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Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

https://doi.org/10.1089/hgtb.2015.048

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Overview of Current Methods in Sedimentation Velocity and Sedimentation Equilibrium Analytical Ultracentrifugation

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Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome

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Development and characterization of a cell line for large‐scale, serum‐free production of recombinant adeno‐associated viral vectors

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Determination of Particle Heterogeneity and Stability of Recombinant Adenovirus by Analytical Ultracentrifugation in CsCl Gradients

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Monitoring the homogeneity of adenovirus preparations (a gene therapy delivery system) using analytical ultracentrifugation

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Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography

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Characterization and evaluation of the immune responses elicited by a novel human papillomavirus (HPV) therapeutic vaccine: HPV 16E7-HBcAg-Hsp65 fusion protein

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Evidence for Encapsidation of Prokaryotic Sequences during Recombinant Adeno-Associated Virus Production and Their in Vivo Persistence after Vector Delivery

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

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Quantification of adeno-associated virus particles and empty capsids by optical density measurement

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Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6

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Analytical Ultracentrifugation for Characterizing Nanocrystals and Their Bioconjugates

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Adeno-associated virus vectors can be efficiently produced without helper virus

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

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Vision 1 Year after Gene Therapy for Leber's Congenital Amaurosis

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Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

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Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

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Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

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Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

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A viral assembly factor promotes AAV2 capsid formation in the nucleolus

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Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors

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Generation and Characterization of Adeno-Associated Virus Producer Cell Lines for Research and Preclinical Vector Production

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Cell Lines for the Production of Recombinant Adeno-Associated Virus

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High-Titer Adeno-Associated Viral Vectors from a Rep/Cap Cell Line and Hybrid Shuttle Virus

inferredcites →https://doi.org/10.1089/hum.2006.088openalex-snapshot

Self-Complementary Recombinant Adeno-Associated Viral Vectors: Packaging Capacity And The Role of Rep Proteins in Vector Purity

inferredcites →https://doi.org/10.1089/hum.2008.107openalex-snapshot

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

inferredcites →https://doi.org/10.1089/hum.2009.070openalex-snapshot

Manufacturing Recombinant Adeno-Associated Viral Vectors from Producer Cell Clones

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Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year

inferredcites →https://doi.org/10.1089/hum.2010.241openalex-snapshot

A Versatile Adeno-Associated Virus Vector Producer Cell Line Method for Scalable Vector Production of Different Serotypes

inferredcites →https://doi.org/10.1089/hum.2011.160openalex-snapshot

Native Molecular State of Adeno-Associated Viral Vectors Revealed by Single-Molecule Sequencing

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inferredcites →https://doi.org/10.1093/emboj/20.12.3282openalex-snapshot

DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids

inferredcites →https://doi.org/10.1128/jvi.03017-12openalex-snapshot

Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release

inferredcites →https://doi.org/10.1128/jvi.33.3.1129-1137.1980openalex-snapshot

Heavy and Light Particles of Adeno-Associated Virus

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Nucleotide sequence and organization of the adeno-associated virus 2 genome

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Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus

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Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells

inferredcites →https://doi.org/10.2174/156652310793797685openalex-snapshot

Production, Purification and Characterization of Adeno-Associated Vectors

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1038/s41434-026-00637-xopenalex-snapshot

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production

inferred← citeshttps://doi.org/10.1038/s41573-019-0012-9openalex-snapshot

Adeno-associated virus vector as a platform for gene therapy delivery

inferred← citeshttps://doi.org/10.1038/s41598-021-82599-1openalex-snapshot

Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

inferred← citeshttps://doi.org/10.1039/d0nr05605gopenalex-snapshot

Adeno-associated virus characterization for cargo discrimination through nanopore responsiveness

inferred← citeshttps://doi.org/10.1039/d3ay01560bopenalex-snapshot

Mass spectrometry friendly pH-gradient anion exchange chromatography for the separation of full and empty adeno-associated virus (AAV) capsids

inferred← citeshttps://doi.org/10.1080/14712598.2020.1693541openalex-snapshot

Current challenges in biotherapeutic particles manufacturing

inferred← citeshttps://doi.org/10.1080/21505594.2021.1928395openalex-snapshot

Staphylococcus aureus N-terminus formylated δ-toxin tends to form amyloid fibrils, while the deformylated δ-toxin tends to form functional oligomer complexes

inferred← citeshttps://doi.org/10.1089/genbio.2022.0007openalex-snapshot

Rapid Quality Control Assessment of Adeno-Associated Virus Vectors Via Stunner

inferred← citeshttps://doi.org/10.1089/hgtb.2016.124openalex-snapshot

Characteristics of Minimally Oversized Adeno-Associated Virus Vectors Encoding Human Factor VIII Generated Using Producer Cell Lines and Triple Transfection

inferred← citeshttps://doi.org/10.1089/hgtb.2016.178openalex-snapshot

Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins

inferred← citeshttps://doi.org/10.1089/hgtb.2016.188openalex-snapshot

Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities

inferred← citeshttps://doi.org/10.1089/hgtb.2019.031openalex-snapshot

Two-Dimensional Droplet Digital PCR as a Tool for Titration and Integrity Evaluation of Recombinant Adeno-Associated Viral Vectors

inferred← citeshttps://doi.org/10.1089/hgtb.2019.088openalex-snapshot

Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process Development

inferred← citeshttps://doi.org/10.1089/hum.2019.041openalex-snapshot

Filling Adeno-Associated Virus Capsids: Estimating Success by Cryo-Electron Microscopy

inferred← citeshttps://doi.org/10.1089/hum.2020.054openalex-snapshot

Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing

inferred← citeshttps://doi.org/10.1089/hum.2020.070openalex-snapshot

Engineered Capsids for Efficient Gene Delivery to the Retina and Cornea

inferred← citeshttps://doi.org/10.1089/hum.2020.317openalex-snapshot

Development and Validation of an Anion Exchange High-Performance Liquid Chromatography Method for Analysis of Empty Capsids and Capsids Encapsidating Genetic Material in a Purified Preparation of Recombinant Adeno-Associated Virus Serotype 5

inferred← citeshttps://doi.org/10.1089/hum.2021.123openalex-snapshot

Size Exclusion Chromatography with Dual Wavelength Detection as a Sensitive and Accurate Method for Determining the Empty and Full Capsids of Recombinant Adeno-Associated Viral Vectors

inferred← citeshttps://doi.org/10.1089/hum.2021.182openalex-snapshot

Insight and Development of Advanced Recombinant Adeno-Associated Virus Analysis Tools Exploiting Single-Particle Quantification by Multidimensional Droplet Digital PCR

inferred← citeshttps://doi.org/10.1089/hum.2022.218openalex-snapshot

Application of Size Exclusion Chromatography with Multiangle Light Scattering in the Analytical Development of a Preclinical Stage Gene Therapy Program

inferred← citeshttps://doi.org/10.1089/hum.2023.148openalex-snapshot

Concise Analysis of Single-Stranded DNA of Recombinant Adeno-Associated Virus By Automated Electrophoresis System

inferred← citeshttps://doi.org/10.1089/hum.2023.169openalex-snapshot

Methodological Validation of Sedimentation Velocity Analytical Ultracentrifugation Method for Adeno-Associated Virus and Collaborative Calibration of System Suitability Substance

inferred← citeshttps://doi.org/10.1089/hum.2024.124openalex-snapshot

Interlaboratory Measurement of Adeno-Associated Virus: Comparative Quantification of Full and Empty Capsids

inferred← citeshttps://doi.org/10.1089/hum.2024.162openalex-snapshot

A Single-Sector Higher Throughput Sedimentation Velocity Analytical Ultracentrifugation Method for Recombinant Adeno-Associated Virus Empty and Full Ratio Analysis

inferred← citeshttps://doi.org/10.1101/2021.07.06.451264openalex-snapshot

A native mass spectrometry-based assay for rapid assessment of the empty/full capsid ratio in AAV gene therapy products

inferred← citeshttps://doi.org/10.1101/2022.08.27.505551openalex-snapshot

Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated Viruses

inferred← citeshttps://doi.org/10.1101/2023.05.08.539919openalex-snapshot

Rapid high-resolution size distribution analysis for adeno-associated virus using high speed SV-AUC

inferred← citeshttps://doi.org/10.1128/spectrum.01806-24openalex-snapshot

Identification of relevant analytical methods for adeno-associated virus stability assessment during formulation development

inferred← citeshttps://doi.org/10.1208/s12248-022-00768-0openalex-snapshot

ACUVRA: Anion-Exchange Chromatography UV-Ratio Analysis—A QC-Friendly Method for Monitoring Adeno-Associated Virus Empty Capsid Content To Support Process Development and GMP Release Testing

inferred← citeshttps://doi.org/10.1371/journal.pcbi.1011454openalex-snapshot

An automated interface for sedimentation velocity analysis in SEDFIT

inferred← citeshttps://doi.org/10.1371/journal.pone.0226245openalex-snapshot

Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease

inferred← citeshttps://doi.org/10.1371/journal.pone.0269139openalex-snapshot

Assessment of the percentage of full recombinant adeno-associated virus particles in a gene therapy drug using CryoTEM

inferred← citeshttps://doi.org/10.1371/journal.pone.0280242openalex-snapshot

Genome concentration, characterization, and integrity analysis of recombinant adeno-associated viral vectors using droplet digital PCR

inferred← citeshttps://doi.org/10.18609/cgti.2023.206openalex-snapshot

Profiling AAV vector heterogeneity & contaminants using next-generation sequencing methods

inferred← citeshttps://doi.org/10.21203/rs.3.rs-1184379/v1openalex-snapshot

Multi-Wavelength Analytical Ultracentrifugation of Biopolymer Mixtures and Interactions

inferred← citeshttps://doi.org/10.2142/biophys.63.202openalex-snapshot

Particle Size Distribution Analysis of Viral Vectors by Multi-wavelength Analytical Ultracentrifugation

inferred← citeshttps://doi.org/10.2174/1566524020666200915105456openalex-snapshot

Rapid Determination of Full and Empty Adeno-Associated Virus Capsid Ratio by Capillary Isoelectric Focusing

inferred← citeshttps://doi.org/10.2217/nnm-2023-0156openalex-snapshot

Characterization and Quantification of Adeno-Associated Virus Capsid-Loading States by Multi-Wavelength Analytical Ultracentrifugation with Ultrascan

inferred← citeshttps://doi.org/10.3389/fbioe.2024.1436857openalex-snapshot

An improved high-resolution method for quantitative separation of empty and filled AAV8 capsids by strong anion exchange HPLC

inferred← citeshttps://doi.org/10.3390/cells12182264openalex-snapshot

Size Exclusion Chromatography–Mass Photometry: A New Method for Adeno-Associated Virus Product Characterization

inferred← citeshttps://doi.org/10.3390/chemosensors13120418openalex-snapshot

Plasmonic Nanopore Sensing to Probe the DNA Loading Status of Adeno-Associated Viruses

inferred← citeshttps://doi.org/10.3390/ijms21051625openalex-snapshot

Metabolic and Redox Signaling of the Nucleoredoxin-Like-1 Gene for the Treatment of Genetic Retinal Diseases

inferred← citeshttps://doi.org/10.3390/ijms27136075openalex-snapshot

Analytical Ultracentrifugation for Biopharmaceutical Characterization and Quality Control

inferred← citeshttps://doi.org/10.3390/pharmaceutics13040586openalex-snapshot

Characterization of Recombinant Adeno-Associated Viruses (rAAVs) for Gene Therapy Using Orthogonal Techniques

inferred← citeshttps://doi.org/10.3390/pharmaceutics13050748openalex-snapshot

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

inferred← citeshttps://doi.org/10.3390/v16040573openalex-snapshot

Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation

inferred← citeshttps://doi.org/10.3390/vaccines10010049openalex-snapshot

Biophysical Characterization of Viral and Lipid-Based Vectors for Vaccines and Therapeutics with Light Scattering and Calorimetric Techniques

inferred← citeshttps://doi.org/10.3410/f.734958350.793573257openalex-snapshot

Faculty Opinions recommendation of Adeno-associated virus vector as a platform for gene therapy delivery.

inferred← citeshttps://doi.org/10.3791/66741openalex-snapshot

A Streamlined and Standardized Procedure for Generating High-Titer, High-Quality Adeno-Associated Virus Vectors Utilizing a Cell Factory Platform

inferred← citeshttps://doi.org/10.3791/66741-vopenalex-snapshot

JoVE Video Dataset

inferred← citeshttps://doi.org/10.56530/lcgc.na.st3379l8openalex-snapshot

Characterization of Adeno-Associated Virus (AAV) Gene Therapy Products

inferred← citeshttps://doi.org/10.64898/2026.05.28.728353openalex-snapshot

A Charge Detection Mass Spectrometer for the Analysis of Megadalton-sized Molecules

inferred← citeshttps://doi.org/10.64898/2026.05.28.728583openalex-snapshot

Single Particle Adsorption and Response Quantification for Functional AAVx Titer and Dose Analysis

inferred← citeshttps://doi.org/10.70675/18b90e76zeb70z4786z90c3z784a7a278900openalex-snapshot

Impact de l’inclusion du domaine C-terminal de la dystrophine sur l’efficacité d’une micro-dystrophine dans le cadre d’une thérapie génique de la Dystrophie Musculaire de Duchenne

inferred← citeshttps://doi.org/10.70675/33e13ef9z7aefz418dz8fdez21352cc194bcopenalex-snapshot

Thermostability of Adeno-Associated Virus (AAV) Vectors

inferred← citeshttps://doi.org/10.70675/c5cff6daz8fe4z430cz80e6z97a11cc59c8eopenalex-snapshot

Characterization of rAAV vectors packaging in baculovirusinfected insect cells

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