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Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Clozapine for the Treatment-Resistant Schizophrenic
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HLA-B38, DR4, DQw3 and Clozapine-Induced Agranulocytosis in Jewish Patients With Schizophrenia
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Genetic Determinants of Clozapine-Induced Agranulocytosis: Recent Results of HLA Subtyping in a Non-Jewish Caucasian Sample
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A Genome‐Wide Association Study Reveals ARL15, a Novel Non‐HLA Susceptibility Gene for Rheumatoid Arthritis in North Indians
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A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals
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Rare Complete Knockouts in Humans: Population Distribution and Significant Role in Autism Spectrum Disorders
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A marker for Stevens–Johnson syndrome
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Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2
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Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis
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A map of human genome variation from population-scale sequencing
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Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
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Guidelines for investigating causality of sequence variants in human disease
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Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
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Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
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Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration
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HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
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A framework for variation discovery and genotyping using next-generation DNA sequencing data
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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
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Principal components analysis corrects for stratification in genome-wide association studies
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A linear complexity phasing method for thousands of genomes
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Improved whole-chromosome phasing for disease and population genetic studies
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A method and server for predicting damaging missense mutations
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The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy
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Whole-genome association study of bipolar disorder
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Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens
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HLA‐B38 and clozapine‐induced agranulocytosis in Israeli Jewish schizophrenic patients
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Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States
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PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
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Haploview: analysis and visualization of LD and haplotype maps
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Fast and accurate short read alignment with Burrows–Wheeler transform
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The Sequence Alignment/Map format and SAMtools
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Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor
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zCall: a rare variant caller for array-based genotyping
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A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population
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Pharmacogenomics of adverse drug reactions: implementing personalized medicine
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HLA associations in clozapine-induced agranulocytosis
inferredcites →https://doi.org/10.1371/journal.pgen.1003147openalex-snapshot
A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)
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Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
inferredcites →https://doi.org/10.4088/jcp.09m05527yelopenalex-snapshot
Candidate Gene Analysis Identifies a Polymorphism inHLA-DQB1Associated With Clozapine-Induced Agranulocytosis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Clozapine's Multiple Cellular Mechanisms: What Do We Know after More than Fifty Years? a Systematic Review and Critical Assessment of Translational Mechanisms Relevant for Innovative Strategies in Treatment-Resistant Schizophrenia
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Successes and Challenges in Precision Medicine in Psychiatry
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HLA ‐Mediated Adverse Drug Reactions: Challenges and Opportunities for Predictive Molecular Modeling
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Schizophrenia and Related Psychoses
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Genome‐wide association study of lymphoblast cell viability after clozapine exposure
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ACKR1 /Duffy‐null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)
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Influence of pharmacokinetics‐related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia
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Incidence and risk estimate of drug‐induced agranulocytosis in Hong Kong Chinese. A population‐based case–control study
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Pharmakogenetik in der Psychiatrie: eine Standortbestimmung
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Increased risk of strontium ranelate-related SJS/TEN is associated with HLA
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Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab Populations
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Clozapine as a Model for Antipsychotic Development
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Impact of New Genomic Technologies on Understanding Adverse Drug Reactions
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Worldwide Differences in Regulations of Clozapine Use
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Correlation Between Serum Concentrations of N-Desmethylclozapine and Granulocyte Levels in Patients with Schizophrenia: A Retrospective Observational Study
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Hepatic Safety of Atypical Antipsychotics: Current Evidence and Future Directions
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Biomarkers for Psychosis: the Molecular Genetics of Psychosis
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Myocarditis and Cardiomyopathy
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Severe Neutropenia and Agranulocytosis
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Clinical Genetics and Referrals
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Pharmacogenomics and antipsychotics: efficacy and adverse drug reactions
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Applying Pharmacogenomics in Drug Therapy of Neurologic and Psychiatric Disorders
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Pharmacogenetics of Adverse Drug Reactions
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Haematological side effects associated with clozapine: A retrospective study from India
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Commentary: More research needed on predictive biomarkers related to clozapine treatment
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Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population
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Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population
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Immunogenetic Variants in Major Mental and Neurodevelopmental Disorders
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Clues of HLAs, metabolic SNPs, and epigenetic factors in T cell-mediated drug hypersensitivity reactions
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New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity
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Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions
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Pharmacogenomics: A road ahead for precision medicine in psychiatry
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Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity
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Clozapine’s multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia
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Incidence des neutropénies et agranulocytoses sous clozapine nécessitant un arrêt ou une surveillance particulière du traitement : étude rétrospective dans un établissement psychiatrique sur une période de 14 ans
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A case of clozapine induced agranulocytosis 25 years after starting treatment: Effective use of lithium for augmentation in rechallenge
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Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
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The road to precision psychiatry: translating genetics into disease mechanisms
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A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia
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Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis
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Cost-effectiveness of HLA-DQB1/HLA-B pharmacogenetic-guided treatment and blood monitoring in US patients taking clozapine
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Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis
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Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits
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HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry
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Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study
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Cost effectiveness of pharmacogenetic-guided clozapine administration based on risk of HLA variants in Japan and the UK
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Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count
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Pharmacogenomics: current status and future perspectives
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Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis
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Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population
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More than 25 years of genetic studies of clozapine-induced agranulocytosis
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Different electronic states of isomorphous chiral vs . racemic organic conducting salts, β′′-(BEDT-TTF) 2 ( S - and rac -PROXYL-CONHCH 2 SO 3 )
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Molecular docking to investigate HLA-associated idiosyncratic drug reactions
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Clozapine’s critical role in treatment resistant schizophrenia: ensuring both safety and use
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Current Treatments for Psychotic Disorders
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Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis
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Clozapine Efficacy and Adverse Drug Reactions Among a Nationwide Study of 1021 Australians Prescribed Clozapine: The ClozaGene Study
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Genetic Susceptibility to Clozapine-Induced Agranulocytosis/Neutropenia Across Ethnicities: Results From a New Cohort of Turkish and Other Caucasian Participants, and Meta-Analysis
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Obstacles, Opportunities, and Ethical Considerations for Genomic Investigations of Individuals Continuously Hospitalized with Treatment-resistant Schizophrenia
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Evolving Role of Pharmacogenetic Biomarkers to Predict Drug-Induced Hematological Disorders
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Omics in schizophrenia: current progress and future directions of antipsychotic treatments
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Analysis of Clozapine Use and Safety by Using Comprehensive National Data From the Japanese Clozapine Patient Monitoring Service
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Extended Requirement of Granulocyte Colony-Stimulating Factor for Clozapine-Associated Neutropenia
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Pharmacogenetic Variant Related Higher-Than-Expected Clozapine Concentrations and Clozapine/Norclozapine Ratios in a Patient With Treatment-Resistant Schizoaffective Disorder
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Concurrence of clozapine-induced diabetic ketoacidosis and neuroleptic malignant syndrome: A case report
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Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring
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New findings in pharmacogenetics of schizophrenia
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Agranulocytosis after long-term clozapine use: a case report
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Polygenic regulation of PTSD severity and outcomes among World Trade Center responders
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Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation loci
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Pharmacogenomics of off‐target adverse drug reactions
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Associations of HLA genotypes with antithyroid drug‐induced agranulocytosis: A systematic review and meta‐analysis of pharmacogenomics studies
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Integration analysis of GWAS and expression quantitative trait loci to identify candidate genes and pathways for clozapine‐related neutropaenia
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HLA‐associated adverse drug reactions ‐ scoping review
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Human leucocyte antigen–adverse drug reaction associations: from a perspective of ethnicity
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Introduction to Pharmacogenomics: Role of the Histocompatibility and Immunogenetics Laboratory in Personalised Medicine—Current Status and Future Prospects
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HLAs: Key regulators of T‐cell‐mediated drug hypersensitivity
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Peculiarities of the Effect of Antipsychotics: Pharmacogenetic Studies
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HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction
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Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis
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Pharmacogenetics of Antipsychotic Drug Treatment: Update and Clinical Implications
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Psychiatric Genomics: An Update and an Agenda
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Pharmacogenomic Clinical Support Tools for the Treatment of Depression
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Chapter 26. Clozapine
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Clozapine-specific proliferative response of peripheral blood-derived mononuclear cells in Japanese patients with clozapine-induced agranulocytosis
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Biomarkers of adverse drug reactions
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Clozapine- and non-clozapine-associated neutropenia in patients with schizophrenia: a retrospective cohort study
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Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide
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Cell type-specific epigenetic links to schizophrenia risk in the brain
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Adverse drug reactions triggered by the common HLA-B*57:01 variant: a molecular docking study
inferred← citeshttps://doi.org/10.1186/s13321-018-0257-zopenalex-snapshot
Adverse drug reactions triggered by the common HLA-B*57:01 variant: virtual screening of DrugBank using 3D molecular docking
inferred← citeshttps://doi.org/10.1186/s40246-019-0254-yopenalex-snapshot
Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics
inferred← citeshttps://doi.org/10.1186/s40345-020-00184-3openalex-snapshot
Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection
inferred← citeshttps://doi.org/10.1192/apt.bp.114.013433openalex-snapshot
Personalised approaches to pharmacotherapy for schizophrenia
inferred← citeshttps://doi.org/10.1192/bjpo.bp.116.003467openalex-snapshot
Successful clozapine re-challenge in a patient with three previous episodes of clozapine-associated blood dyscrasia
inferred← citeshttps://doi.org/10.1371/journal.pgen.1009163openalex-snapshot
Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth
inferred← citeshttps://doi.org/10.1371/journal.pone.0318878openalex-snapshot
Characterization of the atypical antipsychotic drug aripiprazole cytotoxicity in the neutrophil model cell line HL-60
inferred← citeshttps://doi.org/10.1517/17425255.2015.1075003openalex-snapshot
Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia: an update
inferred← citeshttps://doi.org/10.15416/ijcp.2018.7.1.19openalex-snapshot
The Influence of Antipsychotic to Decrease the Score of The Positive and Negative Syndrome Scale-Excited Component
inferred← citeshttps://doi.org/10.17116/jnevro201511511140-46openalex-snapshot
Plasma levels of antipsychotics and the severity of side-effects in the treatment of schizophrenia exacerbation
inferred← citeshttps://doi.org/10.17816/mechnikov20179219-27openalex-snapshot
FROM PATHOLOGICAL PROCESSES TO PATHOGENESIS OF MEdICALLY ALLERGY
inferred← citeshttps://doi.org/10.18231/j.ijcaap.2019.027openalex-snapshot
Effects of antipsychotic treatment on haematological parameters of psychotic patients in tertiary care hospital of India
inferred← citeshttps://doi.org/10.20517/jtgg.2023.11openalex-snapshot
Pharmacogenomic screening for agranulocytosis and efficacy with clozapine
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4246337/v1openalex-snapshot
Shared genetic loci between clozapine metabolism and granulocyte counts
inferred← citeshttps://doi.org/10.2147/pgpm.s115741openalex-snapshot
Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics
inferred← citeshttps://doi.org/10.2174/1574886313666180807094654openalex-snapshot
Safety of a Clozapine Trial Following Quetiapine-Induced Leukopenia: A Case Report
inferred← citeshttps://doi.org/10.2217/pgs-2017-0124openalex-snapshot
Patient Ethnicity and the Risk of Immune-Mediated Adverse Drug Reactions
inferred← citeshttps://doi.org/10.2217/pgs-2018-0188openalex-snapshot
Genetics of Clozapine-Associated Neutropenia: Recent Advances, Challenges and Future Perspective
inferred← citeshttps://doi.org/10.2217/pgs-2022-0006openalex-snapshot
The Role of Alcohol Intake in the Pharmacogenetics of Treatment with Clozapine
inferred← citeshttps://doi.org/10.2217/pgs.15.54openalex-snapshot
Progress in Understanding the Genomic Basis for Adverse Drug Reactions: A Comprehensive Review and Focus on the Role of Ethnicity
inferred← citeshttps://doi.org/10.2217/pgs.15.67openalex-snapshot
How Close are We to a Pharmacogenomic Test for Clozapine-Induced Agranulocytosis?
inferred← citeshttps://doi.org/10.31083/j.fbl2709266openalex-snapshot
HLA-DQA1 and DQB1 Alleles are Associated with Acitretin Response in Patients with Psoriasis
inferred← citeshttps://doi.org/10.31603/pharmacy.v0i0.5190openalex-snapshot
THE CLOZAPINE EFFECT ON BLOOD GLUCOSE LEVELS, LEUKOCYTES AND PLATELETS IN SCHIZOPHRENIC PATIENTS IN THE MENTAL SERVICE UNIT OF BANYUMAS HOSPITAL
inferred← citeshttps://doi.org/10.31887/dcns.2016.18.3/ceapopenalex-snapshot
Personalized prescribing: a new medical model for clinical implementation of psychotropic drugs
inferred← citeshttps://doi.org/10.31887/dcns.2018.20.3/mhoeheopenalex-snapshot
The role of genetics and genomics in clinical psychiatry
inferred← citeshttps://doi.org/10.3238/arztebl.2018.0501openalex-snapshot
Drug Hypersensitivity: Diagnosis, Genetics, and Prevention
inferred← citeshttps://doi.org/10.3238/arztebl.m2025.0214openalex-snapshot
Metamizole: Indications and risks
inferred← citeshttps://doi.org/10.33540/870openalex-snapshot
Towards personalized treatment of clozapine
inferred← citeshttps://doi.org/10.3389/fneur.2026.1808157openalex-snapshot
Precision medicine decision-making under pharmacogenomics in nursing: realizing value from limited evidence to scaled clinical pathways
inferred← citeshttps://doi.org/10.3389/fphar.2016.00396openalex-snapshot
Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions
inferred← citeshttps://doi.org/10.3389/fphar.2018.00158openalex-snapshot
Pathway-Based Analysis of Genome-Wide Association Data Identified SNPs in HMMR as Biomarker for Chemotherapy- Induced Neutropenia in Breast Cancer Patients
inferred← citeshttps://doi.org/10.3389/fphar.2018.01049openalex-snapshot
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis
inferred← citeshttps://doi.org/10.3389/fphar.2022.1016669openalex-snapshot
Pharmacogenomic-guided clozapine administration based on HLA-DQB1, HLA-B and SLCO1B3-SLCO1B7 variants: an effectiveness and cost-effectiveness analysis
inferred← citeshttps://doi.org/10.3389/fphar.2025.1651898openalex-snapshot
Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions
inferred← citeshttps://doi.org/10.3389/fpsyt.2024.1297760openalex-snapshot
Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia
inferred← citeshttps://doi.org/10.3390/brainsci10110840openalex-snapshot
Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety—Particularities in the Context of COVID-19
inferred← citeshttps://doi.org/10.3390/genes11111275openalex-snapshot
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
inferred← citeshttps://doi.org/10.3390/hemato7040032openalex-snapshot
Cross-Reactivity and Drug Rechallenge in Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis
inferred← citeshttps://doi.org/10.3390/hematolrep17030030openalex-snapshot
Ceftriaxone-Induced Pancytopenia: A Case Report
inferred← citeshttps://doi.org/10.3390/ijms17101714openalex-snapshot
The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity
inferred← citeshttps://doi.org/10.3390/neuroglia4020009openalex-snapshot
The Role of Lactylation in Mental Illness: Emphasis on Microglia
inferred← citeshttps://doi.org/10.3390/pharmaceutics16020244openalex-snapshot
Clinical Utility and Implementation of Pharmacogenomics for the Personalisation of Antipsychotic Treatments
inferred← citeshttps://doi.org/10.3390/psychiatryint6030093openalex-snapshot
From Genotype to Guidelines: Rethinking Neutropenia Risk in Clozapine Use
inferred← citeshttps://doi.org/10.4049/jimmunol.2000646openalex-snapshot
Characterization of Clozapine-Responsive Human T Cells
inferred← citeshttps://doi.org/10.4088/jcp.16m11152openalex-snapshot
Evaluating the Effect of the Changes in FDA Guidelines for Clozapine Monitoring
inferred← citeshttps://doi.org/10.51847/plv0omq3wkopenalex-snapshot
Cost-Effectiveness of an Expanded Pharmacogenomic Panel (HLA-B, HLA-DQB1, and SLCO1B3-SLCO1B7) for Preventing Clozapine-Induced Agranulocytosis/Granulocytopenia: A 10-Year Decision-Analytic Model
inferred← citeshttps://doi.org/10.51847/srdvcnybnzopenalex-snapshot
Enhancing Psychiatric Drug Safety: Lessons from Pharmacogenomic Studies of Hypersensitivity Reactions
inferred← citeshttps://doi.org/10.5772/intechopen.108407openalex-snapshot
Interplay between Pharmacokinetics and Pharmacogenomics
inferred← citeshttps://doi.org/10.5772/intechopen.95734openalex-snapshot
Dosage Forms - Innovation and Future Perspectives
inferred← citeshttps://doi.org/10.64898/2026.02.01.703124openalex-snapshot
Functional Annotation of the Major Histocompatibility Complex Locus
inferred← citeshttps://doi.org/10.70675/0c979a0ez843cz4002zabcczdf942e54dc18openalex-snapshot
Rôle des lymphocytes T CD8+ dans les hypersensibilités retardées cutanées médicamenteuses
inferred← citeshttps://doi.org/10.7759/cureus.23226openalex-snapshot
Ceftriaxone-Induced Reversible Agranulocytosis: A Case Report and Review of Drug-Induced Agranulocytosis
inferred← citeshttps://doi.org/10.9740/mhc.2020.05.070openalex-snapshot
Clozapine and hematologic adverse reactions: Impact of the Risk Evaluation and Mitigation Strategy program
inferred← citeshttps://doi.org/10.9758/cpn.2016.14.2.212openalex-snapshot
Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature
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