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CD8+ T-cell responses to adeno-associated virus capsid in humans

https://doi.org/10.1038/nm1549
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/mthe.2000.0031openalex-snapshot
Sustained Expression of Therapeutic Level of Factor IX in Hemophilia B Dogs by AAV-Mediated Gene Therapy in Liver
inferredcites →https://doi.org/10.1016/j.ymthe.2005.09.009openalex-snapshot
Identification of mouse AAV capsid-specific CD8+ T cell epitopes
inferredcites →https://doi.org/10.1038/4751openalex-snapshot
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
inferredcites →https://doi.org/10.1038/nm0402-379openalex-snapshot
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
inferredcites →https://doi.org/10.1038/nm1358openalex-snapshot
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
inferredcites →https://doi.org/10.1038/nm1445openalex-snapshot
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid
inferredcites →https://doi.org/10.1073/pnas.182412299openalex-snapshot
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
inferredcites →https://doi.org/10.1182/blood.v99.8.2670openalex-snapshot
Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene
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Adeno‐associated Viral Vectors in Gene Therapy
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Journey to the Center of the Cell: Tracing the Path of AAV Transduction
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In Utero Gene Therapy: Progress and Challenges
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Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality
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An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T Cells
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Emerging Issues in AAV-Mediated In Vivo Gene Therapy
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inferred← citeshttps://doi.org/10.1016/j.omtm.2019.11.009openalex-snapshot
TPP Combined with DGUC as an Economic and Universal Process for Large-Scale Purification of AAV Vectors
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.05.001openalex-snapshot
Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.08.018openalex-snapshot
High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.10.023openalex-snapshot
Modulation of the liver immune microenvironment by the adeno-associated virus serotype 8 gene therapy vector
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.02.003openalex-snapshot
AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.03.016openalex-snapshot
Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.05.012openalex-snapshot
Monitoring cell-mediated immune responses in AAV gene therapy clinical trials using a validated IFN-γ ELISpot method
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.08.001openalex-snapshot
Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.09.005openalex-snapshot
Safety and efficacy of an engineered hepatotropic AAV gene therapy for ornithine transcarbamylase deficiency in cynomolgus monkeys
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.10.010openalex-snapshot
Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells
inferred← citeshttps://doi.org/10.1016/j.omtm.2022.01.005openalex-snapshot
Differential T cell immune responses to deamidated adeno-associated virus vector
inferred← citeshttps://doi.org/10.1016/j.omtm.2022.07.018openalex-snapshot
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper
inferred← citeshttps://doi.org/10.1016/j.omtm.2023.04.004openalex-snapshot
Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
inferred← citeshttps://doi.org/10.1016/j.omtm.2023.101112openalex-snapshot
Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101273openalex-snapshot
Global seroprevalence of neutralizing antibodies against adeno-associated virus serotypes used for human gene therapies
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101286openalex-snapshot
Evaluation of anti-vector immune responses to adenovirus-mediated lung gene therapy and modulation by αCD20
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101399openalex-snapshot
The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101441openalex-snapshot
A two-pass anion-exchange chromatography strategy for enrichment of full capsids in manufacturing of adeno-associated viral vectors
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101456openalex-snapshot
AAV-mediated inner ear gene delivery triggers mild host immune responses in the mammalian inner ear
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101467openalex-snapshot
iPSC-hepatocyte organoids as a novel platform to predict AAV gene therapy efficacy
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101499openalex-snapshot
AAV yield, bioactivity, and particle heterogeneity are impacted by genome size and non-coding DNA elements
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101506openalex-snapshot
AAV2 delivery of the saCas9 gene results in presentation of an HLA-A∗02:01-restricted T cell epitope potent to induce T cell cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101551openalex-snapshot
Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101584openalex-snapshot
Reduced rAAV interference enhances rcAAV detection sensitivity
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101643openalex-snapshot
Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy
inferred← citeshttps://doi.org/10.1016/j.omtn.2023.05.014openalex-snapshot
Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2026.108071openalex-snapshot
Aquaporin-1 gene therapy as a novel method to treat radiation-induced salivary gland damage: The case for adeno-associated virus vectors
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2019.107453openalex-snapshot
Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2011.04.001openalex-snapshot
T cell responses in experimental viral retinitis: Mechanisms, peculiarities and implications for gene therapy with viral vectors
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2020.100915openalex-snapshot
Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2022.101136openalex-snapshot
Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2024.101323openalex-snapshot
Multiple gene therapy as a tool for regulating the expression of molecules involved in neovascular age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2025.101354openalex-snapshot
Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapy
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2026.101443openalex-snapshot
Ocular gene therapy mediated by AAV vectors: an overview of immunosuppressive treatments and immunomonitoring of patients involved in clinical trials
inferred← citeshttps://doi.org/10.1016/j.siny.2017.05.003openalex-snapshot
Fetal stem cell and gene therapy
inferred← citeshttps://doi.org/10.1016/j.thromres.2020.12.033openalex-snapshot
AAV mediated gene therapy for haemophilia B: From the early attempts to modern trials
inferred← citeshttps://doi.org/10.1016/j.trsl.2012.12.001openalex-snapshot
Gene therapy in cystic fibrosis
inferred← citeshttps://doi.org/10.1016/j.trsl.2012.12.007openalex-snapshot
Gene therapy for retinal disease
inferred← citeshttps://doi.org/10.1016/j.trsl.2012.12.018openalex-snapshot
Immune responses in liver-directed lentiviral gene therapy
inferred← citeshttps://doi.org/10.1016/j.vaccine.2010.04.033openalex-snapshot
Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens
inferred← citeshttps://doi.org/10.1016/j.virusres.2019.197716openalex-snapshot
Molecular characterization of novel Adeno-associated virus variants infecting human tissues
inferred← citeshttps://doi.org/10.1016/j.vph.2026.107709openalex-snapshot
CRISPR-based genome editing of smooth muscle cells: Disease models, therapeutic applications, and future perspectives
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101619openalex-snapshot
Safe and effective liver-directed AAV-mediated homology-independent targeted integration in mouse models of inherited diseases
inferred← citeshttps://doi.org/10.1016/j.xcrm.2025.102422openalex-snapshot
Current regulatory requirements for assessment of immunogenicity for gene therapy medicinal products
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2010.10.017openalex-snapshot
The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2010.11.011openalex-snapshot
Cardiac gene therapy with SERCA2a: From bench to bedside
inferred← citeshttps://doi.org/10.1016/j.ymgme.2014.09.011openalex-snapshot
Lysosomal storage disease: Gene therapy on both sides of the blood–brain barrier
inferred← citeshttps://doi.org/10.1016/j.ymgme.2021.07.006openalex-snapshot
Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.02.014openalex-snapshot
The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.03.033openalex-snapshot
Gene Therapy for Hemophilia
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.09.014openalex-snapshot
Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.09.021openalex-snapshot
Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity
inferred← citeshttps://doi.org/10.1016/j.ymthe.2019.11.011openalex-snapshot
Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells
inferred← citeshttps://doi.org/10.1016/j.ymthe.2019.11.014openalex-snapshot
The Effect of CpG Sequences on Capsid-Specific CD8+ T Cell Responses to AAV Vector Gene Transfer
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