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Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneur.57.10.1439openalex-snapshot

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

inferredcites →https://doi.org/10.1001/archneur.60.1.29openalex-snapshot

Increased Brain β-Amyloid Load, Phosphorylated Tau, and Risk of Alzheimer Disease Associated With an Intronic CYP46 Polymorphism

inferredcites →https://doi.org/10.1006/bbrc.2001.2013openalex-snapshot

Cholesterol, Hydroxycholesterols, and Bile Acids

inferredcites →https://doi.org/10.1006/nbdi.2001.0470openalex-snapshot

Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

inferredcites →https://doi.org/10.1006/nbdi.2002.0551openalex-snapshot

Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles

inferredcites →https://doi.org/10.1007/s007020170068openalex-snapshot

Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17β

inferredcites →https://doi.org/10.1007/s12031-002-0007-5openalex-snapshot

Lipid rafts play an important role in Aβ biogenesis by regulating the β-secretase pathway

inferredcites →https://doi.org/10.1016/0197-4580(95)00035-dopenalex-snapshot

Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease

inferredcites →https://doi.org/10.1016/s0021-9258(20)89517-9openalex-snapshot

Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.

inferredcites →https://doi.org/10.1016/s0022-2275(20)32052-6openalex-snapshot

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

inferredcites →https://doi.org/10.1016/s0022-3956(01)00050-4openalex-snapshot

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

inferredcites →https://doi.org/10.1016/s0140-6736(00)03155-xopenalex-snapshot

Statins and the risk of dementia

inferredcites →https://doi.org/10.1016/s0165-0270(99)00011-4openalex-snapshot

Recombinant adenovirus is an appropriate vector for endocytotic protein trafficking studies in cultured neurons

inferredcites →https://doi.org/10.1016/s0304-3940(01)02277-7openalex-snapshot

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

inferredcites →https://doi.org/10.1016/s0361-9230(97)00461-9openalex-snapshot

Neurotoxicity of 25-OH-Cholesterol on Sympathetic Neurons

inferredcites →https://doi.org/10.1016/s0960-9822(01)00394-3openalex-snapshot

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

inferredcites →https://doi.org/10.1016/s1388-1981(00)00142-6openalex-snapshot

Oxysterol biosynthetic enzymes

inferredcites →https://doi.org/10.1023/a:1022437000893openalex-snapshot

Neurotoxicity of 25-OH-Cholesterol on NGF-Differentiated PC12 Cells

inferredcites →https://doi.org/10.1038/ncb1001-905openalex-snapshot

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

inferredcites →https://doi.org/10.1038/sj.mp.4001109openalex-snapshot

Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease

inferredcites →https://doi.org/10.1073/pnas.081612998openalex-snapshot

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

inferredcites →https://doi.org/10.1073/pnas.081620098openalex-snapshot

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

inferredcites →https://doi.org/10.1073/pnas.1635130100openalex-snapshot

Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

inferredcites →https://doi.org/10.1073/pnas.95.11.6460openalex-snapshot

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

inferredcites →https://doi.org/10.1073/pnas.96.13.7238openalex-snapshot

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

inferredcites →https://doi.org/10.1074/jbc.272.6.3137openalex-snapshot

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

inferredcites →https://doi.org/10.1074/jbc.275.1.215openalex-snapshot

Regulation of Amyloid Precursor Protein Processing by Presenilin 1 (PS1) and PS2 in PS1 Knockout Cells

inferredcites →https://doi.org/10.1074/jbc.m209085200openalex-snapshot

Induction of the Cholesterol Transporter ABCA1 in Central Nervous System Cells by Liver X Receptor Agonists Increases Secreted Aβ Levels

inferredcites →https://doi.org/10.1074/jbc.m300044200openalex-snapshot

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion

inferredcites →https://doi.org/10.1074/jbc.m300468200openalex-snapshot

Ursodeoxycholic Acid Modulates E2F-1 and p53 Expression through a Caspase-independent Mechanism in Transforming Growth Factor β1-induced Apoptosis of Rat Hepatocytes

inferredcites →https://doi.org/10.1074/jbc.m300760200openalex-snapshot

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

inferredcites →https://doi.org/10.1074/jbc.m303415200openalex-snapshot

Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover

inferredcites →https://doi.org/10.1097/00001756-200006260-00030openalex-snapshot

Plasma 24S-hydroxycholesterol

inferredcites →https://doi.org/10.1111/j.1750-3639.1998.tb00162.xopenalex-snapshot

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

inferredcites →https://doi.org/10.1126/science.1090776openalex-snapshot

Generation of Viable Cholesterol-Free Mice

inferredcites →https://doi.org/10.1126/science.8191290openalex-snapshot

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

inferredcites →https://doi.org/10.1172/jci1325openalex-snapshot

A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.

inferredcites →https://doi.org/10.1194/jlr.m100358-jlr200openalex-snapshot

LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells

inferredcites →https://doi.org/10.1385/jmn:20:3:233openalex-snapshot

β-Secretase Processing of the Alzheimer's Amyloid Protein Precursor (APP)

inferredcites →https://doi.org/10.1523/jneurosci.23-13-05645.2003openalex-snapshot

Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid ProductionIn Vivo

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1001/archneur.61.5.641openalex-snapshot

The Neurobiology of Dopamine Signaling

inferred← citeshttps://doi.org/10.1001/archneur.61.8.1178openalex-snapshot

Apolipoprotein E Receptor LR11

inferred← citeshttps://doi.org/10.1002/9781119356752.ch7openalex-snapshot

Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease

inferred← citeshttps://doi.org/10.1002/cne.21605openalex-snapshot

Neuronal expression and subcellular localization of cholesterol 24‐hydroxylase in the mouse brain

inferred← citeshttps://doi.org/10.1002/cne.25436openalex-snapshot

Cholesterol‐24‐hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes

inferred← citeshttps://doi.org/10.1002/ejlt.200800116openalex-snapshot

Sterol lipidomics in health and disease: Methodologies and applications

inferred← citeshttps://doi.org/10.1002/hbm.22030openalex-snapshot

Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults

inferred← citeshttps://doi.org/10.1002/iub.305openalex-snapshot

Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease

inferred← citeshttps://doi.org/10.1002/jnr.22743openalex-snapshot

Liver X receptors regulate cholesterol homeostasis in oligodendrocytes

inferred← citeshttps://doi.org/10.1002/mnfr.201100208openalex-snapshot

Dietary lipids and their oxidized products in Alzheimer's disease

inferred← citeshttps://doi.org/10.1002/path.2754openalex-snapshot

Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity

inferred← citeshttps://doi.org/10.1007/0-387-23226-5_1openalex-snapshot

The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and Aβ Fibrillogenesis

inferred← citeshttps://doi.org/10.1007/978-0-387-35135-3_6openalex-snapshot

Cholesterol and β-Amyloid

inferred← citeshttps://doi.org/10.1007/978-1-4020-6252-0_2openalex-snapshot

Role of oxysterols and cholestenoic acids in a crosstalk between the brain and the liver

inferred← citeshttps://doi.org/10.1007/978-1-84628-440-3_9openalex-snapshot

Cholesterol and Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1007/978-3-031-43883-7_10openalex-snapshot

Enzymatically Formed Oxysterols and Cell Death

inferred← citeshttps://doi.org/10.1007/978-3-031-43883-7_12openalex-snapshot

Implication of Oxysterols and Phytosterols in Aging and Human Diseases

inferred← citeshttps://doi.org/10.1007/978-3-031-43883-7_9openalex-snapshot

Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects

inferred← citeshttps://doi.org/10.1007/978-3-319-12108-6_9openalex-snapshot

Human Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1007/978-3-540-85188-2_95openalex-snapshot

Cholesterol 24-hydroxylase

inferred← citeshttps://doi.org/10.1007/978-90-481-8622-8_2openalex-snapshot

Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders

inferred← citeshttps://doi.org/10.1007/bf03079128openalex-snapshot

Cholesterol: nieuw therapeutisch target bij de ziekte van Alzheimer?

inferred← citeshttps://doi.org/10.1007/s00259-025-07547-xopenalex-snapshot

Quantitative analysis of [18F]CHL2310, a novel PET ligand for cholesterol 24-Hydroxylase, in nonhuman primate brain

inferred← citeshttps://doi.org/10.1007/s00418-010-0718-6openalex-snapshot

Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in a time-dependent manner

inferred← citeshttps://doi.org/10.1007/s00418-011-0781-7openalex-snapshot

Histochemistry and cell biology: the annual review 2010

inferred← citeshttps://doi.org/10.1007/s11011-017-0015-3openalex-snapshot

Cholesterol as a modifying agent of the neurovascular unit structure and function under physiological and pathological conditions

inferred← citeshttps://doi.org/10.1007/s11064-006-9200-1openalex-snapshot

Alzheimer’s Disease and Cholesterol: The Fat Connection

inferred← citeshttps://doi.org/10.1007/s11064-011-0650-8openalex-snapshot

Interactions of Amyloid β Peptide 1–40 and Cerebrosterol

inferred← citeshttps://doi.org/10.1007/s11064-015-1524-2openalex-snapshot

The Oxysterol 27-Hydroxycholesterol Increases Oxidative Stress and Regulate Nrf2 Signaling Pathway in Astrocyte Cells

inferred← citeshttps://doi.org/10.1007/s11745-006-1003-2openalex-snapshot

Rediscovery of Cerebrosterol

inferred← citeshttps://doi.org/10.1007/s12031-008-9145-8openalex-snapshot

Modifications of the Expression of Genes Involved in Cerebral Cholesterol Metabolism in the Rat Following Chronic Ingestion of Depleted Uranium

inferred← citeshttps://doi.org/10.1007/s12035-010-8099-3openalex-snapshot

Changes in Brain Cholesterol Metabolome After Excitotoxicity

inferred← citeshttps://doi.org/10.1007/s12035-016-0281-9openalex-snapshot

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients

inferred← citeshttps://doi.org/10.1007/s12035-020-02232-6openalex-snapshot

Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

inferred← citeshttps://doi.org/10.1007/s12035-023-03529-yopenalex-snapshot

Reexamining the Causes and Effects of Cholesterol Deposition in the Brains of Patients with Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1007/s12264-010-1224-5openalex-snapshot

Distribution of cholesterol 24-hydroxylase in the monkey brain

inferred← citeshttps://doi.org/10.1007/s13311-019-00731-6openalex-snapshot

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

inferred← citeshttps://doi.org/10.1007/s13311-019-00737-0openalex-snapshot

CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice

inferred← citeshttps://doi.org/10.1016/b978-0-12-802101-9.00002-8openalex-snapshot

Patient-Oriented Research

inferred← citeshttps://doi.org/10.1016/b978-0-323-85857-1.00039-0openalex-snapshot

Involvement of cholesterol and β-amyloid in the initiation and progression of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/bs.pmbts.2019.07.003openalex-snapshot

Restoring synaptic function through multimodal therapeutics

inferred← citeshttps://doi.org/10.1016/j.abb.2010.11.023openalex-snapshot

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

inferred← citeshttps://doi.org/10.1016/j.ajpath.2014.03.014openalex-snapshot

Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking

inferred← citeshttps://doi.org/10.1016/j.ajpath.2018.10.013openalex-snapshot

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal

inferred← citeshttps://doi.org/10.1016/j.arr.2014.09.006openalex-snapshot

Involvement of oxysterols in age-related diseases and ageing processes

inferred← citeshttps://doi.org/10.1016/j.bbalip.2010.02.010openalex-snapshot

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.bbalip.2010.03.011openalex-snapshot

Brain cholesterol in normal and pathological aging

inferred← citeshttps://doi.org/10.1016/j.bbalip.2014.12.018openalex-snapshot

The impairment of cholesterol metabolism in Huntington disease

inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.09.011openalex-snapshot

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond

inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.05.033openalex-snapshot

Regulation of α- and β-secretase activity by oxysterols: Cerebrosterol stimulates processing of APP via the α-secretase pathway

inferred← citeshttps://doi.org/10.1016/j.bcp.2012.12.007openalex-snapshot

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bcp.2013.03.015openalex-snapshot

Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid

inferred← citeshttps://doi.org/10.1016/j.biocel.2008.05.029openalex-snapshot

24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis

inferred← citeshttps://doi.org/10.1016/j.biochi.2007.10.007openalex-snapshot

Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain

inferred← citeshttps://doi.org/10.1016/j.biochi.2012.09.025openalex-snapshot

24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.brainres.2009.12.080openalex-snapshot

24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury

inferred← citeshttps://doi.org/10.1016/j.brainresrev.2007.09.004openalex-snapshot

Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans

inferred← citeshttps://doi.org/10.1016/j.cca.2011.07.028openalex-snapshot

Oxysterols in bile acid metabolism

inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2011.04.002openalex-snapshot

Oxysterols as biomarkers in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2011.04.006openalex-snapshot

24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma

inferred← citeshttps://doi.org/10.1016/j.cnd.2015.04.003openalex-snapshot

Cholestérol et pathologies oculaires : focus sur le rôle de la cholestérol 24S-hydroxylase (CYP46A1) dans l’homéostasie du cholestérol

inferred← citeshttps://doi.org/10.1016/j.dmd.2026.100337openalex-snapshot

Human Cytochrome P450 27A1 - a variety of reactions, applications, and potentials for drug targeting

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114612openalex-snapshot

Design and Synthesis of Aryl-Piperidine Derivatives as Potent and Selective PET Tracers for Cholesterol 24-Hydroxylase (CH24H)

inferred← citeshttps://doi.org/10.1016/j.ejmg.2013.09.008openalex-snapshot

Mutation in CYP27A1 identified in family with coronary artery disease

inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175726openalex-snapshot

The potential of CYP46A1 as a novel therapeutic target for neurological disorders: An updated review of mechanisms

inferred← citeshttps://doi.org/10.1016/j.eurpsy.2008.12.005openalex-snapshot

CYP46A1variants influence Alzheimer’s disease risk and brain cholesterol metabolism

inferred← citeshttps://doi.org/10.1016/j.exer.2005.11.018openalex-snapshot

Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina

inferred← citeshttps://doi.org/10.1016/j.exger.2014.09.013openalex-snapshot

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?

inferred← citeshttps://doi.org/10.1016/j.expneurol.2007.01.013openalex-snapshot

Immunomodulatory properties of increased levels of liver X receptor β in peripheral blood mononuclear cells from multiple sclerosis patients

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2006.12.022openalex-snapshot

Effects of heme oxygenase-1 expression on sterol homeostasis in rat astroglia

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.06.036openalex-snapshot

New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.12.020openalex-snapshot

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.10.008openalex-snapshot

Different functions of vitamin E homologues in the various types of cell death induced by oxysterols

inferred← citeshttps://doi.org/10.1016/j.genrep.2021.101070openalex-snapshot

Amyloid Beta sharply increases HMG-CoA reductase protein levels in astrocytes isolated from C57BL/6 mice

inferred← citeshttps://doi.org/10.1016/j.isci.2023.106740openalex-snapshot

Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population

inferred← citeshttps://doi.org/10.1016/j.jchromb.2009.05.017openalex-snapshot

Analysis of neurosterols by GC–MS and LC–MS/MS

inferred← citeshttps://doi.org/10.1016/j.jgg.2014.04.003openalex-snapshot

The Involvement of Lipids in Alzheimer's Disease

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2019.03.003openalex-snapshot

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2020.105785openalex-snapshot

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer’s cerebral pathology and clinical disease progression

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2021.105927openalex-snapshot

Metabolism of oral turinabol by the human brain cholesterol 24-hydroxylase CYP46A1

inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122953openalex-snapshot

Terra incognita of glial cell dynamics in the etiology of leukodystrophies: Broadening disease and therapeutic perspectives

inferred← citeshttps://doi.org/10.1016/j.livres.2019.05.001openalex-snapshot

The acidic pathway of bile acid synthesis: Not just an alternative pathway

inferred← citeshttps://doi.org/10.1016/j.mam.2009.02.001openalex-snapshot

Oxysterols and neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.mam.2009.02.006openalex-snapshot

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis

inferred← citeshttps://doi.org/10.1016/j.mce.2019.02.013openalex-snapshot

24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells

inferred← citeshttps://doi.org/10.1016/j.mehy.2006.04.067openalex-snapshot

Toward prevention of alzheimers disease – Potential nutraceutical strategies for suppressing the production of amyloid beta peptides

inferred← citeshttps://doi.org/10.1016/j.nbd.2014.05.019openalex-snapshot

Nuclear receptors in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105835openalex-snapshot

Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy

inferred← citeshttps://doi.org/10.1016/j.neuint.2006.07.007openalex-snapshot

Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis

inferred← citeshttps://doi.org/10.1016/j.neuint.2015.07.025openalex-snapshot

Cholesterol – A putative endogenous contributor towards Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.neulet.2007.08.014openalex-snapshot

Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders

inferred← citeshttps://doi.org/10.1016/j.neulet.2009.06.073openalex-snapshot

Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.neulet.2012.07.057openalex-snapshot

Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells

inferred← citeshttps://doi.org/10.1016/j.neures.2024.01.003openalex-snapshot

Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort

inferred← citeshttps://doi.org/10.1016/j.neuro.2019.08.007openalex-snapshot

25-hydroxycholesterol impairs neuronal and muscular development in zebrafish

inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2005.08.010openalex-snapshot

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2007.07.006openalex-snapshot

Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition

inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2009.04.022openalex-snapshot

Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons

inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2022.12.014openalex-snapshot

Development and validation of a 13-gene signature associated with immune function for the detection of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2017.06.026openalex-snapshot

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2005.05.060openalex-snapshot

Steroidogenic acute regulatory protein in the brain

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2009.08.003openalex-snapshot

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2006.05.014openalex-snapshot

Cytochrome P450s and cholesterol homeostasis

inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107849openalex-snapshot

Detoxification and age-related neurodegenerative diseases: Correlation and therapeutic potential

inferred← citeshttps://doi.org/10.1016/j.plipres.2011.06.002openalex-snapshot

Cholesterol metabolism in neurons and astrocytes

inferred← citeshttps://doi.org/10.1016/j.prostaglandins.2021.106582openalex-snapshot

Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.prp.2023.154737openalex-snapshot

Unraveling the impact of 27-hydroxycholesterol in autoimmune diseases: Exploring promising therapeutic approaches

inferred← citeshttps://doi.org/10.1016/j.redox.2012.12.001openalex-snapshot

Oxysterols in the pathogenesis of major chronic diseases

inferred← citeshttps://doi.org/10.1016/j.redox.2016.09.001openalex-snapshot

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

inferred← citeshttps://doi.org/10.1016/j.semcdb.2005.01.005openalex-snapshot

Cholesterol homeostasis in neurons and glial cells

inferred← citeshttps://doi.org/10.1016/j.steroids.2015.01.018openalex-snapshot

Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)

inferred← citeshttps://doi.org/10.1016/j.steroids.2015.02.004openalex-snapshot

Oxysterols: Influence on plasma membrane rafts microdomains and development of ocular diseases

inferred← citeshttps://doi.org/10.1016/j.steroids.2015.02.007openalex-snapshot

24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8

inferred← citeshttps://doi.org/10.1016/j.steroids.2015.08.002openalex-snapshot

The estrogenic retina: The potential contribution to healthy aging and age-related neurodegenerative diseases of the retina

inferred← citeshttps://doi.org/10.1016/j.tox.2020.152381openalex-snapshot

Glutamate affects cholesterol homeostasis within the brain via the up-regulation of CYP46A1 and ApoE

inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.101278openalex-snapshot

Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101543openalex-snapshot

Increased intestinal bile acid absorption contributes to age-related cognitive impairment

inferred← citeshttps://doi.org/10.1017/s1092852900010051openalex-snapshot

APP23 Mice as a Model of Alzheimer's Disease: An Example of a Transgenic Approach to Modeling a CNS Disorder

inferred← citeshttps://doi.org/10.1017/s1461145712001587openalex-snapshot

Analysis of oxysterols and cholesterol in prefrontal cortex of suicides

inferred← citeshttps://doi.org/10.1038/cddis.2013.374openalex-snapshot

HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1

inferred← citeshttps://doi.org/10.1038/cddis.2013.524openalex-snapshot

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

inferred← citeshttps://doi.org/10.1038/mt.2009.175openalex-snapshot

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

inferred← citeshttps://doi.org/10.1038/pr.2018.49openalex-snapshot

Upregulation of cholesterol 24-hydroxylase following hypoxia–ischemia in neonatal mouse brain

inferred← citeshttps://doi.org/10.1038/s41467-022-28769-9openalex-snapshot

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models

inferred← citeshttps://doi.org/10.1038/s41514-021-00064-9openalex-snapshot

Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

inferred← citeshttps://doi.org/10.1038/s41537-020-00121-4openalex-snapshot

Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia

inferred← citeshttps://doi.org/10.1038/s41583-025-00908-3openalex-snapshot

Lipid metabolism, remodelling and intercellular transfer in the CNS

inferred← citeshttps://doi.org/10.1038/s41598-020-74036-6openalex-snapshot

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

inferred← citeshttps://doi.org/10.1042/bst0381021openalex-snapshot

Links between ApoE, brain cholesterol metabolism, tau and amyloid β-peptide in patients with cognitive impairment

inferred← citeshttps://doi.org/10.1051/ocl/2014056openalex-snapshot

Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis

inferred← citeshttps://doi.org/10.1073/pnas.0803717105openalex-snapshot

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

inferred← citeshttps://doi.org/10.1073/pnas.0913828107openalex-snapshot

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

inferred← citeshttps://doi.org/10.1074/jbc.m111.236273openalex-snapshot

24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis

inferred← citeshttps://doi.org/10.1074/jbc.m117.794909openalex-snapshot

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

inferred← citeshttps://doi.org/10.1074/jbc.m409071200openalex-snapshot

Oxidation of Cholesterol by Amyloid Precursor Protein and β-Amyloid Peptide

inferred← citeshttps://doi.org/10.1074/jbc.m411420200openalex-snapshot

The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

inferred← citeshttps://doi.org/10.1074/jbc.m504513200openalex-snapshot

Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice

inferred← citeshttps://doi.org/10.1074/jbc.m505179200openalex-snapshot

Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1)

inferred← citeshttps://doi.org/10.1074/jbc.m601019200openalex-snapshot

24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux

inferred← citeshttps://doi.org/10.1074/jbc.r112.431916openalex-snapshot

Cytochromes P450: Roles in Diseases

inferred← citeshttps://doi.org/10.1080/14728222.2023.2235718openalex-snapshot

The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review

inferred← citeshttps://doi.org/10.1089/ars.2024.0674openalex-snapshot

Cholesterol Metabolism in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1089/neu.2007.0444openalex-snapshot

Cortical Injury Increases Cholesterol 24S Hydroxylase (Cyp46) Levels in the Rat Brain

inferred← citeshttps://doi.org/10.1093/bfgp/elad019openalex-snapshot

Quantifying transcriptome diversity: a review

inferred← citeshttps://doi.org/10.1093/braincomms/fcaa180openalex-snapshot

CYP46A1-dependent and independent effects of efavirenz treatment

inferred← citeshttps://doi.org/10.1093/pnasnexus/pgag053openalex-snapshot

APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons

inferred← citeshttps://doi.org/10.1096/fj.12-225649openalex-snapshot

Steroids as γ‐secretase modulators

inferred← citeshttps://doi.org/10.1096/fj.13-231456openalex-snapshot

Suppression of amyloid‐β production by 24S‐hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking

inferred← citeshttps://doi.org/10.1096/fj.13-233791openalex-snapshot

Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE‐knockout mice

inferred← citeshttps://doi.org/10.1096/fj.201700984rropenalex-snapshot

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced neuroplasticity

inferred← citeshttps://doi.org/10.1096/fj.201900092ropenalex-snapshot

The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment

inferred← citeshttps://doi.org/10.1097/00041433-200412000-00007openalex-snapshot

Cholesterol, statins and dementia

inferred← citeshttps://doi.org/10.1097/01.jnen.0000225906.82428.69openalex-snapshot

Lovastatin Modulates Increased Cholesterol and Oxysterol Levels and Has a Neuroprotective Effect on Rat Hippocampal Neurons After Kainate Injury

inferred← citeshttps://doi.org/10.1101/2025.11.29.689498openalex-snapshot

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

inferred← citeshttps://doi.org/10.1107/s0907444908004046openalex-snapshot

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

inferred← citeshttps://doi.org/10.1109/icdmw.2011.98openalex-snapshot

In Vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimers Disease -- Modeling Brain Aging and Disease

inferred← citeshttps://doi.org/10.1111/acel.12206openalex-snapshot

Up‐regulation of β‐amyloidogenesis in neuron‐like human cells by both 24‐ and 27‐hydroxycholesterol: protective effect of N‐acetyl‐cysteine

inferred← citeshttps://doi.org/10.1111/bpa.12691openalex-snapshot

The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

inferred← citeshttps://doi.org/10.1111/cen3.12289openalex-snapshot

Cholesterol: A necessary evil from a multiple sclerosis perspective

inferred← citeshttps://doi.org/10.1111/epi.18174openalex-snapshot

Role of cholesterol in modulating brain hyperexcitability

inferred← citeshttps://doi.org/10.1111/epi.18287openalex-snapshot

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

inferred← citeshttps://doi.org/10.1111/j.1365-2796.2006.01725.xopenalex-snapshot

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

inferred← citeshttps://doi.org/10.1111/j.1471-4159.2007.04689.xopenalex-snapshot

Oxysterols, cholesterol homeostasis, and Alzheimer disease

inferred← citeshttps://doi.org/10.1111/j.1471-4159.2007.05099.xopenalex-snapshot

Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

inferred← citeshttps://doi.org/10.1111/j.1471-4159.2008.05442.xopenalex-snapshot

Transcriptional regulation of the human CYP46A1 brain‐specific expression by Sp transcription factors

inferred← citeshttps://doi.org/10.1111/j.1471-4159.2008.05741.xopenalex-snapshot

Impact of heme oxygenase‐1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia

inferred← citeshttps://doi.org/10.1111/j.1471-4159.2012.07893.xopenalex-snapshot

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

inferred← citeshttps://doi.org/10.1111/j.1474-9726.2011.00681.xopenalex-snapshot

Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer’s disease: three partners in crime

inferred← citeshttps://doi.org/10.1111/j.1600-0404.2006.00684.xopenalex-snapshot

Oxysterols and Alzheimer's disease

inferred← citeshttps://doi.org/10.1111/j.1600-0404.2006.00695.xopenalex-snapshot

The role of pleiotropic effects of statins in dementia

inferred← citeshttps://doi.org/10.1111/j.1749-6632.2012.06513.xopenalex-snapshot

The link between altered cholesterol metabolism and Alzheimer's disease

inferred← citeshttps://doi.org/10.1111/j.1755-3768.2012.02490.xopenalex-snapshot

Steady‐state levels of retinal 24S‐hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat

inferred← citeshttps://doi.org/10.1111/nan.12286openalex-snapshot

Evidence for altered cholesterol metabolism in H untington's disease post mortem brain tissue

inferred← citeshttps://doi.org/10.1111/nan.12753openalex-snapshot

Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease

inferred← citeshttps://doi.org/10.1111/neup.12204openalex-snapshot

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in L ewy bodies

inferred← citeshttps://doi.org/10.1124/dmd.122.000874openalex-snapshot

The Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In Vitro

inferred← citeshttps://doi.org/10.1124/mol.108.048538openalex-snapshot

The Selective Alzheimer’s Disease Indicator-1 Gene (Seladin-1/DHCR24) Is a Liver X Receptor Target Gene

inferred← citeshttps://doi.org/10.1146/annurev.biochem.78.072407.103859openalex-snapshot

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

inferred← citeshttps://doi.org/10.1152/physrev.00015.2012openalex-snapshot

Gastric Acid, Calcium Absorption, and Their Impact on Bone Health

inferred← citeshttps://doi.org/10.1155/2006/202938openalex-snapshot

Identification of Disease Markers in Human Cerebrospinal Fluid Using Lipidomic and Proteomic Methods

inferred← citeshttps://doi.org/10.1155/2012/292598openalex-snapshot

Cholesterol: Its Regulation and Role in Central Nervous System Disorders

inferred← citeshttps://doi.org/10.1155/2012/623257openalex-snapshot

Induction of Mitochondrial Changes Associated with Oxidative Stress on Very Long Chain Fatty Acids (C22:0, C24:0, or C26:0)-Treated Human Neuronal Cells (SK-NB-E)

inferred← citeshttps://doi.org/10.1155/2014/467452openalex-snapshot

RNA Viruses: ROS-Mediated Cell Death

inferred← citeshttps://doi.org/10.1159/000333340openalex-snapshot

Side-Chain-Oxidized Oxysterols Upregulate ACE2 and Mas Receptor in Rat Primary Neurons

inferred← citeshttps://doi.org/10.1167/iovs.09-3655openalex-snapshot

Primary Open-Angle Glaucoma: Association with Cholesterol 24S-Hydroxylase (CYP46A1) Gene Polymorphism and Plasma 24-Hydroxycholesterol Levels

inferred← citeshttps://doi.org/10.1177/0271678x20911910openalex-snapshot

Serum 24S-hydroxycholesterol predicts long-term brain structural and functional outcomes after hypoxia-ischemia in neonatal mice

inferred← citeshttps://doi.org/10.1177/1073858414568122openalex-snapshot

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

inferred← citeshttps://doi.org/10.1177/153331750502000208openalex-snapshot

Cholesterol and apolipoprotein E in Alzheimer's disease

inferred← citeshttps://doi.org/10.1186/1471-2377-11-121openalex-snapshot

Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study

inferred← citeshttps://doi.org/10.1186/1750-1326-2-20openalex-snapshot

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

inferred← citeshttps://doi.org/10.1186/1750-1326-3-5openalex-snapshot

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein

inferred← citeshttps://doi.org/10.1186/1750-1326-4-1openalex-snapshot

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

inferred← citeshttps://doi.org/10.1186/s13195-021-00790-yopenalex-snapshot

27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial

inferred← citeshttps://doi.org/10.1186/s13195-022-01151-zopenalex-snapshot

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s13195-024-01430-xopenalex-snapshot

Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes

inferred← citeshttps://doi.org/10.1186/s13578-023-01127-yopenalex-snapshot

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

inferred← citeshttps://doi.org/10.1186/s40478-021-01190-xopenalex-snapshot

Early onset senescence and cognitive impairment in a murine model of repeated mTBI

inferred← citeshttps://doi.org/10.1186/s40478-025-02054-4openalex-snapshot

Astrocyte-neuron combined targeting for CYP46A1 gene therapy in Huntington’s disease

inferred← citeshttps://doi.org/10.1194/jlr.m027680openalex-snapshot

Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway

showing the first 200 of 259

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