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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

https://doi.org/10.1038/ncomms7769
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.201400040openalex-snapshot
Preparing a cell for nuclear envelope breakdown: Spatio‐temporal control of phosphorylation during mitotic entry
inferredcites →https://doi.org/10.1002/emmm.201202341openalex-snapshot
CDK‐mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC‐driven transcription and tumourigenesis and predicts poor survival in breast cancer
inferredcites →https://doi.org/10.1007/bf00331653openalex-snapshot
The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function
inferredcites →https://doi.org/10.1016/0092-8674(87)90227-3openalex-snapshot
Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+
inferredcites →https://doi.org/10.1016/0092-8674(89)90936-7openalex-snapshot
Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2
inferredcites →https://doi.org/10.1016/0092-8674(89)90949-5openalex-snapshot
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells
inferredcites →https://doi.org/10.1016/0092-8674(94)90535-5openalex-snapshot
A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase
inferredcites →https://doi.org/10.1016/j.ceb.2013.08.004openalex-snapshot
Targeting cyclin-dependent kinases in anti-neoplastic therapy
inferredcites →https://doi.org/10.1016/j.devcel.2010.02.013openalex-snapshot
Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis
inferredcites →https://doi.org/10.1016/j.molcel.2007.02.003openalex-snapshot
Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human Cells
inferredcites →https://doi.org/10.1016/j.molcel.2008.10.022openalex-snapshot
Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells
inferredcites →https://doi.org/10.1016/j.molcel.2010.02.023openalex-snapshot
Quantitative Reconstitution of Mitotic CDK1 Activation in Somatic Cell Extracts
inferredcites →https://doi.org/10.1016/j.molcel.2013.04.003openalex-snapshot
A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression
inferredcites →https://doi.org/10.1016/j.semcdb.2005.02.014openalex-snapshot
A roller coaster ride with the mitotic cyclins
inferredcites →https://doi.org/10.1016/j.tips.2007.10.012openalex-snapshot
CDK inhibitors in cancer therapy: what is next?
inferredcites →https://doi.org/10.1016/s0092-8674(00)81065-xopenalex-snapshot
Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1
inferredcites →https://doi.org/10.1016/s0969-2126(01)00259-3openalex-snapshot
The crystal structure of cyclin A
inferredcites →https://doi.org/10.1021/cb500129topenalex-snapshot
Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?
inferredcites →https://doi.org/10.1021/jm301495vopenalex-snapshot
Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity
inferredcites →https://doi.org/10.1021/jm800382hopenalex-snapshot
Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
inferredcites →https://doi.org/10.1021/ml200241aopenalex-snapshot
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors
inferredcites →https://doi.org/10.1038/10049openalex-snapshot
Temporal and spatial control of cyclin B1 destruction in metaphase
inferredcites →https://doi.org/10.1038/15674openalex-snapshot
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
inferredcites →https://doi.org/10.1038/327031a0openalex-snapshot
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
inferredcites →https://doi.org/10.1038/346760a0openalex-snapshot
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B
inferredcites →https://doi.org/10.1038/363595a0openalex-snapshot
Crystal structure of cyclin-dependent kinase 2
inferredcites →https://doi.org/10.1038/376313a0openalex-snapshot
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
inferredcites →https://doi.org/10.1038/382325a0openalex-snapshot
Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex
inferredcites →https://doi.org/10.1038/emboj.2008.121openalex-snapshot
The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
inferredcites →https://doi.org/10.1038/embor.2011.263openalex-snapshot
Protein phosphatases and their regulation in the control of mitosis
inferredcites →https://doi.org/10.1038/nature06046openalex-snapshot
Cdk1 is sufficient to drive the mammalian cell cycle
inferredcites →https://doi.org/10.1038/nature09131openalex-snapshot
Crystal structure of HIV-1 Tat complexed with human P-TEFb
inferredcites →https://doi.org/10.1038/nature10560openalex-snapshot
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase
inferredcites →https://doi.org/10.1038/nm.2377openalex-snapshot
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
inferredcites →https://doi.org/10.1038/nrc2602openalex-snapshot
Cell cycle, CDKs and cancer: a changing paradigm
inferredcites →https://doi.org/10.1038/nrm1988openalex-snapshot
The anaphase promoting complex/cyclosome: a machine designed to destroy
inferredcites →https://doi.org/10.1038/nsmb.2706openalex-snapshot
Multisite phosphorylation networks as signal processors for Cdk1
inferredcites →https://doi.org/10.1038/nsmb.2707openalex-snapshot
Cks confers specificity to phosphorylation-dependent CDK signaling pathways
inferredcites →https://doi.org/10.1073/pnas.0600447103openalex-snapshot
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
inferredcites →https://doi.org/10.1073/pnas.0809645106openalex-snapshot
Crystal structure of human CDK4 in complex with a D-type cyclin
inferredcites →https://doi.org/10.1073/pnas.0809674106openalex-snapshot
The structure of CDK4/cyclin D3 has implications for models of CDK activation
inferredcites →https://doi.org/10.1073/pnas.1115201109openalex-snapshot
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
inferredcites →https://doi.org/10.1073/pnas.1202492109openalex-snapshot
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma
inferredcites →https://doi.org/10.1073/pnas.85.9.3009openalex-snapshot
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
inferredcites →https://doi.org/10.1074/jbc.274.13.8746openalex-snapshot
Effects of Phosphorylation of Threonine 160 on Cyclin-dependent Kinase 2 Structure and Activity
inferredcites →https://doi.org/10.1074/jbc.274.52.36839openalex-snapshot
The Xenopus Suc1/Cks Protein Promotes the Phosphorylation of G2/M Regulators
inferredcites →https://doi.org/10.1083/jcb.115.1.1openalex-snapshot
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.
inferredcites →https://doi.org/10.1083/jcb.153.1.121openalex-snapshot
Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase
inferredcites →https://doi.org/10.1083/jcb.153.1.137openalex-snapshot
Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint
inferredcites →https://doi.org/10.1083/jcb.200812045openalex-snapshot
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
inferredcites →https://doi.org/10.1093/hmg/dds061openalex-snapshot
Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes
inferredcites →https://doi.org/10.1098/rstb.2011.0069openalex-snapshot
Structural insights into anaphase-promoting complex function and mechanism
inferredcites →https://doi.org/10.1101/gad.12.3.370openalex-snapshot
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity
inferredcites →https://doi.org/10.1101/gad.1933010openalex-snapshot
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot
Phaser crystallographic software
inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot
Features and development of Coot
inferredcites →https://doi.org/10.1107/s090744491003982xopenalex-snapshot
An introduction to data reduction: space-group determination, scaling and intensity statistics
inferredcites →https://doi.org/10.1107/s0907444911007281openalex-snapshot
Presenting your structures: theCCP4mgmolecular-graphics software
inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot
The CCP4 suite: programs for protein crystallography
inferredcites →https://doi.org/10.1107/s0907444996012255openalex-snapshot
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
inferredcites →https://doi.org/10.1126/science.1095920openalex-snapshot
Protein Kinase Inhibitors: Insights into Drug Design from Structure
inferredcites →https://doi.org/10.1126/science.1172867openalex-snapshot
Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution
inferredcites →https://doi.org/10.1128/mcb.15.1.345openalex-snapshot
Effects of Phosphorylation by CAK on Cyclin Binding by CDC2 and CDK2
inferredcites →https://doi.org/10.1128/mcb.22.7.2242-2254.2002openalex-snapshot
Reversal of Growth Suppression by p107 via Direct Phosphorylation by Cyclin D1/Cyclin-Dependent Kinase 4
inferredcites →https://doi.org/10.1242/dev.024919openalex-snapshot
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2
inferredcites →https://doi.org/10.1385/1-59259-857-9:219openalex-snapshot
Methods for Preparation of Proteins and Protein Complexes That Regulate the Eukaryotic Cell Cycle for Structural Studies
inferredcites →https://doi.org/10.1517/14728222.2010.525221openalex-snapshot
Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor–chemotherapy combinations as an anticancer strategy for solid tumors
inferredcites →https://doi.org/10.4161/cc.6.11.4278openalex-snapshot
Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2
inferredcites →https://doi.org/10.4161/cc.6.11.4297openalex-snapshot
The Crystal Structure of Human Cyclin B

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Crystallographic and computational insights into charge-assisted N/C–H···Br− hydrogen bonding in 2-Amino-1-alkylpyridinium bromide salts
inferred← citeshttps://doi.org/10.1016/j.omtn.2021.08.011openalex-snapshot
Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.108009openalex-snapshot
The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.03.012openalex-snapshot
Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs
inferred← citeshttps://doi.org/10.1016/j.phrs.2018.11.035openalex-snapshot
Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs
inferred← citeshttps://doi.org/10.1016/j.psj.2024.103818openalex-snapshot
Mechanism of fibroblast growth factor 1 regulating fatty liver disorder in mule ducks
inferred← citeshttps://doi.org/10.1016/j.rechem.2024.101592openalex-snapshot
Synthesis, structure analysis, Hirshfeld surface studies, molecular docking studies against cyclin-dependent kinases (CDKs) of sulfonamide decorated N6-benzyl aminopurines for cancer treatment
inferred← citeshttps://doi.org/10.1016/j.sciaf.2024.e02268openalex-snapshot
Anticancer potential of silver nanoparticles biosynthesized using Catharanthus roseus leaves extract on cervical (HeLa229) cancer cell line
inferred← citeshttps://doi.org/10.1016/j.semcdb.2020.04.021openalex-snapshot
Chatterboxes: the structural and functional diversity of cyclins
inferred← citeshttps://doi.org/10.1016/j.tcb.2020.11.001openalex-snapshot
CDK1, the Other ‘Master Regulator’ of Autophagy
inferred← citeshttps://doi.org/10.1016/j.tice.2021.101495openalex-snapshot
Hypoxia-inducible lipid droplet-associated (HILPDA) facilitates the malignant phenotype of lung adenocarcinoma cells in vitro through modulating cell cycle pathways
inferred← citeshttps://doi.org/10.1016/j.tjog.2018.11.010openalex-snapshot
Determination of the effects of bone marrow derived mesenchymal stem cells and ovarian stromal stem cells on follicular maturation in cyclophosphamide induced ovarian failure in rats
inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.01.039openalex-snapshot
CDK1-loaded extracellular vesicles promote cell cycle to reverse impaired wound healing in diabetic obese mice
inferred← citeshttps://doi.org/10.1021/acs.jcim.6c00279openalex-snapshot
Cyclin-E/A/CDK1/2 Kinetic Landscapes Drive Cell Cycle Phase-Specific Progression and Guide Cyclin-E Degradation Strategy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00744openalex-snapshot
Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01254openalex-snapshot
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines
inferred← citeshttps://doi.org/10.1021/acs.jpcb.4c03243openalex-snapshot
Binding Modalities and Phase-Specific Regulation of Cyclin/Cyclin-Dependent Kinase Complexes in the Cell Cycle
inferred← citeshttps://doi.org/10.1021/acs.jpcb.5c08630openalex-snapshot
Decoding the Post-translational Modification Crosstalk: Functional Implications of Phosphorylation, Acetylation, and Methylation
inferred← citeshttps://doi.org/10.1021/acschembio.3c00015openalex-snapshot
Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics
inferred← citeshttps://doi.org/10.1021/acsomega.4c05414openalex-snapshot
Discovery of Potential Inhibitors of CDK1 by Integrating Pharmacophore-Based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation Studies, and Evaluation of Their Inhibitory Activity
inferred← citeshttps://doi.org/10.1038/s41467-018-07794-7openalex-snapshot
Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1
inferred← citeshttps://doi.org/10.1038/s41467-022-30264-0openalex-snapshot
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
inferred← citeshttps://doi.org/10.1038/s41467-024-51135-wopenalex-snapshot
Cryo-EM structure of the CDK2-cyclin A-CDC25A complex
inferred← citeshttps://doi.org/10.1038/s41467-025-57538-7openalex-snapshot
Copper is essential for cyclin B1-mediated CDK1 activation
inferred← citeshttps://doi.org/10.1038/s41586-021-03764-0openalex-snapshot
Structural basis of human separase regulation by securin and CDK1–cyclin B1
inferred← citeshttps://doi.org/10.1038/s41586-023-05939-3openalex-snapshot
Lactate regulates cell cycle by remodelling the anaphase promoting complex
inferred← citeshttps://doi.org/10.1038/s41586-024-07888-xopenalex-snapshot
CDK5–cyclin B1 regulates mitotic fidelity
inferred← citeshttps://doi.org/10.1038/s41594-024-01211-yopenalex-snapshot
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens
inferred← citeshttps://doi.org/10.1038/s41598-017-02489-3openalex-snapshot
A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells
inferred← citeshttps://doi.org/10.1038/s41598-020-65009-wopenalex-snapshot
Two-Step Mechanism of Cyclin B Degradation Initiated by Proteolytic Cleavage with the 26 S Proteasome in Fish
inferred← citeshttps://doi.org/10.1038/s41598-021-90384-3openalex-snapshot
Evolution of opposing regulatory interactions underlies the emergence of eukaryotic cell cycle checkpoints
inferred← citeshttps://doi.org/10.1038/s41598-023-37609-9openalex-snapshot
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
inferred← citeshttps://doi.org/10.1038/s41598-024-66173-zopenalex-snapshot
Deriving general structure–activity/selectivity relationship patterns for different subfamilies of cyclin-dependent kinase inhibitors using machine learning methods
inferred← citeshttps://doi.org/10.1038/s41598-024-69243-4openalex-snapshot
Multiwell-based G0-PCC assay for radiation biodosimetry
inferred← citeshttps://doi.org/10.1038/s44318-024-00169-3openalex-snapshot
TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes
inferred← citeshttps://doi.org/10.1039/c7mb00355bopenalex-snapshot
Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms
inferred← citeshttps://doi.org/10.1039/c9nj02924aopenalex-snapshot
Chemistry, chemical biology and photophysics of certain new chromene–triazole–coumarin triads as fluorescent inhibitors of CDK2 and CDK4 induced cancers
inferred← citeshttps://doi.org/10.1039/d2cb00201aopenalex-snapshot
Emerging approaches to CDK inhibitor development, a structural perspective
inferred← citeshttps://doi.org/10.1039/d4ra03538kopenalex-snapshot
2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method
inferred← citeshttps://doi.org/10.1039/d5ra08430jopenalex-snapshot
Exploring the chemical reactivity of 2,6-dimethylchromone toward heterocyclic hydrazines and enamines: experimental and theoretical investigations
inferred← citeshttps://doi.org/10.1053/j.seminoncol.2016.02.003openalex-snapshot
Cyclin-dependent kinase inhibitors for the treatment of chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1073/pnas.1615932113openalex-snapshot
Elucidating the druggable interface of protein−protein interactions using fragment docking and coevolutionary analysis
inferred← citeshttps://doi.org/10.1073/pnas.2010885117openalex-snapshot
Structural basis for CDK7 activation by MAT1 and Cyclin H
inferred← citeshttps://doi.org/10.1074/jbc.m115.683052openalex-snapshot
Thromboxane A2 Receptor Inhibition Suppresses Multiple Myeloma Cell Proliferation by Inducing p38/c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (MAPK)-mediated G2/M Progression Delay and Cell Apoptosis
inferred← citeshttps://doi.org/10.1074/jbc.ra118.002341openalex-snapshot
Mechanistic insights into avian reovirus p17-modulated suppression of cell cycle CDK–cyclin complexes and enhancement of p53 and cyclin H interaction
inferred← citeshttps://doi.org/10.1080/07391102.2020.1742792openalex-snapshot
Amygdalin as multi-target anticancer drug against targets of cell division cycle: double docking and molecular dynamics simulation
inferred← citeshttps://doi.org/10.1080/07391102.2021.1918253openalex-snapshot
Exploring multi-target inhibitors using in silico approach targeting cell cycle dysregulator–CDK proteins
inferred← citeshttps://doi.org/10.1080/07391102.2023.2294175openalex-snapshot
Insights into the selectivity of a brain-penetrant CDK4/6 vs CDK1/2 inhibitor for glioblastoma used in multiple replica molecular dynamics simulations
inferred← citeshttps://doi.org/10.1080/08927022.2023.2202766openalex-snapshot
Cytotoxic activities of the pyrimidine-based acetamide and isophthalimide derivatives: an in vitro and in silico studies
inferred← citeshttps://doi.org/10.1080/15384101.2018.1502574openalex-snapshot
RETRACTED ARTICLE: LncRNA CASC11 promoted gastric cancer cell proliferation, migration and invasion in vitro by regulating cell cycle pathway
inferred← citeshttps://doi.org/10.1080/17460441.2016.1174689openalex-snapshot
The hunt for antimitotic agents: an overview of structure-based design strategies
inferred← citeshttps://doi.org/10.1083/jcb.202107107openalex-snapshot
Small changes in phospho-occupancy at the kinetochore–microtubule interface drive mitotic fidelity
inferred← citeshttps://doi.org/10.1083/jcb.202308034openalex-snapshot
Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses
inferred← citeshttps://doi.org/10.1089/scd.2015.0374openalex-snapshot
Identification of Predictive Gene Markers for Multipotent Stromal Cell Proliferation
inferred← citeshttps://doi.org/10.1091/mbc.e22-06-0196openalex-snapshot
CDK signaling via nonconventional CDK phosphorylation sites
inferred← citeshttps://doi.org/10.1093/biolre/ioy090openalex-snapshot
Follicle capacitation: a meta-analysis to investigate the transcriptome dynamics following follicle-stimulating hormone decline in bovine granulosa cells†
inferred← citeshttps://doi.org/10.1097/bs9.0000000000000009openalex-snapshot
Cell cycle regulation and hematologic malignancies
inferred← citeshttps://doi.org/10.1097/md.0000000000038378openalex-snapshot
Identification of key regulatory genes in the pathogenesis of COVID-19 and sepsis: An observational study
inferred← citeshttps://doi.org/10.1098/rsob.180112openalex-snapshot
Structural insights into the functional diversity of the CDK–cyclin family
inferred← citeshttps://doi.org/10.1098/rsob.220057openalex-snapshot
Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy
inferred← citeshttps://doi.org/10.1101/2021.03.04.433249openalex-snapshot
Network pharmacology of lycopene and Molecular Docking with Top Hub Proteins
inferred← citeshttps://doi.org/10.1101/2023.09.14.557837openalex-snapshot
Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro
inferred← citeshttps://doi.org/10.1101/2024.10.10.617319openalex-snapshot
Identification of Hub Genes and CDK1-Targeting Therapeutics in Hepatocellular Carcinoma: Bioinformatics and Simulation Study
inferred← citeshttps://doi.org/10.1101/2025.09.10.675329openalex-snapshot
Human CDK5–cyclin B1 structures uncover a conserved mitotic CDK activation mechanism
inferred← citeshttps://doi.org/10.1101/325001openalex-snapshot
Pleotropic effects of PPARD accelerate colorectal tumor progression and invasion
inferred← citeshttps://doi.org/10.1101/420000openalex-snapshot
Deacetylation of catalytic lysine in CDK1 is essential for Cyclin-B binding and cell cycle
inferred← citeshttps://doi.org/10.1101/627125openalex-snapshot
Verify Hub Genes of expression profile in aortic dissection
inferred← citeshttps://doi.org/10.1107/s2059798325001883openalex-snapshot
Duplicate entries in the Protein Data Bank: how to detect and handle them
inferred← citeshttps://doi.org/10.1111/cbdd.70336openalex-snapshot
Novel N 9 ‐Substituted 6‐Cycloalkylaminoadenines as Promising Compounds Against Triple Negative Breast Cancer
inferred← citeshttps://doi.org/10.1111/febs.16082openalex-snapshot
Cell cycle regulation by complex nanomachines
inferred← citeshttps://doi.org/10.1111/iwj.70213openalex-snapshot
Low Temperature Plasma Jet Treatment Promotes Skin Wound Healing by Enhancing Cell Proliferation via the PI3K ‐ AKT and AMPK Pathways
inferred← citeshttps://doi.org/10.1111/jcmm.71307openalex-snapshot
In Vitro Effects of Anaesthetic Compounds on a Panel of Solid Tumour Cell Lines—An Exploratory Study
inferred← citeshttps://doi.org/10.1126/science.aad3925openalex-snapshot
Cyclin-dependent kinase 1–dependent activation of APC/C ubiquitin ligase
inferred← citeshttps://doi.org/10.1126/science.adw0053openalex-snapshot
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
inferred← citeshttps://doi.org/10.1128/jvi.01165-25openalex-snapshot
Identification of viral activators of the HSV-2 UL13 protein kinase
inferred← citeshttps://doi.org/10.1134/s0006297920040021openalex-snapshot
Catalytic Subunit of PKA as a Prototype of the Eukaryotic Protein Kinase Family
inferred← citeshttps://doi.org/10.1155/2022/8115474openalex-snapshot
Systematic Pan-Cancer Analysis Identifies CDK1 as an Immunological and Prognostic Biomarker
inferred← citeshttps://doi.org/10.1158/0008-5472.can-16-2546openalex-snapshot
Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-18-1790openalex-snapshot
Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion
inferred← citeshttps://doi.org/10.11606/d.75.2020.tde-16032021-155223openalex-snapshot
Estudo estrutural comparativo das 20 CDKs humanas utilizando ferramentas de bioinformática
inferred← citeshttps://doi.org/10.11606/t.75.2021.tde-25112021-092117openalex-snapshot
Clonagem, expressão, purificação e caracterização biofísica da proteína quinase dependente de ciclina 11 obtida pela expressão em Escherichia coli
inferred← citeshttps://doi.org/10.11606/t.75.2022.tde-17112022-110011openalex-snapshot
Clonagem, expressão, purificação e caracterização da proteína ciclina D3 obtida pela expressão em sistema bacteriano (>i /i<)
inferred← citeshttps://doi.org/10.1177/15353702211008380openalex-snapshot
Cytokinesis regulators as potential diagnostic and therapeutic biomarkers for human hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1186/s12885-025-13448-xopenalex-snapshot
Identification and validation of CDK1 as a promising therapeutic target for Eriocitrin in colorectal cancer: a combined bioinformatics and experimental approach
inferred← citeshttps://doi.org/10.1186/s12885-025-13601-6openalex-snapshot
Limonoid-rich fraction from Azadirachta indica A. Juss. (neem) stem bark triggers ROS-independent ER stress and induces apoptosis in 2D cultured cervical cancer cells and 3D cervical tumor spheroids
inferred← citeshttps://doi.org/10.1186/s13036-025-00606-9openalex-snapshot
Optimization of serum-free medium supplemented with microalgal extract using response surface methodology for human fibroblast culture
inferred← citeshttps://doi.org/10.1186/s13046-023-02781-3openalex-snapshot
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
inferred← citeshttps://doi.org/10.1186/s13065-024-01136-zopenalex-snapshot
New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies
inferred← citeshttps://doi.org/10.1242/dev.170589openalex-snapshot
A chemical-genetics approach to study the role of atypical protein kinase C in Drosophila
inferred← citeshttps://doi.org/10.1371/journal.pbio.3000288openalex-snapshot
ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle
inferred← citeshttps://doi.org/10.1371/journal.pone.0161111openalex-snapshot
Flavonoids as CDK1 Inhibitors: Insights in Their Binding Orientations and Structure-Activity Relationship
inferred← citeshttps://doi.org/10.1371/journal.pone.0186089openalex-snapshot
Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone
inferred← citeshttps://doi.org/10.1371/journal.pone.0224922openalex-snapshot
Verification of hub genes in the expression profile of aortic dissection
inferred← citeshttps://doi.org/10.1371/journal.pone.0255738openalex-snapshot
Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0294311openalex-snapshot
Cytotoxic metabolites from Sinularia levi supported by network pharmacology
inferred← citeshttps://doi.org/10.1371/journal.pone.0299003openalex-snapshot
Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro
inferred← citeshttps://doi.org/10.15252/embj.2019103180openalex-snapshot
Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint
inferred← citeshttps://doi.org/10.15407/bioorganica2020.02.013openalex-snapshot
Synthesis and anticancer activity of 5-sulfonyl derivatives of 1,3-oxazole-4-carboxylates
inferred← citeshttps://doi.org/10.21037/tcr-20-2604openalex-snapshot
Identification of hub genes in key hallmarks of ovarian cancer via bioinformatics analysis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6512879/v1openalex-snapshot
Bioinformatic Analysis of Expression Data from Patients with Multiple Sclerosis
inferred← citeshttps://doi.org/10.2147/ijn.s174515openalex-snapshot
Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue
inferred← citeshttps://doi.org/10.2174/0109298665363165250225100109openalex-snapshot
Unveiling the Potential Role of Hesperetin and Emodin as a Combination Therapy to Inhibit the Pancreatic Cancer Progression against the C-Met Gene
inferred← citeshttps://doi.org/10.2174/0113862073426310251010113112openalex-snapshot
CDK1 Signaling in Cancer Treatment: Advances in AI-based Strategies and Tools for New Cancer Drug Discovery
inferred← citeshttps://doi.org/10.2174/1389450118666161116130155openalex-snapshot
Understanding the Structural Basis for Inhibition of Cyclin-Dependent Kinases. New Pieces in the Molecular Puzzle
inferred← citeshttps://doi.org/10.2478/eabr-2026-0009openalex-snapshot
In Silico Discovery of Novel CDK1 Inhibitors from Linum Species for Targeted Cancer Therapy
inferred← citeshttps://doi.org/10.31083/j.fbl2702050openalex-snapshot
Identification of biomarkers and regulatory networks for cartilage damage patients
inferred← citeshttps://doi.org/10.3389/fcell.2018.00006openalex-snapshot
Mechanisms of Mitotic Kinase Regulation: A Structural Perspective
inferred← citeshttps://doi.org/10.3389/fcell.2021.770939openalex-snapshot
Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos
inferred← citeshttps://doi.org/10.3389/fchem.2023.1264808openalex-snapshot
Computational identification of potential inhibitors targeting cdk1 in colorectal cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1507845openalex-snapshot
Fatty acid metabolism-derived prognostic model for lung adenocarcinoma: unraveling the link to survival and immune response
inferred← citeshttps://doi.org/10.3389/fonc.2023.1307838openalex-snapshot
Anti-tumor target screening of sea cucumber saponin Frondoside A: a bioinformatics and molecular docking analysis
inferred← citeshttps://doi.org/10.3389/fonc.2026.1759160openalex-snapshot
HDAC1-mediated CDK1 decrotonylation inhibits colorectal cancer proliferation by regulating cell cycle and apoptosis
inferred← citeshttps://doi.org/10.3389/fphar.2020.00187openalex-snapshot
Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment
inferred← citeshttps://doi.org/10.3389/fphar.2020.01211openalex-snapshot
Target Analysis and Mechanism of Podophyllotoxin in the Treatment of Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.3389/fphar.2025.1676006openalex-snapshot
In Vitro antiproliferative potential of essential oil extract from Carica papaya L. seeds against cervical cancer
inferred← citeshttps://doi.org/10.3390/antiox14060711openalex-snapshot
Natural Hydroxybenzoic and Hydroxycinnamic Acids Derivatives: Mechanisms of Action and Therapeutic Applications
inferred← citeshttps://doi.org/10.3390/bioengineering13010114openalex-snapshot
ColiFormer: A Transformer-Based Codon Optimization Model Balancing Multiple Objectives for Enhanced E. coli Gene Expression
inferred← citeshttps://doi.org/10.3390/biom9040124openalex-snapshot
Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds
inferred← citeshttps://doi.org/10.3390/biomedicines11010172openalex-snapshot
Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/cells11142189openalex-snapshot
A Mechanistic Model for Cell Cycle Control in Which CDKs Act as Switches of Disordered Protein Phase Separation
inferred← citeshttps://doi.org/10.3390/cimb48101032openalex-snapshot
In vitro chromosome translocations: modelling critical drivers of human neoplasms
inferred← citeshttps://doi.org/10.3390/genes15070906openalex-snapshot
The Potential Links between lncRNAs and Drug Tolerance in Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.3390/ijms18091884openalex-snapshot
Kinases Involved in Both Autophagy and Mitosis
inferred← citeshttps://doi.org/10.3390/ijms241813769openalex-snapshot
In Silico Mixed Ligand/Structure-Based Design of New CDK-1/PARP-1 Dual Inhibitors as Anti-Breast Cancer Agents
inferred← citeshttps://doi.org/10.3390/jcm8050746openalex-snapshot
Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer’s Pathology
inferred← citeshttps://doi.org/10.3390/life15081223openalex-snapshot
The Effect of cdk1 Gene Knockout on Heat Shock-Induced Polyploidization in Loach (Misgurnus anguillicaudatus)
inferred← citeshttps://doi.org/10.3390/molecules27010019openalex-snapshot
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells
inferred← citeshttps://doi.org/10.3390/molecules28062691openalex-snapshot
Novel Steroidal[17,16-d]pyrimidines Derived from Epiandrosterone and Androsterone: Synthesis, Characterization and Configuration-Activity Relationships
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