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Assessing the potential of glucokinase activators in diabetes therapy
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Handbook of Physiology.
inferredcites →https://doi.org/10.1007/978-4-431-75452-7openalex-snapshot
Pancreatic Beta Cell in Health and Disease
inferredcites →https://doi.org/10.1007/978-4-431-75452-7_19openalex-snapshot
Genetic Disorders of the Pancreatic Beta Cell and Diabetes (Permanent Neonatal Diabetes and Maturity-Onset Diabetes of the Young)
inferredcites →https://doi.org/10.1007/978-4-431-75452-7_21openalex-snapshot
Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor
inferredcites →https://doi.org/10.1007/s00018-008-8322-9openalex-snapshot
Molecular Physiology of Mammalian Glucokinase
inferredcites →https://doi.org/10.1007/s00125-004-1498-0openalex-snapshot
Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells
inferredcites →https://doi.org/10.1007/s00125-006-0511-1openalex-snapshot
Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
inferredcites →https://doi.org/10.1007/s00125-007-0646-8openalex-snapshot
Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions
inferredcites →https://doi.org/10.1007/s00125-007-0865-zopenalex-snapshot
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes
inferredcites →https://doi.org/10.1007/s00125-008-1064-2openalex-snapshot
Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
inferredcites →https://doi.org/10.1007/s00125-008-1183-9openalex-snapshot
Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor
inferredcites →https://doi.org/10.1016/0140-6736(92)91958-bopenalex-snapshot
Linkage of type 2 diabetes to the glucokinase gene
inferredcites →https://doi.org/10.1016/b978-0-12-571150-0.50008-1openalex-snapshot
Signaling Mechanisms during the Response of Pituitary Gonadotropes to GnRH
inferredcites →https://doi.org/10.1016/j.ceca.2003.10.002openalex-snapshot
A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic α-cell
inferredcites →https://doi.org/10.1016/j.cmet.2008.11.002openalex-snapshot
Glucose Sensing in L Cells: A Primary Cell Study
inferredcites →https://doi.org/10.1016/j.febslet.2006.03.009openalex-snapshot
Glucokinase regulatory protein is associated with mitochondria in hepatocytes
inferredcites →https://doi.org/10.1016/j.str.2004.02.005openalex-snapshot
Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase
inferredcites →https://doi.org/10.1016/s0021-9258(17)33058-2openalex-snapshot
Hormone secretion and glucose metabolism in islets of Langerhans of the isolated perfused pancreas from normal and streptozotocin diabetic rats.
inferredcites →https://doi.org/10.1016/s0021-9258(17)41910-7openalex-snapshot
Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.
inferredcites →https://doi.org/10.1016/s0021-9258(17)44841-1openalex-snapshot
Glucose regulates glucokinase activity in cultured islets from rat pancreas.
inferredcites →https://doi.org/10.1016/s0021-9258(18)41918-7openalex-snapshot
Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets.
inferredcites →https://doi.org/10.1016/s0021-9258(18)50675-xopenalex-snapshot
A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets.
inferredcites →https://doi.org/10.1016/s0021-9258(18)67451-4openalex-snapshot
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
inferredcites →https://doi.org/10.1016/s0021-9258(18)93432-0openalex-snapshot
Metabolism of Glucose in the Islets of Langerhans
inferredcites →https://doi.org/10.1016/s0021-9258(18)94588-6openalex-snapshot
Feasibility of a Mitochondrial Pyruvate Malate Shuttle in Pancreatic Islets
inferredcites →https://doi.org/10.1016/s0021-9258(19)38722-8openalex-snapshot
Demonstration of a slow conformational change in liver glucokinase by fluorescence spectroscopy.
inferredcites →https://doi.org/10.1016/s0065-2571(64)80012-1openalex-snapshot
Induced biosynthesis of liver glucokinase
inferredcites →https://doi.org/10.1016/s0065-2571(64)80013-3openalex-snapshot
Hormonal and dietary regulation of hepatic glucokinase
inferredcites →https://doi.org/10.1016/s0065-2571(97)00001-0openalex-snapshot
The physiological role of glucokinase binding and translocation in hepatocytes
inferredcites →https://doi.org/10.1016/s0167-4889(97)00150-xopenalex-snapshot
Evolution and regulatory role of the hexokinases
inferredcites →https://doi.org/10.1016/s1097-2765(01)00203-9openalex-snapshot
Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells
inferredcites →https://doi.org/10.1021/bi060253qopenalex-snapshot
Glucose-Induced Conformational Changes in Glucokinase Mediate Allosteric Regulation: Transient Kinetic Analysis
inferredcites →https://doi.org/10.1021/bi0617308openalex-snapshot
A Pre-Steady State Analysis of Ligand Binding to Human Glucokinase: Evidence for a Preexisting Equilibrium
inferredcites →https://doi.org/10.1021/bi702516yopenalex-snapshot
Glucose Modulation of Glucokinase Activation by Small Molecules
inferredcites →https://doi.org/10.1021/jm8003202openalex-snapshot
SAR, Pharmacokinetics, Safety, and Efficacy of Glucokinase Activating 2-(4-Sulfonylphenyl)-N-thiazol-2-ylacetamides: Discovery of PSN-GK1
inferredcites →https://doi.org/10.1038/356162a0openalex-snapshot
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1038/nature01825openalex-snapshot
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
inferredcites →https://doi.org/10.1038/nm1717openalex-snapshot
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
inferredcites →https://doi.org/10.1038/sj.bjp.0706848openalex-snapshot
Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats
inferredcites →https://doi.org/10.1042/bj0900360openalex-snapshot
The role of glucokinase in the phosphorylation of glucose by rat liver
inferredcites →https://doi.org/10.1042/bj20071718openalex-snapshot
Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
inferredcites →https://doi.org/10.1042/bj20080595openalex-snapshot
Glucokinase and molecular aspects of liver glycogen metabolism
inferredcites →https://doi.org/10.1042/bj2960785openalex-snapshot
Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin
inferredcites →https://doi.org/10.1042/bj3090711openalex-snapshot
The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation
inferredcites →https://doi.org/10.1042/bst0330306openalex-snapshot
Glucokinase and glucose homeostasis: proven concepts and new ideas
inferredcites →https://doi.org/10.1055/s-0028-1095102openalex-snapshot
Hepatic Enzyme Activities of Glycolysis and Gluconeogenesis in Diabetes of Man and Laboratory Animals
inferredcites →https://doi.org/10.1055/s-0029-1211414openalex-snapshot
Sulfonylurea receptors and mechanism of sulfonylurea action
inferredcites →https://doi.org/10.1055/s-2007-979899openalex-snapshot
Liver Glucokinase: Decreased Activity in Patients with Type II Diabetes
inferredcites →https://doi.org/10.1056/nejm199801223380404openalex-snapshot
Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation
inferredcites →https://doi.org/10.1056/nejm200105243442104openalex-snapshot
Neonatal Diabetes Mellitus Due to Complete Glucokinase Deficiency
inferredcites →https://doi.org/10.1073/pnas.0605738103openalex-snapshot
Conformational transition pathway in the allosteric process of human glucokinase
inferredcites →https://doi.org/10.1073/pnas.91.7.2863openalex-snapshot
Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia.
inferredcites →https://doi.org/10.1074/jbc.275.11.7826openalex-snapshot
Characterization of Glucokinase Regulatory Protein-deficient Mice
inferredcites →https://doi.org/10.1074/jbc.c000530200openalex-snapshot
A Novel Glucokinase Regulator in Pancreatic β Cells
inferredcites →https://doi.org/10.1074/jbc.m000841200openalex-snapshot
A Novel Cytosolic Dual Specificity Phosphatase, Interacting with Glucokinase, Increases Glucose Phosphorylation Rate
inferredcites →https://doi.org/10.1074/jbc.m105984200openalex-snapshot
Identification of Fructose 6-Phosphate- and Fructose 1-Phosphate-binding Residues in the Regulatory Protein of Glucokinase
inferredcites →https://doi.org/10.1074/jbc.m413146200openalex-snapshot
Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young
inferredcites →https://doi.org/10.1074/jbc.m605186200openalex-snapshot
An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism
inferredcites →https://doi.org/10.1074/jbc.m610094200openalex-snapshot
Glucokinase Thermolability and Hepatic Regulatory Protein Binding Are Essential Factors for Predicting the Blood Glucose Phenotype of Missense Mutations
inferredcites →https://doi.org/10.1074/jbc.m700517200openalex-snapshot
Allosteric Activation of Human Glucokinase by Free Polyubiquitin Chains and Its Ubiquitin-dependent Cotranslational Proteasomal Degradation
inferredcites →https://doi.org/10.1074/jbc.m709235200openalex-snapshot
Elimination of KATP Channels in Mouse Islets Results in Elevated [U-13C]Glucose Metabolism, Glutaminolysis, and Pyruvate Cycling but a Decreased γ-Aminobutyric Acid Shunt
inferredcites →https://doi.org/10.1083/jcb.200301063openalex-snapshot
Regulation of β cell glucokinase by S-nitrosylation and association with nitric oxide synthase
inferredcites →https://doi.org/10.1111/j.1432-1033.1990.tb19147.xopenalex-snapshot
The mechanism by which rat liver glucokinase is inhibited by the regulatory protein
inferredcites →https://doi.org/10.1111/j.1432-1033.1991.tb16217.xopenalex-snapshot
Competitive inhibition of liver glucokinase by its regulatory protein
inferredcites →https://doi.org/10.1111/j.1432-1033.1991.tb16218.xopenalex-snapshot
Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation
inferredcites →https://doi.org/10.1111/j.1432-1033.1997.00259.xopenalex-snapshot
The AMP‐Activated Protein Kinase
inferredcites →https://doi.org/10.1111/j.1463-1326.2008.00951.xopenalex-snapshot
Crucial role of insulin receptor substrate‐2 in compensatory β‐cell hyperplasia in response to high fat diet–induced insulin resistance
inferredcites →https://doi.org/10.1111/j.1464-5491.2007.02285.xopenalex-snapshot
Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy
inferredcites →https://doi.org/10.1113/expphysiol.2006.036004openalex-snapshot
Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?
inferredcites →https://doi.org/10.1126/science.1084073openalex-snapshot
Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
inferredcites →https://doi.org/10.1126/stke.3462006re7openalex-snapshot
Role of Insulin, Adipocyte Hormones, and Nutrient-Sensing Pathways in Regulating Fuel Metabolism and Energy Homeostasis: A Nutritional Perspective of Diabetes, Obesity, and Cancer
inferredcites →https://doi.org/10.1152/ajpendo.00099.2002openalex-snapshot
Genetic approaches to the molecular understanding of type 2 diabetes
inferredcites →https://doi.org/10.1152/ajpregu.00061.2007openalex-snapshot
Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zuckerfa/farats
inferredcites →https://doi.org/10.1152/physrev.1987.67.4.1185openalex-snapshot
Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
inferredcites →https://doi.org/10.1159/000079009openalex-snapshot
Glucokinase and the Regulation of Blood Sugar
inferredcites →https://doi.org/10.1159/000079011openalex-snapshot
Glucokinase: A Monomeric Enzyme with Positive Cooperativity
inferredcites →https://doi.org/10.1159/000079013openalex-snapshot
Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule Allosteric Activator
inferredcites →https://doi.org/10.1159/000079014openalex-snapshot
Molecular Biology of Glucokinase Regulation
inferredcites →https://doi.org/10.1159/000079022openalex-snapshot
Interaction of GK with the Bifunctional Enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (6PF2K/F26P2ase)
inferredcites →https://doi.org/10.1159/000079029openalex-snapshot
Glucokinase in β-Cell Insulin-Secretory Granules
inferredcites →https://doi.org/10.1159/000079030openalex-snapshot
Discovery and Actions of Glucokinase Activators
inferredcites →https://doi.org/10.1159/isbn.978-3-318-01080-0openalex-snapshot
Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics
inferredcites →https://doi.org/10.1172/jci107822openalex-snapshot
Glucose Modulation of Amino Acid-Induced Glucagon and Insulin Release in the Isolated Perfused Rat Pancreas
inferredcites →https://doi.org/10.1172/jci107928openalex-snapshot
Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats.
inferredcites →https://doi.org/10.1172/jci108572openalex-snapshot
Glucose and ATP levels in pancreatic islet tissue of normal and diabetic rats.
inferredcites →https://doi.org/10.1172/jci109652openalex-snapshot
Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity.
inferredcites →https://doi.org/10.1172/jci117256openalex-snapshot
In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.
inferredcites →https://doi.org/10.1172/jci17645openalex-snapshot
Glucokinase and IRS-2 are required for compensatory cell hyperplasia in response to high-fat diet-induced insulin resistance
inferredcites →https://doi.org/10.1172/jci29027openalex-snapshot
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
inferredcites →https://doi.org/10.1172/jci34566openalex-snapshot
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
inferredcites →https://doi.org/10.1177/35.10.3305701openalex-snapshot
Glucokinase in B-cell-depleted islets of Langerhans.
inferredcites →https://doi.org/10.1210/en.2005-0377openalex-snapshot
A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function
inferredcites →https://doi.org/10.1210/er.2006-0007openalex-snapshot
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
inferredcites →https://doi.org/10.1210/rp.56.1.195openalex-snapshot
Cell-specific Roles of Glucokinase in Glucose Homeostasis
inferredcites →https://doi.org/10.1213/00000539-198308000-00015openalex-snapshot
Basic and Clinical Pharmacology
inferredcites →https://doi.org/10.1248/bpb.31.1847openalex-snapshot
Free Fatty Acid Receptors and Drug Discovery
inferredcites →https://doi.org/10.1369/jhc.6a7117.2007openalex-snapshot
Immunohistochemical Evidence for the Presence of Glucokinase in the Gonadotropes and Thyrotropes of the Anterior Pituitary Gland of Rat and Monkey
inferredcites →https://doi.org/10.1517/13543776.18.7.759openalex-snapshot
Glucokinase activators as new type 2 diabetes therapeutic agents
inferredcites →https://doi.org/10.1517/13543784.17.2.145openalex-snapshot
Glucokinase activators in diabetes management
inferredcites →https://doi.org/10.1530/eje-08-0203openalex-snapshot
Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.
inferredcites →https://doi.org/10.2174/092986706777452551openalex-snapshot
Small Molecule Glucokinase Activators as Glucose Lowering Agents: A New Paradigm for Diabetes Therapy
inferredcites →https://doi.org/10.2337/db05-1513openalex-snapshot
From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation
inferredcites →https://doi.org/10.2337/db06-0151openalex-snapshot
A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells
inferredcites →https://doi.org/10.2337/db06-s010openalex-snapshot
Signaling Mechanisms Underlying the Release of Glucagon-Like Peptide 1
inferredcites →https://doi.org/10.2337/db07-0026openalex-snapshot
Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
inferredcites →https://doi.org/10.2337/db07-1755openalex-snapshot
Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia
inferredcites →https://doi.org/10.2337/db07-1807openalex-snapshot
The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population
inferredcites →https://doi.org/10.2337/db08-0516openalex-snapshot
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
inferredcites →https://doi.org/10.2337/db08-1119openalex-snapshot
Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats
inferredcites →https://doi.org/10.2337/diab.26.10.973openalex-snapshot
Glucose and 3-0-Methylglucose Protection Against Alloxan Poisoning of Pancreatic Alpha and Beta Cells
inferredcites →https://doi.org/10.2337/diab.29.1.1openalex-snapshot
Effects of Glucose on Insulin Release and on Intermediary Metabolism of Isolated Perifused Pancreatic Islets from Fed and Fasted Rats
inferredcites →https://doi.org/10.2337/diab.30.11.911openalex-snapshot
Regulation of Glucose Metabolism in Pancreatic Islets
inferredcites →https://doi.org/10.2337/diab.35.1.61openalex-snapshot
The Glucokinase Glucose Sensor in Human Pancreatic Islet Tissue
inferredcites →https://doi.org/10.2337/diab.41.7.792openalex-snapshot
Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture
inferredcites →https://doi.org/10.2337/diab.45.2.223openalex-snapshot
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
inferredcites →https://doi.org/10.2337/diabetes.48.5.1198openalex-snapshot
Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.
inferredcites →https://doi.org/10.2337/diabetes.49.11.1751openalex-snapshot
Triggering and amplifying pathways of regulation of insulin secretion by glucose.
inferredcites →https://doi.org/10.2337/diabetes.50.7.1562openalex-snapshot
Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age
inferredcites →https://doi.org/10.2337/diabetes.51.4.1240openalex-snapshot
The Second Activating Glucokinase Mutation (A456V)
inferredcites →https://doi.org/10.2337/diabetes.52.11.2854openalex-snapshot
Permanent Neonatal Diabetes Caused by Glucokinase Deficiency
inferredcites →https://doi.org/10.2337/diabetes.52.9.2433openalex-snapshot
Insights Into the Biochemical and Genetic Basis of Glucokinase Activation From Naturally Occurring Hypoglycemia Mutations
inferredcites →https://doi.org/10.2337/diabetes.53.3.535openalex-snapshot
Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators
inferredcites →https://doi.org/10.2337/diabetes.53.3.624openalex-snapshot
Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects
inferredcites →https://doi.org/10.2337/diabetes.53.8.2164openalex-snapshot
Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation
inferredcites →https://doi.org/10.2337/diabetes.55.01.06.db05-0926openalex-snapshot
The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy
inferredcites →https://doi.org/10.2337/diacare.24.11.1882openalex-snapshot
Acute Fructose Administration Improves Oral Glucose Tolerance in Adults With Type 2 Diabetes
inferredcites →https://doi.org/10.7164/antibiotics.52.245openalex-snapshot
Glucolipsin A and B, Two New Glucokinase Activators Produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/pharmacia.71.e131072zenodo-depositor-declared
Novel glucokinase activators: A structure-based pharmacophore modeling, QSAR analysis, and molecular dynamics approach
inferred← citeshttps://doi.org/10.1002/9780470910016.ch5openalex-snapshot
Hepatic Metabolic Dysfunctions in Type 2 Diabetes: Insulin Resistance and Impaired Glucose Production and Lipid Synthesis
inferred← citeshttps://doi.org/10.1002/9781118387658.ch13openalex-snapshot
Regulation of glucose metabolism in liver
inferred← citeshttps://doi.org/10.1002/9781119484288.ch87openalex-snapshot
New therapies for diabetes mellitus
inferred← citeshttps://doi.org/10.1002/9781119952930.ch102openalex-snapshot
New Therapies for Diabetes Mellitus
inferred← citeshttps://doi.org/10.1002/9783527343430.ch4openalex-snapshot
Applications of Constrained Helices
inferred← citeshttps://doi.org/10.1002/ajoc.201800012openalex-snapshot
Vanadium‐Catalyzed N‐Benzoylation of 2‐Aminopyridines via Oxidative C(CO)−C(CO) Bond Cleavage of 1,2‐Diketones, N→N′ Aroyl Migration and Hydrolysis of 2‐(Diaroylamino)pyridines
inferred← citeshttps://doi.org/10.1002/ajoc.201900146openalex-snapshot
Visible‐Light‐Enabled Synthesis of Pyridyl Benzamides via Oxidative Decarbethoxylation using Copper(I) Iodide/Air at Room Temperature
inferred← citeshttps://doi.org/10.1002/bab.1209openalex-snapshot
Identification and analysis of novel R 308 K mutation in glucokinase of type 2 diabetic patient and its kinetic correlation
inferred← citeshttps://doi.org/10.1002/bab.2541openalex-snapshot
Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis
inferred← citeshttps://doi.org/10.1002/cmdc.201400009openalex-snapshot
Design, Synthesis, and Activity Evaluation of GK/PPARγ Dual‐Target‐Directed Ligands as Hypoglycemic Agents
inferred← citeshttps://doi.org/10.1002/cmdc.202200020openalex-snapshot
Cyclobutanes in Small‐Molecule Drug Candidates
inferred← citeshttps://doi.org/10.1002/cpdd.289openalex-snapshot
Dose‐Dependent Effect of Piragliatin, a Glucokinase Activator, on the QT Interval Following Short‐Term Multiple Doses in Patients With Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1002/dmrr.1208openalex-snapshot
Advanced glycation end products downregulate glucokinase in mice
inferred← citeshttps://doi.org/10.1002/ejoc.201301383openalex-snapshot
Highly Diastereoselective Esterification of Ketenes Generated In Situ from Acyl Chlorides with (R)‐Pantolactone Derivatives
inferred← citeshttps://doi.org/10.1002/fsn3.3644openalex-snapshot
Assessing the multitargeted antidiabetic potential of three pomegranate peel‐specific metabolites: An in silico and pharmacokinetics study
inferred← citeshttps://doi.org/10.1002/humu.21110openalex-snapshot
Update on mutations in glucokinase ( GCK ), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
inferred← citeshttps://doi.org/10.1002/iub.1001openalex-snapshot
Alberto sols, teacher and mentor of spanish biochemists (1917–1989)
inferred← citeshttps://doi.org/10.1002/jcb.22688openalex-snapshot
Potential role of branched‐chain amino acids in glucose metabolism through the accelerated induction of the glucose‐sensing apparatus in the liver
inferred← citeshttps://doi.org/10.1002/jcph.589openalex-snapshot
Effects of piragliatin, a glucokinase activator, on fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1002/jcph.617openalex-snapshot
Exploratory effects of a strong CYP3A inhibitor (ketoconazole), a strong CYP3A inducer (rifampicin), and concomitant ethanol on piragliatin pharmacokinetics and pharmacodynamics in type 2 diabetic patients
inferred← citeshttps://doi.org/10.1002/jcph.640openalex-snapshot
Lack of Potential Pharmacokinetic and Pharmacodynamic Interactions Between Piragliatin, a Glucokinase Activator, and Simvastatin in Patients With Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1002/pauz.201000362openalex-snapshot
Neue Wirkstoffklassen in der Pipeline. Neues in der Therapie des Diabetes mellitus
inferred← citeshttps://doi.org/10.1002/pro.2473openalex-snapshot
Role of connecting loop I in catalysis and allosteric regulation of human glucokinase
inferred← citeshttps://doi.org/10.1002/psp4.12964openalex-snapshot
Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201
inferred← citeshttps://doi.org/10.1007/3418_2019_31openalex-snapshot
Application of Organometallic Catalysts in API Synthesis
inferred← citeshttps://doi.org/10.1007/8904_2014_383openalex-snapshot
Lack of Glibenclamide Response in a Case of Permanent Neonatal Diabetes Caused by Incomplete Inactivation of Glucokinase
inferred← citeshttps://doi.org/10.1007/978-1-4614-1028-7_1openalex-snapshot
Regulation of Insulin Secretion and Islet Cell Function
inferred← citeshttps://doi.org/10.1007/978-1-4614-5441-0_24openalex-snapshot
Glucose-Induced Insulin Secretion
inferred← citeshttps://doi.org/10.1007/978-3-030-02961-6_3openalex-snapshot
Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism
inferred← citeshttps://doi.org/10.1007/978-3-030-49844-3_8openalex-snapshot
Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/978-3-031-52858-3_4openalex-snapshot
Anwendung von Organometallkatalysatoren in der API-Synthese
inferred← citeshttps://doi.org/10.1007/978-3-319-01574-3_16openalex-snapshot
Genetic and Functional Studies Implicate G6PC2 in the Regulation of Fasting Blood Glucose
inferred← citeshttps://doi.org/10.1007/978-3-642-17214-4_15openalex-snapshot
Research and Development of Glucokinase Activators for Diabetes Therapy: Theoretical and Practical Aspects
inferred← citeshttps://doi.org/10.1007/978-94-007-5971-8_3openalex-snapshot
Diabetes Mellitus: New Challenges and Innovative Therapies
inferred← citeshttps://doi.org/10.1007/978-981-15-8002-4_8openalex-snapshot
Anti-diabetes Research in India: Contributions from Industrial Organizations
inferred← citeshttps://doi.org/10.1007/s00125-010-1839-0openalex-snapshot
Do insulinotropic glucose-lowering drugs do more harm than good? The hypersecretion hypothesis revisited
inferred← citeshttps://doi.org/10.1007/s00125-011-2439-3openalex-snapshot
Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat
inferred← citeshttps://doi.org/10.1007/s00125-012-2521-5openalex-snapshot
Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions
inferred← citeshttps://doi.org/10.1007/s00125-012-2568-3openalex-snapshot
Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-017-4270-yopenalex-snapshot
Human genetics as a model for target validation: finding new therapies for diabetes
inferred← citeshttps://doi.org/10.1007/s00125-021-05390-xopenalex-snapshot
Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00335-011-9345-3openalex-snapshot
Mouse models and type 2 diabetes: translational opportunities
inferred← citeshttps://doi.org/10.1007/s10517-017-3881-0openalex-snapshot
Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase
inferred← citeshttps://doi.org/10.1007/s10527-024-10367-2openalex-snapshot
A structural model of glucose regulation for building prognostic algorithms for controlling insulin therapy
inferred← citeshttps://doi.org/10.1007/s10787-025-01785-zopenalex-snapshot
Safety profile of glucokinase activator AZD1656: systematic review and meta-analysis of 23 randomised trials in diabetic and healthy volunteers with relevance to immunomodulatory therapy
inferred← citeshttps://doi.org/10.1007/s10928-012-9287-8openalex-snapshot
Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model
inferred← citeshttps://doi.org/10.1007/s11030-025-11149-yopenalex-snapshot
An update on current type 2 diabetes mellitus (T2DM) druggable targets and drugs targeting them
inferred← citeshttps://doi.org/10.1007/s11033-021-06294-0openalex-snapshot
Exploring the recent molecular targets for diabetes and associated complications
inferred← citeshttps://doi.org/10.1007/s11739-011-0677-5openalex-snapshot
New oral antidiabetic agents
inferred← citeshttps://doi.org/10.1007/s11892-013-0422-8openalex-snapshot
Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose
inferred← citeshttps://doi.org/10.1007/s12020-013-9884-3openalex-snapshot
Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?
inferred← citeshttps://doi.org/10.1007/s12020-025-04325-5openalex-snapshot
Factors influencing the initial glycemic efficacy of dorzagliatin, a novel glucokinase activator, in type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s12272-012-1201-9openalex-snapshot
Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s12272-014-0441-2openalex-snapshot
Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats
inferred← citeshttps://doi.org/10.1007/s13167-010-0010-9openalex-snapshot
Diabetes mellitus: new challenges and innovative therapies
inferred← citeshttps://doi.org/10.1007/s13205-026-05031-3openalex-snapshot
Lichen-derived secondary metabolites and endophytic fungi as novel antidiabetic leads: Xylaria curta extract preserves β-cell viability and SUR1-mediated glucose sensing
inferred← citeshttps://doi.org/10.1007/s40262-016-0484-2openalex-snapshot
Translational Modeling and Simulation in Supporting Early-Phase Clinical Development of New Drug: A Learn–Research–Confirm Process
inferred← citeshttps://doi.org/10.1016/b978-0-12-378630-2.00073-6openalex-snapshot
Hexokinase/Glucokinase
inferred← citeshttps://doi.org/10.1016/b978-0-323-99616-7.00027-xopenalex-snapshot
Phytonanoparticles toward the treatment of diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-444-62652-3.00001-6openalex-snapshot
Property-Based Design in the Optimisation of Benzamide Glucokinase Activators
inferred← citeshttps://doi.org/10.1016/j.abb.2011.11.007openalex-snapshot
Homotropic allosteric regulation in monomeric mammalian glucokinase
inferred← citeshttps://doi.org/10.1016/j.acthis.2014.10.001openalex-snapshot
β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats
inferred← citeshttps://doi.org/10.1016/j.ailsci.2023.100069openalex-snapshot
Pharmaceutical patent landscaping: A novel approach to understand patents from the drug discovery perspective
inferred← citeshttps://doi.org/10.1016/j.algal.2022.102904openalex-snapshot
Algal metabolites: Paving the way towards new generation antidiabetic therapeutics
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2017.11.035openalex-snapshot
Molecular characterization, expression and activity of glucokinase in golden pompano, Trachinotus ovatus : Response of its expression to carbohydrate in the diet
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.04.020openalex-snapshot
Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase
inferred← citeshttps://doi.org/10.1016/j.bbapap.2012.03.003openalex-snapshot
Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea
inferred← citeshttps://doi.org/10.1016/j.bbapap.2018.12.008openalex-snapshot
First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations
inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.03.097openalex-snapshot
Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice
inferred← citeshttps://doi.org/10.1016/j.bbrep.2016.06.021openalex-snapshot
Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.01.020openalex-snapshot
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.09.019openalex-snapshot
High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.06.024openalex-snapshot
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116499openalex-snapshot
Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants
inferred← citeshttps://doi.org/10.1016/j.bionut.2014.03.006openalex-snapshot
Rosmarinic acid, a polyphenol, ameliorates hyperglycemia by regulating the key enzymes of carbohydrate metabolism in high fat diet – STZ induced experimental diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.biortech.2025.132346openalex-snapshot
Microbial adhesion behavior and participation of adhered and planktonic microorganisms in anaerobic digestion of leaf, epidermis, pith from corn stalk
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.03.008openalex-snapshot
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmc.2013.10.015openalex-snapshot
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.02.009openalex-snapshot
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.08.029openalex-snapshot
2,3-Disubstituted acrylamides as potent glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.03.093openalex-snapshot
Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.06.128openalex-snapshot
Discovery and hit-to-lead optimization of novel allosteric glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.10.090openalex-snapshot
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.11.018openalex-snapshot
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.01.093openalex-snapshot
Design, synthesis and SAR of novel glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.06.036openalex-snapshot
Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.01.016openalex-snapshot
Transporter-mediated tissue targeting of therapeutic molecules in drug discovery
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.03.038openalex-snapshot
Detection of NAD(P)H-dependent enzyme activity by time-domain ratiometry of terbium luminescence
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.10.088openalex-snapshot
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus
inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127249openalex-snapshot
Design, synthesis, and pharmacological evaluation of 2-(4-sulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-N-thiazoleacetamides as glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.bmcl.2025.130192openalex-snapshot
Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl)benzamides for the treatment of metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.bpc.2026.107611openalex-snapshot
Decoding the new dimensions of leucodelphinidin as a dual antioxidant and anti-diabetic candidate: A DFT, docking and dynamics evaluation
inferred← citeshttps://doi.org/10.1016/j.ceca.2020.102339openalex-snapshot
Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice
inferred← citeshttps://doi.org/10.1016/j.cell.2012.02.010openalex-snapshot
Diabetes Mellitus and the β Cell: The Last Ten Years
inferred← citeshttps://doi.org/10.1016/j.cell.2014.09.040openalex-snapshot
Generation of Functional Human Pancreatic β Cells In Vitro
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.12.056openalex-snapshot
Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2014.01.024openalex-snapshot
The polymorphism rs2268574 in Glucokinase gene is associated with gestational Diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2015.09.016openalex-snapshot
Polymorphisms rs144723656, rs2268574, and rs2268575 of the glucokinase gene are not associated with obese women with type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.cmet.2012.09.014openalex-snapshot
Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation
inferred← citeshttps://doi.org/10.1016/j.cmet.2013.12.001openalex-snapshot
Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.05.014openalex-snapshot
Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2015.07.009openalex-snapshot
Theoretical investigations on the interactions of glucokinase regulatory protein with fructose phosphates
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2017.02.011openalex-snapshot
Structure based design, synthesis and biological evaluation of amino phosphonate derivatives as human glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2018.03.026openalex-snapshot
In-silico evidences for binding of Glucokinase activators to EGFR C797S to overcome EGFR resistance obstacle with mutant-selective allosteric inhibition
inferred← citeshttps://doi.org/10.1016/j.coph.2024.102466openalex-snapshot
Modulating regulatory T cell migration in the treatment of autoimmunity and autoinflammation
inferred← citeshttps://doi.org/10.1016/j.devcel.2012.05.014openalex-snapshot
Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT
inferred← citeshttps://doi.org/10.1016/j.diabres.2012.09.025openalex-snapshot
The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food
inferred← citeshttps://doi.org/10.1016/j.diabres.2025.112246openalex-snapshot
Genetically proxied glucokinase activation and risk of diabetic complications: Insights from phenome-wide and multi-omics mendelian randomization
inferred← citeshttps://doi.org/10.1016/j.drudis.2012.03.011openalex-snapshot
Kinase activators as a novel class of antidiabetic agents
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.09.011openalex-snapshot
GPR119 agonists: a promising approach for T2DM treatment? A SWOT analysis of GPR119
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.06.020openalex-snapshot
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.04.063openalex-snapshot
How much successful are the medicinal chemists in modulation of SIRT1: A critical review
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.03.042openalex-snapshot
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.07.051openalex-snapshot
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.06.060openalex-snapshot
Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.030openalex-snapshot
Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.ejphar.2010.04.054openalex-snapshot
A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat
inferred← citeshttps://doi.org/10.1016/j.ejphar.2011.05.009openalex-snapshot
Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice
inferred← citeshttps://doi.org/10.1016/j.ejps.2013.09.005openalex-snapshot
Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells
inferred← citeshttps://doi.org/10.1016/j.febslet.2013.07.014openalex-snapshot
Michaelis and Menten and the long road to the discovery of cooperativity
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e08013openalex-snapshot
Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats
inferred← citeshttps://doi.org/10.1016/j.jff.2019.103636openalex-snapshot
Application of in silico approaches for the generation of milk protein-derived bioactive peptides
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2016.07.015openalex-snapshot
The adipogenic potential of Cr(III). A molecular approach exemplifying metal-induced enhancement of insulin mimesis in diabetes mellitus II
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2018.02.001openalex-snapshot
Synthetic investigation of binary-ternary Cr(III)-hydroxycarboxylic acid-aromatic chelator systems. Structure-specific influence on adipogenic biomarkers linked to insulin mimesis
inferred← citeshttps://doi.org/10.1016/j.jmgm.2012.12.011openalex-snapshot
Toward an understanding of the sequence and structural basis of allosteric proteins
inferred← citeshttps://doi.org/10.1016/j.jmgm.2014.12.003openalex-snapshot
Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators
inferred← citeshttps://doi.org/10.1016/j.jmgm.2015.01.012openalex-snapshot
Molecular modeling and identification of novel glucokinase activators through stepwise virtual screening
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2012.03.020openalex-snapshot
Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion
inferred← citeshttps://doi.org/10.1016/j.mce.2011.05.006openalex-snapshot
The glucokinase activator GKA50 causes an increase in cell volume and activation of volume-regulated anion channels in rat pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.mce.2012.06.001openalex-snapshot
Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich GckD217V mutants
inferred← citeshttps://doi.org/10.1016/j.mce.2013.08.020openalex-snapshot
GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation
inferred← citeshttps://doi.org/10.1016/j.mce.2013.09.003openalex-snapshot
Malondialdehyde regulates glucose-stimulated insulin secretion in murine islets via TCF7L2-dependent Wnt signaling pathway
inferred← citeshttps://doi.org/10.1016/j.metabol.2013.06.007openalex-snapshot
A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs
inferred← citeshttps://doi.org/10.1016/j.molcel.2019.05.019openalex-snapshot
HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101193openalex-snapshot
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101196openalex-snapshot
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
inferred← citeshttps://doi.org/10.1016/j.molmet.2025.102115openalex-snapshot
Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2014.12.003openalex-snapshot
Synthesis and biological evaluation of [11C]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2011.08.009openalex-snapshot
Cellular glucose availability and glucagon-like peptide-1
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2015.08.004openalex-snapshot
Rare sugar d-allulose: Potential role and therapeutic monitoring in maintaining obesity and type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107602openalex-snapshot
Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial
inferred← citeshttps://doi.org/10.1016/j.pisc.2014.12.003openalex-snapshot
Understanding mechanisms of enzyme co-operativity: The importance of not being at equilibrium
inferred← citeshttps://doi.org/10.1016/j.slasd.2022.09.001openalex-snapshot
A perspective on the discovery of enzyme activators
inferred← citeshttps://doi.org/10.1016/j.tem.2015.02.004openalex-snapshot
Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins
inferred← citeshttps://doi.org/10.1016/j.tetlet.2021.153199openalex-snapshot
Copper(I)-catalysed aerobic oxidative selective cleavage of C C bond with DMAP: Facile access to N-substituted benzamides
inferred← citeshttps://doi.org/10.1016/j.tips.2012.11.007openalex-snapshot
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
inferred← citeshttps://doi.org/10.1016/j.tips.2019.05.002openalex-snapshot
Genetic Insights for Drug Development in NAFLD
inferred← citeshttps://doi.org/10.1016/j.ygcen.2010.09.002openalex-snapshot
Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken
inferred← citeshttps://doi.org/10.1016/s2213-8587(18)30105-0openalex-snapshot
Dorzagliatin monotherapy in Chinese patients with type 2 diabetes: a dose-ranging, randomised, double-blind, placebo-controlled, phase 2 study
inferred← citeshttps://doi.org/10.1016/s2213-8587(21)00113-3openalex-snapshot
Treatment of type 2 diabetes: challenges, hopes, and anticipated successes
inferred← citeshttps://doi.org/10.1016/s2221-1691(12)60444-4openalex-snapshot
Musa Paradisiaca flower extract improves carbohydrate metabolism in hepatic tissues of streptozotocin-induced experimental diabetes in rats
inferred← citeshttps://doi.org/10.1017/s0954422414000018openalex-snapshot
Nutritional regulation of glucokinase: a cross-species story
inferred← citeshttps://doi.org/10.1021/acs.chemrev.5b00541openalex-snapshot
Solution NMR Spectroscopy for the Study of Enzyme Allostery
inferred← citeshttps://doi.org/10.1021/acs.jafc.6b03845openalex-snapshot
Comparison of Regulation Mechanisms of Five Mulberry Ingredients on Insulin Secretion under Oxidative Stress
inferred← citeshttps://doi.org/10.1021/acs.jafc.6b05627openalex-snapshot
Rare Sugar Syrup Containing d -Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c02110openalex-snapshot
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132)
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00632openalex-snapshot
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein–Ligand Residence Times
inferred← citeshttps://doi.org/10.1021/acs.joc.6c00194openalex-snapshot
An Electrochemically Driven Dual-Oxidation Strategy for Decarboxylative Amidation of α-Ketoacids and Heteroaryl Amines
inferred← citeshttps://doi.org/10.1021/acs.oprd.6b00415openalex-snapshot
A Practical and Scalable Synthesis of a Glucokinase Activator via Diastereomeric Resolution and Palladium-Catalyzed C–N Coupling Reaction
inferred← citeshttps://doi.org/10.1021/acs.oprd.8b00354openalex-snapshot
Efficient and Scalable Synthesis of Glucokinase Activator with a Chiral Thiophenyl-Pyrrolidine Scaffold
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00140openalex-snapshot
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00145openalex-snapshot
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
inferred← citeshttps://doi.org/10.1021/bi4000782openalex-snapshot
Crystal Structure of Glucokinase Regulatory Protein
inferred← citeshttps://doi.org/10.1021/bi400838topenalex-snapshot
Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein
inferred← citeshttps://doi.org/10.1021/bk-2018-1307.ch007openalex-snapshot
Design and Development of the Glucokinase Activator AZD1656
inferred← citeshttps://doi.org/10.1021/jm100039aopenalex-snapshot
Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675)
inferred← citeshttps://doi.org/10.1021/jm2014887openalex-snapshot
Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1021/jm3008689openalex-snapshot
Discovery of Piragliatin—First Glucokinase Activator Studied in Type 2 Diabetic Patients
inferred← citeshttps://doi.org/10.1021/jm401116kopenalex-snapshot
Identification of a New Class of Glucokinase Activators through Structure-Based Design
inferred← citeshttps://doi.org/10.1021/jm501204zopenalex-snapshot
Discovery of 2-Pyridylureas as Glucokinase Activators
inferred← citeshttps://doi.org/10.1021/jm900839kopenalex-snapshot
Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1021/jo1022712openalex-snapshot
Glucokinase-Activating Sesquinlignans from the Rhizomes of Acorus tatarinowii Schott
inferred← citeshttps://doi.org/10.1021/ml400027yopenalex-snapshot
Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1021/ml400061xopenalex-snapshot
Small-Molecule Allosteric Activation of Human Glucokinase in the Absence of Glucose
inferred← citeshttps://doi.org/10.1021/ml500341wopenalex-snapshot
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
inferred← citeshttps://doi.org/10.1021/ol201875qopenalex-snapshot
General and Scalable Amide Bond Formation with Epimerization-Prone Substrates Using T3P and Pyridine
inferred← citeshttps://doi.org/10.1021/op200068copenalex-snapshot
A Large-Scale Synthesis of Potent Glucokinase Activator MK-0941 via Selective O-Arylation and O-Alkylation
inferred← citeshttps://doi.org/10.1021/op300139gopenalex-snapshot
An Asymmetric Synthesis of a Chiral Sulfone Acid with Concomitant Hydrolysis and Oxidation to Enable the Preparation of a Glucokinase Activator
inferred← citeshttps://doi.org/10.1021/op300194copenalex-snapshot
Multikilogram Synthesis of a Hepatoselective Glucokinase Activator
inferred← citeshttps://doi.org/10.1021/op400152ropenalex-snapshot
Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia
inferred← citeshttps://doi.org/10.1021/op4002164openalex-snapshot
Glucokinase Activator: Practical Asymmetric Hydrogenation and Scalable Synthesis of an API Fragment
inferred← citeshttps://doi.org/10.1021/op400354gopenalex-snapshot
Scalable Synthesis of a Nonracemic α-Arylpropionic Acid via Ketene Desymmetrization for a Glucokinase Activator
inferred← citeshttps://doi.org/10.1021/op500027wopenalex-snapshot
In situ Monitoring of a Heterogeneous Etherification Reaction Using Quantitative Raman Spectroscopy
inferred← citeshttps://doi.org/10.1038/nchem.1597openalex-snapshot
Enantioselective synthesis of tatanans A–C and reinvestigation of their glucokinase-activating properties
inferred← citeshttps://doi.org/10.1038/nchembio.318openalex-snapshot
Turning enzymes ON with small molecules
inferred← citeshttps://doi.org/10.1038/nchembio.453openalex-snapshot
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
inferred← citeshttps://doi.org/10.1038/ncomms6190openalex-snapshot
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
inferred← citeshttps://doi.org/10.1038/nrd.2016.151openalex-snapshot
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
inferred← citeshttps://doi.org/10.1038/nrd4231openalex-snapshot
Targeting the pancreatic β-cell to treat diabetes
inferred← citeshttps://doi.org/10.1038/nrneph.2015.59openalex-snapshot
Emerging treatments for post-transplantation diabetes mellitus
inferred← citeshttps://doi.org/10.1038/nsmb.2717openalex-snapshot
A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators
inferred← citeshttps://doi.org/10.1038/s41420-019-0219-xopenalex-snapshot
Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status
inferred← citeshttps://doi.org/10.1038/s41467-022-29512-0openalex-snapshot
Citrullination of glucokinase is linked to autoimmune diabetes
inferred← citeshttps://doi.org/10.1038/s41574-021-00489-yopenalex-snapshot
Novel therapies with precision mechanisms for type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1038/s41591-022-01802-6openalex-snapshot
Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial
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