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Rational Downstream Development for Aav Full/Empty Capsid Separation – a Streamlined Methodology Based on High-Throughput Screening and Mechanistic Modeling

https://doi.org/10.2139/ssrn.4524980
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Manufacturing Challenges and Rational Formulation Development for AAV Viral Vectors
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Removal of Empty Capsids from Type 1 Adeno-Associated Virus Vector Stocks by Anion-Exchange Chromatography Potentiates Transgene Expression
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AAV vectors: The Rubik’s cube of human gene therapy
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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors
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A Versatile and Scalable Two-Step Ion-Exchange Chromatography Process for the Purification of Recombinant Adeno-associated Virus Serotypes-2 and -5
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AAV Empty Capsids: For Better or for Worse?
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Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1)
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CD8+ T-cell responses to adeno-associated virus capsid in humans
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Adeno-associated virus vector as a platform for gene therapy delivery
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Engineering adeno-associated virus vectors for gene therapy
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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
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A Methodology for the Characterization of Ion-Exchange Resins
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Scalable Purification of Adeno-Associated Virus Type 2, 4, or 5 Using Ion-Exchange Chromatography
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Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities
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Scalable Purification of Adeno-associated Virus Serotype 1 (AAV1) and AAV8 Vectors, Using Dual Ion-Exchange Adsorptive Membranes
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Empty Adeno-Associated Virus Capsids: Contaminant or Natural Decoy?
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Scalable Downstream Strategies for Purification of Recombinant Adeno- Associated Virus Vectors in Light of the Properties
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