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Understanding the role of cysteine in ferroptosis: progress & paradoxes

https://doi.org/10.1111/febs.15842
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice
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Pan‐cancer analysis of iron metabolic landscape across the Cancer Genome Atlas
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Oridonin induces ferroptosis by inhibiting gamma‐glutamyl cycle in TE1 cells
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Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) in Rat Testis Nuclei Is Bound to Chromatin
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Mechanisms of ferroptosis
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Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium
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Excessive l-cysteine induces vacuole-like cell death by activating endoplasmic reticulum stress and mitogen-activated protein kinase signaling in intestinal porcine epithelial cells
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Glutathione: a key component of the cytoplasmic labile iron pool
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Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer
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Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium
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Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes
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Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression
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Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers
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CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.cell.2013.12.010openalex-snapshot
Regulation of Ferroptotic Cancer Cell Death by GPX4
inferredcites →https://doi.org/10.1016/j.cell.2017.02.004openalex-snapshot
mTOR Signaling in Growth, Metabolism, and Disease
inferredcites →https://doi.org/10.1016/j.cell.2017.11.048openalex-snapshot
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
inferredcites →https://doi.org/10.1016/j.cell.2019.04.024openalex-snapshot
The Coming Decade of Cell Death Research: Five Riddles
inferredcites →https://doi.org/10.1016/j.cell.2019.12.035openalex-snapshot
Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis
inferredcites →https://doi.org/10.1016/j.celrep.2017.02.054openalex-snapshot
Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
inferredcites →https://doi.org/10.1016/j.celrep.2017.12.077openalex-snapshot
p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
inferredcites →https://doi.org/10.1016/j.celrep.2019.01.043openalex-snapshot
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity
inferredcites →https://doi.org/10.1016/j.chembiol.2018.01.011openalex-snapshot
N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production
inferredcites →https://doi.org/10.1016/j.chembiol.2018.11.016openalex-snapshot
Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State
inferredcites →https://doi.org/10.1016/j.chembiol.2019.01.008openalex-snapshot
Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model
inferredcites →https://doi.org/10.1016/j.cmet.2017.07.001openalex-snapshot
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
inferredcites →https://doi.org/10.1016/j.cmet.2019.01.020openalex-snapshot
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
inferredcites →https://doi.org/10.1016/j.cmet.2019.09.009openalex-snapshot
Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
inferredcites →https://doi.org/10.1016/j.cmet.2019.11.012openalex-snapshot
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids
inferredcites →https://doi.org/10.1016/j.molcel.2012.08.003openalex-snapshot
Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
inferredcites →https://doi.org/10.1016/j.molcel.2017.05.030openalex-snapshot
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
inferredcites →https://doi.org/10.1016/j.molcel.2017.09.009openalex-snapshot
NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
inferredcites →https://doi.org/10.1016/j.molcel.2018.10.042openalex-snapshot
Role of Mitochondria in Ferroptosis
inferredcites →https://doi.org/10.1016/j.molcel.2020.11.024openalex-snapshot
Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1
inferredcites →https://doi.org/10.1016/j.tcb.2020.02.009openalex-snapshot
Emerging Mechanisms and Disease Relevance of Ferroptosis
inferredcites →https://doi.org/10.1016/s0021-9258(18)65975-7openalex-snapshot
STUDIES ON THE SULFUR METABOLISM OF TISSUES CULTIVATED IN VITRO
inferredcites →https://doi.org/10.1016/s0070-2137(01)80004-2openalex-snapshot
Regulation of glutathione synthesis
inferredcites →https://doi.org/10.1016/s1097-2765(03)00105-9openalex-snapshot
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
inferredcites →https://doi.org/10.1021/acschembio.5b00245openalex-snapshot
Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1021/jacs.6b08016openalex-snapshot
An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells
inferredcites →https://doi.org/10.1038/cdd.2015.93openalex-snapshot
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
inferredcites →https://doi.org/10.1038/embor.2012.156openalex-snapshot
Mammalian proapoptotic factor ChaC1 and its homologues function as γ‐glutamyl cyclotransferases acting specifically on glutathione
inferredcites →https://doi.org/10.1038/nature14344openalex-snapshot
Ferroptosis as a p53-mediated activity during tumour suppression
inferredcites →https://doi.org/10.1038/nature24637openalex-snapshot
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
inferredcites →https://doi.org/10.1038/ncb2432openalex-snapshot
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
inferredcites →https://doi.org/10.1038/ncb3064openalex-snapshot
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
inferredcites →https://doi.org/10.1038/ncb3410openalex-snapshot
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
inferredcites →https://doi.org/10.1038/nchembio.1986openalex-snapshot
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
inferredcites →https://doi.org/10.1038/nchembio.2079openalex-snapshot
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
inferredcites →https://doi.org/10.1038/nchembio.2238openalex-snapshot
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
inferredcites →https://doi.org/10.1038/nchembio.2239openalex-snapshot
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
inferredcites →https://doi.org/10.1038/ncomms15074openalex-snapshot
The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
inferredcites →https://doi.org/10.1038/nm.4232openalex-snapshot
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
inferredcites →https://doi.org/10.1038/onc.2017.146openalex-snapshot
ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
inferredcites →https://doi.org/10.1038/s41416-019-0660-xopenalex-snapshot
Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
inferredcites →https://doi.org/10.1038/s41416-020-01156-1openalex-snapshot
Cysteine metabolic circuitries: druggable targets in cancer
inferredcites →https://doi.org/10.1038/s41467-020-15109-yopenalex-snapshot
DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
inferredcites →https://doi.org/10.1038/s41467-021-21841-wopenalex-snapshot
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
inferredcites →https://doi.org/10.1038/s41556-018-0178-0openalex-snapshot
BAP1 links metabolic regulation of ferroptosis to tumour suppression
inferredcites →https://doi.org/10.1038/s41580-020-00324-8openalex-snapshot
Ferroptosis: mechanisms, biology and role in disease
inferredcites →https://doi.org/10.1038/s41586-019-1170-yopenalex-snapshot
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
inferredcites →https://doi.org/10.1038/s41586-020-2937-xopenalex-snapshot
MFSD12 mediates the import of cysteine into melanosomes and lysosomes
inferredcites →https://doi.org/10.1038/s41589-019-0408-1openalex-snapshot
The chemical basis of ferroptosis
inferredcites →https://doi.org/10.1038/s41589-020-0472-6openalex-snapshot
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
inferredcites →https://doi.org/10.1038/s41589-021-00751-4openalex-snapshot
A compendium of kinetic modulatory profiles identifies ferroptosis regulators
inferredcites →https://doi.org/10.1038/s41598-018-26254-2openalex-snapshot
Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine
inferredcites →https://doi.org/10.1038/s42255-020-0253-2openalex-snapshot
Polyamine pathway activity promotes cysteine essentiality in cancer cells
inferredcites →https://doi.org/10.1038/srep30033openalex-snapshot
Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis
inferredcites →https://doi.org/10.1042/bst20170506openalex-snapshot
Coenzyme A, protein CoAlation and redox regulation in mammalian cells
inferredcites →https://doi.org/10.1073/pnas.1317320111openalex-snapshot
Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
inferredcites →https://doi.org/10.1073/pnas.1821277116openalex-snapshot
Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53
inferredcites →https://doi.org/10.1073/pnas.1821323116openalex-snapshot
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
inferredcites →https://doi.org/10.1073/pnas.1913788117openalex-snapshot
Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells
inferredcites →https://doi.org/10.1073/pnas.2009943117openalex-snapshot
Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53
inferredcites →https://doi.org/10.1073/pnas.93.15.7923openalex-snapshot
Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.
inferredcites →https://doi.org/10.1074/jbc.m114.635144openalex-snapshot
Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element
inferredcites →https://doi.org/10.1074/jbc.m117.798405openalex-snapshot
The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
inferredcites →https://doi.org/10.1080/15384101.2019.1597506openalex-snapshot
Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1
inferredcites →https://doi.org/10.1080/15548627.2021.1872241openalex-snapshot
Tumor heterogeneity in autophagy-dependent ferroptosis
inferredcites →https://doi.org/10.1093/jn/130.7.1835sopenalex-snapshot
Dispensable and Indispensable Amino Acids for Humans
inferredcites →https://doi.org/10.1093/jn/nxaa094openalex-snapshot
Metabolism of Sulfur-Containing Amino Acids: How the Body Copes with Excess Methionine, Cysteine, and Sulfide
inferredcites →https://doi.org/10.1126/science.aan6298openalex-snapshot
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
inferredcites →https://doi.org/10.1126/science.aaw9872openalex-snapshot
Cysteine depletion induces pancreatic tumor ferroptosis in mice
inferredcites →https://doi.org/10.1126/scisignal.aao6604openalex-snapshot
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
inferredcites →https://doi.org/10.1128/jb.00277-15openalex-snapshot
Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli
inferredcites →https://doi.org/10.1128/jb.185.6.1942-1950.2003openalex-snapshot
High Levels of Intracellular Cysteine Promote Oxidative DNA Damage by Driving the Fenton Reaction
inferredcites →https://doi.org/10.1146/annurev-cancerbio-030518-055844openalex-snapshot
The Hallmarks of Ferroptosis
inferredcites →https://doi.org/10.1158/0008-5472.can-14-2211openalex-snapshot
Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
inferredcites →https://doi.org/10.1158/0008-5472.can-18-3037openalex-snapshot
The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
inferredcites →https://doi.org/10.1158/0008-5472.can-18-3855openalex-snapshot
Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
inferredcites →https://doi.org/10.1158/2159-8290.cd-19-0338openalex-snapshot
Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11
inferredcites →https://doi.org/10.1158/2159-8290.cd-20-0789openalex-snapshot
Modes of Regulated Cell Death in Cancer
inferredcites →https://doi.org/10.1186/s13046-019-1413-7openalex-snapshot
Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
inferredcites →https://doi.org/10.1293/tox.2017-0002openalex-snapshot
Comparisons of L-cysteine and D-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration
inferredcites →https://doi.org/10.1371/journal.pone.0034680openalex-snapshot
Free Cysteine Modulates the Conformation of Human C/EBP Homologous Protein
inferredcites →https://doi.org/10.1371/journal.pone.0200783openalex-snapshot
Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences
inferredcites →https://doi.org/10.1515/hsz-2020-0237openalex-snapshot
Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism
inferredcites →https://doi.org/10.15252/embr.201847563openalex-snapshot
Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
inferredcites →https://doi.org/10.18632/oncotarget.23055openalex-snapshot
CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway
inferredcites →https://doi.org/10.7554/elife.02523openalex-snapshot
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
inferredcites →https://doi.org/10.7554/elife.27713openalex-snapshot
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
inferredcites →https://doi.org/10.7554/elife.28083openalex-snapshot
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
inferredcites →https://doi.org/10.7554/elife.45572openalex-snapshot
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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eIF2α Phosphorylation-Mediated Transcriptional Reprogramming Suppresses Impairment of Mitochondrial and GSH Homeostasis and Thereby Ferroptosis During ER Stress
inferred← citeshttps://doi.org/10.2139/ssrn.4830886openalex-extracted
Simple, Rapid and Enzyme-Free Assay for Potentiometric Determination of L-Cysteine Based on Meso-2,3-Dimercaptosuccinic Acid Self-Assembled Gold Electrode
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Glucose Deprivation‐Driven Concurrent Induction of Apoptosis/Disulfidptosis/Ferroptosis by Tumor Targeting Nanoassemblies in Triple‐Negative Breast Cancer Therapy
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Multifunctional Fluorescent Probes for Profiling Cys, Hcy, GSH, and SO₂: Illuminating Their Dynamics in Apoptosis and Ferroptosis
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Unraveling Ferroptosis Mechanisms: Tracking Cellular Viscosity with Small Molecular Fluorescent Probes
inferred← citeshttps://doi.org/10.1002/cbf.70012openalex-snapshot
Silver Nanoparticles and L‐Cysteine Composite Redresses Carbon Tetrachloride‐Induced Hepatotoxicity in Swiss Albino Rats
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Mitochondrial Dysfunction and Its Role in Ferroptosis: Molecular Mechanisms and Therapeutic Targets
inferred← citeshttps://doi.org/10.1002/jbt.70479openalex-snapshot
Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF‐κB Signaling Pathway
inferred← citeshttps://doi.org/10.1002/prp2.70330openalex-snapshot
Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation‐Induced Mitochondrial Dysfunction
inferred← citeshttps://doi.org/10.1002/smll.202400326openalex-snapshot
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy
inferred← citeshttps://doi.org/10.1007/s00216-026-06782-xopenalex-snapshot
An excitation-customized ICT-type turn-on probe for visualization of cysteine fluctuation in diverse drug-induced ferroptosis pathways
inferred← citeshttps://doi.org/10.1007/s00284-025-04114-3openalex-snapshot
Screening of Regulatory mRNAs and miRNAs that Suppress Staphylococcus aureus Proliferation via Macrophage Ferroptosis
inferred← citeshttps://doi.org/10.1007/s11033-025-11319-zopenalex-snapshot
The role and interplay among Autophagy, Apoptosis, and ferroptosis in acute pancreatitis: mechanisms and therapeutic approaches
inferred← citeshttps://doi.org/10.1007/s11064-023-04096-3openalex-snapshot
A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis
inferred← citeshttps://doi.org/10.1007/s12011-022-03523-wopenalex-snapshot
Ferroptosis As a Mechanism for Health Effects of Essential Trace Elements and Potentially Toxic Trace Elements
inferred← citeshttps://doi.org/10.1007/s12011-026-05113-6openalex-snapshot
Amelioration of Fe-Induced Na+/K+-ATPase Inhibition: A Twist of Fate for Two Endogenous Thiols
inferred← citeshttps://doi.org/10.1007/s12032-026-03402-7openalex-snapshot
Lapatinib suppresses cysteine deprivation-induced ferroptotic cell death by modulating mitochondrial function
inferred← citeshttps://doi.org/10.1007/s12035-026-05986-7openalex-snapshot
PLD3-mediated Mitophagy Attenuates Neuronal Ferroptosis and Promotes Functional Recovery after Spinal Cord Injury
inferred← citeshttps://doi.org/10.1007/s12035-026-06121-2openalex-snapshot
The Amino Acid–Neurodegeneration Axis: Excitotoxicity and Oxidative Stress as Context-Dependent Amplifiers of Metabolic Dysfunction
inferred← citeshttps://doi.org/10.1016/bs.mcb.2022.05.003openalex-snapshot
Assessment of lipid peroxidation in irradiated cells
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103384openalex-snapshot
Ferroptosis-driven inflammaging in age-associated degenerative disorders: Molecular mechanisms and therapeutic potential of natural products
inferred← citeshttps://doi.org/10.1016/j.bbrep.2023.101529openalex-snapshot
Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108865openalex-snapshot
Dual channel fluorescent probe for revealing the fluctuation of cysteine levels and viscosity in cancer cells during erastin-induced ferroptosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116547openalex-snapshot
Vitamin B6 alleviates chronic sleep deprivation-induced hippocampal ferroptosis through CBS/GSH/GPX4 pathway
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111838openalex-snapshot
Oridonin exposure induces testicular impairment through regulating ferroptosis via HIF-1α/HO-1 activation and STUB1-driven GPX4 ubiquitination-dependent degradation
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116543openalex-snapshot
Inducing ferroptosis to impede metastasis by inhibiting the calcium channel TRPC6
inferred← citeshttps://doi.org/10.1016/j.chembiol.2022.10.006openalex-snapshot
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
inferred← citeshttps://doi.org/10.1016/j.chembiol.2025.10.006openalex-snapshot
An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels
inferred← citeshttps://doi.org/10.1016/j.cmet.2025.03.012openalex-snapshot
Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids
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Cysteine metabolism at the crossroads of ferroptosis and cancer therapy
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Modeling microbiome modulation of tumor metabolic networks to predict synergistic therapies
inferred← citeshttps://doi.org/10.1016/j.exer.2024.110156openalex-snapshot
Deferiprone protects photoreceptors by inhibiting ferroptosis after experimental retinal detachment
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.07.029openalex-snapshot
Untargeted metabolomics and transcriptomics study reveals an activated ferroptosis metabolic spectrum in recurrent spontaneous abortion
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e20405openalex-snapshot
Role of ferroptosis in effects of anesthetics on multiple organ diseases: A literature review
inferred← citeshttps://doi.org/10.1016/j.jacbts.2026.101573openalex-snapshot
Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101703openalex-snapshot
Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation–induced ferroptosis
inferred← citeshttps://doi.org/10.1016/j.jot.2026.101174openalex-snapshot
Cysteine metabolism dysregulation promotes ferroptosis in osteoarthritis: Insights from multi-species bioinformatics and experimental validation
inferred← citeshttps://doi.org/10.1016/j.microc.2024.111548openalex-snapshot
Simple, rapid and enzyme-free assay for potentiometric determination of L-cysteine based on meso-2,3-dimercaptosuccinic acid self-assembled gold electrode
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Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.02.007openalex-snapshot
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
inferred← citeshttps://doi.org/10.1016/j.molcel.2023.08.004openalex-snapshot
Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.07.020openalex-snapshot
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.06.014openalex-snapshot
LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance
inferred← citeshttps://doi.org/10.1016/j.neuint.2024.105773openalex-snapshot
Ferroptosis: A new strategy for targeting Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2026.109625openalex-snapshot
Development of a novel xCT transporter imaging using a radiopharmaceutical with inhibitor-type compounds
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107370openalex-snapshot
Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases
inferred← citeshttps://doi.org/10.1016/j.redox.2025.103988openalex-snapshot
Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response
inferred← citeshttps://doi.org/10.1016/j.talanta.2023.125532openalex-snapshot
Treatment evaluation of Rheumatoid arthritis by in situ fluorescence imaging of the Golgi cysteine
inferred← citeshttps://doi.org/10.1016/j.talanta.2023.125610openalex-snapshot
A single mitochondria-targetable fluorescent probe for visualizing cysteine and glutathione in ferroptosis of myocardial ischemia/reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.tcb.2022.02.009openalex-snapshot
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer
inferred← citeshttps://doi.org/10.1016/j.tem.2026.06.006openalex-snapshot
Mitochondria setting the stage for ferroptosis
inferred← citeshttps://doi.org/10.1016/j.tibs.2024.05.003openalex-snapshot
Functional implications of fumarate-induced cysteine succination
inferred← citeshttps://doi.org/10.1016/j.watres.2024.121381openalex-snapshot
Blue-light irradiation induced partial nitrification
inferred← citeshttps://doi.org/10.1016/j.watres.2026.125931openalex-snapshot
Selective regulation of partial nitrification/denitrification via light irradiation: Microbial niche differentiation and metabolic adaptation mechanisms
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2022.10.004openalex-snapshot
Ferroptosis in heart failure
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c00922openalex-snapshot
NIR Fluorescent/Photoacoustic Bimodal Imaging of Ferroptosis in Pancreatic Cancer Using Biothiols-Activable Probes
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6c00392openalex-snapshot
Cysteine/GSH-Responsive Lipid Switch Development for Liposome Triggered Cargo Release
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c02091openalex-snapshot
Computational Insights into Cyst(e)inase for Cysteine and Cystine Depletion Therapies: Free Energy Calculations, Evolutionary Conservation, and Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1021/acs.jafc.6c01962openalex-snapshot
Fungicide Chlorothalonil Exposure Induced Intestinal Impairment via the Microbiota/Sphinganine/Ferroptosis Axis
inferred← citeshttps://doi.org/10.1038/s41380-024-02725-zopenalex-snapshot
The multifaceted role of mitochondria in autism spectrum disorder
inferred← citeshttps://doi.org/10.1038/s41419-022-05529-7openalex-snapshot
TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response
inferred← citeshttps://doi.org/10.1038/s41419-024-07216-1openalex-snapshot
Inhibition of VDAC1 oligomerization blocks cysteine deprivation-induced ferroptosis via mitochondrial ROS suppression
inferred← citeshttps://doi.org/10.1038/s41419-025-08333-1openalex-snapshot
Transsulfuration metabolism is essential for ferroptosis resistance in quiescent endothelial cells
inferred← citeshttps://doi.org/10.1038/s41467-025-65491-8openalex-snapshot
Context-dependent serotonin signaling links dietary quality to foraging decisions
inferred← citeshttps://doi.org/10.1038/s41556-022-00973-1openalex-snapshot
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis
inferred← citeshttps://doi.org/10.1038/s41580-025-00843-2openalex-snapshot
Recommendations for robust and reproducible research on ferroptosis
inferred← citeshttps://doi.org/10.1038/s41581-023-00689-xopenalex-snapshot
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
inferred← citeshttps://doi.org/10.1038/s41585-024-00869-9openalex-snapshot
Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
inferred← citeshttps://doi.org/10.1038/s42255-026-01499-8openalex-snapshot
Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells
inferred← citeshttps://doi.org/10.1038/s42255-026-01616-7openalex-snapshot
Cysteine excess triggers a mitochondrial iron-dependent cell death
inferred← citeshttps://doi.org/10.1038/s43018-022-00355-4openalex-snapshot
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
inferred← citeshttps://doi.org/10.1039/d2nr03756dopenalex-snapshot
Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds
inferred← citeshttps://doi.org/10.1039/d2tb01815bopenalex-snapshot
A vinyl-decorated covalent organic framework for ferroptotic cancer therapy via visible-light-triggered cysteine depletion
inferred← citeshttps://doi.org/10.1039/d4nj04163aopenalex-snapshot
A novel Cys-activated NIR-II fluorescent probe for rheumatoid arthritis fluorescence imaging in vivo
inferred← citeshttps://doi.org/10.1039/d5bm01369kopenalex-snapshot
Advances and therapeutic potential of ferritin-involved drug delivery systems for ferroptosis-targeted therapy
inferred← citeshttps://doi.org/10.1039/d6cs00041jopenalex-snapshot
From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation
inferred← citeshttps://doi.org/10.1073/pnas.2118300119openalex-snapshot
Epstein–Barr virus latency programs dynamically sensitize B cells to ferroptosis
inferred← citeshttps://doi.org/10.1080/08916934.2023.2289362openalex-snapshot
The crosstalk between ferroptosis and autophagy in cancer
inferred← citeshttps://doi.org/10.1080/09553002.2023.2194399openalex-snapshot
Ferrostatin-1 mitigates ionizing radiation-induced intestinal injuries by inhibiting apoptosis and ferroptosis: an in vitro and in vivo study
inferred← citeshttps://doi.org/10.1080/13510002.2023.2269331openalex-snapshot
Deeper insight into ferroptosis: association with Alzheimer’s, Parkinson’s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis
inferred← citeshttps://doi.org/10.1089/ars.2022.0179openalex-snapshot
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills
inferred← citeshttps://doi.org/10.1096/fj.202600188ropenalex-snapshot
Multi‐Omics Integration Identifies the CBS – CTH – GSH Axis as a Critical Regulator of β‐Cell Ferroptosis in Type 2 Diabetes
inferred← citeshttps://doi.org/10.1101/2023.03.10.532018openalex-snapshot
Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition
inferred← citeshttps://doi.org/10.1101/2025.01.05.631367openalex-snapshot
C. elegans interprets dietary quality through context-dependent serotonergic modulation
inferred← citeshttps://doi.org/10.1101/2025.06.06.657909openalex-snapshot
JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux
inferred← citeshttps://doi.org/10.1111/febs.16244openalex-snapshot
Emerging roles of ferroptosis in infectious diseases
inferred← citeshttps://doi.org/10.1111/febs.16382openalex-snapshot
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal
inferred← citeshttps://doi.org/10.1111/pcmr.13141openalex-snapshot
Single‐cell profiling of MC1R ‐inhibited melanocytes
inferred← citeshttps://doi.org/10.1155/2022/2634431openalex-snapshot
Ferroptosis: A New Regulatory Mechanism in Osteoporosis
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-24-0194openalex-snapshot
Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT
inferred← citeshttps://doi.org/10.1172/jci.insight.186703openalex-snapshot
Lomitapide enhances cytotoxic effects of temozolomide in chemotherapy-resistant glioblastoma
inferred← citeshttps://doi.org/10.1177/15230864261421487openalex-snapshot
Metabolic Reprogramming and Ferroptosis: Unlocking New Therapeutic Frontiers in Cancer and Diabetes
inferred← citeshttps://doi.org/10.1186/s12964-024-01980-5openalex-snapshot
The therapeutic potential of RNA m(6)A in lung cancer
inferred← citeshttps://doi.org/10.12998/wjcc.v11.i27.6318openalex-snapshot
Characteristics of amino acid metabolism in colorectal cancer
inferred← citeshttps://doi.org/10.1515/tjb-2021-0233openalex-snapshot
KIM-1 and GADDI-153 gene expression in paracetamol-induced acute kidney injury: effects of N-acetylcysteine, N-acetylmethionine, and N-acetylglucosamine
inferred← citeshttps://doi.org/10.1523/eneuro.0174-24.2024openalex-snapshot
Baicalein Inhibits Cerebral Ischemia-Reperfusion Injury through SIRT6-Mediated FOXA2 Deacetylation to Promote SLC7A11 Expression
inferred← citeshttps://doi.org/10.15252/embj.2021109575openalex-snapshot
AMPK CA(R)Sts a new light on amino acid sensing
inferred← citeshttps://doi.org/10.21203/rs.3.rs-8727447/v1openalex-snapshot
Single-cell analysis reveals multicellular immune coordination and drug targets in driver-mutated NSCLC
inferred← citeshttps://doi.org/10.26508/lsa.202503324openalex-snapshot
Differential cell survival outcomes in response to diverse amino acid stress
inferred← citeshttps://doi.org/10.3389/fnagi.2025.1512980openalex-snapshot
Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia
inferred← citeshttps://doi.org/10.3389/fnagi.2025.1587986openalex-snapshot
Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update
inferred← citeshttps://doi.org/10.3389/fphar.2022.1055911openalex-snapshot
MicroRNAs in doxorubicin-induced cardiotoxicity: The DNA damage response
inferred← citeshttps://doi.org/10.3390/antiox12020261openalex-snapshot
α-Synuclein Toxicity in Drosophila melanogaster Is Enhanced by the Presence of Iron: Implications for Parkinson’s Disease
inferred← citeshttps://doi.org/10.3390/antiox13030298openalex-snapshot
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors
inferred← citeshttps://doi.org/10.3390/antiox14121434openalex-snapshot
HDGF Protects Retinal Pigment Epithelium from Glyoxal-Induced Ferroptosis via SIRT1/PGC-1α/Nrf2 Pathway
inferred← citeshttps://doi.org/10.3390/biology13020103openalex-snapshot
Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review
inferred← citeshttps://doi.org/10.3390/biology14081062openalex-snapshot
Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms
inferred← citeshttps://doi.org/10.3390/cancers14235788openalex-snapshot
Meta-Analysis of RNA-Seq Datasets Identifies Novel Players in Glioblastoma
inferred← citeshttps://doi.org/10.3390/cells11233829openalex-snapshot
Iron Brain Menace: The Involvement of Ferroptosis in Parkinson Disease
inferred← citeshttps://doi.org/10.3390/cimb47010004openalex-snapshot
Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype
inferred← citeshttps://doi.org/10.3390/ijms222312731openalex-snapshot
Phosphocatalytic Kinome Activity Profiling of Apoptotic and Ferroptotic Agents in Multiple Myeloma Cells
inferred← citeshttps://doi.org/10.3390/ijms23052484openalex-snapshot
The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3390/ijms231911913openalex-snapshot
Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia
inferred← citeshttps://doi.org/10.3390/ijms252011284openalex-snapshot
Reciprocal Dynamics of Metabolism and mRNA Translation in Tumor Angiogenesis
inferred← citeshttps://doi.org/10.3390/ijms26083632openalex-snapshot
Enzymes Drive Glutathione Shunt to Explain Oxidative State Using an In-Parallel Multi-Omic Method
inferred← citeshttps://doi.org/10.3390/ijms26136430openalex-snapshot
Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid
inferred← citeshttps://doi.org/10.3390/ijms26146588openalex-snapshot
The Molecular Interplay Between p53-Mediated Ferroptosis and Non-Coding RNAs in Cancer
inferred← citeshttps://doi.org/10.3390/ijms262211008openalex-snapshot
Transmetalation in Cancer Pharmacology
inferred← citeshttps://doi.org/10.3390/ijms27010207openalex-snapshot
Potential Physiological and Molecular Mechanisms Underlying Low Viability of Gynogenetic WW-Type Super-Female Sterlet (Acipenser ruthenus)
inferred← citeshttps://doi.org/10.3390/molecules27041416openalex-snapshot
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine
inferred← citeshttps://doi.org/10.3390/nano16100590openalex-snapshot
Transcriptomic Profiling of Toxic Copper Overload Induced by CuO Nanoparticles or Copper Ions in Human Lung Epithelial and Liver Cells
inferred← citeshttps://doi.org/10.3390/nu15132879openalex-snapshot
Dietary Manipulation of Amino Acids for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/proteomes14010006openalex-snapshot
Evaluating the Impact of Two Different Diets on the Protein Profile of the Brain, Liver, and Intestine of the Barramundi
inferred← citeshttps://doi.org/10.4062/biomolther.2021.105openalex-snapshot
Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc- Inhibitors
inferred← citeshttps://doi.org/10.64898/2026.03.27.714827openalex-snapshot
Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer
inferred← citeshttps://doi.org/10.70675/77e3e307zb59fz4c77z817ez07f713290c6bopenalex-snapshot
Study of the role of inflammatory cell death in the regulation of pulmonary bacterial infections : Identification of novel factors involved in pulmonary pathology mediated by the Exotoxin U of P. aeruginosa
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