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HSPA8 and 3,4,5-Tricaffeoylquinic Acid May Be Essential Hub Genes and Active Components for the Treatment of Alzheimer's Disease with Erigeron Breviscapus (Vant.) Hand-Mazz by Regulating Ferroptosis: A Study Based on WGCNA, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations

https://doi.org/10.2139/ssrn.4702812
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1 of the 71 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.3389/fphar.2021.628988 (notice 2026-02-02).

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Fast and accurate predictions of binding free energies using MM‐PBSA and MM‐GBSA
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Quantitative Proteomic Profiling of Cerebrospinal Fluid to Identify Candidate Biomarkers for Alzheimer's Disease
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An overview of the Amber biomolecular simulation package
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Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling
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Baicalin attenuates Alzheimer-like pathological changes and memory deficits induced by amyloid β1–42 protein
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Ferroptosis and Its Role in Diverse Brain Diseases
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Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition
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Preface
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Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention
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Cathepsin B is an executioner of ferroptosis
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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
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Design, synthesis and evaluation of novel scutellarin and scutellarein-N,N-bis-substituted carbamate-l-amino acid derivatives as potential multifunctional therapeutics for Alzheimer’s disease
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Proteomic Architecture of Valvular Extracellular Matrix
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Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years
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Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer’s disease
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Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer’s disease: Limitations, and current and future perspectives
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ACSF2-mediated ferroptosis is involved in ulcerative colitis
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Overexpression of the 14-3-3gamma protein in embryonic mice results in neuronal migration delay in the developing cerebral cortex
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Prevalencia e incidencia de la enfermedad de Alzheimer en Europa: metaanálisis
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Prevalence and incidence of Alzheimer's disease in Europe: A meta-analysis
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The role of iron in brain ageing and neurodegenerative disorders
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Rational Design of a Humanized Antibody Inhibitor of Cathepsin B
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Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
inferredcites →https://doi.org/10.1038/aps.2011.115openalex-extracted
Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase
inferredcites →https://doi.org/10.1038/d41586-021-01546-2openalex-extracted
Landmark Alzheimer’s drug approval confounds research community
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Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41418-021-00859-zopenalex-extracted
Organelle-specific regulation of ferroptosis
inferredcites →https://doi.org/10.1038/s41422-023-00859-3openalex-extracted
HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation
inferredcites →https://doi.org/10.1038/s41587-019-0114-2openalex-extracted
Determining cell type abundance and expression from bulk tissues with digital cytometry
inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-extracted
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
inferredcites →https://doi.org/10.1074/jbc.m110.158980openalex-extracted
Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation
inferredcites →https://doi.org/10.1093/biostatistics/kxj037openalex-extracted
Adjusting batch effects in microarray expression data using empirical Bayes methods
inferredcites →https://doi.org/10.1093/nar/gkw937openalex-extracted
The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
inferredcites →https://doi.org/10.1111/cns.13086openalex-extracted
Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP 3 inflammasomes and TLR 4/ NF ‐κB signaling pathway
inferredcites →https://doi.org/10.1111/jnc.15519openalex-extracted
Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
inferredcites →https://doi.org/10.1126/science.7939645openalex-extracted
14-3-3: Modulators of Signaling Proteins?
inferredcites →https://doi.org/10.1155/2020/5786053openalex-extracted
Integrating Network Pharmacology with Molecular Docking to Unravel the Active Compounds and Potential Mechanism of Simiao Pill Treating Rheumatoid Arthritis
inferredcites →https://doi.org/10.1155/2022/7769355openalex-extracted
Quercetin Protects against MPP + /MPTP‐Induced Dopaminergic Neuron Death in Parkinson’s Disease by Inhibiting Ferroptosis
inferredcites →https://doi.org/10.1158/0008-5472.can-22-3169openalex-extracted
HBx-Induced HSPA8 Stimulates HBV Replication and Suppresses Ferroptosis to Support Liver Cancer Progression
inferredcites →https://doi.org/10.1159/000510083openalex-extracted
Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases
inferredcites →https://doi.org/10.1186/s40001-023-01043-4openalex-extracted
Immune-associated biomarkers identification for diagnosing carotid plaque progression with uremia through systematical bioinformatics and machine learning analysis
inferredcites →https://doi.org/10.1515/revneuro-2022-0121openalex-extracted
Ferroptosis: a potential therapeutic target for Alzheimer’s disease
inferredcites →https://doi.org/10.18632/aging.101748openalex-extracted
3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice
inferredcites →https://doi.org/10.21037/tcr-20-1860openalex-extracted
A LASSO-based survival prediction model for patients with synchronous colorectal carcinomas based on SEER
inferredcites →https://doi.org/10.2147/ijn.s200490openalex-extracted
Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
inferredcites →https://doi.org/10.2174/1389200221666201217093255openalex-extracted
Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus
inferredcites →https://doi.org/10.2174/1389450119666181022153016openalex-extracted
Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
inferredcites →https://doi.org/10.3233/jad-200133openalex-extracted
Pharmaceutical Treatment for Alzheimer’s Disease and Related Dementias: Utilization and Disparities
inferredcites →https://doi.org/10.3233/jad-201369openalex-extracted
The Potential Role of Ferroptosis in Alzheimer’s Disease
inferredcites →https://doi.org/10.3233/jad-221005openalex-extracted
Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition
inferredcites →https://doi.org/10.3389/fgene.2022.944425openalex-extracted
Revealing the novel ferroptosis-related therapeutic targets for diabetic foot ulcer based on the machine learning
inferredcites →https://doi.org/10.3389/fnins.2017.00254openalex-extracted
The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
inferredcites →https://doi.org/10.3389/fphar.2017.00289openalex-extracted
Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
inferredcites →https://doi.org/10.3389/fphar.2021.628988openalex-extracted
Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis
inferredcites →https://doi.org/10.3389/fphar.2021.656335openalex-extracted
Advances in Chemical Constituents, Clinical Applications, Pharmacology, Pharmacokinetics and Toxicology of Erigeron breviscapus
inferredcites →https://doi.org/10.3389/fphar.2022.877872openalex-extracted
Erigeron breviscapus (Vant.) Hand-Mazz.: A Promising Natural Neuroprotective Agent for Alzheimer’s Disease
inferredcites →https://doi.org/10.3390/cells8020198openalex-extracted
Iron Exposure and the Cellular Mechanisms Linked to Neuron Degeneration in Adult Mice
inferredcites →https://doi.org/10.3390/ijms20153647openalex-extracted
Behavioral Disturbances in Dementia and Beyond: Time for a New Conceptual Frame?
inferredcites →https://doi.org/10.3390/ijms23168902openalex-extracted
New Possibilities in the Therapeutic Approach to Alzheimer’s Disease
inferredcites →https://doi.org/10.3390/ijms23169305openalex-extracted
Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer’s Disease: Towards a Personalized Polypharmacology Patient-Centered Approach
inferredcites →https://doi.org/10.3390/ijms24076328openalex-extracted
The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms
inferredcites →https://doi.org/10.3390/jcdd9010030openalex-extracted
The Identification and Validation of Hub Genes Associated with Acute Myocardial Infarction Using Weighted Gene Co-Expression Network Analysis
inferredcites →https://doi.org/10.3390/mps3040064openalex-extracted
Become Competent within One Day in Generating Boxplots and Violin Plots for a Novice without Prior R Experience
inferredcites →https://doi.org/10.3390/ph16010050openalex-extracted
Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz
inferredcites →https://doi.org/10.3892/mmr.2018.9482openalex-extracted
Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis
inferredcites →https://doi.org/10.4161/auto.26448openalex-extracted
HSPA8/HSC70 chaperone protein
inferredcites →https://doi.org/10.7150/ijms.76660openalex-extracted
A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis-related Immune Cell Infiltration in Alzheimer's Disease
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Drug treatments in Alzheimer’s disease
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