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Organocatalytic diastereoselective [3+2] cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2–p53 interaction

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Stereoselective Construction of Halogenated Quaternary Carbon Centers by Brønsted Base Catalyzed [4+2] Cycloaddition of α‐Haloaldehydes

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Nutlin‐3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation

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Medicinal Chemistry Strategies to Disrupt the p53–MDM2/MDMX Interaction

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Design, synthesis, and biological evaluation of imidazoline derivatives as p53–MDM2 binding inhibitors

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Design, synthesis and CoMFA studies of N1-amino acid substituted 2,4,5-triphenyl imidazoline derivatives as p53–MDM2 binding inhibitors

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Discovery of DS-5272 as a promising candidate: A potent and orally active p53–MDM2 interaction inhibitor

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2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation

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Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer

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Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core

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Biologically active compounds based on the privileged 2-imidazoline scaffold: The world beyond adrenergic/imidazoline receptor modulators

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Three-component cascade reaction synthesis of polycyclic 1,4-dihydropyridine derivatives in water

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Phosphine-catalyzed [3+3] annulation reaction of modified tert-butyl allylic carbonates and substituted alkylidenemalononitriles

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Discovery of 4-((3′ R ,4′ S ,5′ R )-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical…

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1,4,5-Trisubstituted Imidazole-Based p53–MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers

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Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents

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Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3′-Spirocyclopentene Oxindole Derivatives

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Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2–p53 Interaction

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Lewis-Base-Catalyzed Asymmetric [3 + 3] Annulation Reaction of Morita–Baylis–Hillman Carbonates: Enantioselective Synthesis of Spirocyclohexenes

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Synthesis of Heterocycles Mediated by Benzotriazole. 2. Bicyclic Systems

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Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations

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Arylglyoxals in Synthesis of Heterocyclic Compounds

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Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

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Phosphine-Catalyzed Highly Enantioselective [3 + 3] Cycloaddition of Morita–Baylis–Hillman Carbonates with C,N-Cyclic Azomethine Imines

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Inhibition of the Human Proteasome by Imidazoline Scaffolds

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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

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Phosphine-Triggered Tandem Annulation between Morita–Baylis–Hillman Carbonates and Dinucleophiles: Facile Syntheses of Oxazepanes, Thiazepanes, and Diazepanes

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A Phosphine-Catalyzed [3 + 2] Annulation Reaction of Modified Allylic Compounds and N -Tosylimines

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Organocatalytic asymmetric transformations of modified Morita–Baylis–Hillman adducts

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Regio- and diastereoselective synthesis of 3,4-dihydro-2H-benzo [4,5]imidazo[2,1-b] [1,3]thiazine derivatives via DBU-catalyzed [3+3] annulation of MBH carbonates with 2-mercaptobenzimidazoles

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Directing Group-Controlled Regioselective [4 + 3] Annulation of Indole-2-Carboxamides with MBH Carbonates toward Highly Substituted Indole-1,2-Fused Diazepanones

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Fe-Catalyzed Radical Trifluoromethylation and Cyclization of Ortho-Vinyl Enaminones with 1-(Trifluoromethyl)-1,3-benzo-[d][1,2]iodaoxol-3(1H)-one to Construct Functionalized Quinolines

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