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Mitochondrial DNA replication in mammalian cells: overview of the pathway

https://doi.org/10.1042/ebc20170100

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Unique features of DNA replication in mitochondria: A functional and evolutionary perspective

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Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA.

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Multiple Protein-Binding Sites in the TAS-Region of Human and Rat Mitochondrial DNA

inferredcites →https://doi.org/10.1016/0022-2836(74)90355-6openalex-snapshot

Mechanism of mitochondrial DNA replication in mouse L-cells: Asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence

inferredcites →https://doi.org/10.1016/0022-2836(78)90269-3openalex-snapshot

Mechanism of mitochondrial DNA replication in mouse L-cells: Kinetics of synthesis and turnover of the initiation sequence

inferredcites →https://doi.org/10.1016/0022-2836(79)90440-6openalex-snapshot

Mechanism of mitochondrial DNA replication in mouse L-cells: Localization and sequence of the light-strand origin of replication

inferredcites →https://doi.org/10.1016/0022-2836(86)90272-xopenalex-snapshot

Structural conservation and variation in the D-loop-containing region of vertebrate mitochondrial DNA

inferredcites →https://doi.org/10.1016/0022-2836(87)90308-1openalex-snapshot

Nucleotide sequences required for a ColE1-type plasmid to replicate in Escherichia coli cells with or without RNase H

inferredcites →https://doi.org/10.1016/0092-8674(85)90291-0openalex-snapshot

In vitro replication of human mitochondrial DNA: Accurate initiation at the origin of light-strand synthesis

inferredcites →https://doi.org/10.1016/0092-8674(90)90370-topenalex-snapshot

A mechanism of formation of a persistent hybrid between elongating RNA and template DNA

inferredcites →https://doi.org/10.1016/0378-1119(93)90370-iopenalex-snapshot

Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB)

inferredcites →https://doi.org/10.1016/j.bbagrm.2011.11.005openalex-snapshot

Mitochondrial DNA nucleoid structure

inferredcites →https://doi.org/10.1016/j.cell.2017.10.036openalex-snapshot

Structural Basis of Mitochondrial Transcription Initiation

inferredcites →https://doi.org/10.1016/j.celrep.2014.05.046openalex-snapshot

In Vitro-Reconstituted Nucleoids Can Block Mitochondrial DNA Replication and Transcription

inferredcites →https://doi.org/10.1016/j.jmb.2006.02.073openalex-snapshot

A Novel Processive Mechanism for DNA Synthesis Revealed by Structure, Modeling and Mutagenesis of the Accessory Subunit of Human Mitochondrial DNA Polymerase

inferredcites →https://doi.org/10.1016/j.jmb.2008.01.035openalex-snapshot

Structure–Function Defects of the TWINKLE Linker Region in Progressive External Ophthalmoplegia

inferredcites →https://doi.org/10.1016/j.mito.2013.08.003openalex-snapshot

Exonuclease of human DNA polymerase gamma disengages its strand displacement function

inferredcites →https://doi.org/10.1016/j.molcel.2009.12.021openalex-snapshot

Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

inferredcites →https://doi.org/10.1016/j.molcel.2013.09.025openalex-snapshot

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

inferredcites →https://doi.org/10.1016/j.molcel.2017.11.033openalex-snapshot

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

inferredcites →https://doi.org/10.1016/j.tcb.2013.04.009openalex-snapshot

mtDNA makes a U-turn for the mitochondrial nucleoid

inferredcites →https://doi.org/10.1016/j.tibs.2014.07.003openalex-snapshot

Holliday junction processing enzymes as guardians of genome stability

inferredcites →https://doi.org/10.1016/j.tig.2005.11.007openalex-snapshot

Bacteriophage origins of mitochondrial replication and transcription proteins

inferredcites →https://doi.org/10.1016/s0006-3495(98)77988-3openalex-snapshot

Geometry and Physics of Catenanes Applied to the Study of DNA Replication

inferredcites →https://doi.org/10.1016/s0021-9258(18)42629-4openalex-snapshot

Purification and identification of subunit structure of the human mitochondrial DNA polymerase.

inferredcites →https://doi.org/10.1016/s0092-8674(00)80688-1openalex-snapshot

Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA

inferredcites →https://doi.org/10.1016/s1097-2765(03)00088-1openalex-snapshot

Failure to Produce Mitochondrial DNA Results in Embryonic Lethality in Rnaseh1 Null Mice

inferredcites →https://doi.org/10.1021/bi992104wopenalex-snapshot

Human Mitochondrial DNA Polymerase Holoenzyme: Reconstitution and Characterization

inferredcites →https://doi.org/10.1038/216647a0openalex-snapshot

Catenated Circular DNA Molecules in HeLa Cell Mitochondria

inferredcites →https://doi.org/10.1038/90058openalex-snapshot

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

inferredcites →https://doi.org/10.1038/embor.2012.161openalex-snapshot

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication

inferredcites →https://doi.org/10.1038/nature02517openalex-snapshot

Premature ageing in mice expressing defective mitochondrial DNA polymerase

inferredcites →https://doi.org/10.1038/nchembio.2102openalex-snapshot

Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes

inferredcites →https://doi.org/10.1038/ncomms2001openalex-snapshot

Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A

inferredcites →https://doi.org/10.1038/ncomms8303openalex-snapshot

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

inferredcites →https://doi.org/10.1038/ng.2501openalex-snapshot

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

inferredcites →https://doi.org/10.1038/nsmb.2159openalex-snapshot

The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA

inferredcites →https://doi.org/10.1038/nsmb.2160openalex-snapshot

Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

inferredcites →https://doi.org/10.1038/sj.emboj.7600257openalex-snapshot

Reconstitution of a minimal mtDNA replisome in vitro

inferredcites →https://doi.org/10.1038/sj.emboj.7601392openalex-snapshot

Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand

inferredcites →https://doi.org/10.1073/pnas.0805399105openalex-snapshot

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

inferredcites →https://doi.org/10.1073/pnas.1006026107openalex-snapshot

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

inferredcites →https://doi.org/10.1073/pnas.1109263108openalex-snapshot

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

inferredcites →https://doi.org/10.1073/pnas.1119738109openalex-snapshot

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

inferredcites →https://doi.org/10.1073/pnas.1503653112openalex-snapshot

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication

inferredcites →https://doi.org/10.1073/pnas.1512131112openalex-snapshot

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

inferredcites →https://doi.org/10.1073/pnas.1600537113openalex-snapshot

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

inferredcites →https://doi.org/10.1073/pnas.69.3.737openalex-snapshot

Replication of Mitochondrial DNA. Circular Replicative Intermediates in Mouse L Cells

inferredcites →https://doi.org/10.1073/pnas.77.5.2450openalex-snapshot

Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H.

inferredcites →https://doi.org/10.1073/pnas.78.10.6116openalex-snapshot

Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences.

inferredcites →https://doi.org/10.1073/pnas.82.2.351openalex-snapshot

Priming of human mitochondrial DNA replication occurs at the light-strand promoter.

inferredcites →https://doi.org/10.1074/jbc.272.24.15275openalex-snapshot

In Vivo Determination of Replication Origins of Human Mitochondrial DNA by Ligation-mediated Polymerase Chain Reaction

inferredcites →https://doi.org/10.1074/jbc.274.21.14779openalex-snapshot

Functional Interactions of Mitochondrial DNA Polymerase and Single-stranded DNA-binding Protein

inferredcites →https://doi.org/10.1074/jbc.274.53.38197openalex-snapshot

The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance

inferredcites →https://doi.org/10.1074/jbc.m105230200openalex-snapshot

The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit

inferredcites →https://doi.org/10.1074/jbc.m207030200openalex-snapshot

DNA Binding Properties of Human pol γB

inferredcites →https://doi.org/10.1074/jbc.m306981200openalex-snapshot

TWINKLE Has 5′ → 3′ DNA Helicase Activity and Is Specifically Stimulated by Mitochondrial Single-stranded DNA-binding Protein

inferredcites →https://doi.org/10.1074/jbc.m509730200openalex-snapshot

Functional Human Mitochondrial DNA Polymerase γ Forms a Heterotrimer

inferredcites →https://doi.org/10.1074/jbc.m602429200openalex-snapshot

Conserved Sequence Box II Directs Transcription Termination and Primer Formation in Mitochondria

inferredcites →https://doi.org/10.1091/mbc.e07-05-0404openalex-snapshot

The Mitochondrial Transcription Factor TFAM Coordinates the Assembly of Multiple DNA Molecules into Nucleoid-like Structures

inferredcites →https://doi.org/10.1093/hmg/ddh342openalex-snapshot

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number

inferredcites →https://doi.org/10.1093/hmg/ddi184openalex-snapshot

Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis

inferredcites →https://doi.org/10.1093/hmg/ddq163openalex-snapshot

High mitochondrial DNA copy number has detrimental effects in mice

inferredcites →https://doi.org/10.1093/hmg/dds506openalex-snapshot

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance

inferredcites →https://doi.org/10.1093/hmg/ddt051openalex-snapshot

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

inferredcites →https://doi.org/10.1093/hmg/ddu336openalex-snapshot

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease

inferredcites →https://doi.org/10.1093/molbev/msn225openalex-snapshot

Evidence for Variable Selective Pressures at a Large Secondary Structure of the Human Mitochondrial DNA Control Region

inferredcites →https://doi.org/10.1093/nar/13.5.1703openalex-snapshot

Characterization of a mitochondrial protein binding to single-stranded DNA

inferredcites →https://doi.org/10.1093/nar/8.12.2605openalex-snapshot

Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA

inferredcites →https://doi.org/10.1093/nar/gkq1224openalex-snapshot

TEFM (c17orf42) is necessary for transcription of human mtDNA

inferredcites →https://doi.org/10.1093/nar/gks802openalex-snapshot

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

inferredcites →https://doi.org/10.1093/nar/gkt196openalex-snapshot

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

inferredcites →https://doi.org/10.1093/nar/gku384openalex-snapshot

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II and II in vertebrate mitochondria

inferredcites →https://doi.org/10.1093/nar/gkv105openalex-snapshot

TEFM is a potent stimulator of mitochondrial transcription elongation in vitro

inferredcites →https://doi.org/10.1093/nar/gkv804openalex-snapshot

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element

inferredcites →https://doi.org/10.1093/nar/gkw350openalex-snapshot

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

inferredcites →https://doi.org/10.1111/j.1432-1033.1994.tb18756.xopenalex-snapshot

Single‐stranded‐DNA‐binding proteins from human mitochondria and Escherichia coli have analogous physicochemical properties

inferredcites →https://doi.org/10.1126/sciadv.1600963openalex-snapshot

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA

inferredcites →https://doi.org/10.1126/science.279.5356.1534openalex-snapshot

A Model for the Mechanism of Human Topoisomerase I

inferredcites →https://doi.org/10.1126/science.aaa0986openalex-snapshot

Replication-transcription switch in human mitochondria

inferredcites →https://doi.org/10.1126/science.aaf5549openalex-snapshot

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

inferredcites →https://doi.org/10.1128/mcb.00237-17openalex-snapshot

DNA Polymerase Beta Participates in Mitochondrial DNA Repair

inferredcites →https://doi.org/10.1128/mcb.05694-11openalex-snapshot

Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction

inferredcites →https://doi.org/10.1128/mcb.15.1.580openalex-snapshot

A Persistent RNA-DNA Hybrid Is Formed during Transcription at a Phylogenetically Conserved Mitochondrial DNA Sequence

inferredcites →https://doi.org/10.1128/mcb.19.5.3869openalex-snapshot

The Human DNA Ligase III Gene Encodes Nuclear and Mitochondrial Proteins

inferredcites →https://doi.org/10.1128/mcb.26.10.3935-3941.2006openalex-snapshot

Early Embryonic Lethality Due to Targeted Inactivation of DNA Ligase III

inferredcites →https://doi.org/10.1146/annurev-biochem-060815-014402openalex-snapshot

Maintenance and Expression of Mammalian Mitochondrial DNA

inferredcites →https://doi.org/10.1146/annurev.cb.07.110191.002321openalex-snapshot

Replication and Transcription of Vertebrate Mitochondrial DNA

inferredcites →https://doi.org/10.1371/journal.pgen.1004832openalex-snapshot

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

inferredcites →https://doi.org/10.1371/journal.pone.0041094openalex-snapshot

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

inferredcites →https://doi.org/10.1371/journal.pone.0119687openalex-snapshot

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

inferredcites →https://doi.org/10.1371/journal.pone.0140409openalex-snapshot

Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome

inferredcites →https://doi.org/10.2741/4510openalex-snapshot

DNA polymerases in the mitochondria A critical review of the evidence

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inferred← citeshttps://doi.org/10.1080/15384101.2019.1646563openalex-snapshot

Beyond the unwinding: role of TOP1MT in mitochondrial translation

inferred← citeshttps://doi.org/10.1080/15384101.2024.2314440openalex-snapshot

TOP3A coupling with replication forks and repair of TOP3A cleavage complexes

inferred← citeshttps://doi.org/10.1080/19490976.2019.1592421openalex-snapshot

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

inferred← citeshttps://doi.org/10.1093/brain/awag037openalex-snapshot

Mitochondrial DNA release and inflammation in mitochondrial disease pathogenesis

inferred← citeshttps://doi.org/10.1093/genetics/iyab116openalex-snapshot

Mitochondrial mutations in Caenorhabditis elegans show signatures of oxidative damage and an AT-bias

inferred← citeshttps://doi.org/10.1093/hmg/ddaa043openalex-snapshot

Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro

inferred← citeshttps://doi.org/10.1093/iob/obad029openalex-snapshot

Tissue Distribution of mtDNA Copy Number And Expression Pattern of An mtDNA-Related Gene in Three Teleost Fish Species

inferred← citeshttps://doi.org/10.1093/med/9780197574522.003.0014openalex-snapshot

Mitochondrial genetics and bipolar disorder

inferred← citeshttps://doi.org/10.1093/nar/gkaa622openalex-snapshot

MtDNA sequence features associated with ‘selfish genomes’ predict tissue-specific segregation and reversion

inferred← citeshttps://doi.org/10.1093/nar/gkaa804openalex-snapshot

Mechanisms of replication and repair in mitochondrial DNA deletion formation

inferred← citeshttps://doi.org/10.1093/nar/gkab770openalex-snapshot

A rapid method to visualize human mitochondrial DNA replication through rotary shadowing and transmission electron microscopy

inferred← citeshttps://doi.org/10.1093/nar/gkac1089openalex-snapshot

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

inferred← citeshttps://doi.org/10.1093/nar/gkac581openalex-snapshot

In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing

inferred← citeshttps://doi.org/10.1093/nar/gkac720openalex-snapshot

A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism

inferred← citeshttps://doi.org/10.1093/nar/gkad1204openalex-snapshot

Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome

inferred← citeshttps://doi.org/10.1093/nar/gkz056openalex-snapshot

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

inferred← citeshttps://doi.org/10.1093/noajnl/vdab191openalex-snapshot

Mitochondrial DNA copy number as a prognostic marker is age-dependent in adult glioblastoma

inferred← citeshttps://doi.org/10.1097/mop.0000000000000686openalex-snapshot

Mitochondrial disease genetics update: recent insights into the molecular diagnosis and expanding phenotype of primary mitochondrial disease

inferred← citeshttps://doi.org/10.1098/rsob.210168openalex-snapshot

Controlling the topology of mammalian mitochondrial DNA

inferred← citeshttps://doi.org/10.1101/2024.01.11.575236openalex-snapshot

Increased mitochondrial transcription initiation does not promote oxidative phosphorylation

inferred← citeshttps://doi.org/10.1101/2025.02.19.638439openalex-snapshot

A Quantitative Look at Mitochondrial DNA in Genealogy

inferred← citeshttps://doi.org/10.1101/2025.06.05.657263openalex-snapshot

Unique molecular identifier-based single strand mitochondrial DNA sequencing for rare substitution mutations

inferred← citeshttps://doi.org/10.1101/842617openalex-snapshot

DNA repair and mutagenesis in vertebrate mitochondria: evidence for the asymmetric DNA strand inheritance

inferred← citeshttps://doi.org/10.1111/joim.13064openalex-snapshot

Mitochondrial diseases in adults

inferred← citeshttps://doi.org/10.1126/sciadv.adw4954openalex-snapshot

Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations

inferred← citeshttps://doi.org/10.1126/scitranslmed.abl6992openalex-snapshot

SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA

inferred← citeshttps://doi.org/10.1128/msystems.01002-22openalex-snapshot

Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation

inferred← citeshttps://doi.org/10.1134/s0006297919080042openalex-snapshot

DNA Replication in Human Mitochondria

inferred← citeshttps://doi.org/10.1146/annurev-biochem-052621-092014openalex-snapshot

Replication and Transcription of Human Mitochondrial DNA

inferred← citeshttps://doi.org/10.1152/ajpcell.00508.2020openalex-snapshot

Mitochondrial functional resilience after TFAM ablation in the adult heart

inferred← citeshttps://doi.org/10.1152/ajpheart.00686.2025openalex-snapshot

Mitochondrial DNA is an important signaling molecule in cardiovascular aging and pathophysiology

inferred← citeshttps://doi.org/10.1152/ajpheart.00905.2025openalex-snapshot

Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs

inferred← citeshttps://doi.org/10.1155/2024/5577506openalex-snapshot

Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell‐Related Diseases

inferred← citeshttps://doi.org/10.11606/d.17.2024.tde-30072024-131423openalex-snapshot

Caracterização clínica e laboratorial de pacientes com oftalmoplegia externa progressiva crônica causada por deleção única do DNA mitocondrial

inferred← citeshttps://doi.org/10.1161/circresaha.126.328769openalex-snapshot

Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease

inferred← citeshttps://doi.org/10.1186/s12863-021-01005-xopenalex-snapshot

The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection

inferred← citeshttps://doi.org/10.1186/s12864-025-11480-6openalex-snapshot

Enhanced dynamicity: evolutionary insights into amphibian mitogenomes architecture

inferred← citeshttps://doi.org/10.1186/s12915-019-0668-yopenalex-snapshot

Mitochondrial DNA: the overlooked oncogenome?

inferred← citeshttps://doi.org/10.1186/s12929-023-00967-7openalex-snapshot

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations

inferred← citeshttps://doi.org/10.1186/s12964-026-03033-5openalex-snapshot

R-loops and D-loops: a delicate balance in genomic stability and instability

inferred← citeshttps://doi.org/10.1186/s13071-019-3492-xopenalex-snapshot

Long-read sequencing reveals a 4.4 kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1

inferred← citeshttps://doi.org/10.12688/f1000research.21490.1openalex-snapshot

Recent advances in understanding mitochondrial genome diversity

inferred← citeshttps://doi.org/10.1371/journal.pbio.3000745openalex-snapshot

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

inferred← citeshttps://doi.org/10.1371/journal.pgen.1009808openalex-snapshot

Decreasing mitochondrial RNA polymerase activity reverses biased inheritance of hypersuppressive mtDNA

inferred← citeshttps://doi.org/10.1515/hsz-2021-0416openalex-snapshot

Starting the engine of the powerhouse: mitochondrial transcription and beyond

inferred← citeshttps://doi.org/10.15252/embj.2022113256openalex-snapshot

Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

inferred← citeshttps://doi.org/10.18297/etd/3748openalex-snapshot

Investigation of mitochondrial inheritance in the smut fungus sporisorium reilianum.

inferred← citeshttps://doi.org/10.20517/2574-1209.2022.28openalex-snapshot

Challenges of mitochondrial DNA editing in mammalian cells: focus on treatment of cardiovascular disease

inferred← citeshttps://doi.org/10.21248/gups.86244openalex-snapshot

Interaction proteomics display the spatio-temporal complexity of mitochondrial RNA granules

inferred← citeshttps://doi.org/10.2147/ijn.s537166openalex-snapshot

Mitochondrial Transplantation: A Paradigm Shift in Osteoporosis Therapy

inferred← citeshttps://doi.org/10.2174/1573396319666221221110728openalex-snapshot

Mitochondria in Early Life

inferred← citeshttps://doi.org/10.2478/enr-2022-0025openalex-snapshot

Mitochondria and mitochondrial disorders: an overview update

inferred← citeshttps://doi.org/10.26508/lsa.202302563openalex-snapshot

POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels

inferred← citeshttps://doi.org/10.26686/wgtn.17145686openalex-snapshot

Investigations of Intercellular Mitochondrial Transfer in Neural Cells by Applied Single Molecule Genotyping

inferred← citeshttps://doi.org/10.26686/wgtn.17145686.v1openalex-snapshot

Investigations of Intercellular Mitochondrial Transfer in Neural Cells by Applied Single Molecule Genotyping

inferred← citeshttps://doi.org/10.31083/j.fbl2706172openalex-snapshot

Mitochondrial DNA in Visceral Adipose Tissue in Severe Obesity: From Copy Number to D-Loop Methylation

inferred← citeshttps://doi.org/10.31489/2026feb3/30-42openalex-snapshot

Evidence for asymmetric DNA strand inheritance in vertebrate mitochondria

inferred← citeshttps://doi.org/10.3233/jad-200286openalex-snapshot

Mitochondrial DNA Manipulations Affect Tau Oligomerization

inferred← citeshttps://doi.org/10.3389/fcell.2021.773381openalex-snapshot

The Novel LncRNA AK035396 Drives Cardiomyocyte Apoptosis Through Mterf1 in Myocardial Ischemia/Reperfusion Injury

inferred← citeshttps://doi.org/10.3389/fimmu.2020.00521openalex-snapshot

Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity

inferred← citeshttps://doi.org/10.3389/fopht.2023.1309836openalex-snapshot

Mitochondrial DNA D-loop variants correlate with a primary open-angle glaucoma subgroup

inferred← citeshttps://doi.org/10.3390/antiox10071022openalex-snapshot

The Use of Antioxidants as Potential Co-Adjuvants to Treat Chronic Chagas Disease

inferred← citeshttps://doi.org/10.3390/biom15091337openalex-snapshot

The First Heterozygous TWNK Nonsense Mutation Associated with Progressive External Ophthalmoplegia: Evidence for a New Piece in the Puzzle of Mitochondrial Diseases

inferred← citeshttps://doi.org/10.3390/biom16081116openalex-snapshot

A Function-Centric Framework for Mitochondrial Quality Control

inferred← citeshttps://doi.org/10.3390/biomedicines11061598openalex-snapshot

Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment

inferred← citeshttps://doi.org/10.3390/biomedicines8120591openalex-snapshot

Mitochondrial Dysfunction in Parkinson’s Disease: Focus on Mitochondrial DNA

inferred← citeshttps://doi.org/10.3390/cancers15204986openalex-snapshot

R-Loops in Genome Instability and Cancer

inferred← citeshttps://doi.org/10.3390/genes11020192openalex-snapshot

Pathogenic Mitochondria DNA Mutations: Current Detection Tools and Interventions

inferred← citeshttps://doi.org/10.3390/genes11050585openalex-snapshot

The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links

inferred← citeshttps://doi.org/10.3390/genes12121866openalex-snapshot

Saccharomyces cerevisiae as a Tool for Studying Mutations in Nuclear Genes Involved in Diseases Caused by Mitochondrial DNA Instability

inferred← citeshttps://doi.org/10.3390/genes13010125openalex-snapshot

Characterisation of the Complete Mitochondrial Genome of Critically Endangered Mustela lutreola (Carnivora: Mustelidae) and Its Phylogenetic and Conservation Implications

inferred← citeshttps://doi.org/10.3390/genes15050617openalex-snapshot

Mitochondrial DNA: Inherent Complexities Relevant to Genetic Analyses

inferred← citeshttps://doi.org/10.3390/ijms20112770openalex-snapshot

Organization of DNA in Mammalian Mitochondria

inferred← citeshttps://doi.org/10.3390/ijms21010013openalex-snapshot

How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor

inferred← citeshttps://doi.org/10.3390/ijms21051706openalex-snapshot

One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA

inferred← citeshttps://doi.org/10.3390/ijms21072350openalex-snapshot

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway

inferred← citeshttps://doi.org/10.3390/ijms21113883openalex-snapshot

Mitochondrial Inheritance in Phytopathogenic Fungi—Everything Is Known, or Is It?

inferred← citeshttps://doi.org/10.3390/ijms22041811openalex-snapshot

Nanopore Sequencing Resolves Elusive Long Tandem-Repeat Regions in Mitochondrial Genomes

inferred← citeshttps://doi.org/10.3390/ijms222313059openalex-snapshot

Mitochondrial Biogenesis in Neurons: How and Where

inferred← citeshttps://doi.org/10.3390/ijms24108481openalex-snapshot

17β-Estradiol Induced Sex Reversal and Gonadal Transcriptome Analysis in the Oriental River Prawn (Macrobrachium nipponense): Mechanisms, Pathways, and Potential Harm

inferred← citeshttps://doi.org/10.3390/ijms24119430openalex-snapshot

The C-Terminal Tail of Mitochondrial Transcription Factor A Is Dispensable for Mitochondrial DNA Replication and Transcription In Situ

inferred← citeshttps://doi.org/10.3390/ijms24119711openalex-snapshot

Dynamic Patterns of Mammalian Mitochondrial DNA Replication Uncovered Using SSiNGLe-5′ES

inferred← citeshttps://doi.org/10.3390/ijms241512062openalex-snapshot

Genome-Wide Profiling of Endogenous Single-Stranded DNA Using the SSiNGLe-P1 Method

inferred← citeshttps://doi.org/10.3390/ijms262110275openalex-snapshot

Mitochondrial DNA Replication and Disease: A Historical Perspective on Molecular Insights and Therapeutic Advances

inferred← citeshttps://doi.org/10.3390/life10090164openalex-snapshot

The Maintenance of Mitochondrial DNA Integrity and Dynamics by Mitochondrial Membranes

inferred← citeshttps://doi.org/10.3390/life11121351openalex-snapshot

Mitochondria and Their Relationship with Common Genetic Abnormalities in Hematologic Malignancies

inferred← citeshttps://doi.org/10.3390/life13091923openalex-snapshot

Mitochondrial DNA Copy Number Drives the Penetrance of Acute Intermittent Porphyria

inferred← citeshttps://doi.org/10.3390/pharmaceutics13060810openalex-snapshot

Engineering Genetic Systems for Treating Mitochondrial Diseases

inferred← citeshttps://doi.org/10.3390/plants8120533openalex-snapshot

Structure–Function Analysis Reveals the Singularity of Plant Mitochondrial DNA Replication Components: A Mosaic and Redundant System

inferred← citeshttps://doi.org/10.3410/f.736145727.793565296openalex-snapshot

Faculty Opinions recommendation of Mitochondrial DNA: the overlooked oncogenome?

inferred← citeshttps://doi.org/10.3892/br.2020.1292openalex-snapshot

Evaluation of non‑coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity

inferred← citeshttps://doi.org/10.3892/ijmm.2022.5160openalex-snapshot

Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)

inferred← citeshttps://doi.org/10.3892/mmr.2025.13443openalex-snapshot

Mitochondrial DNA copy number alterations: Key players in the complexity of glioblastoma (Review)

inferred← citeshttps://doi.org/10.4103/fjs.fjs_15_20openalex-snapshot

Role of mitochondrial DNA copy number alteration in non-small cell lung cancer

inferred← citeshttps://doi.org/10.5005/jp-journals-11002-0053openalex-snapshot

Mitochondrial Dynamics during Development

inferred← citeshttps://doi.org/10.5114/wo.2022.115674openalex-snapshot

Research highlights on contributions of mitochondrial DNA microsatellite instability in solid cancers – an overview

inferred← citeshttps://doi.org/10.52547/jrums.21.12.1307openalex-snapshot

Genetic Analysis of D-Loop Region of Mitochondrial DNA Sequence in Iranian Patients with Familial Adenomatous Polyposis (FAP): A Case-Control Study

inferred← citeshttps://doi.org/10.53846/goediss-9880openalex-snapshot

Monitoring mitochondrial translation with spatial resolution and high throughput strategies

inferred← citeshttps://doi.org/10.70675/381af2e4zf397z4e20z8f8dz5b80b0f86450openalex-snapshot

Could the overexpression of neuroglobin, via an intravenous administration of an AAV2/9 vector, durably attenuate cerebellar ataxia in Harlequin mice by preserving mitochondrial homeostasis?

inferred← citeshttps://doi.org/10.70675/7d145f6az2700z4c8bzad56z3286d493fb31openalex-snapshot

Maintenance télomérique : intérêt dans le diagnostic des gliomes en lien avec le métabolisme mitochondrial

inferred← citeshttps://doi.org/10.70675/a6e97303z9403z43f4zb4b3ze23004da7753openalex-snapshot

OEX1, une exonuclease/flap endonuclease nécessaire à la stabilité du génome mitochondrial d'arabidopsis thaliana

inferred← citeshttps://doi.org/10.70675/b7c67c11z879ez4065z9186zf5e18b62eadeopenalex-snapshot

Le stress mitochondrial induit par le Virus de l’Herpès Simplex de type 1 entraîne la surexpression de la cytidine désaminase APOBEC3A

inferred← citeshttps://doi.org/10.70675/de3add71zf189z451cz9f97z14b635db330copenalex-snapshot

Infections virales, stress mitochondrial, et cytidines désaminases APOBEC3

inferred← citeshttps://doi.org/10.7868/s0032874x25050032openalex-snapshot

Birds mitochondrion – ultimate life-form or “clock-bomb”?

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