apocynaceae as a Potential Source for Acetylcholinesterase Inhibition in Symptomatic Regulation and Management of Alzheimer's Disease
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Aducanumab in Alzheimer’s Disease: A Critical Update
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Neuroproteomics Chip-Based Mass Spectrometry and Other Techniques for Alzheimer’s Disease Biomarkers – Update
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Recent Advances In Tacrine-Based Anti-Alzheimer’s Drug Design
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6G and Artificial Intelligence Technologies for Dementia Care: Literature Review and Practical Analysis
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Aducanumab for Alzheimer's disease: An update
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MULTIFACTORIALITY OF ALZHEIMER’S DISEASE: SCIENTIFIC AND SOCIO-ECONOMIC DIMENSION
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α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer’s Disease
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A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer’s Disease
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JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model1
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Insights into the Pathophysiology of Alzheimer’s Disease and Potential Therapeutic Targets: A Current Perspective
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Alzheimer’s Disease: A Systems View Provides a Unifying Explanation of Its Development
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Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer’s Disease
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Ophthalmic Biomarkers for Alzheimer’s Disease: A Review
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Editorial: Immunological Mechanisms, Biomarkers and Immunotherapies of Alzheimer's Disease
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Hub Genes, Diagnostic Model, and Predicted Drugs Related to Iron Metabolism in Alzheimer's Disease
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An interpretable Alzheimer’s disease oligogenic risk score informed by neuroimaging biomarkers improves risk prediction and stratification
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GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer’s Disease
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Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients
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Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
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Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
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Topical Insights Into the Post-Approval Controversies of Aducanumab
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Integrating Public Participation, Transparency and Accountability Into Governance of Marketing Authorisation for Genome Editing Products
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Alzheimer’s Disease: Current Perspectives and Advances in Physiological Modeling
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Neuroprotective Action of Humanin and Humanin Analogues: Research Findings and Perspectives
inferred← citeshttps://doi.org/10.3390/biom12070996openalex-snapshot
Amylin and Secretases in the Pathology and Treatment of Alzheimer’s Disease
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The Potential of a Stratified Approach to Drug Repurposing in Alzheimer’s Disease
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Direct Oral Anticoagulants (DOACs) for Therapeutic Targeting of Thrombin, a Key Mediator of Cerebrovascular and Neuronal Dysfunction in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/biomedicines13020279openalex-snapshot
Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer’s Disease Therapeutics
inferred← citeshttps://doi.org/10.3390/ijms222312987openalex-snapshot
Role of Receptors in Relation to Plaques and Tangles in Alzheimer’s Disease Pathology
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miRNAs as Therapeutic Tools in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms23158497openalex-snapshot
The Relationship between the Aberrant Long Non-Coding RNA-Mediated Competitive Endogenous RNA Network and Alzheimer’s Disease Pathogenesis
inferred← citeshttps://doi.org/10.3390/ijms24119272openalex-snapshot
Recent Mechanisms of Neurodegeneration and Photobiomodulation in the Context of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms241210176openalex-snapshot
A Systematic Review of the Effects of Capsaicin on Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms241310946openalex-snapshot
Phototherapy of Alzheimer’s Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review
inferred← citeshttps://doi.org/10.3390/ijms25105549openalex-snapshot
Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/molecules26216573openalex-snapshot
Hybrid Quinoline-Thiosemicarbazone Therapeutics as a New Treatment Opportunity for Alzheimer’s Disease‒Synthesis, In Vitro Cholinesterase Inhibitory Potential and Computational Modeling Analysis
inferred← citeshttps://doi.org/10.3390/ph15020174openalex-snapshot
Traditional East Asian Herbal Medicine Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.3390/ph17060788openalex-snapshot
Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer’s Disease
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Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier
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Alzheimer : nouveaux espoirs de traitements
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Analyzing the Use of 5XFAD Model Mice in Determining Late-Stage Alzheimer’s Disease Treatment
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Alzheimer’s Disease Therapy, and the Effects of Genetic Polymorphisms on Its Efficacy and Safety
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Additional file 1 of Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
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Additional file 1 of Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer’s disease
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FDA approval of controversial Alzheimer’s drug could delay discovery of more promising treatments
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U.S. Food and Drug Administration Reasoning in Approval Decisions When Efficacy Evidence Is Borderline, 2013–2018
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