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Cannabis use and risk of schizophrenia: a Mendelian randomization study
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence
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Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
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Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
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Bias due to participant overlap in two‐sample Mendelian randomization
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Re: Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation” by Bautista et al.
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Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways
inferredcites →https://doi.org/10.1016/j.biopsych.2015.08.001openalex-snapshot
Association Between Cannabis and Psychosis: Epidemiologic Evidence
inferredcites →https://doi.org/10.1016/j.biopsych.2016.01.011openalex-snapshot
Human Laboratory Studies on Cannabinoids and Psychosis
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Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
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Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
inferredcites →https://doi.org/10.1017/s0033291712000062openalex-snapshot
Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender
inferredcites →https://doi.org/10.1017/s0033291714000531openalex-snapshot
Associations of cannabis and cigarette use with psychotic experiences at age 18: findings from the Avon Longitudinal Study of Parents and Children
inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot
Biological insights from 108 schizophrenia-associated genetic loci
inferredcites →https://doi.org/10.1038/tp.2016.36openalex-snapshot
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
inferredcites →https://doi.org/10.1093/aje/kwf043openalex-snapshot
Cannabis Use and Psychosis: A Longitudinal Population-based Study
inferredcites →https://doi.org/10.1093/aje/kwv017openalex-snapshot
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SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
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European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
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Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease
inferredcites →https://doi.org/10.1093/eurheartj/ehw106openalex-snapshot
2016 European Guidelines on cardiovascular disease prevention in clinical practice
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Calculating statistical power in Mendelian randomization studies
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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
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Mendelian randomization: where are we now and where are we going?
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Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic
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Epidemiological Analysis of Alcohol and Drug Use as Risk Factors for Psychotic Experiences
inferredcites →https://doi.org/10.1111/ajad.12186openalex-snapshot
A review of co‐morbid tobacco and cannabis use disorders: Possible mechanisms to explain high rates of co‐use
inferredcites →https://doi.org/10.1111/j.1530-0277.2008.00800.xopenalex-snapshot
Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence
inferredcites →https://doi.org/10.1136/bmj.325.7374.1199openalex-snapshot
Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study
inferredcites →https://doi.org/10.1136/bmj.325.7374.1212openalex-snapshot
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
inferredcites →https://doi.org/10.1136/bmj.38267.664086.63openalex-snapshot
Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people
inferredcites →https://doi.org/10.1136/bmj.g4164openalex-snapshot
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
inferredcites →https://doi.org/10.1177/0962280215597579openalex-snapshot
A review of instrumental variable estimators for Mendelian randomization
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
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A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians
inferredcites →https://doi.org/10.20996/1819-6446-2005-1-3-57-65openalex-snapshot
EUROPEAN GUIDELINES ON CARDIOVASCULAR DISEASE PREVENTION IN CLINICAL PRACTICE
inferredcites →https://doi.org/10.2337/db16-0418openalex-snapshot
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization
inferredcites →https://doi.org/10.7892/boris.89711openalex-snapshot
2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited…
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The Relationship Between Cannabis, Cognition, and Schizophrenia: It’s Complicated
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Big data and the goal of personalized health interventions
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Molecular mechanisms underlying cannabis-induced risk of psychosis
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A Summary of Recent Updates on the Genetic Determinants of Depression
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Close parallels between cannabis use and deteriorating US Mental Health at four levels supports and extends the epidemiological salience of demonstrated causal mental health relationships: A geospatiotemporal study
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Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene
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Where there’s smoke, there’s fire: Cannabis, P2RX7 and inflammatory pathways intersect to increase psychosis susceptibility
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Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders
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Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis
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Schizophrenia and substance use disorder: Characteristics of coexisting issues in a forensic setting
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Endorsement of psychotic-like experiences and problematic cannabis use associated with worse executive functioning performance in undergraduates
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Genetic Predisposition to Diabetes and Abdominal Aortic Aneurysm: A Two Stage Mendelian Randomisation Study
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Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function
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inferred← citeshttps://doi.org/10.1073/pnas.2013180118openalex-snapshot
Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies
inferred← citeshttps://doi.org/10.1080/0886022x.2024.2438848openalex-snapshot
Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study
inferred← citeshttps://doi.org/10.1080/10826084.2022.2034872openalex-snapshot
Cannabis and Mental Health: Adverse Outcomes and Self-Reported Impact of Cannabis Use by Mental Health Status
inferred← citeshttps://doi.org/10.1080/14659891.2025.2566636openalex-snapshot
Cannabis use and risk of suicidal behavior-related outcomes: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1080/15504263.2019.1674991openalex-snapshot
Cannabis Use and the Risk for Psychosis and Affective Disorders
inferred← citeshttps://doi.org/10.1080/15622975.2022.2038797openalex-snapshot
Consensus paper of the WFSBP task force on cannabis, cannabinoids and psychosis
inferred← citeshttps://doi.org/10.1080/1612197x.2023.2284327openalex-snapshot
Fast walking reduces the risk of breast cancer: evidence from a Mendelian randomisation study
inferred← citeshttps://doi.org/10.1093/bib/bbae589openalex-snapshot
Deciphering the genetic interplay between depression and dysmenorrhea: a Mendelian randomization study
inferred← citeshttps://doi.org/10.1093/gerona/glad187openalex-snapshot
Causal Associations Between Lifestyle Habits and Risk of Benign Prostatic Hyperplasia: A Two-Sample Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1093/her/cyag016openalex-snapshot
Health education interventions to reduce cannabis and tobacco smoking-related harms among people who use cannabis: a systematic review
inferred← citeshttps://doi.org/10.1093/ije/dyz070openalex-snapshot
Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study
inferred← citeshttps://doi.org/10.1093/ijnp/pyaa031openalex-snapshot
Psychosis-Relevant Effects of Intravenous Delta-9-Tetrahydrocannabinol: A Mega Analysis of Individual Participant-Data from Human Laboratory Studies
inferred← citeshttps://doi.org/10.1093/postmj/qgaf114openalex-snapshot
Causal effects of one-carbon metabolism molecules on cancers risk: a Mendelian randomization study
inferred← citeshttps://doi.org/10.1093/schbul/sbaa193openalex-snapshot
Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population
inferred← citeshttps://doi.org/10.1093/schbul/sbac095openalex-snapshot
Influences on the Genetic Relationship Between Cannabis Use and Schizophrenia: The Role of the Externalizing Spectrum
inferred← citeshttps://doi.org/10.1093/schbul/sbad008openalex-snapshot
A Sex-Dependent Association Between Doxycycline Use and Development of Schizophrenia
inferred← citeshttps://doi.org/10.1097/cd9.0000000000000019openalex-snapshot
Insomnia and Coronary Artery Diseases: A Mendelian Randomisation Study
inferred← citeshttps://doi.org/10.1097/ede.0000000000001822openalex-snapshot
Examining the Interactive Associations of Cannabis and Alcohol Outlets With Self-harm Injuries in California: A Spatiotemporal Analysis
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000001963openalex-snapshot
Adverse effects of heavy cannabis use: even plants can harm the brain
inferred← citeshttps://doi.org/10.1097/mao.0000000000004266openalex-snapshot
Mendelian Randomization Study Reveals a Predicted Relationship between Sensorineural Hearing Loss and Mitochondrial Proteins
inferred← citeshttps://doi.org/10.1097/md.0000000000039709openalex-snapshot
Causal relationship between thyroid function and multiple sclerosis: A bidirectional Mendelian randomization study
inferred← citeshttps://doi.org/10.1097/md.0000000000042437openalex-snapshot
Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach
inferred← citeshttps://doi.org/10.1097/md.0000000000042450openalex-snapshot
Causal validation of the relationship between air pollution and lung cancer: A bidirectional Mendelian randomization study and meta-analysis
inferred← citeshttps://doi.org/10.1097/md.0000000000042854openalex-snapshot
Causal effects of office-associated behaviors on spinal stenosis: Two-sample Mendelian randomization study
inferred← citeshttps://doi.org/10.1097/md.0000000000043188openalex-snapshot
The relationship between major depression, attention-deficit hyperactivity disorder and coronary artery disease: A two-sample Mendelian randomization analysis
inferred← citeshttps://doi.org/10.1097/md.0000000000047571openalex-snapshot
Causal effect of chloride intracellular channel protein 5 on chronic periodontitis: A Mendelian randomization study
inferred← citeshttps://doi.org/10.1097/md.0000000000048543openalex-snapshot
Two-sample Mendelian randomization analysis unveils a potential genetic association between rheumatic diseases and the risk of idiopathic pulmonary fibrosis
inferred← citeshttps://doi.org/10.1101/196790openalex-snapshot
Relating C-reactive Protein to Psychopathology after Cardiac Surgery and Intensive Care Unit Admission: A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1101/234294openalex-snapshot
Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use
inferred← citeshttps://doi.org/10.1101/440909openalex-snapshot
∆ 9 -tetrahydrocannabinol negatively regulates neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons
inferred← citeshttps://doi.org/10.1101/844803openalex-snapshot
The independent and combined influence of schizophrenia polygenic risk score and heavy cannabis use on risk for psychotic disorder: A case-control analysis from the EUGEI study.
inferred← citeshttps://doi.org/10.1111/acps.12847openalex-snapshot
Risk factors and peripheral biomarkers for schizophrenia spectrum disorders: an umbrella review of meta‐analyses
inferred← citeshttps://doi.org/10.1111/acps.12869openalex-snapshot
Patterns and predictors of conversion to bipolar disorder in 91 587 individuals diagnosed with unipolar depression
inferred← citeshttps://doi.org/10.1111/adb.13030openalex-snapshot
Bipolar disorder and cannabis use: A bidirectional two‐sample Mendelian randomization study
inferred← citeshttps://doi.org/10.1111/add.14186openalex-snapshot
Commentary on Degenhardt et al. (2018): Cause or consequence? Disentangling the relationship between psychosis and substance use
inferred← citeshttps://doi.org/10.1111/add.14842openalex-snapshot
‘Standard THC units’: a proposal to standardize dose across all cannabis products and methods of administration
inferred← citeshttps://doi.org/10.1111/add.15534openalex-snapshot
The relationship between cannabis and schizophrenia: a genetically informed perspective
inferred← citeshttps://doi.org/10.1111/add.15873openalex-snapshot
Unknown risks of psychosis and addiction with delta‐8‐THC: A call for research, regulation, and clinical caution
inferred← citeshttps://doi.org/10.1111/ajad.12959openalex-snapshot
Use of Guanfacine for Cannabis Use Disorder and Related Symptomology
inferred← citeshttps://doi.org/10.1111/ejn.14544openalex-snapshot
Addiction in focus: molecular mechanisms, model systems, circuit maps, risk prediction and the quest for effective interventions
inferred← citeshttps://doi.org/10.1111/gbb.12639openalex-snapshot
Association between polygenic liability for schizophrenia and substance involvement: A nationwide population‐based study in Taiwan
inferred← citeshttps://doi.org/10.1111/pcn.13555openalex-snapshot
Influence of cannabis use on incidence of psychosis in people at clinical high risk
inferred← citeshttps://doi.org/10.1126/sciadv.abl5744openalex-snapshot
Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling
inferred← citeshttps://doi.org/10.1136/bmjopen-2022-068626openalex-snapshot
Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies
inferred← citeshttps://doi.org/10.1155/2024/4434466openalex-snapshot
Relationship Between Mitochondrial Biological Function and Breast Cancer
inferred← citeshttps://doi.org/10.1172/jci172887openalex-snapshot
Cannabis use disorder: from neurobiology to treatment
inferred← citeshttps://doi.org/10.1176/appi.ajp.20230298openalex-snapshot
What is the Link Between Substance-Induced Psychosis and Primary Psychotic Disorders?
inferred← citeshttps://doi.org/10.1176/appi.ajp.20260100openalex-snapshot
Doxycycline Use, Developmental Vulnerability, Patterns of Care, and Antibiotic Selection
inferred← citeshttps://doi.org/10.1177/02698811261430501openalex-snapshot
Cannabidiol for psychotic disorders: A meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.1177/0706743720984679openalex-snapshot
How High? Trends in Cannabis Use Prior to First Admission to Inpatient Psychiatry in Ontario, Canada, between 2007 and 2017
inferred← citeshttps://doi.org/10.1177/1049732318820523openalex-snapshot
Methods to Assess Cannabis Consumption in Population Surveys: Results of Cognitive Interviewing
inferred← citeshttps://doi.org/10.1177/11795549251341559openalex-snapshot
Causal Association Between Lung Cancer and Rash: A Bidirectional Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1186/s11689-026-09687-zopenalex-snapshot
Phase 2, open-label INSPIRE trial to assess the tolerability and effectiveness of transdermal cannabidiol gel in children and adolescents with 22q11.2 deletion syndrome (ZYN2-CL-031)
inferred← citeshttps://doi.org/10.1186/s12872-023-03641-wopenalex-snapshot
Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study
inferred← citeshttps://doi.org/10.1186/s12877-024-05511-2openalex-snapshot
Exploring the relationship of sleep duration on cognitive function among the elderly: a combined NHANES 2011–2014 and mendelian randomization analysis
inferred← citeshttps://doi.org/10.1186/s12885-022-09382-xopenalex-snapshot
Mendelian randomization study of circulating lipids and biliary tract cancer among East Asians
inferred← citeshttps://doi.org/10.1186/s12889-020-09748-5openalex-snapshot
Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
inferred← citeshttps://doi.org/10.1186/s12890-023-02759-zopenalex-snapshot
The association between walking pace and hand grip strength with the risk of chronic obstructive pulmonary disease: a bidirectional Mendelian randomization study
inferred← citeshttps://doi.org/10.1186/s12920-021-01035-5openalex-snapshot
Genetic basis of cannabis use: a systematic review
inferred← citeshttps://doi.org/10.1186/s12920-023-01497-9openalex-snapshot
Sleep traits and risk of end-stage renal disease: a mendelian randomization study
inferred← citeshttps://doi.org/10.1186/s13073-017-0423-3openalex-snapshot
Schizophrenia and substance use comorbidity: a genome-wide perspective
inferred← citeshttps://doi.org/10.1186/s40246-025-00718-9openalex-snapshot
Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues
inferred← citeshttps://doi.org/10.1192/bjp.2020.116openalex-snapshot
Cigarette smoking and schizophrenia: Mendelian randomisation study
inferred← citeshttps://doi.org/10.1371/journal.pone.0304121openalex-snapshot
Impact of negative emotions on upper gastrointestinal diseases: A Mendel randomization study
inferred← citeshttps://doi.org/10.1503/jpn.190136openalex-snapshot
Cannabis legalization: Did we make a mistake? Update 2019
inferred← citeshttps://doi.org/10.1515/med-2025-1171openalex-snapshot
Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
inferred← citeshttps://doi.org/10.15212/cvia.2025.0003openalex-snapshot
Genetic and Molecular Relationships Between Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm: Insights from a Multi-Omics Approach
inferred← citeshttps://doi.org/10.17711/sm.0185-3325.2025.001openalex-snapshot
Legislation: Plant vs. Drug
inferred← citeshttps://doi.org/10.20900/jpbs.20190018openalex-snapshot
Genetic Risk of Psychosis in Relation to Cannabis Use: Findings from Polygenic Risk Score Approaches
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4191858/v1openalex-snapshot
Cathepsin causal association with pulmonary embolism: a Mendelian randomization analysis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4724629/v1openalex-snapshot
Association Between substance addiction and cortical changes in Adults：A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9633381/v1openalex-snapshot
Disentangling genetic and social confounding in schizophrenia
inferred← citeshttps://doi.org/10.2147/itt.s510102openalex-snapshot
Exploring the Association Between Immune Cell Phenotypes and Osteoporosis Mediated by Inflammatory Cytokines: Insights from GWAS and Single-Cell Transcriptomics
inferred← citeshttps://doi.org/10.2147/ndt.s379811openalex-snapshot
Environmental Factors in the Etiology of Mental Disorders in the Czech Republic
inferred← citeshttps://doi.org/10.2174/0118715303288685240808073238openalex-snapshot
Mendelian Randomization Studies: Opening a New Window in the Study of Metabolic Diseases and Chronic Kidney Disease
inferred← citeshttps://doi.org/10.2174/1570159x21666230817153631openalex-snapshot
Stress, Environment and Early Psychosis
inferred← citeshttps://doi.org/10.2196/33693openalex-snapshot
Online Knowledge Translation Program Involving Video Games and University Student–Led Tutorials About Cannabis and Psychosis for Black Youth: Mixed Method Feasibility Study
inferred← citeshttps://doi.org/10.2196/36758openalex-snapshot
Insights About Cannabis and Psychosis Using Video Games for Young People With a First Episode of Psychosis, Particularly Those From Black Racialized Communities: Protocol for a Mixed Methods Study
inferred← citeshttps://doi.org/10.25176/rfmh.v19i3.2150openalex-snapshot
Una preocupación en la actualidad: el consumo de cannabis asociado a la esquizofrenia
inferred← citeshttps://doi.org/10.30574/wjbphs.2022.12.1.0151openalex-snapshot
A comparison of efficacy, mechanism, and side effects of clozapine and risperidone in patients with schizophrenia
inferred← citeshttps://doi.org/10.31014/aior.1994.03.04.143openalex-snapshot
Schizophrenia: Epidemiology, Causes, Neurobiology, Pathophysiology, and Treatment
inferred← citeshttps://doi.org/10.31083/ap46108openalex-snapshot
Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study
inferred← citeshttps://doi.org/10.3233/jad-220787openalex-snapshot
Aspirin Use and Risk of Alzheimer’s Disease: A 2-Sample Mendelian Randomization Study
inferred← citeshttps://doi.org/10.3389/fcvm.2021.676850openalex-snapshot
Cannabis Use and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.3389/fendo.2022.996863openalex-snapshot
The causal relationship between obesity and skin and soft tissue infections: A two-sample Mendelian randomization study
inferred← citeshttps://doi.org/10.3389/fendo.2023.1159258openalex-snapshot
Causal relationship between nonalcoholic fatty liver disease and different sleep traits: a bidirectional Mendelian randomized study
inferred← citeshttps://doi.org/10.3389/fendo.2024.1407503openalex-snapshot
Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study
inferred← citeshttps://doi.org/10.3389/fgene.2021.686666openalex-snapshot
Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions
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