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Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamapsychiatry.2015.3278openalex-snapshot
Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
inferredcites →https://doi.org/10.1007/978-1-4419-1170-4_2openalex-snapshot
Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses
inferredcites →https://doi.org/10.1007/s00213-014-3748-2openalex-snapshot
NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence
inferredcites →https://doi.org/10.1007/s10654-015-0011-zopenalex-snapshot
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors
inferredcites →https://doi.org/10.1007/s10654-017-0255-xopenalex-snapshot
Interpreting findings from Mendelian randomization using the MR-Egger method
inferredcites →https://doi.org/10.1016/j.ajhg.2014.01.015openalex-snapshot
A Common 16p11.2 Inversion Underlies the Joint Susceptibility to Asthma and Obesity
inferredcites →https://doi.org/10.1016/j.biopsych.2010.09.055openalex-snapshot
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 Influence Different Pathways Leading to Smoking Behavior from Adolescence to Mid-Adulthood
inferredcites →https://doi.org/10.1016/j.drugalcdep.2016.09.022openalex-snapshot
Short communication: Genetic association between schizophrenia and cannabis use
inferredcites →https://doi.org/10.1016/j.heliyon.2017.e00349openalex-snapshot
Replication and characterization of CADM2 and MSRA genes on human behavior
inferredcites →https://doi.org/10.1016/j.jpsychires.2017.03.007openalex-snapshot
The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals
inferredcites →https://doi.org/10.1016/s0140-6736(07)61162-3openalex-snapshot
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
inferredcites →https://doi.org/10.1016/s0140-6736(87)92620-1openalex-snapshot
CANNABIS AND SCHIZOPHRENIA A Longitudinal Study of Swedish Conscripts
inferredcites →https://doi.org/10.1017/s0033291716003172openalex-snapshot
Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study
inferredcites →https://doi.org/10.1037/0021-843x.116.4.645openalex-snapshot
Linking antisocial behavior, substance use, and personality: An integrative quantitative model of the adult externalizing spectrum.
inferredcites →https://doi.org/10.1038/mp.2014.51openalex-snapshot
Genetic predisposition to schizophrenia associated with increased use of cannabis
inferredcites →https://doi.org/10.1038/mp.2015.37openalex-snapshot
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
inferredcites →https://doi.org/10.1038/mp.2016.252openalex-snapshot
Cannabis use and risk of schizophrenia: a Mendelian randomization study
inferredcites →https://doi.org/10.1038/mp.2017.153openalex-snapshot
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
inferredcites →https://doi.org/10.1038/nature09298openalex-snapshot
Integrating common and rare genetic variation in diverse human populations
inferredcites →https://doi.org/10.1038/nature10405openalex-snapshot
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot
Biological insights from 108 schizophrenia-associated genetic loci
inferredcites →https://doi.org/10.1038/ncomms4934openalex-snapshot
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3367openalex-snapshot
A gene-based association method for mapping traits using reference transcriptome data
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1038/ng.3551openalex-snapshot
Physical and neurobehavioral determinants of reproductive onset and success
inferredcites →https://doi.org/10.1038/ng.3643openalex-snapshot
A reference panel of 64,976 haplotypes for genotype imputation
inferredcites →https://doi.org/10.1038/ng.474openalex-snapshot
Microduplications of 16p11.2 are associated with schizophrenia
inferredcites →https://doi.org/10.1038/nprot.2014.071openalex-snapshot
Quality control and conduct of genome-wide association meta-analyses
inferredcites →https://doi.org/10.1038/tp.2016.36openalex-snapshot
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
inferredcites →https://doi.org/10.1046/j.1360-0443.2000.951116213.xopenalex-snapshot
The effects of adolescent cannabis use on educational attainment: a review
inferredcites →https://doi.org/10.1056/nejmoa075974openalex-snapshot
Association between Microdeletion and Microduplication at 16p11.2 and Autism
inferredcites →https://doi.org/10.1089/bio.2015.0032openalex-snapshot
A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project
inferredcites →https://doi.org/10.1093/bioinformatics/btq340openalex-snapshot
METAL: fast and efficient meta-analysis of genomewide association scans
inferredcites →https://doi.org/10.1093/bioinformatics/btq419openalex-snapshot
LocusZoom: regional visualization of genome-wide association scan results
inferredcites →https://doi.org/10.1093/hmg/ddl426openalex-snapshot
Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1097/00004583-200212000-00022openalex-snapshot
Sensation Seeking, Puberty, and Nicotine, Alcohol, and Marijuana Use in Adolescence
inferredcites →https://doi.org/10.1097/ypg.0b013e328012d850openalex-snapshot
NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences
inferredcites →https://doi.org/10.1101/045260openalex-snapshot
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
inferredcites →https://doi.org/10.1101/078972openalex-snapshot
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
inferredcites →https://doi.org/10.1101/126102openalex-snapshot
Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption
inferredcites →https://doi.org/10.1101/pdb.top81openalex-snapshot
Meta-Analysis of Genome-Wide Association Studies
inferredcites →https://doi.org/10.1111/j.1360-0443.2004.00683.xopenalex-snapshot
Cannabis use and the risk of later schizophrenia: a review
inferredcites →https://doi.org/10.1111/j.1360-0443.2009.02831.xopenalex-snapshot
Genetic and environmental influences on cannabis use initiation and problematic use: a meta‐analysis of twin studies
inferredcites →https://doi.org/10.1159/000335662openalex-snapshot
Co-Occurrence of Addictive Behaviours: Personality Factors Related to Substance Use, Gambling and Computer Gaming
inferredcites →https://doi.org/10.1186/s13742-015-0047-8openalex-snapshot
Second-generation PLINK: rising to the challenge of larger and richer datasets
inferredcites →https://doi.org/10.1210/jc.2003-030090openalex-snapshot
The Cell Adhesion Molecules N-Cadherin and Neural Cell Adhesion Molecule Regulate Human Growth Hormone: A Novel Mechanism for Regulating Pituitary Hormone Secretion
inferredcites →https://doi.org/10.1371/journal.pcbi.1004219openalex-snapshot
MAGMA: Generalized Gene-Set Analysis of GWAS Data
inferredcites →https://doi.org/10.1371/journal.pgen.1003491openalex-snapshot
Effectively Identifying eQTLs from Multiple Tissues by Combining Mixed Model and Meta-analytic Approaches
inferredcites →https://doi.org/10.1586/14737175.8.7.1037openalex-snapshot
Cannabis and schizophrenia: towards a cannabinoid hypothesis of schizophrenia
inferredcites →https://doi.org/10.17863/cam.26250openalex-snapshot
Abstract

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1001/jamapsychiatry.2018.2546openalex-snapshot
Genetic Predisposition vs Individual-Specific Processes in the Association Between Psychotic-like Experiences and Cannabis Use
inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2019.01.015openalex-snapshot
Association between polygenic risk for tobacco or alcohol consumption and liability to licit and illicit substance use in young Australian adults
inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2019.107704openalex-snapshot
Associations between polygenic risk for tobacco and alcohol use and liability to tobacco and alcohol use, and psychiatric disorders in an independent sample of 13,999 Australian adults
inferred← citeshttps://doi.org/10.1016/j.schres.2018.06.067openalex-snapshot
Maternal and paternal cannabis use during pregnancy and the risk of psychotic-like experiences in the offspring
inferred← citeshttps://doi.org/10.1016/j.ypmed.2018.08.036openalex-snapshot
An epidemiological, developmental and clinical overview of cannabis use during pregnancy
inferred← citeshttps://doi.org/10.1017/s0033291718002817openalex-snapshot
Genetic risk for schizophrenia is associated with substance use in emerging adulthood: an event-level polygenic prediction model
inferred← citeshttps://doi.org/10.1038/s41398-019-0598-zopenalex-snapshot
Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance
inferred← citeshttps://doi.org/10.1038/s41398-020-0800-3openalex-snapshot
Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort
inferred← citeshttps://doi.org/10.1093/ntr/nty150openalex-snapshot
Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use
inferred← citeshttps://doi.org/10.1101/157636openalex-snapshot
Genetic risk for schizophrenia influences substance use in emerging adulthood: An event-level polygenic prediction model
inferred← citeshttps://doi.org/10.1111/add.14186openalex-snapshot
Commentary on Degenhardt et al. (2018): Cause or consequence? Disentangling the relationship between psychosis and substance use
inferred← citeshttps://doi.org/10.1111/add.14512openalex-snapshot
Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement
inferred← citeshttps://doi.org/10.1523/jneurosci.2662-18.2019openalex-snapshot
Genome-wide association studies of impulsive personality traits (BIS-11 and UPPSP) and drug experimentation in up to 22,861 adult research participants identify loci in the CACNA1I and CADM2 genes
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