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Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cmdc.201000428openalex-snapshot
A Combined Ligand‐ and Structure‐Based Virtual Screening Protocol Identifies Submicromolar PPARγ Partial Agonists
inferredcites →https://doi.org/10.1007/s00005-008-0037-yopenalex-snapshot
Structure and physiological functions of the human peroxisome proliferator-activated receptor γ
inferredcites →https://doi.org/10.1016/0003-2697(89)90616-7openalex-snapshot
Variation in enzymatic transient gene expression assays
inferredcites →https://doi.org/10.1016/j.bbalip.2007.02.013openalex-snapshot
PPARs and molecular mechanisms of transrepression
inferredcites →https://doi.org/10.1016/j.bmc.2012.01.025openalex-snapshot
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists
inferredcites →https://doi.org/10.1016/j.bmcl.2008.01.126openalex-snapshot
Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists
inferredcites →https://doi.org/10.1016/j.ejmech.2009.09.042openalex-snapshot
Identification of (β-carboxyethyl)-rhodanine derivatives exhibiting peroxisome proliferator-activated receptor γ activity
inferredcites →https://doi.org/10.1016/j.ejmech.2013.02.015openalex-snapshot
Molecular determinants for nuclear receptors selectivity: Chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists
inferredcites →https://doi.org/10.1016/j.jmb.2013.05.010openalex-snapshot
Molecular Mechanism of Peroxisome Proliferator-Activated Receptor α Activation by WY14643: a New Mode of Ligand Recognition and Receptor Stabilization
inferredcites →https://doi.org/10.1016/j.str.2007.07.014openalex-snapshot
Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism
inferredcites →https://doi.org/10.1016/s0022-2275(20)32433-0openalex-snapshot
Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation
inferredcites →https://doi.org/10.1016/s0065-2458(08)60034-0openalex-snapshot
Clustering Methodologies in Exploratory Data Analysis
inferredcites →https://doi.org/10.1016/s0955-0674(98)80014-8openalex-snapshot
Co-activators and co-repressors in the integration of transcriptional responses
inferredcites →https://doi.org/10.1021/acschembio.5b00580openalex-snapshot
SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism
inferredcites →https://doi.org/10.1021/ci3001277openalex-snapshot
ZINC: A Free Tool to Discover Chemistry for Biology
inferredcites →https://doi.org/10.1021/cr2001355openalex-snapshot
PPARs and Lipid Ligands in Inflammation and Metabolism
inferredcites →https://doi.org/10.1021/jm030331xopenalex-snapshot
Structural Interaction Fingerprint (SIFt): A Novel Method for Analyzing Three-Dimensional Protein−Ligand Binding Interactions
inferredcites →https://doi.org/10.1021/jm0306430openalex-snapshot
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
inferredcites →https://doi.org/10.1021/jm030644sopenalex-snapshot
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening
inferredcites →https://doi.org/10.1021/jm049312topenalex-snapshot
Interaction Profiles of Protein Kinase−Inhibitor Complexes and Their Application to Virtual Screening
inferredcites →https://doi.org/10.1021/jm0502844openalex-snapshot
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of New Chiral Fibrates with PPARα and PPARγ Agonist Activity
inferredcites →https://doi.org/10.1021/jm051197eopenalex-snapshot
MolDock: A New Technique for High-Accuracy Molecular Docking
inferredcites →https://doi.org/10.1021/jm051256oopenalex-snapshot
Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes
inferredcites →https://doi.org/10.1021/jm101360sopenalex-snapshot
Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators
inferredcites →https://doi.org/10.1021/jm201306qopenalex-snapshot
Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity
inferredcites →https://doi.org/10.1021/jm2014293openalex-snapshot
Peroxisome Proliferator-Activated Receptors (PPARs) Have Multiple Binding Points That Accommodate Ligands in Various Conformations: Phenylpropanoic Acid-Type PPAR Ligands Bind to PPAR in Different Conformations, Depending on the Subtype
inferredcites →https://doi.org/10.1021/jm201624hopenalex-snapshot
Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening
inferredcites →https://doi.org/10.1021/jm3017199openalex-snapshot
Discovery of a Novel Small Molecule Inhibitor Targeting the Frataxin/Ubiquitin Interaction via Structure-Based Virtual Screening and Bioassays
inferredcites →https://doi.org/10.1021/jm501155fopenalex-snapshot
Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage
inferredcites →https://doi.org/10.1021/jm800733hopenalex-snapshot
Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design
inferredcites →https://doi.org/10.1021/jm801594xopenalex-snapshot
Design and Structural Analysis of Novel Pharmacophores for Potent and Selective Peroxisome Proliferator-activated Receptor γ Agonists
inferredcites →https://doi.org/10.1038/nature09291openalex-snapshot
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
inferredcites →https://doi.org/10.1038/nrd1549openalex-snapshot
Docking and scoring in virtual screening for drug discovery: methods and applications
inferredcites →https://doi.org/10.1038/nri912openalex-snapshot
Emerging roles of PPARS in inflammation and immunity
inferredcites →https://doi.org/10.1074/jbc.m702316200openalex-snapshot
Insights into the Mechanism of Partial Agonism
inferredcites →https://doi.org/10.1107/97809553602060000865openalex-snapshot
PHENIX: a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0108767393007597openalex-snapshot
AMoRe: an automated package for molecular replacement
inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot
PHENIX : a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0907444910048675openalex-snapshot
iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM
inferredcites →https://doi.org/10.1107/s0907444998003254openalex-snapshot
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
inferredcites →https://doi.org/10.1111/j.1365-2443.2012.01607.xopenalex-snapshot
Ligand‐dependent nucleo‐cytoplasmic shuttling of peroxisome proliferator‐activated receptors, PPARα and PPARγ
inferredcites →https://doi.org/10.1128/mcb.20.13.4699-4707.2000openalex-snapshot
Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene
inferredcites →https://doi.org/10.1146/annurev.physiol.66.032802.154710openalex-snapshot
LIGAND CONTROL OF COREGULATOR RECRUITMENT TO NUCLEAR RECEPTORS
inferredcites →https://doi.org/10.1146/annurev.physiol.69.031905.160308openalex-snapshot
Nuclear Receptor Structure: Implications for Function
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-1249openalex-snapshot
Discovery of New Small Molecules Targeting the Vitronectin-Binding Site of the Urokinase Receptor That Block Cancer Cell Invasion
inferredcites →https://doi.org/10.1186/1471-2105-9-396openalex-snapshot
FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
inferredcites →https://doi.org/10.1371/journal.pone.0050816openalex-snapshot
Identification of PPARgamma Partial Agonists of Natural Origin (I): Development of a Virtual Screening Procedure and In Vitro Validation
inferredcites →https://doi.org/10.18632/oncotarget.4016openalex-snapshot
Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion
inferredcites →https://doi.org/10.18632/oncotarget.5473openalex-snapshot
Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displayingin vitroefficacy against melanoma cells
inferredcites →https://doi.org/10.2174/092986711798347243openalex-snapshot
Rational Targeting of Peroxisome Proliferating Activated Receptor Subtypes
inferredcites →https://doi.org/10.2174/1874-470210902010046openalex-snapshot
Peroxisome Proliferator-Activated Receptor (PPAR)β /δ: A New Potential Therapeutic Target for the Treatment of Metabolic Syndrome
inferredcites →https://doi.org/10.2337/dc07-2270openalex-snapshot
Rosiglitazone-Associated Fractures in Type 2 Diabetes
inferredcites →https://doi.org/10.3233/jrs-2012-0559openalex-snapshot
The rosiglitazone decision process at FDA and EMA. What should we learn?
inferredcites →https://doi.org/10.4414/smw.2010.13071openalex-snapshot
Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4782907openalex-extracted
Comparative Molecular Simulation of Pparg Protein Interactions with Omega-3 and Omega-6 Lipid Mediators
inferred← citeshttps://doi.org/10.1002/0471266949.bmc274openalex-snapshot
Therapeutic Approaches for Nonalcoholic Steatohepatitis ( NASH )
inferred← citeshttps://doi.org/10.1002/adbi.202300037openalex-snapshot
Partial Activation of PPAR‐ γ by Synthesized Quercetin Derivatives Modulates TGF‐ β 1‐Induced EMT in Lung Cancer Cells
inferred← citeshttps://doi.org/10.1002/hep4.1474openalex-snapshot
Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK
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HDAC4 Inhibitors with Cyclic Linker and Non‐hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation.
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_6openalex-snapshot
PPARα and δ Ligand Design: Honing the Traditional Empirical Method with a More Holistic Overview
inferred← citeshttps://doi.org/10.1007/978-3-031-81728-1_21openalex-snapshot
Roles of Pharmacophores in Drug Discovery
inferred← citeshttps://doi.org/10.1007/s11010-025-05207-0openalex-snapshot
Autophagy and the peroxisome proliferator-activated receptor signaling pathway: A molecular ballet in lipid metabolism and homeostasis
inferred← citeshttps://doi.org/10.1007/s11030-024-10988-5openalex-snapshot
Repurposing FDA-approved drugs for combating tigecycline resistance in Acinetobacter baumannii: in silico screening against BaeR protein
inferred← citeshttps://doi.org/10.1007/s11030-025-11395-0openalex-snapshot
Rational in silico design of PPARγ agonists for type 2 diabetes: an integrated study using pharmacophore modeling, 3D-QSAR, molecular docking, MD simulations, DFT, and toxicity prediction
inferred← citeshttps://doi.org/10.1007/s11030-026-11700-5openalex-snapshot
Interpretable QSAR modelling for PPAR-γ agonist prediction by integrating a stacking strategy, docking, and MD simulations
inferred← citeshttps://doi.org/10.1007/s12010-022-04190-2openalex-snapshot
Identification of Selective PPAR-γ Modulators by Combining Pharmacophore Modeling, Molecular Docking, and Adipogenesis Assay
inferred← citeshttps://doi.org/10.1007/s12038-019-9962-7openalex-snapshot
Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments
inferred← citeshttps://doi.org/10.1016/b978-0-323-95700-7.00025-5openalex-snapshot
Involvement of FABPs in cell signaling, gene expression, and angiogenesis
inferred← citeshttps://doi.org/10.1016/j.arabjc.2024.105690openalex-snapshot
Black pepper (Piper nigrum L.) essential oil counteracts dexamethasone-induced hepatic injury via modulating PGC-1α/ PPAR-α pathway in rats
inferred← citeshttps://doi.org/10.1016/j.bbih.2025.101061openalex-snapshot
Exploring GPR120/FFAR4 pharmacology: Unveiling novel therapeutic avenues through molecular signaling pathways for Alzheimer's disease intervention
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105600openalex-snapshot
Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.09.074openalex-snapshot
Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.05.028openalex-snapshot
2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.03.010openalex-snapshot
Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113330openalex-snapshot
A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.01.067openalex-snapshot
Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114240openalex-snapshot
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116567openalex-snapshot
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117494openalex-snapshot
A new potent and selective peroxisome proliferator-activated receptor alpha partial agonist displays anti-steatotic effects In vitro and behaves as a safe hypolipidemic and hypoglycemic agent in a diabetic mouse model
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117657openalex-snapshot
Enhancing the activity of γ-hydroxy lactone derivatives as innovative peroxisome proliferator-activated receptor γ non-agonists inhibiting cyclin-dependent kinase 5-mediated phosphorylation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174244openalex-snapshot
Synthesis, molecular docking, dynamic simulation and pharmacological characterization of potent multifunctional agent (dual GPR40-PPARγ agonist) for the treatment of experimental type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.04.031openalex-snapshot
Secoiridoid-enriched extra virgin olive oil extracts enhance mitochondrial activity and antioxidant response in colorectal cancer cells: The role of Oleacein and Oleocanthal in PPARγ interaction
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101727openalex-snapshot
PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates
inferred← citeshttps://doi.org/10.1016/j.jaim.2026.101373openalex-snapshot
Multitarget anticancer profiling of Withania somnifera - Dual herbal combination with P. emblica, B. monnieri, and O. basilicum through integrated In silico docking and In vitro Jurkat cell line analysis
inferred← citeshttps://doi.org/10.1016/j.jep.2020.112543openalex-snapshot
Antidiabetic effect of Cordia morelosana, chemical and pharmacological studies
inferred← citeshttps://doi.org/10.1016/j.jff.2018.10.027openalex-snapshot
Eicosapentaenoic acid-containing phosphatidylcholine promotes osteogenesis:mechanism of up-regulating Runx2 and ERK-mediated phosphorylation of PPARγ at serine 112
inferred← citeshttps://doi.org/10.1016/j.kint.2019.08.019openalex-snapshot
Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120468openalex-snapshot
Ischemia-reperfusion damage is attenuated by GQ-11, a peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, after aorta clamping in rats.
inferred← citeshttps://doi.org/10.1016/j.mce.2022.111839openalex-snapshot
Peroxisome proliferator-activated receptors-alpha and gamma synergism modulate the gut-adipose tissue axis and mitigate obesity
inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100867openalex-snapshot
Evaluation of antioxidant and liver protective activity of ethanolic extract of Vitex peduncularis wall (Lamiaceae) stem bark against carbon tetrachloride (CCl4) induced liver damage using in –vitro, in- vivo and in-silico approaches
inferred← citeshttps://doi.org/10.1016/j.scib.2021.01.023openalex-snapshot
Identification of an allosteric hotspot for additive activation of PPARγ in antidiabetic effects
inferred← citeshttps://doi.org/10.1016/j.tiv.2020.104886openalex-snapshot
Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway
inferred← citeshttps://doi.org/10.1016/j.tox.2025.154155openalex-snapshot
DockTox: Targeting molecular initiating events in organ toxicity through molecular docking
inferred← citeshttps://doi.org/10.1016/j.tox.2025.154362openalex-snapshot
Interaction-profile cheminformatic read-across identifies the UV filter benzophenone-4 as a PPARγ agonist and potential obesogen
inferred← citeshttps://doi.org/10.1016/j.toxlet.2025.08.011openalex-snapshot
Cluster-based read-across of ToxCast data identifies buprofezin as a partial PPARγ agonist with obesogenic potential
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.4c00091openalex-snapshot
Cheminformatic Read-Across Approach Revealed Ultraviolet Filter Cinoxate as an Obesogenic Peroxisome Proliferator-Activated Receptor γ Agonist
inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00838openalex-snapshot
Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c02093openalex-snapshot
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00835openalex-snapshot
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01189openalex-snapshot
Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders
inferred← citeshttps://doi.org/10.1021/acsomega.4c11128openalex-snapshot
From Apo to Ligand-Bound: Unraveling PPARγ-LBD Conformational Shifts via Advanced Molecular Dynamics
inferred← citeshttps://doi.org/10.1038/s41467-017-02543-8openalex-snapshot
Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes
inferred← citeshttps://doi.org/10.1038/s41467-018-08157-yopenalex-snapshot
Recurrent activating mutations of PPARγ associated with luminal bladder tumors
inferred← citeshttps://doi.org/10.1038/s41467-024-49493-6openalex-snapshot
Chemogenomics for NR1 nuclear hormone receptors
inferred← citeshttps://doi.org/10.1038/s41598-017-05666-6openalex-snapshot
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis
inferred← citeshttps://doi.org/10.1038/s41598-018-34259-0openalex-snapshot
VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity
inferred← citeshttps://doi.org/10.1038/s41598-019-43337-wopenalex-snapshot
Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)
inferred← citeshttps://doi.org/10.1038/s41598-020-64527-xopenalex-snapshot
Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives
inferred← citeshttps://doi.org/10.1038/s41598-023-47157-xopenalex-snapshot
Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists
inferred← citeshttps://doi.org/10.1038/s44321-025-00216-4openalex-snapshot
Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
inferred← citeshttps://doi.org/10.1039/c6ra27740copenalex-snapshot
The molecular mechanism of hPPARα activation
inferred← citeshttps://doi.org/10.1039/d3cc00954hopenalex-snapshot
Opportunities and challenges in targeting orphan nuclear receptors
inferred← citeshttps://doi.org/10.1080/07391102.2021.1892528openalex-snapshot
Ligand and structure-based computational designing of multi-target molecules directing FFAR-1, FFAR-4 and PPAR-G as modulators of insulin receptor activity
inferred← citeshttps://doi.org/10.1080/07391102.2025.2507812openalex-snapshot
Targeting TetR-family transcription regulators for combating tetracycline resistance in resilient Acinetobacter baumannii: in silico identification of potent inhibitors
inferred← citeshttps://doi.org/10.1096/fj.202504659ropenalex-snapshot
The PPARβ/ Delta‐Induced Mesenchymal Stromal Cell Secretome Has Cytoprotective Effects via ANGPTL4 in a Pre‐Clinical Model of Acute Lung Inflammation
inferred← citeshttps://doi.org/10.1101/127050openalex-snapshot
Human Missense Variation is Constrained by Domain Structure and Highlights Functional and Pathogenic Residues
inferred← citeshttps://doi.org/10.1101/2024.07.26.605318openalex-snapshot
Limitations in PPAR⍺-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
inferred← citeshttps://doi.org/10.1101/2024.12.17.629058openalex-snapshot
Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity
inferred← citeshttps://doi.org/10.1111/1440-1681.13252openalex-snapshot
GQ‐130, a novel analogue of thiazolidinedione, improves obesity‐induced metabolic alterations in rats: Evidence for the involvement of PPARβ/δ pathway
inferred← citeshttps://doi.org/10.1111/bph.16244openalex-snapshot
A partial agonist of PPARγ prevents paclitaxel‐induced peripheral neuropathy in mice, by inhibiting neuroinflammation
inferred← citeshttps://doi.org/10.1155/2017/1069718openalex-snapshot
Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs
inferred← citeshttps://doi.org/10.1155/2020/5314187openalex-snapshot
To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1155/2020/6198628openalex-snapshot
PPARs and the Development of Type 1 Diabetes
inferred← citeshttps://doi.org/10.11606/t.76.2018.tde-29012018-102600openalex-snapshot
Estudos estruturais de novos ligantes sintéticos do receptor PPARY
inferred← citeshttps://doi.org/10.1186/s40643-023-00696-7openalex-snapshot
Chitobiose exhibited a lipid-lowering effect in ob/ob−/− mice via butyric acid enrolled liver–gut crosstalk
inferred← citeshttps://doi.org/10.1248/yakushi.21-00138openalex-snapshot
PPARα-Ligand Binding Modes Revealed by X-ray Crystallography
inferred← citeshttps://doi.org/10.1371/journal.pone.0283743openalex-snapshot
Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations
inferred← citeshttps://doi.org/10.17635/lancaster/thesis/1108openalex-snapshot
Actions of cannabinoids on amoebae
inferred← citeshttps://doi.org/10.21203/rs.3.rs-490889/v1openalex-snapshot
Increasing endogenous PPARγ ligands improves insulin sensitivity and protects against diet-induced obesity without side effects of thiazolidinediones
inferred← citeshttps://doi.org/10.2174/1381612825666190716094852openalex-snapshot
The Journey of Thiazolidinediones as Modulators of PPARs for the Management of Diabetes: A Current Perspective
inferred← citeshttps://doi.org/10.29090/psa.2023.02.22.334openalex-snapshot
In silico drug discovery of flavonoids as potential PPAR agonists in treatment of metabolic syndrome
inferred← citeshttps://doi.org/10.32895/ump.mpr.5.4.5openalex-snapshot
Structure-based virtual screening of plant-derived natural compounds as potential PPARα agonists for the treatment of dyslipidemia
inferred← citeshttps://doi.org/10.3389/fncel.2019.00162openalex-snapshot
Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors
inferred← citeshttps://doi.org/10.3390/app14219994openalex-snapshot
Naturally Occurring Compounds Targeting Peroxisome Proliferator Receptors: Potential Molecular Mechanisms and Future Perspectives for Promoting Human Health
inferred← citeshttps://doi.org/10.3390/biom13040694openalex-snapshot
Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
inferred← citeshttps://doi.org/10.3390/cells11203215openalex-snapshot
PPAR-γ Partial Agonists in Disease-Fate Decision with Special Reference to Cancer
inferred← citeshttps://doi.org/10.3390/cells9010037openalex-snapshot
Anti-NASH Drug Development Hitches a Lift on PPAR Agonism
inferred← citeshttps://doi.org/10.3390/ijms21239074openalex-snapshot
Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide
inferred← citeshttps://doi.org/10.3390/ijms22084034openalex-snapshot
Synthesis of a Coumarin-Based PPARγ Fluorescence Probe for Competitive Binding Assay
inferred← citeshttps://doi.org/10.3390/ijms23158732openalex-snapshot
Exploring Ligand Binding Domain Dynamics in the NRs Superfamily
inferred← citeshttps://doi.org/10.3390/ijms252313072openalex-snapshot
AhR-Induced Anti-Inflammatory Effects on a Caco-2/THP-1 Co-Culture Model of Intestinal Inflammation Are Mediated by PPARγ
inferred← citeshttps://doi.org/10.3390/ijms27073003openalex-snapshot
Effects of Passiflora edulis Leaf Extract on Lipid Accumulation in HepG2 Cells: In Vitro Evidence and Molecular Docking Analysis Involving PPARα and SREBP-1
inferred← citeshttps://doi.org/10.3390/molecules23020340openalex-snapshot
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids
inferred← citeshttps://doi.org/10.3390/molecules29204881openalex-snapshot
Identification of Novel PPARγ Partial Agonists Based on Virtual Screening Strategy: In Silico and In Vitro Experimental Validation
inferred← citeshttps://doi.org/10.3390/org7020026openalex-snapshot
Synthesis and In Silico Evaluation of the Ninhydrin Derivatives Interaction with Target Proteins Involved in Cancer Pathogenesis and Progression
inferred← citeshttps://doi.org/10.3390/ph14090914openalex-snapshot
In Silico-Based Design and In Vivo Evaluation of an Anthranilic Acid Derivative as a Multitarget Drug in a Diet-Induced Metabolic Syndrome Model
inferred← citeshttps://doi.org/10.4062/biomolther.2022.097openalex-snapshot
Macakurzin C Derivatives as a Novel Pharmacophore for Pan-Peroxisome Proliferator-Activated Receptor Modulator
inferred← citeshttps://doi.org/10.4103/1673-5374.386410openalex-snapshot
Dual PPAR delta/gamma agonists offer therapeutic potential for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.26637978openalex-snapshot
Additional file 1 of Chitobiose exhibited a lipid-lowering effect in ob/ob−/− mice via butyric acid enrolled liver–gut crosstalk
inferred← citeshttps://doi.org/10.70675/ba485de5zaaacz49c6z9687z91bc6a719799openalex-snapshot
Développements méthodologiques en spectrométrie de masse structurale pour la caractérisation de complexes biologiques multiprotéiques
inferred← citeshttps://doi.org/10.7150/thno.46873openalex-snapshot
Inhibitory effect of PPARγ on NLRP3 inflammasome activation
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