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Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function
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Modulation of Chaperone Function and Cochaperone Interaction by Novobiocin in the C-terminal Domain of Hsp90
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Nelfinavir Plasma Levels Under Twice-Daily and Three-Times-Daily Regimens: High Interpatient and Low Intrapatient Variability
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Repositioning HIV protease inhibitors as cancer therapeutics
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The Consensus Coding Sequences of Human Breast and Colorectal Cancers
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Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy
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HIV Protease Inhibitor Nelfinavir Inhibits Growth of Human Melanoma Cells by Induction of Cell Cycle Arrest
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Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer
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Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo
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Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
inferredcites →https://doi.org/10.1177/135965350501000203openalex-snapshot
The HIV Protease Inhibitors Nelfinavir and Saquinavir, but Not a Variety of HIV Reverse Transcriptase Inhibitors, Adversely Affect Human Proteasome Function
inferredcites →https://doi.org/10.1186/bcr51openalex-snapshot
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
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The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patients With Mutations in BRCA1 and BRCA2
inferredcites →https://doi.org/10.1200/jco.2007.15.2355openalex-snapshot
Phase I Trial of the Human Immunodeficiency Virus Protease Inhibitor Nelfinavir and Chemoradiation for Locally Advanced Pancreatic Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0004009openalex-snapshot
Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes
inferredcites →https://doi.org/10.1593/neo.07124openalex-snapshot
The HIV Protease Inhibitor Nelfinavir Downregulates Akt Phosphorylation by Inhibiting Proteasomal Activity and Inducing the Unfolded Protein Response
inferredcites →https://doi.org/10.2174/156802609789895728openalex-snapshot
Update on Hsp90 Inhibitors in Clinical Trial
inferredcites →https://doi.org/10.3892/or_00001034openalex-snapshot
Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation
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BindingDB Entry 50022499: ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Breast cancer characteristics and HIV among 1,092 women in Soweto, South Africa
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The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition
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inferred← citeshttps://doi.org/10.1016/j.bbcan.2018.05.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.biochi.2016.01.014openalex-snapshot
Nelfinavir targets multiple drug resistance mechanisms to increase the efficacy of doxorubicin in MCF-7/Dox breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2017.09.009openalex-snapshot
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.12.015openalex-snapshot
Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments
inferred← citeshttps://doi.org/10.1016/j.ctro.2016.12.002openalex-snapshot
The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.05.073openalex-snapshot
Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e05948openalex-snapshot
Drug combination and repurposing for cancer therapy: the example of breast cancer
inferred← citeshttps://doi.org/10.1016/j.leukres.2013.12.017openalex-snapshot
Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations
inferred← citeshttps://doi.org/10.1016/j.tips.2020.02.005openalex-snapshot
Multiparametric Assays for Accelerating Early Drug Discovery
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Drug-Repurposing Screening Identifies a Gallic Acid Binding Site on SARS-CoV-2 Non-structural Protein 7
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Eighth Korea–Japan Chemical Biology symposium: chemical biology notes from a small island
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Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death
inferred← citeshttps://doi.org/10.1038/s41416-024-02774-9openalex-snapshot
HIV-protease inhibitors potentiate the activity of carfilzomib in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/srep09698openalex-snapshot
Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer
inferred← citeshttps://doi.org/10.1093/jnci/djt238openalex-snapshot
Re: Selective Inhibition of Her2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir
inferred← citeshttps://doi.org/10.1097/cco.0b013e328363dfeeopenalex-snapshot
Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention
inferred← citeshttps://doi.org/10.1097/qad.0000000000001053openalex-snapshot
Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?
inferred← citeshttps://doi.org/10.1097/qad.0b013e3283635232openalex-snapshot
Association of early HIV viremia with mortality after HIV-associated lymphoma
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Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
inferred← citeshttps://doi.org/10.1128/jvi.03790-13openalex-snapshot
Nelfinavir Inhibits Maturation and Export of Herpes Simplex Virus 1
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Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer
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Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
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Promising activity of nelfinavir-bortezomib-dexamethasone in proteasome inhibitor–refractory multiple myeloma
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The HIV Protease Inhibitor Nelfinavir Down-Regulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells
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Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity
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Faculty Opinions recommendation of Association of early HIV viremia with mortality after HIV-associated lymphoma.
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[A report of lung adenocarcinoma with HIV carrier and the literature review].
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Rhizoma Pinelliae trypsin inhibitor separation, purification and inhibitory activity on the proliferation of BGC-823 gastric adenocarcinoma cells
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Factors that contribute to B cell oncogenesis in people living with HIV
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