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Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Enhanced growth of sf-9 cells to a maximum density of 5.2 × 107 cells per mL and production of β-galactosidase at high cell density by fed batch culture
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Rational plasmid design and bioprocess optimization to enhance recombinant adeno‐associated virus (AAV) productivity in mammalian cells
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Improving adeno‐associated vector yield in high density insect cell cultures
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Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures
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Critical assessment of current adeno-associated viral vector production and quantification methods
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Development of hybrid viral vectors for gene therapy
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Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases
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Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system
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Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells
inferredcites →https://doi.org/10.1016/j.jviromet.2007.05.020openalex-snapshot
Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales
inferredcites →https://doi.org/10.1016/j.jviromet.2013.10.038openalex-snapshot
Production of adeno-associated virus (AAV) serotypes by transient transfection of HEK293 cell suspension cultures for gene delivery
inferredcites →https://doi.org/10.1016/j.ymthe.2005.08.018openalex-snapshot
Successful Production of Pseudotyped rAAV Vectors Using a Modified Baculovirus Expression System
inferredcites →https://doi.org/10.1016/j.ymthe.2017.03.006openalex-snapshot
Systemic AAV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases
inferredcites →https://doi.org/10.1016/j.ymthe.2017.08.003openalex-snapshot
Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells
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A helper virus-free packaging system for recombinant adeno-associated virus vectors
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Production of Recombinant Adeno-Associated Viral Vectors Using a Baculovirus/Insect Cell Suspension Culture System: From Shake Flasks to a 20-L Bioreactor
inferredcites →https://doi.org/10.1038/mt.2008.35openalex-snapshot
Intron Splicing–mediated Expression of AAV Rep and Cap Genes and Production of AAV Vectors in Insect Cells
inferredcites →https://doi.org/10.1038/mt.2009.128openalex-snapshot
A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells
inferredcites →https://doi.org/10.1038/mt.2012.194openalex-snapshot
Endgame: Glybera Finally Recommended for Approval as the First Gene Therapy Drug in the European Union
inferredcites →https://doi.org/10.1038/mtm.2016.2openalex-snapshot
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inferredcites →https://doi.org/10.1038/nrg2141openalex-snapshot
Engineering targeted viral vectors for gene therapy
inferredcites →https://doi.org/10.1073/pnas.0810614106openalex-snapshot
An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells
inferredcites →https://doi.org/10.1089/10430340260355347openalex-snapshot
Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors
inferredcites →https://doi.org/10.1089/10430349950018427openalex-snapshot
Highly Purified Recombinant Adeno-Associated Virus Vectors Are Biologically Active and Free of Detectable Helper and Wild-Type Viruses
inferredcites →https://doi.org/10.1089/hgtb.2015.048openalex-snapshot
Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors
inferredcites →https://doi.org/10.1089/hgtb.2016.021openalex-snapshot
Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis ® Fixed-Bed Bioreactor
inferredcites →https://doi.org/10.1089/hgtb.2016.151openalex-snapshot
Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System
inferredcites →https://doi.org/10.1089/hum.1998.9.16-2353openalex-snapshot
High-Titer Adeno-Associated Viral Vectors from a Rep/Cap Cell Line and Hybrid Shuttle Virus
inferredcites →https://doi.org/10.1089/hum.2009.094openalex-snapshot
Large-Scale Adeno-Associated Viral Vector Production Using a Herpesvirus-Based System Enables Manufacturing for Clinical Studies
inferredcites →https://doi.org/10.1089/hum.2010.202openalex-snapshot
Good Manufacturing Practice Production of Self-Complementary Serotype 8 Adeno-Associated Viral Vector for a Hemophilia B Clinical Trial
inferredcites →https://doi.org/10.1089/hum.2013.184openalex-snapshot
OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy
inferredcites →https://doi.org/10.1089/hum.2015.050openalex-snapshot
OneBac 2.0: Sf 9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA
inferredcites →https://doi.org/10.1099/0022-1317-83-5-973openalex-snapshot
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
inferredcites →https://doi.org/10.1128/genomea.00829-17openalex-snapshot
Whole-Genome Sequence of the Spodoptera frugiperda Sf9 Insect Cell Line
inferredcites →https://doi.org/10.1128/jvi.72.3.2224-2232.1998openalex-snapshot
Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus
inferredcites →https://doi.org/10.1128/jvi.76.4.1884-1891.2002openalex-snapshot
The VP1 N-Terminal Sequence of Canine Parvovirus Affects Nuclear Transport of Capsids and Efficient Cell Infection
inferredcites →https://doi.org/10.1128/jvi.76.4.2014-2018.2002openalex-snapshot
The VP1 Unique Region of Parvovirus B19 and Its Constituent Phospholipase A2-Like Activity
inferredcites →https://doi.org/10.1159/000350083openalex-snapshot
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
inferredcites →https://doi.org/10.1186/1472-6750-7-39openalex-snapshot
Population kinetics during simultaneous infection of insect cells with two different recombinant baculoviruses for the production of rotavirus-like particles
inferredcites →https://doi.org/10.1385/1-59259-304-6:237openalex-snapshot
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inferredcites →https://doi.org/10.1385/1-59259-304-6:255openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Transcriptome analysis of Sf9 insect cells during production of recombinant Adeno‐associated virus
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Production of adeno‐associated viral vector serotype 6 by triple transfection of suspension HEK293 cells at higher cell densities
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Intensification of rAAV Production Based on HEK293 Cell Transient Transfection
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Anion‐Exchange Membrane Chromatography for the Separation of Empty and Full Adeno‐Associated Viral Capsids
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Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing
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Recent advances in upstream process development for production of recombinant adeno‐associated virus
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Identification of optimal flow rate for culture media, cell density, and oxygen toward maximization of virus production in a fed‐batch baculovirus‐insect cell system
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A Mechanistic Model of rAAV Production in Synthetic Cell Lines
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What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
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Preparation and Administration of Adeno-associated Virus Vectors for Corneal Gene Delivery
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Baculovirus protein kinase 1 activates AMPK-protein phosphatase 5 axis to hijack transcription factor EB for self-proliferation
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Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells
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Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system
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