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Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.279.17.1343openalex-snapshot
Antiretroviral Therapy for HIV Infection
inferredcites →https://doi.org/10.1002/hed.23664openalex-snapshot
Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial
inferredcites →https://doi.org/10.1002/ijc.23993openalex-snapshot
An HIV protease inhibitor, ritonavir targets the nuclear factor‐kappaB and inhibits the tumor growth and infiltration of EBV‐positive lymphoblastoid B cells
inferredcites →https://doi.org/10.1002/jcb.24513openalex-snapshot
Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: Potential role of the NFkappa B pathway
inferredcites →https://doi.org/10.1007/s00280-012-1961-4openalex-snapshot
Phase I study of nelfinavir in liposarcoma
inferredcites →https://doi.org/10.1007/s00280-013-2156-3openalex-snapshot
Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo
inferredcites →https://doi.org/10.1007/s10637-009-9281-1openalex-snapshot
Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib
inferredcites →https://doi.org/10.1007/s11060-013-1303-3openalex-snapshot
A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme
inferredcites →https://doi.org/10.1007/s11912-009-0016-4openalex-snapshot
Perifosine: Update on a novel Akt inhibitor
inferredcites →https://doi.org/10.1016/0092-8674(94)90234-8openalex-snapshot
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
inferredcites →https://doi.org/10.1016/j.archoralbio.2009.12.001openalex-snapshot
HIV protease inhibitors block oral epithelial cell DNA synthesis
inferredcites →https://doi.org/10.1016/j.arcmed.2012.04.005openalex-snapshot
Matrix Metalloproteinase-2 and -9 in Glioblastoma: A Trio of Old Drugs—Captopril, Disulfiram and Nelfinavir—Are Inhibitors with Potential as Adjunctive Treatments in Glioblastoma
inferredcites →https://doi.org/10.1016/j.bbrc.2008.10.167openalex-snapshot
Nelfinavir induces TRAIL receptor upregulation in ovarian cancer cells
inferredcites →https://doi.org/10.1016/j.canlet.2009.03.007openalex-snapshot
Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress
inferredcites →https://doi.org/10.1016/j.canlet.2012.05.030openalex-snapshot
Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors
inferredcites →https://doi.org/10.1016/j.ijrobp.2009.03.004openalex-snapshot
Radiation Response in Two HPV-Infected Head-and-Neck Cancer Cell Lines in Comparison to a Non–HPV-Infected Cell Line and Relationship to Signaling Through AKT
inferredcites →https://doi.org/10.1016/j.leukres.2008.06.010openalex-snapshot
PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines
inferredcites →https://doi.org/10.1016/j.leukres.2013.12.017openalex-snapshot
Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations
inferredcites →https://doi.org/10.1016/j.radonc.2013.03.023openalex-snapshot
Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer
inferredcites →https://doi.org/10.1016/j.taap.2012.08.011openalex-snapshot
Inhibin beta E is upregulated by drug-induced endoplasmic reticulum stress as a transcriptional target gene of ATF4
inferredcites →https://doi.org/10.1016/j.urology.2011.11.033openalex-snapshot
Ritonavir Interacts With Bortezomib to Enhance Protein Ubiquitination and Histone Acetylation Synergistically in Renal Cancer Cells
inferredcites →https://doi.org/10.1016/j.ygyno.2008.11.028openalex-snapshot
The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells
inferredcites →https://doi.org/10.1016/s0092-8674(00)81360-4openalex-snapshot
A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response
inferredcites →https://doi.org/10.1016/s0163-7827(02)00046-2openalex-snapshot
Effects of HIV protease inhibitor therapy on lipid metabolism
inferredcites →https://doi.org/10.1016/s0167-8140(01)00311-5openalex-snapshot
Ionizing radiation affects 26s proteasome function and associated molecular responses, even at low doses
inferredcites →https://doi.org/10.1016/s0190-9622(98)70124-0openalex-snapshot
Regression of Kaposi’s sarcoma during therapy with HIV-1 protease inhibitors: A prospective pilot study
inferredcites →https://doi.org/10.1016/s1470-2045(03)01192-6openalex-snapshot
Use of HIV protease inhibitors to block Kaposi's sarcoma and tumour growth
inferredcites →https://doi.org/10.1016/s1470-2045(08)70334-6openalex-snapshot
Anti-HIV drugs for cancer therapeutics: back to the future?
inferredcites →https://doi.org/10.1016/s1734-1140(13)71075-2openalex-snapshot
Metabolic effects of the HIV protease inhibitor – saquinavir in differentiating human preadipocytes
inferredcites →https://doi.org/10.1038/bcj.2013.2openalex-snapshot
Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance
inferredcites →https://doi.org/10.1038/bjc.2011.275openalex-snapshot
Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells
inferredcites →https://doi.org/10.1038/bjc.2014.272openalex-snapshot
Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation
inferredcites →https://doi.org/10.1038/cddis.2012.87openalex-snapshot
Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells
inferredcites →https://doi.org/10.1038/cddis.2013.206openalex-snapshot
Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential
inferredcites →https://doi.org/10.1038/nm0302-225openalex-snapshot
HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma
inferredcites →https://doi.org/10.1038/sj.bjc.6603435openalex-snapshot
NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines
inferredcites →https://doi.org/10.1038/sj.onc.1209990openalex-snapshot
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
inferredcites →https://doi.org/10.1073/pnas.050010197openalex-snapshot
mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response
inferredcites →https://doi.org/10.1073/pnas.95.22.13120openalex-snapshot
An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses
inferredcites →https://doi.org/10.1074/jbc.274.50.35734openalex-snapshot
How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity
inferredcites →https://doi.org/10.1074/jbc.m104557200openalex-snapshot
HIV Protease Inhibitor Induces Fatty Acid and Sterol Biosynthesis in Liver and Adipose Tissues Due to the Accumulation of Activated Sterol Regulatory Element-binding Proteins in the Nucleus
inferredcites →https://doi.org/10.1074/jbc.m110.197665openalex-snapshot
Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)
inferredcites →https://doi.org/10.1074/jbc.m607007200openalex-snapshot
Endoplasmic Reticulum Stress Triggers Autophagy
inferredcites →https://doi.org/10.1093/jnci/djs396openalex-snapshot
Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir
inferredcites →https://doi.org/10.1093/toxsci/kfp140openalex-snapshot
Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening
inferredcites →https://doi.org/10.1097/00002030-199807000-00002openalex-snapshot
Clinical and biological impact of antiretroviral therapy with protease inhibitors on HIV-related Kaposiʼs sarcoma
inferredcites →https://doi.org/10.1097/00002030-199906180-00026openalex-snapshot
Complete regression of AIDS-related Kaposi‚s sarcoma in a child treated with highly active antiretroviral therapy
inferredcites →https://doi.org/10.1097/00002030-200209060-00005openalex-snapshot
The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1)
inferredcites →https://doi.org/10.1097/01.cad.0000224448.08706.76openalex-snapshot
Nelfinavir induces liposarcoma apoptosis and cell cycle arrest by upregulating sterol regulatory element binding protein-1
inferredcites →https://doi.org/10.1097/cco.0b013e328363dfeeopenalex-snapshot
Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention
inferredcites →https://doi.org/10.1097/coh.0b013e328313915dopenalex-snapshot
Repositioning HIV protease inhibitors as cancer therapeutics
inferredcites →https://doi.org/10.1097/jto.0b013e3182435aa6openalex-snapshot
A Phase I Trial of the HIV Protease Inhibitor Nelfinavir with Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer: A Report of Toxicities and Clinical Response
inferredcites →https://doi.org/10.1097/qad.0b013e328351f7a5openalex-snapshot
Ritonavir or saquinavir impairs the invasion of cervical intraepithelial neoplasia cells via a reduction of MMP expression and activity
inferredcites →https://doi.org/10.1097/qai.0b013e3181aa13c7openalex-snapshot
The Impact of Nelfinavir Exposure on Cancer Development Among a Large Cohort of HIV-Infected Patients
inferredcites →https://doi.org/10.1101/gad.12.20.3182openalex-snapshot
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
inferredcites →https://doi.org/10.1109/iembs.2010.5626274openalex-snapshot
Quantitative analysis of tumor vascular structure after drug treatment
inferredcites →https://doi.org/10.1111/j.1349-7006.2005.00063.xopenalex-snapshot
HIV‐1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling
inferredcites →https://doi.org/10.1111/j.1349-7006.2010.01724.xopenalex-snapshot
CH05‐10, a novel indinavir analog, is a broad‐spectrum antitumor agent that induces cell cycle arrest, apoptosis, endoplasmic reticulum stress and autophagy
inferredcites →https://doi.org/10.1111/j.1742-4658.2012.08619.xopenalex-snapshot
Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein‐1 and activating transcription factor 6 in castration‐resistant prostate cancer
inferredcites →https://doi.org/10.1124/dmd.108.022046openalex-snapshot
Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
inferredcites →https://doi.org/10.1124/jpet.104.065342openalex-snapshot
HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
inferredcites →https://doi.org/10.1124/jpet.104.077263openalex-snapshot
Protease Inhibitor Treatments Reveal Specific Involvement of Matrix Metalloproteinase-9 in Human Adipocyte Differentiation
inferredcites →https://doi.org/10.1124/jpet.106.111849openalex-snapshot
Inhibition of Human Preadipocyte Proteasomal Activity by HIV Protease Inhibitors or Specific Inhibitor Lactacystin Leads to a Defect in Adipogenesis, Which Involves Matrix Metalloproteinase-9
inferredcites →https://doi.org/10.1126/science.1106148openalex-snapshot
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
inferredcites →https://doi.org/10.1128/aac.45.4.1086-1093.2001openalex-snapshot
Circulating Metabolites of the Human Immunodeficiency Virus Protease Inhibitor Nelfinavir in Humans: Structural Identification, Levels in Plasma, and Antiviral Activities
inferredcites →https://doi.org/10.1158/0008-5472.can-05-1220openalex-snapshot
HIV Protease Inhibitors Block Akt Signaling and Radiosensitize Tumor Cells Both In vitro and In vivo
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1239openalex-snapshot
Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3377openalex-snapshot
HIV Protease Inhibitor Nelfinavir Inhibits Growth of Human Melanoma Cells by Induction of Cell Cycle Arrest
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3398openalex-snapshot
Phosphatase and Tensin Homologue Deficiency in Glioblastoma Confers Resistance to Radiation and Temozolomide that Is Reversed by the Protease Inhibitor Nelfinavir
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3684openalex-snapshot
HIV Protease Inhibitors Enhance the Efficacy of Irradiation
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0796openalex-snapshot
HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2782openalex-snapshot
Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-0161openalex-snapshot
Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo
inferredcites →https://doi.org/10.1158/1078-0432.ccr-09-1324openalex-snapshot
Radiosensitization of Epidermal Growth Factor Receptor/HER2–Positive Pancreatic Cancer Is Mediated by Inhibition of Akt Independent of Ras Mutational Status
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-3216openalex-snapshot
Nelfinavir Induces Liposarcoma Apoptosis through Inhibition of Regulated Intramembrane Proteolysis of SREBP-1 and ATF6
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-1407openalex-snapshot
Akt Inhibitors MK-2206 and Nelfinavir Overcome mTOR Inhibitor Resistance in Diffuse Large B-cell Lymphoma
inferredcites →https://doi.org/10.1158/1535-7163.473.3.4openalex-snapshot
HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0998openalex-snapshot
The antitumor properties of a nontoxic, nitric oxide–modified version of saquinavir are independent of Akt
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0497openalex-snapshot
Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0321openalex-snapshot
Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas
inferredcites →https://doi.org/10.1161/01.atv.20.12.2625openalex-snapshot
HIV Protease Inhibitors Stimulate Hepatic Triglyceride Synthesis
inferredcites →https://doi.org/10.1177/135965350501000203openalex-snapshot
The HIV Protease Inhibitors Nelfinavir and Saquinavir, but Not a Variety of HIV Reverse Transcriptase Inhibitors, Adversely Affect Human Proteasome Function
inferredcites →https://doi.org/10.1177/135965350601100607openalex-snapshot
Specific HIV Protease Inhibitors Inhibit the Ability of Hpv16 E6 to Degrade P53 and Selectively Kill E6-Dependent Cervical Carcinoma Cells In Vitro
inferredcites →https://doi.org/10.1177/135965350601100812openalex-snapshot
Nelfinavir Induces Adipocyte Insulin Resistance through the Induction of Oxidative Stress: Differential Protective Effect of Antioxidant Agents
inferredcites →https://doi.org/10.1177/1947601910383011openalex-snapshot
The Unfolded Protein Response, Degradation from the Endoplasmic Reticulum, and Cancer
inferredcites →https://doi.org/10.1179/1973947812y.0000000011openalex-snapshot
Antitumour effects of a protease inhibitor, nelfinavir, in hepatocellular carcinoma cancer cells
inferredcites →https://doi.org/10.1182/blood.v96.10.3553openalex-snapshot
HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells
inferredcites →https://doi.org/10.1186/1476-4598-9-19openalex-snapshot
The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization
inferredcites →https://doi.org/10.1186/bcr2602openalex-snapshot
Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells
inferredcites →https://doi.org/10.1200/jco.2007.15.2355openalex-snapshot
Phase I Trial of the Human Immunodeficiency Virus Protease Inhibitor Nelfinavir and Chemoradiation for Locally Advanced Pancreatic Cancer
inferredcites →https://doi.org/10.1210/jc.2013-3369openalex-snapshot
The HIV Protease Inhibitor Nelfinavir Down-Regulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells
inferredcites →https://doi.org/10.1345/aph.18089openalex-snapshot
Nelfinavir Mesylate: A Protease Inhibitor
inferredcites →https://doi.org/10.1371/journal.pcbi.1002037openalex-snapshot
Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
inferredcites →https://doi.org/10.1371/journal.pone.0011052openalex-snapshot
Dendritic Cells/Natural Killer Cross-Talk: A Novel Target for Human Immunodeficiency Virus Type-1 Protease Inhibitors
inferredcites →https://doi.org/10.1371/journal.pone.0103109openalex-snapshot
Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells
inferredcites →https://doi.org/10.1530/erc-13-0473openalex-snapshot
Repositioning therapy for thyroid cancer: new insights on established medications
inferredcites →https://doi.org/10.1593/neo.06535openalex-snapshot
HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells
inferredcites →https://doi.org/10.18632/oncotarget.2415openalex-snapshot
A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors
inferredcites →https://doi.org/10.18632/oncotarget.969openalex-snapshot
A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
inferredcites →https://doi.org/10.2174/156800911796798913openalex-snapshot
Bortezomib Targets the Caspase-Like Proteasome Activity in Cervical Cancer Cells, Triggering Apoptosis That Can be Enhanced by Nelfinavir
inferredcites →https://doi.org/10.3109/10428194.2013.781168openalex-snapshot
Identification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignancies
inferredcites →https://doi.org/10.3171/foc-07/10/e9openalex-snapshot
Nelfinavir potentiation of imatinib cytotoxicity in meningioma cells via survivin inhibition
inferredcites →https://doi.org/10.3324/haematol.2011.049981openalex-snapshot
The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo
inferredcites →https://doi.org/10.3785/j.issn.1008-9292.2004.04.008openalex-snapshot
[Impairment of IRS-2 signaling in rat insulinoma INS-1 cells by nelfinavir].
inferredcites →https://doi.org/10.3892/or.2011.1582openalex-snapshot
In vitro anti-neuroblastoma activity of saquinavir and its association with imatinib
inferredcites →https://doi.org/10.3892/or.2012.1840openalex-snapshot
Unique antineoplastic profile of Saquinavir-NO, a novel NO-derivative of the protease inhibitor Saquinavir, on the in vitro and in vivo tumor formation of A375 human melanoma cells
inferredcites →https://doi.org/10.4161/auto.5224openalex-snapshot
Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy
inferredcites →https://doi.org/10.4161/cbt.12.7.17172openalex-snapshot
Nelfinavir induces radiation sensitization in pituitary adenoma cells
inferredcites →https://doi.org/10.4161/cbt.7.5.5728openalex-snapshot
Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans
inferredcites →https://doi.org/10.4161/cbt.7.5.6087openalex-snapshot
Progress towards the use of HIV proteases in cancer therapy
inferredcites →https://doi.org/10.4161/cbt.8.20.9596openalex-snapshot
Signaling pathways in adenoid cystic cancers: Implications for treatment
inferredcites →https://doi.org/10.4161/cbt.8.3.7339openalex-snapshot
Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis
inferredcites →https://doi.org/10.4161/cc.7.24.7244openalex-snapshot
Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors
inferredcites →https://doi.org/10.4269/ajtmh.2010.09-0427openalex-snapshot
HIV Protease Inhibitors, Indinavir or Nelfinavir, Augment Antimalarial Action of Artemisinin in vitro
inferredcites →https://doi.org/10.6064/2012/857516openalex-snapshot
Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Photoinduced Electron Donor–Acceptor Complex Strategy for Forging CS Bond via β ‐Fragmentation of Alkoxy Radicals
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Diversity‐Oriented Synthesis of Diol‐Based Peptidomimetics as Potential HIV Protease Inhibitors and Antitumor Agents
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HIV‐1, HAART and cancer: A complex relationship
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Drug repurposing in oncology: Bridging computational discovery to clinical application
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Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum
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inferred← citeshttps://doi.org/10.1007/978-3-031-81728-1_17openalex-snapshot
Theoretical Analysis of Repurposed Drugs Invoking CDFT-Based Descriptors
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Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis
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Nanotechnology Based Repositioning of an Anti-Viral Drug for Non-Small Cell Lung Cancer (NSCLC)
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The effect of fenofibrate, a PPARα activator on toll-like receptor-4 signal transduction in melanoma both in vitro and in vivo
inferred← citeshttps://doi.org/10.1007/s44178-023-00064-7openalex-snapshot
Role of signaling pathways in the interaction between microbial, inflammation and cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-819059-3.00012-5openalex-snapshot
The Specificity protein 1 (Sp1) transcription factor
inferred← citeshttps://doi.org/10.1016/b978-0-12-819059-3.00016-2openalex-snapshot
Pharmacological interventions part IV: Metabolic modifiers
inferred← citeshttps://doi.org/10.1016/b978-0-12-819668-7.00006-3openalex-snapshot
The success story of drug repurposing in breast cancer
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Lipid metabolism part I
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Clinical trials of nelfinavir protease inhibitor in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.adcanc.2022.100065openalex-snapshot
Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer
inferred← citeshttps://doi.org/10.1016/j.biochi.2016.01.014openalex-snapshot
Nelfinavir targets multiple drug resistance mechanisms to increase the efficacy of doxorubicin in MCF-7/Dox breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.02.085openalex-snapshot
Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology
inferred← citeshttps://doi.org/10.1016/j.clon.2017.03.002openalex-snapshot
Modulating the DNA Damage Response to Improve Treatment Response in Cervical Cancer
inferred← citeshttps://doi.org/10.1016/j.ejps.2020.105401openalex-snapshot
Understanding Breast cancer: from conventional therapies to repurposed drugs
inferred← citeshttps://doi.org/10.1016/j.heliyon.2019.e02526openalex-snapshot
Extracellular binding of indinavir to matrix metalloproteinase-2 and the alpha-7-nicotinic acetylcholine receptor: implications for use in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2018.03.021openalex-snapshot
Primary evidence of the mechanisms of action of HIV aspartyl peptidase inhibitors on Trypanosoma cruzi trypomastigote forms
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2016.12.027openalex-snapshot
Anti-angiogenic potential of trypsin inhibitor purified from Cucumis melo seeds: Homology modeling and molecular docking perspective
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101875openalex-snapshot
Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation
inferred← citeshttps://doi.org/10.1016/j.jconrel.2017.06.001openalex-snapshot
Nanomedicine for prostate cancer using nanoemulsion: A review
inferred← citeshttps://doi.org/10.1016/j.plipres.2020.101080openalex-snapshot
Advances in understanding and in multi-disciplinary methodology used to assess lipid regulation of signalling cascades from the cancer cell plasma membrane
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.03.005openalex-snapshot
Old drugs, new uses: Drug repurposing in hematological malignancies
inferred← citeshttps://doi.org/10.1016/j.semradonc.2016.06.001openalex-snapshot
Translation of Targeted Radiation Sensitizers into Clinical Trials
inferred← citeshttps://doi.org/10.1016/j.tranon.2019.04.006openalex-snapshot
Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00003openalex-snapshot
Induction of the Endoplasmic Reticulum Stress Pathway by Highly Cytotoxic Organoruthenium Schiff-Base Complexes
inferred← citeshttps://doi.org/10.1038/oncsis.2015.49openalex-snapshot
Lipid metabolic reprogramming in cancer cells
inferred← citeshttps://doi.org/10.1038/s41392-025-02539-7openalex-snapshot
Antiviral drug discovery and development: challenges and future directions
inferred← citeshttps://doi.org/10.1038/s41401-023-01165-9openalex-snapshot
Targeting PRSS23 with tipranavir induces gastric cancer stem cell apoptosis and inhibits growth of gastric cancer via the MKK3/p38 MAPK-IL24 pathway
inferred← citeshttps://doi.org/10.1038/s41420-025-02761-wopenalex-snapshot
Nelfinavir triggers ferroptosis by inducing ER stress mediated downregulation of GPX4/GSH system, upregulation of NRF2/HO-1 axis, and mitochondrial impairment in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1038/s41467-022-35089-5openalex-snapshot
PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
inferred← citeshttps://doi.org/10.1038/s41598-019-53207-0openalex-snapshot
Exploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential
inferred← citeshttps://doi.org/10.1038/s41598-022-07247-8openalex-snapshot
Anti-glioblastoma effects of phenolic variants of benzoylphenoxyacetamide (BPA) with high potential for blood brain barrier penetration
inferred← citeshttps://doi.org/10.1038/srep43373openalex-snapshot
Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice
inferred← citeshttps://doi.org/10.1124/molpharm.120.000116openalex-snapshot
Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
inferred← citeshttps://doi.org/10.1128/aac.01002-20openalex-snapshot
The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
inferred← citeshttps://doi.org/10.1136/jclinpath-2015-203467openalex-snapshot
Molecular characteristics and potential therapeutic targets in Merkel cell carcinoma
inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-3323openalex-snapshot
Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
inferred← citeshttps://doi.org/10.1186/s12944-021-01593-8openalex-snapshot
How cancer cells remodel lipid metabolism: strategies targeting transcription factors
inferred← citeshttps://doi.org/10.1186/s43046-022-00137-0openalex-snapshot
Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline—a review
inferred← citeshttps://doi.org/10.1200/oa-25-00088openalex-snapshot
Chemoradiation and Image-Guided Brachytherapy Alone or in Combination With Protease Inhibitor (Nelfinavir Mesylate) in Stage III Cervical Cancer: Results From a Phase III Trial
inferred← citeshttps://doi.org/10.15252/embr.201642194openalex-snapshot
Pharmacological eEF2K activation promotes cell death and inhibits cancer progression
inferred← citeshttps://doi.org/10.2147/ott.s136484openalex-snapshot
The HIV protease inhibitor, nelfinavir, as a novel therapeutic approach for the treatment of refractory pediatric leukemia
inferred← citeshttps://doi.org/10.2174/0929867326666190610152934openalex-snapshot
Repositioning of HIV Aspartyl Peptidase Inhibitors for Combating the Neglected Human Pathogen Trypanosoma cruzi
inferred← citeshttps://doi.org/10.2174/1574885518666230207143523openalex-snapshot
Computational Techniques for Drug Repurposing: A Paradigm Shift in Drug Discovery
inferred← citeshttps://doi.org/10.2174/1871520621666210805125426openalex-snapshot
Formulation and Evaluation of Isradipine Nanosuspension and Exploring its Role as a Potential Anticancer Drug by Computational Approach
inferred← citeshttps://doi.org/10.31083/j.fbl2907242openalex-snapshot
Antiretroviral Drugs Impact Autophagy: Opportunities for Drug Repurposing
inferred← citeshttps://doi.org/10.3389/fonc.2022.809014openalex-snapshot
Epigenetics-Associated Risk Reduction of Hematologic Neoplasms in a Nationwide Cohort Study: The Chemopreventive and Therapeutic Efficacy of Hydralazine
inferred← citeshttps://doi.org/10.3389/fonc.2022.910494openalex-snapshot
Identification of therapeutically potential targets and their ligands for the treatment of OSCC
inferred← citeshttps://doi.org/10.3389/fonc.2024.1329986openalex-snapshot
Impact of oseltamivir on the risk of cancer
inferred← citeshttps://doi.org/10.3389/fphys.2018.00500openalex-snapshot
Drug Repositioning for Effective Prostate Cancer Treatment
inferred← citeshttps://doi.org/10.3390/cancers12051113openalex-snapshot
Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer
inferred← citeshttps://doi.org/10.3390/cancers12113437openalex-snapshot
The Anti-Cancer Properties of the HIV Protease Inhibitor Nelfinavir
inferred← citeshttps://doi.org/10.3390/cancers13050949openalex-snapshot
HIV-1 Protease Inhibitors Slow HPV16-Driven Cell Proliferation through Targeted Depletion of Viral E6 and E7 Oncoproteins
inferred← citeshttps://doi.org/10.3390/cancers13112545openalex-snapshot
Molecular and Cellular Mechanisms of Metformin in Cervical Cancer
inferred← citeshttps://doi.org/10.3390/cancers16132381openalex-snapshot
Discovering Potential in Non-Cancer Medications: A Promising Breakthrough for Multiple Myeloma Patients
inferred← citeshttps://doi.org/10.3390/ijms20174278openalex-snapshot
Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies
inferred← citeshttps://doi.org/10.3390/ijms20215438openalex-snapshot
Synergy Between Low Dose Metronomic Chemotherapy and the pH-Centered Approach Against Cancer
inferred← citeshttps://doi.org/10.3390/ijms22116070openalex-snapshot
Off-Target-Based Design of Selective HIV-1 PROTEASE Inhibitors
inferred← citeshttps://doi.org/10.3390/v13091852openalex-snapshot
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo
inferred← citeshttps://doi.org/10.3892/ijo.2020.4966openalex-snapshot
New drugs are not enough‑drug repositioning in oncology: An update
inferred← citeshttps://doi.org/10.3892/ol.2023.13899openalex-snapshot
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro
inferred← citeshttps://doi.org/10.5530/ijper.56.2s.83openalex-snapshot
Repurposing: A Potentially Emerging Discipline
inferred← citeshttps://doi.org/10.6084/m9.figshare.17010237openalex-snapshot
Additional file 1 of How cancer cells remodel lipid metabolism: strategies targeting transcription factors
inferred← citeshttps://doi.org/10.70675/1d51b9d6z9a12z41f9z8f98z0c7f955aeb54openalex-snapshot
Factors that contribute to B cell oncogenesis in people living with HIV
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