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Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/9780470475973openalex-snapshot
Glutathione and Sulfur Amino Acids in Human Health and Disease
inferredcites →https://doi.org/10.1007/s00726-010-0571-xopenalex-snapshot
Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium
inferredcites →https://doi.org/10.1016/0006-2952(94)90486-3openalex-snapshot
Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes
inferredcites →https://doi.org/10.1016/j.cell.2012.03.017openalex-snapshot
mTOR Signaling in Growth Control and Disease
inferredcites →https://doi.org/10.1016/j.cell.2012.03.042openalex-snapshot
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.cell.2013.12.010openalex-snapshot
Regulation of Ferroptotic Cancer Cell Death by GPX4
inferredcites →https://doi.org/10.1016/j.mam.2008.05.005openalex-snapshot
Regulation of glutathione synthesis
inferredcites →https://doi.org/10.1016/j.molcel.2015.06.011openalex-snapshot
Glutaminolysis and Transferrin Regulate Ferroptosis
inferredcites →https://doi.org/10.1016/j.tcb.2015.10.014openalex-snapshot
Ferroptosis: Death by Lipid Peroxidation
inferredcites →https://doi.org/10.1016/j.tem.2009.05.008openalex-snapshot
ATF4-dependent transcription mediates signaling of amino acid limitation
inferredcites →https://doi.org/10.1016/s0006-2952(02)01176-0openalex-snapshot
Cell signalling and the glutathione redox system
inferredcites →https://doi.org/10.1016/s0014-5793(99)00304-xopenalex-snapshot
Structural requirement of leucine for activation of p70 S6 kinase
inferredcites →https://doi.org/10.1038/nrm3522openalex-snapshot
Amino acid signalling upstream of mTOR
inferredcites →https://doi.org/10.1038/sj.embor.7400645openalex-snapshot
The role of glutathione in disulphide bond formation and endoplasmic‐reticulum‐generated oxidative stress
inferredcites →https://doi.org/10.1038/sj.onc.1209888openalex-snapshot
mTOR, translation initiation and cancer
inferredcites →https://doi.org/10.1042/0300-5127:0290717openalex-snapshot
Molecular mechanisms of cystine transport
inferredcites →https://doi.org/10.1042/bj3340261openalex-snapshot
Amino acid availability regulates p70 S6 kinase and multiple translation factors
inferredcites →https://doi.org/10.1042/bst0340007openalex-snapshot
Coping with stress: eIF2 kinases and translational control
inferredcites →https://doi.org/10.1042/bst20060007openalex-snapshot
Coping with stress: eIF2 kinases and translational control
inferredcites →https://doi.org/10.1074/jbc.270.5.2320openalex-snapshot
Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes
inferredcites →https://doi.org/10.1074/jbc.273.23.14484openalex-snapshot
Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
inferredcites →https://doi.org/10.1074/jbc.m413660200openalex-snapshot
Phosphorylation of the α-Subunit of the Eukaryotic Initiation Factor-2 (eIF2α) Reduces Protein Synthesis and Enhances Apoptosis in Response to Proteasome Inhibition
inferredcites →https://doi.org/10.1074/jbc.m506096200openalex-snapshot
Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex
inferredcites →https://doi.org/10.1074/jbc.m809608200openalex-snapshot
A Novel, Species-specific Class of Uncompetitive Inhibitors of γ-Glutamyl Transpeptidase
inferredcites →https://doi.org/10.1093/jn/134.3.489openalex-snapshot
Glutathione Metabolism and Its Implications for Health
inferredcites →https://doi.org/10.1093/jn/136.6.1652sopenalex-snapshot
Mammalian Cysteine Metabolism: New Insights into Regulation of Cysteine Metabolism
inferredcites →https://doi.org/10.1096/fasebj.13.10.1169openalex-snapshot
Regulation of hepatic glutathione synthesis: current concepts and controversies
inferredcites →https://doi.org/10.1098/rstb.2005.1770openalex-snapshot
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?
inferredcites →https://doi.org/10.1126/scisignal.aaa0899openalex-snapshot
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma
inferredcites →https://doi.org/10.1155/2013/972913openalex-snapshot
Role of Glutathione in Cancer Progression and Chemoresistance
inferredcites →https://doi.org/10.1182/blood-2011-10-388132openalex-snapshot
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Deuterated polyunsaturated fatty acids alleviate in vitro skeletal muscle dysfunction induced by oxidative stress
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
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Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells
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Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
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Effects of Glutamine and Glycine Supplementation on Invitro Vitrification of Immature bovine oocytes
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A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death
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Multistability maintains redox homeostasis in human cells
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A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells
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Reduction of Oxidative Stress by Seluang Fish (Rasbora spp.) in Brain of Malnourished Rats (Rattus norvegicus)
inferred← citeshttps://doi.org/10.18297/etd/3407openalex-snapshot
Mechanistic insight of the role of NHERF1 in cisplatin-induced acute kidney injury.
inferred← citeshttps://doi.org/10.18297/etd/3428openalex-snapshot
The role of Slc7a11 in controlling extracellular and intracellular redox environments of lung fibroblasts - potential targets for intervention in aging and idiopathic pulmonary fibrosis.
inferred← citeshttps://doi.org/10.18632/oncotarget.23843openalex-snapshot
Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2702878/v1openalex-snapshot
CYP2E1 overexpression protects COS-7 cancer cells against ferroptosis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3553140/v1openalex-snapshot
A ferroptosis-related gene signature and immune infiltration for predicting the lymph node metastasis of patients with lung adenocarcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5008451/v1openalex-snapshot
Construction of a nomogram model for predicting peritoneal metastasis in gastric cancer based on ferroptosis-relate genes and clinicopathological features
inferred← citeshttps://doi.org/10.2147/dddt.s383054openalex-snapshot
Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice
inferred← citeshttps://doi.org/10.2147/ijn.s372947openalex-snapshot
Ionizing Radiation-Induced Ferroptosis Based on Nanomaterials
inferred← citeshttps://doi.org/10.2174/0113895575273164231130070920openalex-snapshot
Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis
inferred← citeshttps://doi.org/10.2174/0929867329666220817141227openalex-snapshot
Cysteine Metabolism in Tumor Redox Homeostasis
inferred← citeshttps://doi.org/10.3389/fonc.2017.00319openalex-snapshot
The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
inferred← citeshttps://doi.org/10.3389/fonc.2018.00148openalex-snapshot
Pushing the Limits of Cancer Therapy: The Nutrient Game
inferred← citeshttps://doi.org/10.3389/fonc.2020.00723openalex-snapshot
Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
inferred← citeshttps://doi.org/10.3389/fonc.2022.997919openalex-snapshot
The versatile utility of cysteine as a target for cancer treatment
inferred← citeshttps://doi.org/10.3389/fonc.2023.1085581openalex-snapshot
The potential of ferroptosis combined with radiotherapy in cancer treatment
inferred← citeshttps://doi.org/10.3389/fvets.2022.873460openalex-snapshot
Plasma and Whole Blood Taurine Concentrations in Dogs May Not Be Sensitive Indicators of Taurine Deficiency When Dietary Sulfur Amino Acid Content Is Reduced
inferred← citeshttps://doi.org/10.3390/agronomy12051032openalex-snapshot
Zinc Supplementation Enhances Glutathione-Mediated Antioxidant Defense and Glyoxalase Systems to Conferring Salt Tolerance in Soybean (Glycine max L.)
inferred← citeshttps://doi.org/10.3390/antiox10071036openalex-snapshot
Na/H Exchange Regulatory Factor 1 Deficient Mice Show Evidence of Oxidative Stress and Altered Cisplatin Pharmacokinetics
inferred← citeshttps://doi.org/10.3390/antiox10101543openalex-snapshot
Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1
inferred← citeshttps://doi.org/10.3390/antiox10111739openalex-snapshot
The Impact of N-Acetyl Cysteine and Coenzyme Q10 Supplementation on Skeletal Muscle Antioxidants and Proteome in Fit Thoroughbred Horses
inferred← citeshttps://doi.org/10.3390/antiox10122007openalex-snapshot
An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis
inferred← citeshttps://doi.org/10.3390/antiox12040916openalex-snapshot
Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer
inferred← citeshttps://doi.org/10.3390/antiox13111329openalex-snapshot
Interactions Between Ferroptosis and Oxidative Stress in Ischemic Stroke
inferred← citeshttps://doi.org/10.3390/antiox13121461openalex-snapshot
Alterations in Glutathione Redox Homeostasis in Metabolic Dysfunction-Associated Fatty Liver Disease: A Systematic Review
inferred← citeshttps://doi.org/10.3390/antiox9090853openalex-snapshot
Restraint Stress Alters Expression of Glucocorticoid Bioavailability Mediators, Suppresses Nrf2, and Promotes Oxidative Stress in Liver Tissue
inferred← citeshttps://doi.org/10.3390/cancers13020304openalex-snapshot
Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer
inferred← citeshttps://doi.org/10.3390/cancers16101921openalex-snapshot
Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia
inferred← citeshttps://doi.org/10.3390/cells10051238openalex-snapshot
Hypertension and Aging Affect Liver Sulfur Metabolism in Rats
inferred← citeshttps://doi.org/10.3390/cells9122709openalex-snapshot
Regulated Necrotic Cell Death in Alternative Tumor Therapeutic Strategies
inferred← citeshttps://doi.org/10.3390/ijerph191912901openalex-snapshot
Psychophysiological and Metabolomics Responses of Adults during Horticultural Activities Using Soil Inoculated with Streptomyces rimosus: A Pilot Study
inferred← citeshttps://doi.org/10.3390/ijms21165676openalex-snapshot
Role of Excitatory Amino Acid Carrier 1 (EAAC1) in Neuronal Death and Neurogenesis After Ischemic Stroke
inferred← citeshttps://doi.org/10.3390/ijms231911913openalex-snapshot
Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia
inferred← citeshttps://doi.org/10.3390/ijms24076208openalex-snapshot
Novel Insights in the Potential of Halogenated Polyketide–Peptide Molecules as Lead Compounds in Cancer Drug Discovery
inferred← citeshttps://doi.org/10.3390/molecules24040747openalex-snapshot
Gas-Phase Fragmentation Reactions of Protonated Cystine using High-Resolution Tandem Mass Spectrometry
inferred← citeshttps://doi.org/10.3390/nu12113224openalex-snapshot
Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors
inferred← citeshttps://doi.org/10.3390/ph12010026openalex-snapshot
Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells against Iron Toxicity and Erastin-Induced Ferroptosis
inferred← citeshttps://doi.org/10.3390/ruminants2020019openalex-snapshot
Ruminal Bacterial Communities and Metabolome Variation in Beef Heifers Divergent in Feed Efficiency
inferred← citeshttps://doi.org/10.3724/abbs.2024016openalex-snapshot
Ferroptosis: a potential target for the treatment of atherosclerosis
inferred← citeshttps://doi.org/10.37349/eemd.2025.101444openalex-snapshot
Disruption of the transsulfuration pathway as a sulfur-driven etiology of insulin resistance: proinsulin misfolding, disulfide bond deformation, and PDI dysregulation
inferred← citeshttps://doi.org/10.37349/eemd.2025.101445openalex-snapshot
Pharmacological inhibition of type 5 adenylyl cyclase, a model for healthful aging, enhanced exercise capacity and glucose tolerance
inferred← citeshttps://doi.org/10.3892/ijo.2024.5660openalex-snapshot
Glutathione‑degrading enzymes in the complex landscape of tumors (Review)
inferred← citeshttps://doi.org/10.3945/jn.116.246710openalex-snapshot
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice
inferred← citeshttps://doi.org/10.5433/1679-0359.2023v44n6p2095openalex-snapshot
Light intensity, blood fraction, fasting and storage time affect blood biochemical metabolites in broiler chickens
inferred← citeshttps://doi.org/10.6084/m9.figshare.25998587openalex-snapshot
Additional file 1 of Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
inferred← citeshttps://doi.org/10.6084/m9.figshare.25998652openalex-snapshot
Additional file 2 of Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
inferred← citeshttps://doi.org/10.6084/m9.figshare.26731411openalex-snapshot
Additional file 3 of Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer’s disease by the analysis of the feasible signaling pathway of network pharmacology
inferred← citeshttps://doi.org/10.64898/2026.01.30.702627openalex-snapshot
IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis
inferred← citeshttps://doi.org/10.70675/34bdea7fz8e7bz4ba1z997ez5d01dd3c712eopenalex-snapshot
Protéostase cellulaire et tumeurs solides
inferred← citeshttps://doi.org/10.70675/f3a31948zabb5z4be0z8f59zbcac02c1cd4dopenalex-snapshot
Cardiac manifestations of inherited metabolic disease linked to cellular metabolism of vitamin B12 : study in two murine models of invalidation of Mtr and MMACHC genes
inferred← citeshttps://doi.org/10.7150/ijbs.64982openalex-snapshot
Regulation of Ferroptosis by Amino Acid Metabolism in Cancer
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