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Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Multicenter phase II study of brequinar sodium in patients with advanced lung cancer

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New isoxazole derivatives designed as nicotinic acetylcholine receptor ligand candidates

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Side effects of brequinar and brequinar analogues, in combination with cyclosporine, in the rat

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Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

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Analysis of Ligand-Bound Water Molecules in High-Resolution Crystal Structures of Protein−Ligand Complexes

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Significance of Water Molecules in the Inhibition of Cylin-Dependent Kinase 2 and 5 Complexes

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Classification of Water Molecules in Protein Binding Sites

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Small-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water Cluster

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Dual Binding Mode of a Novel Series of DHODH Inhibitors

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Impact of Lipophilic Efficiency on Compound Quality

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Methyl Effects on Protein–Ligand Binding

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Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO– Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes

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Water-Mediated Interactions Influence the Binding of Thapsigargin to Sarco/Endoplasmic Reticulum Calcium Adenosinetriphosphatase

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Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

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Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase

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Robust Classification of “Relevant” Water Molecules in Putative Protein Binding Sites

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The regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides

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The Protein Data Bank

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A graphical user interface to the CCP 4 program suite

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Features and development of Coot

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The CCP4 suite: programs for protein crystallography

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Refinement of Macromolecular Structures by the Maximum-Likelihood Method

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The Rossmann Fourier autoindexing algorithm in MOSFLM

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Thermodynamic consequences of disrupting a water‐mediated hydrogen bond network in a protein:pheromone complex

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives

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Drug repurposing of ilepcimide that ameliorates experimental autoimmune encephalomyelitis via restricting inflammatory response and oxidative stress

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Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

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Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

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HsDHODH Microdomain–Membrane Interactions Influenced by the Lipid Composition

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Investigation of Novel Quinoline–Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches

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Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenase

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Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents

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E-pharmacophore screening and induced fit docking of phytocompounds against human dihydroorotate dehydrogenase

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